JU open plus最新文献

{"title":"Variability of Commercial Saw Palmetto–Based Supplements for the Management of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms","authors":"B. Chughtai, N. Bhojani, K. Zorn, D. Elterman","doi":"10.1097/ju9.0000000000000040","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000040","url":null,"abstract":"\u0000 \u0000 \u0000 Some men with mild-to-moderate benign prostatic hyperplasia/lower urinary tract symptoms use saw palmetto supplements to proactively manage their symptoms as an alternative to watchful waiting and/or to avoid prescription medication side effects. This study assessed the potency and authenticity of commercially available saw palmetto–based supplements in the United States.\u0000 \u0000 \u0000 \u0000 Twenty-eight saw palmetto berry powders, powdered extracts, berry blends, lipid extracts, and multiactive products (lycopene, pumpkin oil, etc) were purchased from major online retailers and retail stores. Total fatty acid content (% weight/weight) and individual fatty acid profile of each product were determined using validated gas chromatography-fatty acid methyl ester methodology and compared with the US Pharmacopeia monograph standards for lipidosterolic extracts of Serenoa repens.\u0000 \u0000 \u0000 \u0000 \u0000 Total fatty acid content ranged from 0.796% for a berry powder product to 89.923% for a lipid extract product. None of the berry powders or powdered extracts, 6 of 9 lipid extracts, and 1 multiactive product met criteria for ≥80% total fatty acid content. Only 1 of the 28 products met the US Pharmacopeia criteria for a standardized lipidosterolic extract, defined as total fatty acid content ≥80% and a fatty acid profile indicative of authentic S. repens based on the ratios of the lauric acid concentration to 9 other individual fatty acid concentrations.\u0000 \u0000 \u0000 \u0000 There is substantial heterogeneity in fatty acid content and profile in saw palmetto supplements. Lipidosterolic extracts of saw palmetto berries standardized to ≥80% fatty acids are most likely to meet established criteria for quality and identity.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45951875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoma of Renal Pelvis, Case Report of a Rare Upper Urinary Tract Tumor","authors":"A. Schwartz, Eric E. Santos, Metin Aksu","doi":"10.1097/ju9.0000000000000044","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000044","url":null,"abstract":"\u0000 \u0000 \u0000 We report an exceptionally rare case, documenting the diagnosis and treatment of a lipoma of the renal pelvis in a 66-year-old White woman. This case represents the second reported lipoma in the upper urinary tract.\u0000 \u0000 \u0000 \u0000 An incidentally found filling defect in the right renal pelvis identified on CT scan in a 66-year-old woman resulted in referral to urology. Ureteroscopy was used to visualize, biopsy, and remove the tumor, with complete sparing of the kidney and associated structures. Histological analysis of the lesion revealed a benign tumor of mature adipocytes. The patient has been monitored for over 15 months postoperatively with no evidence of recurrence.\u0000 \u0000 \u0000 \u0000 This case serves as a reminder that many different nonmalignant lesions may be found throughout the upper urinary tract. It also highlights the kidney-sparing benefits of using ureteroscopic approaches whenever feasible in the timely diagnosis and treatment of upper urinary tract lesions.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47927123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Review of Periurethral Lymph Node Dissection in Clinically Localized Prostate Cancer","authors":"Charla Holdren, Christopher Pulford, Kevin T. Keating, David Peifer, R. Eames, S. Wisnewski, T. Maatman","doi":"10.1097/ju9.0000000000000043","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000043","url":null,"abstract":"\u0000 \u0000 \u0000 The purpose of this study was to evaluate the prevalence of positive periurethral lymph nodes during robotic-assisted radical prostatectomy (RARP) and to investigate the relationship between secondary end points of tumor staging, PSA, and Gleason score.\u0000 \u0000 \u0000 \u0000 This study is a retrospective review of 1177 RARPs performed from October 2011 to February 2022. Using pathology reports, the study population was condensed to 58 patients who had periurethral lymph node tissue. This population was then analyzed for the prevalence of malignant tissue in the specimen. A secondary analysis was performed for data on PSA, Gleason score (preoperative and postoperative), and tumor-nodes-metastases (TNM) staging.\u0000 \u0000 \u0000 \u0000 Retrospective analysis demonstrated 9 of 58 specimens (15.5%) to be positive for malignancy. There was a statistically significant (P < .004) correlation between lymph node status and PSA. The average PSA was 17.60 (SD = 15.54) for those with positive periurethral lymph nodes and 7.96 (SD = 6.65) for those with negative periurethral lymph nodes. There was no statistically significant association between lymph node status and preoperative Gleason scores. There was, however, a statistically significant difference across lymph node status and postoperative Gleason scores (X2 (3) = 11.09, P = .01).\u0000 \u0000 \u0000 \u0000 Positive periurethral lymph nodes demonstrated higher average PSAs, postoperative Gleason scores, and TNM staging. Further analysis is required to evaluate potential prognostic implications.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41318000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical surgical skill assessment of neurovascular bundle dissection and urinary continence recovery after robotic-assisted radical prostatectomy.","authors":"Runzhuo Ma, Steven Cen, Edward Forsyth, Patrick Probst, Aeen Asghar, William Townsend, Alvin Hui, Aditya Desai, Michael Tzeng, Emily Cheng, Ashwin Ramaswamy, Christian Wagner, Jim C Hu, Andrew J Hung","doi":"10.1097/ju9.0000000000000035","DOIUrl":"10.1097/ju9.0000000000000035","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the association between the <i>quality</i> of neurovascular bundle dissection and urinary continence recovery after robotic-assisted radical prostatectomy.</p><p><strong>Materials and methods: </strong>Patients who underwent RARPs from 2016 to 2018 in two institutions with ≥1-year postoperative follow-up were included. The primary outcomes were time to urinary continence recovery. Surgical videos were independently assessed by 3 blinded raters using the validated <i>Dissection Assessment for Robotic Technique (DART)</i> tool after standardized training. Cox regression was used to test the association between DART scores and urinary continence recovery while adjusting for relevant patient features.</p><p><strong>Results: </strong>121 RARP performed by 23 surgeons with various experience levels were included. The median follow-up was 24 months (95% CI 20 - 28 months). The median time to continence recovery was 7.3 months (95% CI 4.7 - 9.8 months). After adjusting for patient age, higher scores of certain DART domains, specifically <i>tissue retraction</i> and <i>efficiency</i>, were significantly associated with increased odds of continence recovery (p<0.05).</p><p><strong>Conclusions: </strong>Technical skill scores of neurovascular bundle dissection vary among surgeons and correlate with urinary continence recovery. Unveiling the specific robotic dissection skillsets which impact patient outcomes has the potential to focus surgical training.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49626475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Urinary PCA3 for Prostate Cancer in Thai Patients With PSA Levels of 3 to 10 ng/ml Undergoing an Initial Prostate Biopsy","authors":"Pasin Limudomporn, N. Sathirapongsasuti, S. Worawichawong, Pokket Sirisreetreeru, W. Kongcharoensombat, K. Kijvikai, Samapat Jittawera, Jitpanu Kocharoenwat, P. Jenjitranant","doi":"10.1097/ju9.0000000000000039","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000039","url":null,"abstract":"\u0000 \u0000 To examine the diagnostic accuracy of the urinary prostate cancer gene 3 score for prostate cancer in Thai patients with prostate-specific antigen levels of 3 to 10 ng/ml undergoing an initial prostate biopsy.\u0000 \u0000 \u0000 \u0000 In this prospective, single-center study, urine samples were collected after prostate massage. Urinary prostate cancer gene 3 mRNA levels were measured by real-time quantitative polymerase chain reaction. Data, including age, biopsy results, preoperative prostate-specific antigen levels, prostate-specific antigen density, prostate-specific antigen velocity, prostate volume, and prostate imaging findings, were collected between June 1, 2020, and May 15, 2021.\u0000 \u0000 \u0000 \u0000 The median prostate-specific antigen level of the 70 included patients was 6.31 ng/ml. Sixteen patients had positive biopsy results (22.9%). The prostate cancer gene 3 score (695.09 vs 268.79, P < .01), prostate-specific antigen density (0.19 vs 0.13, P < .01), and prostate-specific antigen velocity (2.68 vs 0.44, P < .01) significantly differed between the positive and negative biopsy groups. The predictive power of the prostate cancer gene 3 score was evaluated using receiver operating characteristic curves. At a prostate cancer gene 3 score threshold of 366.02, the sensitivity and specificity were 78.57% and 79.25%, respectively. Meanwhile, the areas under the curve of the prostate cancer gene 3 score, prostate-specific antigen velocity, and prostate-specific antigen density were better than that of prostate-specific antigen for predicting a positive biopsy.\u0000 \u0000 \u0000 \u0000 Our study confirmed the diagnostic accuracy of prostate cancer gene 3 for predicting a positive biopsy in Thai men with prostate-specific antigen levels of 3 to 10 ng/mL. Combining the prostate cancer gene 3 score and prostate-specific antigen derivatives might be helpful for identifying patients who can avoid unnecessary biopsies and subsequent complications.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45531807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Budget Impact of Minimally Invasive Surgical Treatments of Benign Prostatic Hyperplasia: An Analysis of 6 States With Limited New Technology Coverage","authors":"S. Rojanasarot, Julie Baxter, Emi Suzuki, J. Bresee, B. Chughtai","doi":"10.1097/ju9.0000000000000033","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000033","url":null,"abstract":"\u0000 \u0000 Prostatic urethral lift (PUL) and water vapor thermal therapy (WVTT) for benign prostatic hyperplasia (BPH) differ in treatment durability and cost of disposables, possibly leading to different long-term costs. This study compares the budget impact of PUL and WVTT for US payers in 6 states (Alabama, New Jersey, New York, Oregon, Pennsylvania, and Washington) over a 5-year time horizon.\u0000 \u0000 \u0000 \u0000 An Excel-based budget impact model was developed to estimate average total medical costs per patient of PUL and WVTT at years 1 and 5 for men with moderate-to-severe BPH. After undergoing an index procedure, men could experience adverse events (AEs) or retreatment while accumulating costs over time. Clinical inputs were derived from PUL and WVTT clinical trials while cost inputs were derived from 2021 Medicare reimbursement rates.\u0000 \u0000 \u0000 \u0000 At year 1, per-patient costs of PUL ranged from $5690 (Alabama) to $7323 (New Jersey) compared with year 1 costs of WVTT that ranged from $1829 (Alabama) to $2330 (New Jersey). The lower year 1 costs of WVTT stemmed from both lower procedural costs relative to PUL and better durability (lower costs associated with fewer retreatments and AEs). The cost differences between the 2 treatments continued to diverge in years 2 to 5. Through year 5, the cost savings associated with WVTT vs PUL ranged from $4383 (Alabama) to $5649 (New Jersey).\u0000 \u0000 \u0000 \u0000 Compared with PUL, the use of WVTT could potentially allow payers to cover BPH treatments for more members without compromising clinical outcomes or increasing budgets.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42461550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LithoVue Elite Compared With Single-Use and Reusable Ureteroscopes: A Bench and Human Cadaver Study","authors":"N. Bhojani, N. Shalabi, A. Reicherz, R. Herout, Kyle Searles, K. Wong, B. Chew","doi":"10.1097/ju9.0000000000000038","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000038","url":null,"abstract":"\u0000 \u0000 To compare the attributes of the next-generation LithoVue Elite (LVE, Boston Scientific Corporation) with current state-of-the-art single-use and reusable flexible ureteroscopes.\u0000 \u0000 \u0000 \u0000 LithoVue Elite is the latest single-use flexible ureteroscope with improved functionality and a novel ability to measure intrarenal pressure. In this study, we compare LVE with 3 single-use ureteroscopes (Pusen, WiScope, and Anqing) and 1 reusable ureteroscope (Olympus). A bench model was used to measure the physical characteristics (tip deflection and irrigation) and image quality (resolution, color accuracy, field of view, and latency). A human cadaveric model was used to score the maneuverability and ergonomics. This abstract shows the least square means from multiway ANOVAs used for analysis.\u0000 \u0000 \u0000 \u0000 The ureteroscopes showed a tip deflection ranging from 243° to 306° with LVE at 279°. The irrigation rates ranged from 28 to 44 mL/min with LVE at 40 ml/min. LVE had a resolution of 6.34 line pair/mm, while the other scopes ranged from 4.86 to 5.77 line pairs/mm. The color accuracy was quantified with Delta E, an image analysis variable, which ranged from 14 to 42 with LVE at 28. The field of view ranged from 55° to 89°, and LVE was at 89°. The image latency ranged from 41 to 92 ms with LVE at 58 ms. Finally, the maneuverability scores ranged from 3.8 to 4.1 of 5 with LVE scoring 4.1 while the ergonomics scores ranged from 2.4 to 4.8 with LVE scoring 4.4.\u0000 \u0000 \u0000 \u0000 LithoVue Elite had above average performance compared with single-use and reusable ureteroscopes and upper-range scores for resolution, field of view, maneuverability, and ergonomics. Accordingly, LVE shows promise; however, further research is needed to assess the impact of intrarenal pressure on the standard of care.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48947646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability of Functional Outcomes After MRI-Guided Transurethral Ultrasound Ablation of the Prostate","authors":"G. Hatiboglu, S. Nair, J. Relle, J. Hafron, Z. Kassam, K. Nandalur, M. Mueller-Wolf, D. Bonekamp, P. Doerwald, G. Clarke, H. Schlemmer, Matthias Roethke, S. Pahernik, Joseph L K Chin","doi":"10.1097/ju9.0000000000000034","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000034","url":null,"abstract":"\u0000 \u0000 Long-term data on functional outcomes after MRI-guided transurethral ultrasound ablation (TULSA) are limited. We assess the 5-year post-TULSA durability of outcomes for patient-reported genitourinary function, bowel function, and adverse events in 30 patients with primary, localized prostate cancer treated with TULSA across 3 centers. Patients received a conservative treatment plan in a phase 1 study designed to assess safety and feasibility. Follow-up visits took place at 1, 3, 6, 12 months, and biannually up to 5 years. Median (interquartile range) age at baseline was 69 (67-71) years. Erectile dysfunction (International Index of Erectile Function [IIEF] ≤17) was prevalent at baseline, with a mean (95% confidence interval [CI]) score of 16 (12-19), decreasing to 9 (4-14) at 5 years. At the 5-year visit, 71% of men who attempted intercourse in the recall period reported preservation of IIEF Q2 ≥2 erections sufficient for penetration. The mean (95% CI) International Prostate Symptom Score (IPSS) decreased from 9.0 (7.0-11) to 7.1 (5.0-9.1) from baseline to 5 years; IPSS-quality of life, maximum urinary flow rate, and post-void residual urine were stable or improved. Maintenance of bowel function and urinary continence was 100%. There was no new attributable serious or severe adverse event from 1 to 5 years. With a durably favorable safety profile, TULSA has the potential to treat cancer conservatively while simultaneously alleviating lower urinary tract symptoms. Data from larger studies are pending.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42833865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JU Open Plus: The Urologic Training Graduation Season","authors":"John W. Davis","doi":"10.1097/ju9.0000000000000048","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000048","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43651138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Adherent Perinephric Fat and Sex Hormone Levels in Serum and Fat in Patients Undergoing Robotic-Assisted Partial Nephrectomy: A Prospective Study","authors":"Y. Miyazawa, M. Nomura, Nozomi Matsumura, Y. Fujizuka, Y. Sekine, Y. Tsuji, T. Syuto, H. Yokoo, Kazuhiro Suzuki","doi":"10.1097/ju9.0000000000000042","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000042","url":null,"abstract":"\u0000 \u0000 Perinephric fat removal is essential for safe and effective robotic-assisted partial nephrectomy (RAPN). Adherent perinephric fat (APF) occasionally compromises RAPN, but the relationship between such fat and sex hormone levels is unclear. We explored a possible association between APF and sex hormone levels in serum and APF tissue.\u0000 \u0000 \u0000 \u0000 We conducted a prospective study from 2021 to 2022 at Gunma University Hospital. Fifty patients treated using RAPN were analyzed. We measured the testosterone (T) and estradiol (E) levels in serum and perinephric fat using liquid chromatography-mass spectrometry (LC-MS/MS). The correlations between the extent of adherence measured intraoperatively and hormone concentrations were examined.\u0000 \u0000 \u0000 \u0000 Of the 50 cases, 36 were male, and 14 were female. APF was observed in 16 of the male patients but in no female patients. In male patients, the T levels in perinephric fat were significantly higher in patients with APF. E2 levels in perinephric fat tissue were also significantly higher in patients with APF.\u0000 \u0000 \u0000 \u0000 In the 36 male patients lacking APF, there were no significant differences in the serum levels of T compared with those with APF, but a significant difference was apparent in APF tissue. The changed T level in APF tissue may have affected APF development.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42441381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}