Kidney cancer journal : official journal of the Kidney Cancer Association最新文献

Cytoreductive Nephrectomy Following Immunotherapy for Metastatic Renal Cell Carcinoma and IVC Tumor Thrombus Arising from a Horseshoe Kidney. 免疫疗法治疗转移性肾细胞癌和马蹄肾IVC肿瘤血栓后的去细胞肾切除术

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2024-06-01

Sean A Fletcher, Rachel Schendzielos, Michael E Rezaee, Ying Wei Lum, Nirmish Singla

{"title":"Cytoreductive Nephrectomy Following Immunotherapy for Metastatic Renal Cell Carcinoma and IVC Tumor Thrombus Arising from a Horseshoe Kidney.","authors":"Sean A Fletcher, Rachel Schendzielos, Michael E Rezaee, Ying Wei Lum, Nirmish Singla","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Performing surgery for renal cell carcinoma (RCC) in patients with horseshoe kidneys presents unique anatomic challenges. The complexities of clinical decision-making and technical challenges are further compounded by the presence of both IVC tumor thrombus extension and metastatic disease.Case presentation: We encountered the unique case of a 66-year-old woman with a horseshoe kidney who presented with a 14cm mass in her right kidney with level II tumor thrombus extension into the IVC, retroperitoneal lymphadenopathy, and pulmonary nodules that were biopsy-proven to be consistent with metastatic clear cell RCC (cT3aN1M1). She was treated with combination immune checkpoint inhibition (ICI) and targeted therapy upfront. Given her durable response to systemic therapy, we elected to perform a consolidative cytoreductive nephrectomy for residual ypT3aN0 disease, and she has since remained disease-free radiographically. Using step-by-step illustrative photographs obtained intraoperatively, we detail our surgical approach and highlight technical pearls to manage similar cases of advanced RCC arising from horseshoe kidneys.Conclusion: We present a complex case of metastatic RCC with IVC tumor thrombus arising from a horseshoe kidney. We share our clinical and technical approach to overcoming the medical and surgical challenges inherent to her case. The optimal role and timing of cytoreductive nephrectomy relative to ICI administration continue to evolve based on both tumor- and patient-related factors. Indeed, we favor a multidisciplinary approach to optimize patient outcomes.","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"22 2","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney Cancer Research Highlights from ASCO-GU 2024 Meeting. ASCO-GU 2024 会议肾癌研究亮点。

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2024-03-01

Yasser Ged, Nirmish Singla

引用次数: 0

Commentary for the KCJ article "Molecular and Immune Landscape of Fumarate Hydratase-Mutated Renal Cell Carcinoma". 为 KCJ 文章 "富马酸氢化酶突变的肾细胞癌的分子和免疫景观 "撰写评论。

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-12-01 Epub Date: 2022-12-31 DOI: 10.52733/KCJ21n4-commentary

Nirmish Singla

引用次数: 0

KCJ Medical Intelligence KCJ医疗情报

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-10-06 DOI: 10.52733/kcj21n3-mi

引用次数: 0

Current perspective on the impact of endogenous retroviruses in clear cell renal cell carcinoma 内源性逆转录病毒对透明细胞肾细胞癌影响的最新研究进展

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-10-06 DOI: 10.52733/kcj21n3-r2

Kathryn Gessner, Mi Zhou, Tracy Rose, Matthew Milowsky, William Kim, Marc Bjurlin

引用次数: 0

An Opportunity to Study Mechanisms of Palliative Care by Integrating into Management of The Treatment of Renal Cancer Carcinoma 结合肾癌治疗管理研究姑息治疗机制的机会

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-10-06 DOI: 10.52733/kcj21n3-r3

Hiren V. Patel, Brandon Wilton, Eric A. Singer, Login George, Biren Saraiya

{"title":"An Opportunity to Study Mechanisms of Palliative Care by Integrating into Management of The Treatment of Renal Cancer Carcinoma","authors":"Hiren V. Patel, Brandon Wilton, Eric A. Singer, Login George, Biren Saraiya","doi":"10.52733/kcj21n3-r3","DOIUrl":"https://doi.org/10.52733/kcj21n3-r3","url":null,"abstract":"Achieving patient-centered care requires helping patients understand their illness, eliciting patient values, and developing a collaborative care plan with input from patient and physician. Combining existing models in communication skills and shared decision making provides a road map for accomplishing these tasks in delivering patient-centered care. In this article, we highlight the importance of patient understanding of their prognosis as a key step in delivering patient-centered care. We then review literature suggesting that both patient and patient’s physicians’ emotions play an inhibitory role in accurate formulation and communication of prognosis by physicians and accurate incorporation of this information by patients. We postulate that the finding of benefit of early integration of palliative care (PC) in improving patient-centered outcomes may be addressing these inhibitory factors. Key skills of empathic communication by a PC team that is focused on addressing patient emotions may facilitate better understanding of prognosis and thus improved patient-centered decision leading to improved patient centered outcomes. Finally, we propose advances treatment of renal cell carcinoma makes it an ideal disease that can inform this hypothesis of how integration of PC works. Specifically, we propose that the curability potential in metastatic RCC, amplifies challenges associated with patient prognostic understanding and decision making. Studying which discipline – primary oncology team or palliative care team – can help patients achieve more accurate prognostic understanding leading to more patient centered choices and improved patient-centered care.","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma – Current Concepts and Contentions in the Era of Immune Checkpoint Inhibitors 转移性肾细胞癌的细胞减少性肾切除术-免疫检查点抑制剂时代的当前概念和争论

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-10-06 DOI: 10.52733/kcj21n3-r1

Daniel Shapiro, Jason Abel, Viraj Master, Brandon Manley, Jad Chahoud, Surena Matin, Jose Karam, Philippe Spiess

{"title":"Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma – Current Concepts and Contentions in the Era of Immune Checkpoint Inhibitors","authors":"Daniel Shapiro, Jason Abel, Viraj Master, Brandon Manley, Jad Chahoud, Surena Matin, Jose Karam, Philippe Spiess","doi":"10.52733/kcj21n3-r1","DOIUrl":"https://doi.org/10.52733/kcj21n3-r1","url":null,"abstract":"Cytoreductive nephrectomy (CN), or the removal of the primary kidney tumor in the setting of metastatic disease, plays a critical role in the treatment of metastatic renal cell carcinoma (mRCC). The benefits of CN, are multifactorial including alleviating symptoms but also eliminating cells potentially prone to future metastasis, and potentially extending a patient's survival. As innovations in mRCC treatment continue to emerge, the importance and timing of CN in patient care remains the subject of ongoing debate in the scientific community. With advancements in modern therapies and the introduction of immune checkpoint inhibitors (ICI), the optimal integration of CN in mRCC management becomes even more important to investigate. This manuscript reviews the key literature related to CN and critically evaluates data that investigated CN efficacy. Furthermore, this article summarizes data to help identify ideal candidates for CN, and explores options for integrating CN within the contemporary systemic therapy landscape.","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KCJ Journal Club KCJ杂志俱乐部

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-10-06 DOI: 10.52733/kcj21n3-jc

Robert Figlin

引用次数: 0

HIF Pathway Inhibition hold much promise and Point Toward an expanding RCC Armamentarium HIF通路抑制具有很大的前景，并指向扩大RCC的武器

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-10-06 DOI: 10.52733/kcj21n3-e

Senthil Pazhanisamy

引用次数: 0

Kidney Cancer Updates from the 2023 American Society of Clinical Oncology Annual Meeting in Chicago. 来自芝加哥 2023 年美国临床肿瘤学会年会的肾癌最新信息。

Kidney cancer journal : official journal of the Kidney Cancer Association Pub Date : 2023-06-01

Roy Elias, Yasser Ged, Nirmish Singla

{"title":"Kidney Cancer Updates from the 2023 American Society of Clinical Oncology Annual Meeting in Chicago.","authors":"Roy Elias, Yasser Ged, Nirmish Singla","doi":"","DOIUrl":"","url":null,"abstract":"This report highlights key research from the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, with a focus on clear cell renal cell carcinoma (ccRCC) and non-clear cell RCC (nccRCC) across clinical trials and translational studies. Essential updates in the metastatic ccRCC clinical space encompass results from the CONTACT-03 study, which evaluated an immunotherapy containing regimen for patients who progressed on an initial immunotherapy containing regimen, alongside updated results from the KEYNOTE-426 and CLEAR trials. In the metastatic nccRCC domain, we review clinical trials of combination immunotherapies and tyrosine kinase inhibitors (TKIs). Additionally, we highlight exciting early-phase studies exploring novel targets in RCC and engineered T-cell methodologies. Finally, we summarize notable efforts in translational research, emphasizing biomarker investigations to determine predictors of immunotherapy response, the application of molecular classifiers in RCC, and the relationship between the microbiome and RCC. There were many important RCC related abstracts presented at this year's ASCO conference, attesting to the continued momentum of research in the field. All conference materials, including abstracts and presentations, can be accessed online through the conference website.","PeriodicalId":74040,"journal":{"name":"Kidney cancer journal : official journal of the Kidney Cancer Association","volume":"21 2","pages":"58-63"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10829942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0