Ayoung Kang, Sung Hwan Cho, Byung-Soo Park, Gyung Mo Son, Hyun Sung Kim, Jae-Joon Kim, Su Jin Kim, Dong Hoon Shin, Tae Un Kim
{"title":"Perianal extragastrointestinal stromal tumor.","authors":"Ayoung Kang, Sung Hwan Cho, Byung-Soo Park, Gyung Mo Son, Hyun Sung Kim, Jae-Joon Kim, Su Jin Kim, Dong Hoon Shin, Tae Un Kim","doi":"10.14216/kjco.20021","DOIUrl":"https://doi.org/10.14216/kjco.20021","url":null,"abstract":"<p><p>An extragastrointestinal stromal tumor (EGIST) is a gastrointestinal stromal tumor that arises outside of the gastrointestinal tract. Most EGISTs are located in the omentum, mesentery, and retroperitoneum. The occurrence of an EGIST at the perianal region is very rare. Herein, we report our experience with EGISTs in the perianal area and review the literature. A 70-year-old man presented to our hospital with a 2-year history of anal discomfort. A pelvic magnetic resonance imaging scan showed a homogenous, well-defined, soft tissue density mass. The patient underwent mass excision, and the pathological examination confirmed that the mass was an EGIST. The size of the tumor was 4.3×3.2 cm, and the mitotic count was 1 per 50 high-power fields. The tumor cells were immunohistochemically positive for KIT and CD34 but were negative for S-100 and alpha-smooth muscle actin. There were no other abnormal findings in the gastrointestinal tract; upon pathological review, this case was confirmed as perianal EGIST. Therefore, EGIST should be considered as a differential diagnosis of perianal masses.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"138-141"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/27/kjco-16-2-138.PMC9942734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk factors of elderly patients with postoperative delirium following major abdominal surgery for cancer.","authors":"Seung Chul Heo, Hye Seong Ahn, Rumi Shin, Chang-Sup Lim, Dong-Seok Han","doi":"10.14216/kjco.20016","DOIUrl":"https://doi.org/10.14216/kjco.20016","url":null,"abstract":"<p><strong>Purpose: </strong>Postoperative delirium (POD) is a common complication in elderly patients after major abdominal surgery for cancer. Although POD is related with a poor outcome, there have not been many reports about POD after abdominal surgery in Korea. The aims of study were to analyze the characteristics and surgical outcomes of elderly patients with POD and to identify the risk factors of POD.</p><p><strong>Methods: </strong>From November 2016 to January 2019, we prospectively enrolled 63 patients who were aged ≥75 years and underwent major abdominal surgery for cancer. POD was daily assessed for up to 10 days postoperatively with the Confusion Assessment Method and a validated chart review.</p><p><strong>Results: </strong>POD occurred in eight patients (12.7%). Univariate analysis showed that the occurrence of POD was related to sodium <135 mEq/L (P=0.037), combined resection (P=0.023), longer surgery/anesthesia time (P=0.023 and P=0.037, respectively), increased blood loss (P=0.004), postoperative admission to intensive care unit (ICU) (P=0.023), and duration of Foley catheter (P=0.011), however, multivariate analysis identified no significant risk factors of POD. There was no difference in postoperative outcomes such as hospital stay, mortality, reoperation, and morbidity between patients with POD and without POD.</p><p><strong>Conclusion: </strong>Elderly patients with hyponatremia, combined resection, longer operation/anesthesia time and admission to ICU had tendencies to develop POD after major abdominal surgery. Surgeons should pay more attention to prevent POD, and a large-scale prospective study is needed to identify the risk factors of POD.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"104-109"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/4a/kjco-16-2-104.PMC9942723.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seo Ree Kim, Sang Hoon Chun, Ji Hyun Kim, Sang-Yeob Kim, Bo-In Lee, Chan Kwon Jung, Jin Hyoung Kang
{"title":"Clinical experience of immune checkpoint inhibitor for a metastatic jejunal cancer patient with a high tumor mutational burden and low expression of programmed death-ligand 1.","authors":"Seo Ree Kim, Sang Hoon Chun, Ji Hyun Kim, Sang-Yeob Kim, Bo-In Lee, Chan Kwon Jung, Jin Hyoung Kang","doi":"10.14216/kjco.20010","DOIUrl":"https://doi.org/10.14216/kjco.20010","url":null,"abstract":"<p><p>Recent data showed that DNA mismatch repair deficiency can be a predictive biomarker for a favorable response of immune checkpoint inhibitors regardless of tumor type due to give rise to high tumor mutational burden (TMB) and microsatellite instability (MSI). Loss-of-function mutations of a specific tumor suppressor gene can also lead to good response to immunotherapy. Herein, we report a case exhibiting good response to pembrolizumab in a jejunal adenocarcinoma patient with low programmed death-ligand 1 (PD-L1) expression. A 67-year-old man underwent surgical resection followed by adjuvant chemotherapy. After 10 months, he was treated with palliative chemotherapy due to hepatic and pulmonary metastases. However, palliative chemotherapy did not have any effect whatsoever. Based on genetic testing results of high TMB and high MSI in the resected primary tumor, pembrolizumab treatment was performed. After the three cycles of treatment, all metastatic lesions shrank remarkably. Considering the mechanism of immune checkpoint inhibitors, this case establishes the importance of genetic markers as TMB and MSI rather than PD-L1 expression by the prediction of their anti-tumor activities..</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/51/kjco-16-1-57.PMC9942715.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youngki Hong, Jaelim Kim, Yoon Jung Choi, Jung Gu Kang
{"title":"Clinical study of colorectal cancer operation: Survival analysis.","authors":"Youngki Hong, Jaelim Kim, Yoon Jung Choi, Jung Gu Kang","doi":"10.14216/kjco.20002","DOIUrl":"https://doi.org/10.14216/kjco.20002","url":null,"abstract":"<p><strong>Purpose: </strong>Overall 5-year survival rates for colon and rectal cancer reported recently by the American Cancer Society were 89%, 90% for localized disease, 71%, 71% for regional disease, and 14%, 15% for distant disease. But the results of survival rate of colorectal cancer in a single institution were very rare. The aim of this study is to evaluate surgical results and survival rates of colorectal cancer.</p><p><strong>Methods: </strong>We conducted a retrospective study with patients who underwent curative resection for a primary colorectal adenocarcinoma between 2009 and 2018.</p><p><strong>Results: </strong>Five-year overall and disease-free survival were 79.5% and 69.9%, respectively. The overall 5-year survival by stages was 94.7% in stage I, 88.4% in stage II, 74.3% in stage III and 31.5% in stage IV. Five-year disease-free survival was 91% in stage I, 79.8% in stage II, 63.3% in stage III, and 18.9% in stage IV. The overall 5-year survival in rectal cancer was superior to colon cancer (P=0.014) while there was no difference in 5-year disease-free survival (P=0.338). Overall survival in female patients was better than male patient (P=0.029). Overall survival by age was worst in group of less than 40 years old (62.5%), and best in group between 41 and 65 years old (86.5%). Postoperative mortality within 30 days was 0.4%, and the recurrence rate was 19.2%.</p><p><strong>Conclusion: </strong>With the development of surgical skills and various treatments, postoperative outcome of colorectal cancer is expected to improve. It may be helpful for surgeons to improve their surgical outcomes when they review their data and conduct active researches.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/06/kjco-16-1-3.PMC9942716.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youn Joo Jung, Seungju Lee, Hyun Yul Kim, Hyun-June Paik, Chang Shin Jung, Jee Yeon Kim, Hyuk Jae Jung, Seokwon Lee, Choongrak Kim
{"title":"What predicts better prognosis in elderly breast cancer patients?","authors":"Youn Joo Jung, Seungju Lee, Hyun Yul Kim, Hyun-June Paik, Chang Shin Jung, Jee Yeon Kim, Hyuk Jae Jung, Seokwon Lee, Choongrak Kim","doi":"10.14216/kjco.20009","DOIUrl":"https://doi.org/10.14216/kjco.20009","url":null,"abstract":"<p><strong>Purpose: </strong>As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes.</p><p><strong>Methods: </strong>In this retrospective study, the data of 286 breast cancer patients aged 65 years and older, who underwent treatment at the Pusan National University Hospital and Pusan National University Yangsan Hospital from 2008 to 2014, were analyzed. The patients were divided into two groups: those with recurrence or metastasis and those without. Cox-regression model was used to analyze the risk factors for recurrence or metastasis. Kaplan-Meier method was used to analyze survival rates by the log-rank test.</p><p><strong>Results: </strong>Among the 286 patients with invasive breast cancer, 43 patients (15.0%) had recurrence or distant metastasis during a median follow-up period of 61 months. Advanced stages of breast cancer and patients who are not adapted to endocrine therapy were associated with poor prognosis.</p><p><strong>Conclusion: </strong>In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an earlier stage, which can lead to a better prognosis. Moreover, endocrine therapy should be administered to elderly patients who manifest favorable intrinsic subtypes of breast cancer.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"52-56"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/3e/kjco-16-1-52.PMC9942720.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ha Rim Ahn, Sang Yull Kang, Hyun Jo Youn, Sung Hoo Jung
{"title":"Risk factor for contralateral occult carcinoma in patients with unilateral papillary thyroid carcinoma.","authors":"Ha Rim Ahn, Sang Yull Kang, Hyun Jo Youn, Sung Hoo Jung","doi":"10.14216/kjco.20006","DOIUrl":"https://doi.org/10.14216/kjco.20006","url":null,"abstract":"<p><strong>Purpose: </strong>The extent of surgery necessary in patients with unilateral papillary thyroid carcinoma (PTC) on preoperative radiologic imaging is still in doubt. In this study, we aimed to define risk factors that could be indicators for malignant nodules in the contralateral thyroid lobe.</p><p><strong>Methods: </strong>We included 438 patients who underwent total thyroidectomy between January 2011 and December 2014 at our institution. In this study, patients were divided into two groups according to the presence of contralateral occult carcinoma identified by postoperative pathological examination. We analyzed the clinicopathologic factors including characteristics of coexistent nodules in the contralateral lobe based on preoperative radiological imaging.</p><p><strong>Results: </strong>A total of 96 patients (21.9%) had PTC in the contralateral lobe. There were no significant differences between patients with or without contralateral occult carcinoma with respect to gender, age, primary tumor size, central lymph node metastasis, extrathyroidal extension and stage. The presence of Hashimoto's thyroiditis was an independent predictive factor for contralateral occult carcinoma (P=0.01).</p><p><strong>Conclusion: </strong>A risk factor for contralateral occult carcinoma in unilateral PTC patients is Hashimoto's thyroiditis. Therefore, more caution is needed when determining optimal surgical methods for PTC patients with Hashimoto's thyroiditis.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/1b/kjco-16-1-33.PMC9942722.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heein Jo, Eun-Gyeong Lee, Eunjin Song, Jai Hong Han, So-Youn Jung, Han-Sung Kang, Eun Sook Lee, Seeyoun Lee
{"title":"Comparison of clinical outcomes between sentinel lymph node biopsy and axillary lymph node dissection in a single-center Z0011-eligible breast cancer cohort.","authors":"Heein Jo, Eun-Gyeong Lee, Eunjin Song, Jai Hong Han, So-Youn Jung, Han-Sung Kang, Eun Sook Lee, Seeyoun Lee","doi":"10.14216/kjco.20004","DOIUrl":"https://doi.org/10.14216/kjco.20004","url":null,"abstract":"<p><strong>Purpose: </strong>The ACOSOG Z0011 trial has proven the oncological safety of sentinel lymph node biopsy (SLBx) for node negative breast cancer. Accordingly, treatment paradigm including axilla surgery was changed. We retrospectively reviewed breast cancer patients to evaluate the clinical effect of paradigm shift in breast cancer surgery after applying the Z0011 criteria.</p><p><strong>Methods: </strong>All women who underwent breast-conserving surgery at the National Cancer Center between January 1, 2000, and December 31, 2015, were enrolled and classified according to the Z0011 criteria. The primary endpoint of the study was the disease-free survival rates, and the secondary was the adverse events, especially arm lymphedema.</p><p><strong>Results: </strong>Total 361 patients were enrolled the study (271 axillary lymph node dissection [ALND] group, 90 SLBx group). After the Z0011 guideline was adopted in our institute, the use of ALND decreased, and lymph node sampling (removing only a few axillary lymph nodes) replaced ALND. The total mean number of retrieved nodes were more in ALND group (13.02) than SLBx group (3.43). However, there was no difference in the mean number of positive nodes between two groups (2.34 in ALND group vs. 1.12 in SLBx group, P=0.001). During follow-up, 25 patients experienced disease recurrence: 22 from the ALND group and three from the SLBx group. All of died seven patients were from the ALND group. The ALND group had more complications than the SLBx group (P=0.02). Arm edema occurred more frequently in the ALND group (29.5%) than in the SLBx group (5.6%), although without statistical significance (P=0.07).</p><p><strong>Conclusion: </strong>In our study, we concluded that SLBx can be used safely in Z0011-eligible cohort without increased risk of locoregional recurrence. Moreover, we found that omission of ALND is favored to reduce some serious complications such as arm lymphedema.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/22/kjco-16-1-18.PMC9942717.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanghoon Kim, Sung Uk Bae, Seong Kyu Baek, Woon Kyung Jeong
{"title":"Comparing the initiation of adjuvant chemotherapy after robotic and laparoscopic colon cancer surgeries: A case-controlled study with propensity score matching.","authors":"Sanghoon Kim, Sung Uk Bae, Seong Kyu Baek, Woon Kyung Jeong","doi":"10.14216/kjco.20003","DOIUrl":"https://doi.org/10.14216/kjco.20003","url":null,"abstract":"<p><strong>Purpose: </strong>Early initiation of adjuvant chemotherapy after colon cancer surgery has shown better oncologic outcomes in previous studies. However, the clinical impact of robotic and laparoscopic surgeries on the initiation of adjuvant chemotherapy has not been widely evaluated. Hence, the study's aim was to compare the influence of both surgical approaches on the initiation of adjuvant chemotherapy after colon cancer surgery.</p><p><strong>Methods: </strong>From June 2011 to September 2017, 289 patients underwent curative robotic or laparoscopic surgery followed by adjuvant chemotherapy for stage II and III colon cancer. To control for different demographic factors in the two groups, propensity score case matching was used at a 1:4 ratio. Finally, 190 patients were matched with 38 patients of the robotic surgery group and 152 patients of the laparoscopic surgery group.</p><p><strong>Results: </strong>The operation time was longer in the robotic surgery group (297 minutes vs. 170 minutes, respectively; P<0.001). However, conversion rate, number of retrieved lymph nodes, first flatus, first soft diet, length of stay, postoperative complication rate, and Clavien-Dindo grade were not significantly different between the two groups. Additionally, there was no difference in the time to initiation of adjuvant chemotherapy between the two groups (31.5 days vs. 29.0 days, respectively; P=0.226). Disease-free and overall survival rates were also not significantly different.</p><p><strong>Conclusion: </strong>Robotic and laparoscopic surgeries showed no different impact on the initiation of adjuvant chemotherapy. This finding suggests that the two surgical approaches offer similar postoperative outcomes.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/9b/kjco-16-1-9.PMC9942714.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jieon Go, Suyeon Park, Kyeong Sik Kim, Min Chang Kang, Myong Hoon Ihn, Sangchul Yun, Sang Hyun Kim, Sung Hoon Hong, Jong Eun Lee, Sun Wook Han, Sung Yong Kim, Zisun Kim, Sung Mo Hur, Jihyoun Lee
{"title":"Risk of osteoporosis and fracture in long-term breast cancer survivors.","authors":"Jieon Go, Suyeon Park, Kyeong Sik Kim, Min Chang Kang, Myong Hoon Ihn, Sangchul Yun, Sang Hyun Kim, Sung Hoon Hong, Jong Eun Lee, Sun Wook Han, Sung Yong Kim, Zisun Kim, Sung Mo Hur, Jihyoun Lee","doi":"10.14216/kjco.20007","DOIUrl":"https://doi.org/10.14216/kjco.20007","url":null,"abstract":"<p><strong>Purpose: </strong>High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought to determine whether long-term breast cancer survivors had an elevated risk of low bone density compared to the general population.</p><p><strong>Methods: </strong>Long-term breast cancer survivors who had been treated for more than 5 years were selected for this study. Data were obtained from medical records and using a questionnaire from the Korea National Health and Nutrition Examination Survey (KNHANES). An age-matched non-cancer control group was selected from the KNHANES records. Incidence of fracture and bone mineral density (BMD) were compared between the two groups.</p><p><strong>Results: </strong>In total, 74 long-term breast cancer survivors and 296 non-cancer controls were evaluated. The incidence of fracture did not differ between the two groups (P=0.130). No differences were detected in lumbar BMD (P=0.051) following adjustment for body mass index, while hip BMD was significantly lower in breast cancer survivors (P=0.028). Chemotherapy and endocrine treatment were not related to low BMD in breast cancer survivors. In more than half of the survivors, the 10-year risk of osteoporotic fracture was less than 1%.</p><p><strong>Conclusion: </strong>Long-term breast cancer survivors had low bone density but a comparable risk of fracture compared to non-cancer age-matched controls. Further studies on the factors related to low bone density in long-term breast cancer survivors are required.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/ca/kjco-16-1-39.PMC9942721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}