MalariaWorld journal最新文献

{"title":"Africa cannot afford to wait for malaria treatment failure.","authors":"Deepa Pindolia, Rosario Martinez-Vega, Gulnaz Uzakbayeva, Deus Ishengoma, Olivia Ngou, Roly Gosling","doi":"10.5281/zenodo.19825249","DOIUrl":"https://doi.org/10.5281/zenodo.19825249","url":null,"abstract":"<p><p>For more than two decades, artemisinin-based combination therapies (ACTs) have been the backbone of malaria treatment across Africa. They have saved millions of lives and averted many malaria cases. That foundation is now under threat. Artemisinin partial resistance (ART-R) is now being detected using molecular surveillance across eastern Africa, the Horn of Africa, and southern Africa. It has already been confirmed in four countries: Rwanda, Uganda, Eritrea and Tanzania, with signals reported in several neighbouring countries [1].</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical malaria hotspots according to transmission levels in two health areas of the Kolondieba health district, Mali.","authors":"Ibrahima Berthé, Mady Cissoko, Modibo Diarra, Donatien Serge Mbaga, Mamady Koné, Ahmadou Boly, Ousmane Boua Togola, Bayaya Haidara, Ismaila Théra, Abdoulaye Ongoiba, Tahirou Togola, Amagoron Dit Mathias Dolo, El Hadji Issa Amaguiré Sy, Abdramane Konaté, Youssouf Coulibaly, Lassana Sissoko, Issa Bougoudogo, Bakary Niangado, Abdou Togola, Dramane Traore, Leon Paul Rabarijaona, Kalifa Keita, Bouyagui Traoré, Cheick Amadou Tidiane Traoré, Issaka Sagara","doi":"10.5281/zenodo.19822964","DOIUrl":"https://doi.org/10.5281/zenodo.19822964","url":null,"abstract":"<p><strong>Background: </strong>Despite significant progress, malaria remains a major challenge in Mali, due to heterogeneous transmission. The WHO 'High Burden to High Impact' strategy advocates targeting of high-transmission areas. This study aimed to identify clinical malaria hotspots in two health areas within the Kolondieba district with differing transmission levels.</p><p><strong>Materials and methods: </strong>A retrospective cross-sectional study analysed 35,934 confirmed malaria cases extracted from consultation registers between 2019 and 2021 in the health areas of Kadiana (high risk) and Kolondieba Central (moderate risk). Transmission periods were determined in each zone by analysing variations in mean incidence trends, and high-risk clusters (hotspots) were identified using Kulldorff's method according to these periods.</p><p><strong>Results: </strong>Transmission periods and hotspot identification (2019-2021) revealed distinct dynamics between the two health areas. In Kadiana, the majority of clusters remained stable, with persistent hotspots across all eight periods (Kadiana and Tienkourani; RR: 1.8-6.3). In Kolondieba Central, hotspot dynamics evolved from a localised configuration (1 to 2 villages) towards spatial expansion, with more extensive clusters appearing during the final periods (RR: 1.7-2.2). Kolondieba town remained a persistent hotspot.</p><p><strong>Conclusions: </strong>This study confirms the heterogeneity of transmission at a fine scale, with stable hotspots even in both moderate and high-risk areas. It is essential to focus on human mobility to guide malaria control interventions.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Zionist decolonisation of rural malaria control in Palestine from 1922 onwards - what it teaches.","authors":"Anton Alexander","doi":"10.5281/zenodo.19186768","DOIUrl":"10.5281/zenodo.19186768","url":null,"abstract":"<p><p>In 1918, the British Army, having just defeated the Turkish Army in Palestine, intimated that the future of Palestine was considered hopeless due to the severity of malaria in the country. The British Army's victory was partially attributable to its employment for six months of thousands of mainly Egyptian labourers to control the disease in the country through destruction of mosquito breeding sites. When the control ceased on 19^th September 1918, the disease returned shortly thereafter. Due to the disease, the country was desolate and was either almost empty or uninhabitable in many rural areas. With the dream of a Jewish Homeland somewhere in Palestine, the Zionists were obliged to view malaria control as a priority. But the Zionists were unable to conduct malaria control in the same manner as that carried out by the British Army due to lack of finances and manpower that were available to the British Army. The Zionists were obliged, therefore, to think creatively and set about launching the first start of a sustainable malaria control programme for the whole country, of which it is only now realised that it was also the first step anywhere in the decolonisation of malaria control, an approach that was conducted by all the inhabitants for all the inhabitants.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musings from a Vectosaur: Malaria in 2026.","authors":"Manuel F Lluberas","doi":"10.5281/zenodo.18923229","DOIUrl":"https://doi.org/10.5281/zenodo.18923229","url":null,"abstract":"<p><p>For more than two decades, global malaria reports have presented an encouraging narrative: expanding programme coverage, billions invested, and steady declines in mortality. Yet those who spend their evenings beside light traps and breeding sites often see a more complicated reality. Beneath the reassuring graphs lies a persistent operational question: Are we winning the fight against malaria, or are we simply becoming better at reporting progress while our ability to measure it remains uncertain? The 2025 Africa Malaria Progress Report captured this tension candidly, noting that \"behind the figures lies a stark truth: we remain off-course and the 'perfect storm' of threats has intensified.\" I argue that the problem confronting malaria control today is not merely financial or clinical. Rather, it is structural. Modern malaria programmes rely overwhelmingly on two tools: Long-lasting insecticidal nets and indoor residual spraying. Both interventions have saved countless lives, but neither was ever designed to carry the entire burden of vector control indefinitely. Under sustained pressure, mosquito populations are responding exactly as evolutionary biology predicts: Through increasing insecticide resistance and shifts in feeding and resting behaviour that circumvent indoor interventions. At the same time, new ecological challenges, including climate change and the expansion of <i>Anopheles stephensi</i> into African urban environments, are adding complexity to already strained systems. Equally troubling is the fragmentation of malaria control across numerous institutions, funding streams, and implementation structures that often operate in parallel rather than as a unified system. Re-establishing integrated vector management by combining surveillance, larval source management, environmental control, and targeted adult mosquito control interventions under coordinated national programmes may offer a more resilient path forward. Mosquitoes respond to pressure. Successful malaria programmes must learn to do the same.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semi-field evaluation of efficacy and residual activity of a microencapsulated pyriproxyfen formulation on <i>Anopheles arabiensis</i> emergence inhibition.","authors":"Anitha Mutashobya, Augustino Thabiti Mmbaga, Simon Twaha Mnzava, Hulda Swai, Halfan Ngowo, Dickson Wilson Lwetoijera","doi":"10.5281/zenodo.18649256","DOIUrl":"https://doi.org/10.5281/zenodo.18649256","url":null,"abstract":"<p><strong>Background: </strong>The integration of larviciding as a supplementary tool for malaria vector control requires effective larvicide formulations that are specifically suited to the target vector species, environmentally friendly, and cost-effective to reflect the needs of resource-limited settings in sub-Saharan Africa. This study evaluated the sublethal effect and its residual activity of two microencapsulated pyriproxyfen formulations containing 33% and 50% active ingredient (AI) against <i>Anopheles arabiensis</i> larvae exposed to sublethal doses.</p><p><strong>Materials and methods: </strong>Sublethal effects on fitness parameters, including fecundity and wing length, were evaluated at concentrations that resulted in 20%, 50%, and 70% emergence inhibition, obtained from a dose-response curve. In three replicates across all three concentrations, fecundity was assessed in 25 adult females, while wing length was measured in 33 adult males and 33 adult females. Residual activity was assessed by exposing 200 3^rd-instar larvae of <i>An. arabiensis</i> to each formulation at 0.06 mg/L 33% AI and 0.09 mg/L 50% AI in 5 replicates of artificial habitats. Once all mosquitoes had either emerged or died, a new batch of larvae was introduced every 2 weeks for 6 months.</p><p><strong>Results: </strong>Females emerged from concentrations inhibiting 70% of larval emergence exhibited significantly reduced fecundity; 88% for 33% AI [RR = 0.12, 95% CI: 0.11, 0.13, p < 0.001] and 85% for 50% AI [RR = 0.14, 95% CI: 0.07, 0.32, p < 0.001]. Adults emerged from sublethal concentrations had reduced body size, decreasing as concentration increased. Residual activity on emergence inhibition was 14.4% [13.2%, 15.6%], and 23.1% [18.7%, 27.5%], relative to 23% and 14% for 33% and 50% AI, respectively in the 6^th month. Control mortality was consistently below 10% during the entire evaluation period.</p><p><strong>Conclusion: </strong>These findings demonstrate the efficaciousness and long-lasting potential of microencapsulated pyriproxyfen formulations to target <i>An. arabiensis</i>, and highlight its consideration for application in larviciding programmes<b>.</b></p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12926616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No G6PD A- (G202A) variant detected among <i>Plasmodium falciparum</i>-positive patients in Awka, Southeast Nigeria: a hospital-based study.","authors":"Moses Ikegbunam, Nwokike Uchechukwu, Harrison Abone, Ani Ezinne Grace, Mercy Ezeunala, Nnanna Joy, Nzeukwu Chibumma Immaculata, Joy Ogugua Igwe, Obiageli Okeke, Frances Nworji, Peter Ihekwereme","doi":"10.5281/zenodo.18552048","DOIUrl":"https://doi.org/10.5281/zenodo.18552048","url":null,"abstract":"<p><strong>Background: </strong>Glucose-6-phosphate dehydrogenase (G6PD) deficiency, prevalent in malaria-endemic regions, has been associated with a reduced risk of severe malaria due to impaired parasite growth in deficient erythrocytes. The G6PD gene, located on the X chromosome, harbours various mutations associated with differing enzyme activity levels. This study investigates the prevalence of G6PD deficiency variants and their impact on parasite density and haemoglobin levels among malaria-positive patients in Awka, Anambra State, Nigeria.</p><p><strong>Materials and methods: </strong>Blood samples were collected from 100 malaria positive participants; 64 participants with complete genotyping and clinical data were included in the analysis and screened for the A376G and G202A variants using PCR and Sanger sequencing.</p><p><strong>Results: </strong>Molecular analysis indicated that the B variant (normal) was predominant, with 83% of the participants possessing this variant. None of the participants tested had the A- variant, associated with G6PD defciency, suggesting no evidence of the G202A (A-) variant in this hospital-based sample. The B variant and the A+ variant showed no significant impact on the haemoglobin and parasitaemia levels of the study participants.</p><p><strong>Conclusions: </strong>The findings support the absence of the G202A (A-) variant in this cohort and show no detectable differences in parasitaemia or haemoglobin between A+ and B genotypes. Broader genotyping and/or G6PD enzyme activity testing in community representative samples is recommended before drawing population-level conclusions or informing treatment policy.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12906981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining the Wash Resistance Index to predict insecticidal durability of mosquito nets.","authors":"Ole Skovmand, Duoc M Dang, Trung Q Tran, Rune Bosselmann, Sarah J Moore","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Insecticide-treated nets (ITNs) are a core malaria vector control intervention recommended by the World Health Organization (WHO). To obtain WHO endorsement, ITNs must demonstrate sustained bio-efficacy after repeated washing through standardised laboratory and semi-field evaluations. Wash resistance (WR) is typically evaluated over 20 washes (WR20) to approximate three years of use. Routine WR20 testing is impractical for quality control. To address this, the Collaborative International Pesticides Analytical Council (CIPAC) introduced the Wash Retention Index (WRI), based on four consecutive daily washes. The WRI was defined as the fourth root of the ratio of insecticide content after four washes to the initial content and adopted as a quality-control specification. This article examines the WRI and the prediction of WR20 when including or excluding the first wash with the aim to define a WRI method that more accurately reflects WR20, while remaining practical. Because surface insecticide may increase during storage due to diffusion from the polymer, the effect of excluding the first wash from index calculations to reduce storage-related variability was assessed.</p><p><strong>Materials and methods: </strong>WR data were extracted from WHO Pesticide Evaluation Scheme (WHOPES) reports, and WRI values calculated assuming 1-day washing intervals. Additional data were generated from polyester and polyethylene nets with insecticide content quantified.</p><p><strong>Results: </strong>When WR20 was regressed on WRI (including the first wash), the model fit was weaker and significant effects of insecticide chemistry and polymer were retained, indicating that WRI does not capture intrinsic wash-off kinetics. In contrast, new WR (excluding the first wash) explained more variance in WR20 (adjusted R²= 0.76 vs 0.71), with a slope approaching proportionality (0.66 vs 0.31) and with no residual effects of chemistry or polymer.</p><p><strong>Conclusions: </strong>Excluding the first wash from WRI improves prediction of WR20. First-wash loss reflects production and storage effects rather than intrinsic wash resistance. Wash resistance can be more intuitively expressed as the Wash-Off Rate Index (WORI), representing average wash-off between washes 1-5.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria in Palestine: the elephant in the room.","authors":"Anton Alexander","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper examines the overlooked, forgotten or even ignored role played by malaria when considering the start of the Arab-Israel conflict in the Middle East. It would seem that anything associated with Zionism or Israel today is vilified, boycotted or shunned in certain quarters. Thus, by choosing to boycott anything that had a connection with Zionism or Israel, a study of the steps and events leading to the launch of the first start of sustainable malaria control has been missed, discouraging the malaria community of an opportunity to consider why and how certain methods were employed to achieve a desired successful outcome. In particular, there appears to be an attempt to suppress the fact that Palestine over 100 years ago was desolate, in many rural areas it was either almost empty or uninhabitable, due to the severity of the disease.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative proteomic profiling of malaria-derived microparticles: A mass spectrometry-based study.","authors":"Samuel Antwi-Baffour, Jonathan Kofi Adjei, Francis Agyemang-Yeboah, Max Annani-Akollor, Ransford Kyeremeh, George Awuku Asare, Ben Gyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains a major public health challenge, causing high mortality and morbidity, particularly in developing countries. Microparticles (MPs), also known as plasma membrane-derived extracellular vesicles (PMEVs), are sub-cellular structures formed by budding off the plasma membrane. Although present in healthy individuals, their numbers increase during pathological conditions such as malaria. While several studies have examined proteins in cell-specific MPs, limited information exists on the protein composition of circulating MPs in malaria and their link to disease symptoms. This study aimed to perform proteomic analyses of MPs from malaria-positive samples, parasite culture supernatants, and healthy controls to elucidate their role in malaria infection.</p><p><strong>Materials and methods: </strong>Plasma samples were obtained from forty-three (43) malaria diagnosed patients (cases) and ten (10) healthy individuals (controls). MPs were isolated from malaria parasite culture supernatant and confirmed using flow cytometry. 2D LC-MS was done to obtain their protein content. Resultant data were analysed using SPSS Ver. 21.0 statistical software, Kruskal Wallis test and Spearman's correlation coefficient r.</p><p><strong>Results: </strong>In all, 1806 proteins were isolated from the samples. The MPs from malaria-positive samples recorded 1729 proteins, those from culture supernatant 333 while the control samples recorded 234 proteins. The mean number of proteins in MPs of malaria positive samples was significantly higher than that in the control samples. Significantly, higher quantities of haemoglobin subunits were seen in MPs from malaria samples and culture supernatant compared to control samples.</p><p><strong>Conclusions: </strong>A great number of proteins were observed to be carried in the MPs from malaria samples and culture supernatant compared to controls. The greater loss of haemoglobin from erythrocytes via MPs from malaria patients could serve as the initiation and progression of anaemia in <i>P. falciparum</i> infection. Also while some proteins were up-regulated in circulating MPs in malaria, others were down-regulated.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"17 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, perception and influences on uptake of the RTS,S/AS01 malaria vaccine among caregivers for children under 5 years in South West region, Cameroon.","authors":"Jude Che Anye, Loveline Lum Niba, Omarine Njimanted, Eugene Enah Fang, Besong Tabot Itoe, Ebua Gallus Fung, Hermann Georges Ewi-Kang, Helen Kuokuo Kimbi","doi":"10.5281/zenodo.18008087","DOIUrl":"10.5281/zenodo.18008087","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains a major cause of morbidity and mortality among children under five in Cameroon. The recent introduction of the RTS,S/AS01 malaria vaccine provides an important opportunity to reduce the disease burden. However, little is known about caregivers' awareness and perceptions during the early vaccine rollout. This study explored caregivers' understanding, attitudes, and experiences regarding the malaria vaccine in selected urban and rural communities in the South West Region of Cameroon, forming part of a broader mixed-methods project aimed at informing strategies to strengthen vaccine uptake.</p><p><strong>Methods: </strong>An exploratory qualitative design was used, involving two focus group discussions with 20 mothers and caregivers of children aged 11-30 months. Participants were purposively selected to capture diverse perspectives across settings. Discussions examined awareness, perceived benefits, misconceptions, and contextual factors shaping vaccine uptake. Data were audio-recorded, transcribed, translated, and analysed thematically using an inductive deductive coding approach.</p><p><strong>Results: </strong>Findings showed that caregivers in the urban setting had high awareness of the malaria vaccine, though understanding was often limited and sometimes confused with other malaria interventions. Rural caregivers displayed uneven awareness but strong trust in health workers, which positively influenced acceptance. Across both settings, perceived benefits such as reduced severity of malaria episodes enhanced confidence in the vaccine. Barriers included communication gaps, misinformation, gender dynamics, long waiting times, and distance to health facilities. Caregivers recommended strengthening community-based communication through churches, town criers, health talks, outreach sessions, and visual materials.</p><p><strong>Conclusion: </strong>These findings highlight the importance of clear, consistent communication and trust-building as Cameroon expands malaria vaccine implementation. Enhanced community engagement and improved service delivery may support equitable uptake. The insights from this qualitative phase offer a foundation for further research within the wider mixed-methods project.</p>","PeriodicalId":74100,"journal":{"name":"MalariaWorld journal","volume":"16 ","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12741994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}