Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献_第6页

Serum Matrix Metalloproteinase-2: A Possible Link between COVID-19 and Periodontitis 血清基质金属蛋白酶-2:COVID-19与牙周炎的可能联系

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-02-28 DOI: 10.32947/ajps.v23i1.985

Suhad Jumaa Abd-Alkareem, Saad Hikmat Abdullah, Noor Dhia Hasan

{"title":"Serum Matrix Metalloproteinase-2: A Possible Link between COVID-19 and Periodontitis","authors":"Suhad Jumaa Abd-Alkareem, Saad Hikmat Abdullah, Noor Dhia Hasan","doi":"10.32947/ajps.v23i1.985","DOIUrl":"https://doi.org/10.32947/ajps.v23i1.985","url":null,"abstract":"Background: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is a severe infection primarily targeting the respiratory system. However, many other extrapulmonary body organs are also \u0000affected with a varying degree of severity. Some evidence indicated the development of periodontist in patients, although the pathogenesis is not well-defined. \u0000Aims: This study aimed to investigate the association of COVID-19 severity and role of matrix metalloproteinase 2 in development of periodontitis. \u0000Patients and Methods: This is a cross sectional study which included a total of 160 patients with COVID-19. Patients were categorized into severe and mild-moderated according to World Health Organization criteria. Periodontitis was diagnosed in those patients according to clinical criteria. Serum level of matrix metalloproteinase 2 was estimated in all patients using enzyme linked immunosorbent assay (ELISA). Demographic and laboratory data were obtained from the patients’ records. \u0000Results: Forty-two patients (26.25%) had severe COVID-19. Demographically, older ages and the presence of comorbidities were significantly associated with COVID-19 severity. Besides the inflammatory markers, the median serum level of MMP-2 was higher in severe than mild-moderate COVID-19 cases (208.12 ng/ml vs. 196.33 ng/ml) with a significant difference. The PO rate in severe and mild-moderate COVID-19 was 23.81% and 10.17%, respectively, with a significant difference. The median serum MMP-2 in patients with PO was 228.5 ng/ml which was significantly higher than those without PO 193.81 ng/ml. \u0000Conclusions: These data indicate the significant association between COVID-19 severity and development of PO. Matrix metalloproteinase-2 could be the possible link between severe COVID-19 and PO.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79741458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Insights into medicated films as attractive dosage forms 洞察药物薄膜作为有吸引力的剂型

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-02-28 DOI: 10.32947/ajps.v23i1.981

Noor Hameed Alsaide, Nidhal Khazaal Maraie

引用次数: 0

Tamoxifen Citrate- loaded synthetic high-density lipoproteins: Assessment of cellular toxicity in breast cancer cells 负载柠檬酸他莫昔芬的合成高密度脂蛋白:乳腺癌细胞毒性的评估

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-02-28 DOI: 10.32947/ajps.v23i1.987

Ameerah A. Radhi, Wedad K. Ali, Fitua Al-Saedi

{"title":"Tamoxifen Citrate- loaded synthetic high-density lipoproteins: Assessment of cellular toxicity in breast cancer cells","authors":"Ameerah A. Radhi, Wedad K. Ali, Fitua Al-Saedi","doi":"10.32947/ajps.v23i1.987","DOIUrl":"https://doi.org/10.32947/ajps.v23i1.987","url":null,"abstract":"Tamoxifen Citrate (TC) is the standard endocrine therapy for estrogen receptor (ER) positive breast cancer. TC is a selective estrogen receptor modulator (SERM) whose estrogenic properties in uterus have been linked to increased side \u0000effects like blood clots, endometrial polyps and cancer. Therefore, significant amount of research has been carried out to develop tamoxifen loaded nano-formulations with a preferential accumulation in tumor tissue rather than healthy tissues. \u0000Synthetic high-density lipoproteins (sHDL) are novel nanocarriers with inherent active-targeting ability towards tumor cells through the ligand–receptor interaction between apolipoprotein A-I (Apo A-I) and scavenger receptor class B type I (SR-BI) overexpressed in various malignant cells. The current study was carried out to investigate whether encapsulation of TC in sHDL could improve the cytotoxic effect of TC against malignant cells. For this purpose, the cytotoxicity of TC-sHDL was evaluated in MCF-7 cell line in vitro. MTT assay demonstrated the increased cytotoxicity of TC-sHDL against cancer cells as compared with the cytotoxic effect of the free drug.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76795930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Cr, Se, Ge, and V in Hypothyroidism Patients by Using Graphite Furnace Atomic Absorption Spectrometry and mixture matrix modification 石墨炉原子吸收光谱法和混合基体改性法测定甲状腺功能减退患者的Cr、Se、Ge和V

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-02-28 DOI: 10.32947/ajps.v23i1.986

Halah Hamid Hammadi

{"title":"Determination of Cr, Se, Ge, and V in Hypothyroidism Patients by Using Graphite Furnace Atomic Absorption Spectrometry and mixture matrix modification","authors":"Halah Hamid Hammadi","doi":"10.32947/ajps.v23i1.986","DOIUrl":"https://doi.org/10.32947/ajps.v23i1.986","url":null,"abstract":"A simple, accurate and rapid method was developed for routine determination of trace elements in blood serum. The method based on the direct determination for Cr, Se, Ge, and V in hypothyroidism patients before therapy. By using atomic absorption spectrometry with graphite surface coated and uncoated pyrolysis GF-AAS, and a mixture of palladium nitrate and magnesium nitrate as the matrix modifier, with deuterium background correction and no sample pretreatment except dilution was necessary. This permitted direct determination hence the risk of sample contamination was reduced. Further, the use of graphite surface-coated GF-AAS decreased the ashing and atomization temperatures of Cr, Ge, and V to values that were lesser than the corresponding values obtained using uncoated pyrolysis GF-AAS, by 100°C; in case of Se, the atomization temperature decreased to a value that was 200°C lesser than that obtained using uncoated pyrolysis GF-AAS. \u0000A mixture of (3µL) palladium nitrate, and (2µL) magnesium nitrate was successfully applied to improve the sensitivity, reproducibility, recovery, limit of detection and the accuracy of the measurements. The correlation coefficients of the calibration curves of Cr, Se, Ge, and V were found to be (0.9999, 0.9999, 0.9995 and 0.9999) respectively, the relative standard deviation of the measurements for Cr, Se, Ge and V were (0.027, 0.075, 0.054 and 0.068) respectively. The statistical analysis of the acquired data showed acceptable accuracy. The analyses thus performed indicated that the levels of serum trace elements Cr, Se, Ge, and V in hypothyroidism patients were lower than those in the control group.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84396476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of antenatal depressive and anxiety symptoms on adverse birth outcomes in Baghdad, Iraq: a prospective cohort study 伊拉克巴格达产前抑郁和焦虑症状对不良分娩结局的影响:一项前瞻性队列研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-02-28 DOI: 10.32947/ajps.v23i1.988

Ola Ali Nassr, Mohammed Mahmood Mohammed, Hind abdulkhaliq Showman

{"title":"Impact of antenatal depressive and anxiety symptoms on adverse birth outcomes in Baghdad, Iraq: a prospective cohort study","authors":"Ola Ali Nassr, Mohammed Mahmood Mohammed, Hind abdulkhaliq Showman","doi":"10.32947/ajps.v23i1.988","DOIUrl":"https://doi.org/10.32947/ajps.v23i1.988","url":null,"abstract":"Background: Psychiatric symptoms are common during pregnancy, potentially leading to an increased risk of adverse birth outcomes. Studies assessing the impact of depression and/or anxiety on adverse birth outcomes in Iraq are currently lacking. This study aims to \u0000 \u0000determine whether depression and/or anxiety is independently associated with preterm birth (PTB) and low birth weight (LBW). \u0000Methods: A prospective cohort study included 352 pregnant women from outpatient clinics of Al-Yarmouk hospital and private clinics in Baghdad, Iraq from March 2021 to February 2022 using a convenience sampling. They were screened for depression using Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and followed up to assess adverse birth outcomes. Multivariable logistic regression was used to determine predictors associated with adverse birth outcomes. \u0000Results: The prevalence of PTB and LBW was 7.7% and 11.6%, respectively. After adjustment of all potential sociodemographic, clinical and obstetric confounders, depression was independently associated with giving birth to LBW neonate (odd ratio (OR):3.64; 95% confidence interval (CI) 1.70, 7.79), but not PTB. Prevalence of LBW in depressed was 21.2% compared to 7.7% for non-depressed. LBW was also associated with a history of LBW and PTB. In contrast, anxiety did not seem to affect birth outcomes. \u0000Conclusion: Depression during pregnancy, regardless of the trimester, is independently associated with a higher likelihood of giving birth to LBW neonates (OR: 3.64; 95% CI 1.70, 7.79). Effective interventions that target maternal depression are vital to decrease morbidity and mortality associated with LBW. ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91328052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Molecular Docking, Synthesis and Preliminary Evaluation of Antibacterial Activity of Levofloxacin Carboxamides with Certain Amino Acids 含氨基酸左氧氟沙星羧胺类药物的硅分子对接、合成及抗菌活性初步评价

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-02-28 DOI: 10.32947/ajps.v23i1.984

Sarah Abdul-Razzaq makki, Shakir M. Alwan, Mayada H. Al-Qaissy

{"title":"In Silico Molecular Docking, Synthesis and Preliminary Evaluation of Antibacterial Activity of Levofloxacin Carboxamides with Certain Amino Acids","authors":"Sarah Abdul-Razzaq makki, Shakir M. Alwan, Mayada H. Al-Qaissy","doi":"10.32947/ajps.v23i1.984","DOIUrl":"https://doi.org/10.32947/ajps.v23i1.984","url":null,"abstract":"Levofloxacin carboxamides with certain amino acids were prepared through an amide linkage to the amino acid (glycine, histidine, or serine). These carboxamides were subjected to an in silico molecular docking evaluation on \u0000 \u0000DNA gyrase to predict their antibacterial activity using the GOLD suite. The binding affinities were very significant and encouraged the synthesis of the suggested carboxamides for intensive evaluation. These carboxamides were also subjected to Swiss ADME software to predict their ADME parameters. Levofloxacin carboxamides were prepared in high yield, and their chemical structures were confirmed by spectral analysis, such as 1H-NMR, 13C-NMR and FT-IR spectroscopy. Antibacterial activities were evaluated for the new carboxamides against two G-ve (Klebsiella and P. aeruginosa) and one G+ve (Streptococcus pneumonia) bacteria. When compared to levofloxacin, all of the synthesized carboxamides 1-3 demonstrated good activity against three types of bacteria. These carboxamides showed significant antibacterial activities against S. pneumoniae and lower activities against Klebsiella.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87938871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and in-vitro Evaluation of Ethosomes using Anastrozole as a Modeling Drug 以阿那曲唑为模型药的溶栓体的制备及体外评价

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-01-15 DOI: 10.32947/ajps.v22i4.971

Neven Nasef AlEbadi, M. Al-lami

{"title":"Formulation and in-vitro Evaluation of Ethosomes using Anastrozole as a Modeling Drug","authors":"Neven Nasef AlEbadi, M. Al-lami","doi":"10.32947/ajps.v22i4.971","DOIUrl":"https://doi.org/10.32947/ajps.v22i4.971","url":null,"abstract":"Anastrozole (ANZ) is a potent non-steroidal aromatase II inhibitor (AI) used to decrease or delay the progression of breast tumor growth in some women. Since ANZ could be delivered transdermally due to its physicochemical characteristics as (log p of 3.5, aqueous solubility of 0.5 mg /mL, low dosage and half-life of 46.8 hr.) so, it could be used as a modelling drug evaluation of ethosomes, the current study aimed to formulate ANZ loaded ethosomes and evaluate the formulated ethosomes for particle size and PDI, entrapment efficiency and in vitro release profile. Film hydration method was used to prepare ANZ-loaded ethosoms. using different ratios of phospholipid (Soy phosphatidyl choline) and ethanol at variables probe sonication energy and time ratios. \u0000 polydispersity index and particle size were used to evaluate the prepared ANZ-loaded ethosoms. The optimized formula of ethosomes which contain (1% Soy phosphatidyl choline,20% ethanol subjected to 300watt sonication energy with 1/3 sonication on /off ratio) was studied for in vitro drug release. It had 127.75±0.36 nm particle diameter and 74.7136 ± 3.457 % entrapment efficiency, the release kinetics obey Korsmeyer-Peppas and non-Fickian release as R2=0.9779 and n=0.737. \u0000 The ratios of Soy phosphatidyl choline, ethanol, sonication energy and duration had a significant impact on the particle size of ethosomes at (p0.05). The preformulating analysis of Powder X-ray diffraction (P-XRD) indicate amorphous ethosomes. Fourier transform infrared (FTIR) showed the inertness among components.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76068925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmacological Evaluation of New 4, 5-dihydro-1H- Pyrazole-1-yl acetate Derivatives as anti-cancer agents 新型4,5 -二氢- 1h -吡唑-1-乙酸酯衍生物抗癌药物的药理评价

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-01-15 DOI: 10.32947/ajps.v22i4.963

Shahlaa Zuhair Abdul-Majeed, Monther Faisal Mahdi, Suhad Faisal Hatem Al-Mugdadi

{"title":"Pharmacological Evaluation of New 4, 5-dihydro-1H- Pyrazole-1-yl acetate Derivatives as anti-cancer agents","authors":"Shahlaa Zuhair Abdul-Majeed, Monther Faisal Mahdi, Suhad Faisal Hatem Al-Mugdadi","doi":"10.32947/ajps.v22i4.963","DOIUrl":"https://doi.org/10.32947/ajps.v22i4.963","url":null,"abstract":"A series of nine novel 4, 5-dihydro-1H- pyrazole-1-yl acetate derivatives (IVa-i) by Shahlaa et al. was investigated in vitro for their antiproliferative activity against two cancer cell lines, breast cancer cell line (MCF-7) and lung cancer cell lines (A549), According to \u0000 \u0000the cytotoxicity effect of these compounds, IVa, IVc and IVi compounds have antiproliferative effect with percentage (81.30%, 87.4% & 54.66%) respectively at 72h treatment on MCF-7 cell line compared to other compounds, these results indicate that the new compound IVc have the higher antiproliferative percent comparable to tamoxifen as a standard anti-tumour for oestrogen receptor positive breast cancer cell line after 72h followed by IVa after 72h (83.31%). cytotoxicity effect of compound IVb was highest among tested compounds on lung cancer cell line (A549) with antiproliferative percentage (58.49% & 75.04%) at 48 & 72h respectively, but it is less than erlotinib as a standard anti-tumour for lung cancer cell line cytotoxicity effect (77.10% & 82.46%) at these times. three compounds (IVa, IVc & IVi) have antiproliferative effect on breast cancerous cell line (MCF-7) and compound (IVc) have inhibition percentage comparable to that of the authorized medication Tamoxifen. One compound (IVb) had antiproliferative activity, but less than that of erlotinib on lung cancerous cell line (A549) and there is good agreement between our docking results and the experimental results.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86186164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis A New Bis Oxazine and Thiazine Derivatives and Study Their Biological Activities 一种新的双恶嗪和噻嗪衍生物的合成及其生物活性研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-01-15 DOI: 10.32947/ajps.v22i4.962

Dina Saleem M. Ameen

引用次数: 0

Case study of two Iraqi patients with Mucopolysaccharidosis (Hurler syndrome "type I" and Maroteaux-Lamy syndrome "type VI") treated with Hematopoietic Stem Cell Transplantation (HSCT) 造血干细胞移植治疗伊拉克粘多糖病(Hurler综合征“I型”和Maroteaux-Lamy综合征“VI型”)2例

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2023-01-15 DOI: 10.32947/ajps.v22i4.958

Furqan M. Abdulelah, Mohammed M. Mohammed, Rabab Hassan Baaker

{"title":"Case study of two Iraqi patients with Mucopolysaccharidosis (Hurler syndrome \"type I\" and Maroteaux-Lamy syndrome \"type VI\") treated with Hematopoietic Stem Cell Transplantation (HSCT)","authors":"Furqan M. Abdulelah, Mohammed M. Mohammed, Rabab Hassan Baaker","doi":"10.32947/ajps.v22i4.958","DOIUrl":"https://doi.org/10.32947/ajps.v22i4.958","url":null,"abstract":"Mucopolysaccharidosis I (MPS I) or Hurler and Mucopolysaccharidosis VI (MPS VI) or Maroteaux-Lamy syndrome are infrequent genetic disorder inherited as an autosomal recessive disease attributed to genetic \u0000 \u0000variants genetic variant causing α-L iduronidase (IDUA) and arylsulfatase B (ARSB)enzyme deficiency, respectively. Here, two cases of children suffering from MPS disorder were described, the first case was MPS I while the second case was MPS VI and both cases were treated with allogenic Hematopoietic Stem Cell Transplantation approach in order to limit skeletal deterioration and retard neurocognitive alterations and hence, improve the quality of life of affected children. Following Transplantations outcomes reveal a full engraftment of donor cells as well as improvement of recipient enzymatic activity, enzyme replacement therapy post-transplantation will augment transplantation clinical outcomes. Transplantation will be more successful if the disease diagnosed early before the severe irreversible symptoms ensue.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72945691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0