JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2024.10.014
Elizabeth C. Ghandakly MD, JD, Faisal G. Bakaeen MD
{"title":"Multivessel coronary disease should be treated with coronary artery bypass grafting in all patients who are not (truly) high risk","authors":"Elizabeth C. Ghandakly MD, JD, Faisal G. Bakaeen MD","doi":"10.1016/j.xjon.2024.10.014","DOIUrl":"10.1016/j.xjon.2024.10.014","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 264-268"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2025.01.005
Ignazio Condello PhD
{"title":"Advocating MiECC: Proven benefits for high-risk cardiac surgery patients based on COMICS trial evidence","authors":"Ignazio Condello PhD","doi":"10.1016/j.xjon.2025.01.005","DOIUrl":"10.1016/j.xjon.2025.01.005","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Page 269"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitral regurgitation at the time of left ventricular assist device implantation: Should it be treated or not?","authors":"Hiroki Kohno MD, PhD , Goro Matsumiya MD, PhD , Yoshikatsu Saiki MD, PhD , Koichiro Kinugawa MD, PhD , Minoru Ono MD, PhD","doi":"10.1016/j.xjon.2025.02.002","DOIUrl":"10.1016/j.xjon.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>Mitral regurgitation may persist or progress after left ventricular assist device implantation. However, whether preexisting mitral regurgitation should be corrected at the time of implantation remains to be determined.</div></div><div><h3>Methods</h3><div>A retrospective, registry-based analysis was performed on 1398 continuous-flow left ventricular assist device recipients who underwent implantation between 2010 and 2022. Patients were compared for significant mitral regurgitation, defined as moderate-to-severe or greater mitral regurgitation after implantation, and major adverse events during left ventricular assist device support. Comparisons were made between patients untreated for mitral regurgitation but who had moderate or greater preexisting mitral regurgitation (n = 414) and those who had no or mild preexisting mitral regurgitation (n = 368) (cohort 1), and between patients with moderate or greater mitral regurgitation who underwent concomitant mitral valve surgery (n = 86) and those who did not (n = 414) (cohort 2).</div></div><div><h3>Results</h3><div>The cumulative incidence of significant mitral regurgitation was higher in patients with untreated moderate or greater mitral regurgitation in both cohorts (<em>P</em> < .001 and <em>P</em> = .025, cohorts 1 and 2, respectively). However, the cumulative incidence of all-cause mortality and readmission, and the risk of other major left ventricular assist device complications such as stroke and right heart failure were comparable between groups in both cohorts. The results were also consistent for the propensity score–matched population created in each cohort.</div></div><div><h3>Conclusions</h3><div>Significant mitral regurgitation may be prevented by concomitant surgery, but late survival and the risk of other major adverse events were not significantly improved by the procedure and were similar between patients with untreated moderate or greater mitral regurgitation and those with no or untreated mild mitral regurgitation. Our results suggest that mitral regurgitation during left ventricular assist device implantation may have only limited benefits from concomitant surgery.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 96-112"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2025.02.013
Zohaib R. Khawaja BS , Gabriel E. Cambronero MD , Yusuf M. Aboutabl BS , Elizabeth C. Wood MD , James E. Jordan PhD , Timothy E. Craven MSPH , Patrick M. Kozak MD , Prashant D. Bhave MD , Adrian L. Lata MD , Edward H. Kincaid MD , Neal D. Kon MD , Bartlomiej R. Imielski MD
{"title":"Corrigendum to ‘Superior transseptal versus left atriotomy approaches in isolated mitral valve surgery’[JTCVS Open Volume 22, December 2024, Pages 208-213]","authors":"Zohaib R. Khawaja BS , Gabriel E. Cambronero MD , Yusuf M. Aboutabl BS , Elizabeth C. Wood MD , James E. Jordan PhD , Timothy E. Craven MSPH , Patrick M. Kozak MD , Prashant D. Bhave MD , Adrian L. Lata MD , Edward H. Kincaid MD , Neal D. Kon MD , Bartlomiej R. Imielski MD","doi":"10.1016/j.xjon.2025.02.013","DOIUrl":"10.1016/j.xjon.2025.02.013","url":null,"abstract":"","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 113-114"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcomes of isolated tricuspid replacement versus repair among older patients with tricuspid regurgitation in the United States","authors":"Tomonari M. Shimoda MD , Hiroki A. Ueyama MD , Yoshihisa Miyamoto MD , Atsuyuki Watanabe MD , Hiroshi Gotanda MD, PhD , Sammy Elmariah MD, MPH , Yujiro Yokoyama MD , Shinichi Fukuhara MD , Tsuyoshi Kaneko MD , Toshiki Kuno MD, PhD , Yusuke Tsugawa MD, PhD","doi":"10.1016/j.xjon.2024.10.018","DOIUrl":"10.1016/j.xjon.2024.10.018","url":null,"abstract":"<div><h3>Objective</h3><div>Evidence is limited regarding early-term outcomes after isolated tricuspid operations for tricuspid regurgitation (TR). We compared the early-term outcomes after isolated tricuspid valve replacement versus repair using the contemporary data.</div></div><div><h3>Methods</h3><div>We analyzed the national data on Medicare beneficiaries aged ≥65 years who underwent isolated tricuspid valve replacement or repair for TR between January 2016 and December 2020. The primary outcome was early-term (up to 3 years) all-cause mortality. The secondary outcomes included early-term major adverse cardiovascular events (MACE) and heart failure hospitalizations. MACE encompassed all-cause mortality, heart failure hospitalization, stroke, and tricuspid reoperations. A propensity score matching analysis was conducted to compare between replacement and repair.</div></div><div><h3>Results</h3><div>A total of 1501 patients were included (replacement: 610 patients, repair: 891 patients). In the matched cohort (n = 547 in each group), the overall mortality and MACE were 39% and 46% at 3 years, respectively. Tricuspid valve replacement was associated with similar all-cause mortality in comparison to repair (adjusted hazard ratio [HR], 1.06; 95% confidence interval [CI], 0.86-1.30; <em>P</em> = .600). Similarly, the rates of MACE and heart failure hospitalizations were similar (adjusted HR, 1.01; 95% CI, 0.84-1.22, <em>P</em> = .910; subdistribution HR, 1.04; 95% CI, 0.72-1.49, <em>P</em> = .850, respectively) between these 2 procedures.</div></div><div><h3>Conclusions</h3><div>Isolated surgical tricuspid valve replacement was associated with similar clinical outcomes compared to repair. Importantly, the high overall early-term mortality and morbidity with either treatment underscores the need for alternative intervention choices and further research to optimize the indication and timing of intervention.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 127-146"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of lower-body ischemia duration in aortic arch surgery under mild-to-moderate hypothermic circulatory arrest","authors":"Giacomo Murana MD , Chiara Nocera MD , Luca Zanella MD , Luca Di Marco MD , Silvia Snaidero MD , Sabrina Castagnini MD , Carlo Mariani MD , Davide Pacini MD, PhD","doi":"10.1016/j.xjon.2025.01.015","DOIUrl":"10.1016/j.xjon.2025.01.015","url":null,"abstract":"<div><h3>Objectives</h3><div>Aortic arch surgery is performed at increasingly higher circulatory arrest temperatures. This might affect visceral protection. We analyzed the effect of visceral ischemic time in arch surgery under mild-to-moderate hypothermia.</div></div><div><h3>Methods</h3><div>We divided the population into 3 groups: group 1 (visceral ischemic time ≤30 minutes), group 2 (31-60 minutes), and group 3 (>60 minutes). The link between visceral ischemic times and in-hospital outcomes, and visceral function biomarker levels were retrospectively analyzed through chi-square test, nonparametric analysis of variance, and cubic spline interpolation.</div></div><div><h3>Results</h3><div>From 1995 to 2023, 1325 patients underwent aortic arch surgery under circulatory arrest at our center. Mild-to-moderate hypothermia (nasopharyngeal temperature ≥25°) was used in 960 cases. There was no significant difference among the groups for in-hospital death (group 1 = 8.5%, group 2 = 13.2%, group 3 = 11.3%; <em>P</em> = .224), renal complications (group 1 = 13.0%, group 2 = 19.7%, group 3 = 22.6%; <em>P</em> = .056), and gastrointestinal complications (group 1 = 5%, group 2 = 5.5%, group 3 = 7.1%; <em>P</em> = .696). However, respiratory complications (group 1 = 19.4%, group 2 = 28.1%, group 3 = 21.4%; <em>P</em> = .027) and transient dialysis (group 1 = 2.8%, group 2 = 7.8%, group 3 = 11.3%; <em>P</em> = .011) were linked to longer visceral ischemic times. Groups 2 and 3 presented significantly higher levels of creatinine (<em>P</em> < .01), glutamic-oxaloacetic transaminase (<em>P</em> < .05), and glutamic pyruvic transaminase (24 and 48 hours postsurgery, <em>P</em> < .01). Cubic spline analysis showed that the incidence of renal complications reached a minimum at a low visceral ischemic time and then consistently increased. Respiratory complications showed a maximum incidence at approximately 50 minutes of visceral ischemic time and then subsequently decreased.</div></div><div><h3>Conclusions</h3><div>Mild-to-moderate hypothermia is a safe strategy for visceral organ protection regardless of visceral ischemic time. However, longer visceral ischemic times are linked to renal complications.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 58-66"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2025.02.004
Sanford Zeigler MD , Kyle W. Blackburn BS , Ahmad Tabatabaeishoorijeh BS , Veronica A. Glover PhD , Susan Y. Green MPH , Marc R. Moon MD , Scott A. LeMaire MD , Joseph S. Coselli MD
{"title":"Obesity and outcomes after elective thoracoabdominal aortic aneurysm repair","authors":"Sanford Zeigler MD , Kyle W. Blackburn BS , Ahmad Tabatabaeishoorijeh BS , Veronica A. Glover PhD , Susan Y. Green MPH , Marc R. Moon MD , Scott A. LeMaire MD , Joseph S. Coselli MD","doi":"10.1016/j.xjon.2025.02.004","DOIUrl":"10.1016/j.xjon.2025.02.004","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity can complicate surgical repair, but its relationship to outcomes after open thoracoabdominal aortic aneurysm (TAAA) repair remains uncertain. Therefore, we examined whether obesity is associated with greater operative risk after elective TAAA repair.</div></div><div><h3>Methods</h3><div>We retrospectively evaluated data from 2517 open, elective, single-practice TAAA repairs (from 1986 to 2023) and compared patients without obesity or underweight (body mass index [BMI] 18.6-29.9; n = 1977) with patients with obesity (BMI ≥30; n = 540 [21.5%]). Multivariable logistic regression modeling identified predictors of operative mortality in patients with obesity. We created propensity-matched cohorts (n = 540 pairs) and compared their early and late outcomes, including late survival, by Kaplan-Meier analysis and log-rank testing.</div></div><div><h3>Results</h3><div>Compared with patients without obesity, patients with obesity were younger (median age, 64 years [Q1-Q3: 56-71] vs 68 [59-73] years; <em>P</em> < .001) and had greater rates of aortic dissection (45.7% vs 34.5%; <em>P</em> < .001) and diabetes (13.1% vs 6.9%; <em>P</em> < .001). Extent I repairs were more frequent in patients with obesity (30.6% vs 24.9%; <em>P</em> = .008). Operative mortality did not differ between groups (5.6% vs 6.6%; <em>P</em> = .9); however, persistent stroke was more frequent in patients with obesity (3.7% vs 2.0%, <em>P</em> = .02). Overall, BMI was not associated with operative mortality; within the patients with obesity, multivariable modeling found aortic dissection was independently associated with operative mortality. Propensity matching revealed no substantial differences in examined outcomes.</div></div><div><h3>Conclusions</h3><div>Patients with obesity undergoing TAAA repair differed from their counterparts without obesity regarding several factors. However, adjusted early outcomes after TAAA replacement did not differ by the presence or severity of obesity. We conclude that obesity alone should not deter surgeons from offering elective TAAA repair.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 16-30"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2024.12.015
Hamza Rshaidat MD , Isheeta Madeka MD , Gregory L. Whitehorn BS , Jonathan Martin BS , Shale J. Mack BS , Sneha Alaparthi MD , Tyler R. Grenda MD , Nathaniel R. Evans III MD , Olugbenga T. Okusanya MD
{"title":"Describing the intersection of ethnicity and gender in early-stage non–small cell lung cancer","authors":"Hamza Rshaidat MD , Isheeta Madeka MD , Gregory L. Whitehorn BS , Jonathan Martin BS , Shale J. Mack BS , Sneha Alaparthi MD , Tyler R. Grenda MD , Nathaniel R. Evans III MD , Olugbenga T. Okusanya MD","doi":"10.1016/j.xjon.2024.12.015","DOIUrl":"10.1016/j.xjon.2024.12.015","url":null,"abstract":"<div><h3>Objective</h3><div>Female sex has been associated with improved survival after lung cancer resection. Our aim is to use a national database to describe sex disparities in early lung cancer treatment and evaluate whether outcomes of ethnic groups who traditionally have poorer outcomes are attenuated by female sex.</div></div><div><h3>Methods</h3><div>This is a retrospective cohort study using the 2020 National Cancer Database. Adult patients diagnosed between 2010 and 2019 with early-stage non–small cell lung cancer (clinical T1 or T2, N0, M0) who received surgical resection with a known vital status were included. Patients who received neoadjuvant systemic or radiation therapy were excluded. Demographic data; clinicopathologic variables; 30-day, 90-day, 5-year mortality; and 5-year overall survival were analyzed.</div></div><div><h3>Results</h3><div>We identified 192,927 patients with surgically resected early-stage non–small cell lung cancer. Mean patient age was 69 years (interquartile range, 62-75). Five-year overall survival among women was 72.8% versus 60.4% in men (<em>P</em> < .001), with the largest difference between Asian Pacific Islander women and men. Among women, White and Black women had the lowest 5-year overall survival. White and Black women had a higher 5-year overall survival than White, Black, Hispanic, and Other men.</div></div><div><h3>Conclusions</h3><div>Female sex was associated with improved overall survival in patients with early-stage lung cancer regardless of ethnicity. However, there is significant variation between ethnic groups in the absolute size of this association. Additional studies are necessary to determine which factors contribute to this disparity, including but not limited to biological, clinical, and health-systems related.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 438-450"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2025.01.003
Hope Conrad MD , Ahmed Elkamel MBBS , Anthony Maltagliati MD , Kevin Wang MD , Chiu-Hsieh Hsu PhD , Wendy Linville BA , Michal Lada MD , Praveen Sridhar MD , Stephanie Worrell MD
{"title":"Outcomes of jejunostomy-tube placement in surgical patients with esophageal cancer","authors":"Hope Conrad MD , Ahmed Elkamel MBBS , Anthony Maltagliati MD , Kevin Wang MD , Chiu-Hsieh Hsu PhD , Wendy Linville BA , Michal Lada MD , Praveen Sridhar MD , Stephanie Worrell MD","doi":"10.1016/j.xjon.2025.01.003","DOIUrl":"10.1016/j.xjon.2025.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with esophageal cancer who undergo esophagectomy are at high risk for malnutrition. Jejunostomy tubes are often placed to provide enteral access for nutritional support. Traditionally, jejunostomy placement occurs at the time of esophagectomy. However, benefits have been described in patients with earlier jejunostomy placement. The purpose of this study is to determine outcomes of surgical patients with esophageal cancer on the basis of jejunostomy tube placement as well as to analyze the effect of placement timing on these factors.</div></div><div><h3>Methods</h3><div>This is a retrospective, multi-institutional study including 2 academic hospital systems. Patients with esophageal cancer who underwent esophagectomy were included. Patients who received a jejunostomy tube were compared with patients who did not receive a jejunostomy tube. Further analysis comparing early and routine jejunostomy placement timing was then performed.</div></div><div><h3>Results</h3><div>Of 327 included patients, 48.32% (158) had a jejunostomy tube and 51.68% (169) did not have any form of enteral access. For every day a patient had a jejunostomy tube in place, there was a reduction in hospital length of stay (LOS) and intensive care unit LOS (<em>P</em> ≤ .001 and < .001).</div></div><div><h3>Conclusions</h3><div>Jejunostomy tube placement in patients with esophageal cancer undergoing esophagectomy significantly enhances nutritional outcomes, particularly in malnourished patients, and reduces 90-day mortality and recurrence rates. Patients with esophageal cancer who underwent esophagectomy and received an early jejunostomy tube had shorter hospital and intensive care unit LOS. Early placement of jejunostomy tubes should be considered to optimize nutritional support and improve overall patient resilience before surgery. Further prospective studies are warranted to confirm these findings and refine guidelines for jejunostomy tube placement in patients with esophageal cancer.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 496-509"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JTCVS openPub Date : 2025-04-01DOI: 10.1016/j.xjon.2025.01.019
Chunyuan Wang MD , Meice Tian MD , Yang Wang PhD , Lei Song MD , Zhihui Hou MD , Sipeng Chen MS , Wei Feng MD , Yan Zhang MD , Zhan Hu MD
{"title":"Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass grafting","authors":"Chunyuan Wang MD , Meice Tian MD , Yang Wang PhD , Lei Song MD , Zhihui Hou MD , Sipeng Chen MS , Wei Feng MD , Yan Zhang MD , Zhan Hu MD","doi":"10.1016/j.xjon.2025.01.019","DOIUrl":"10.1016/j.xjon.2025.01.019","url":null,"abstract":"<div><h3>Objectives</h3><div>Radial artery grafts and saphenous vein grafts exhibit heterogeneous responses to competitive flow, a phenomenon assessable through quantitative flow ratio. The present study aims to compare the patency of radial artery and saphenous vein grafts across various quantitative flow ratio ranges.</div></div><div><h3>Methods</h3><div>The clinical data and quantitative flow ratio values for each target vessel were retrospectively collected in patients receiving radial artery or conventional saphenous vein grafts in our center from 2017 to 2021. The primary outcome was graft occlusion assessed by coronary computed tomography angiography and coronary angiography, and the secondary outcome was major adverse cardiac or cerebrovascular events. Mixed-effect multivariable Cox regression models were used to assess the independent effect of graft conduit type and quantitative flow ratio on graft occlusion.</div></div><div><h3>Results</h3><div>A total of 1314 patients with 292 radial artery target vessels and 1736 saphenous vein graft target vessels were included. The median follow-up duration was 3 years. Quantitative flow ratio value of 0.57 was identified as the optimal threshold. Compared with saphenous vein graft, the radial artery exhibited lower patency in target vessels where quantitative flow ratio was greater than 0.57 (adjusted hazard ratio, 4.63, 95% CI, 2.61-8.21, <em>P</em> < .001), but higher patency in vessels in which the quantitative flow ratio was 0.57 or less (adjusted hazard ratio, 0.14, 95% CI, 0.03-0.68, <em>P</em> = .015).</div></div><div><h3>Conclusions</h3><div>Radial artery grafts may achieve superior patency in target vessels with low quantitative flow ratio values, whereas saphenous vein grafts may be associated with higher short-term patency in vessels with higher quantitative flow ratio values.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 206-216"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}