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Harnessing Big Data with Machine Learning in Precision Oncology. 在精准肿瘤学中利用大数据和机器学习。
Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2020-09-01
Nirmish Singla, Shyamli Singla
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引用次数: 0
What morphology can teach us about renal cell carcinoma clonal evolution. 形态学对肾细胞癌克隆进化的启示。
Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2020-09-01 DOI: 10.52733/kcj18n3-a1
Payal Kapur, A. Christie, Satwik Rajaram, J. Brugarolas
{"title":"What morphology can teach us about renal cell carcinoma clonal evolution.","authors":"Payal Kapur, A. Christie, Satwik Rajaram, J. Brugarolas","doi":"10.52733/kcj18n3-a1","DOIUrl":"https://doi.org/10.52733/kcj18n3-a1","url":null,"abstract":"While cancer is a clonal process, cumulative evidence suggest that tumors are rather heterogenous and are composed of multiple genetically-distinct subclones that arise at different times and either persist and co-exist, expand and evolve, or are eliminated. A paradigm of tumor heterogeneity is renal cell carcinoma (RCC). By exploiting morphological traits and building upon a framework around three axes (architecture, cytology and the microenvironment), we review recent advances in our understanding of RCC evolution leading to an integrated molecular genetic and morphologic evolutionary model with both prognostic and therapeutic implications. The ability to predict cancer evolution may have profound implications for clinical care and is central to oncology.","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"18 3 1","pages":"68-76"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42420363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
What morphology can teach us about renal cell carcinoma clonal evolution. 形态学对肾细胞癌克隆进化的启示。
Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2020-09-01
Payal Kapur, Alana Christie, Satwik Rajaram, James Brugarolas
{"title":"What morphology can teach us about renal cell carcinoma clonal evolution.","authors":"Payal Kapur,&nbsp;Alana Christie,&nbsp;Satwik Rajaram,&nbsp;James Brugarolas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While cancer is a clonal process, cumulative evidence suggest that tumors are rather heterogenous and are composed of multiple genetically-distinct subclones that arise at different times and either persist and co-exist, expand and evolve, or are eliminated. A paradigm of tumor heterogeneity is renal cell carcinoma (RCC). By exploiting morphological traits and building upon a framework around three axes (architecture, cytology and the microenvironment), we review recent advances in our understanding of RCC evolution leading to an integrated molecular genetic and morphologic evolutionary model with both prognostic and therapeutic implications. The ability to predict cancer evolution may have profound implications for clinical care and is central to oncology.</p>","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"18 3","pages":"68-76"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232548/pdf/nihms-1634438.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39110987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uveal Melanoma and Kidney Cancer: More Similar than Meets the Eye. 葡萄膜黑色素瘤和肾癌:比表面看起来更相似。
Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2020-01-01
Nirmish Singla
{"title":"Uveal Melanoma and Kidney Cancer: More Similar than Meets the Eye.","authors":"Nirmish Singla","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"18 2","pages":"61"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405959/pdf/nihms-1613131.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38241521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next Generation Sequencing in Renal Cell Carcinoma: Towards Precision Medicine. 下一代肾细胞癌测序:迈向精准医学。
Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2019-01-01
Roy Elias, Akanksha Sharma, Nirmish Singla, James Brugarolas
{"title":"Next Generation Sequencing in Renal Cell Carcinoma: Towards Precision Medicine.","authors":"Roy Elias,&nbsp;Akanksha Sharma,&nbsp;Nirmish Singla,&nbsp;James Brugarolas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"17 4","pages":"94-104"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089604/pdf/nihms-1066623.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37765649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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