Haris Patail MD, Imran Naeem Aziz MD, MSc, Joshua Anapoell BS, Gabrielle Amar BA, Joshua Goldberg MD, Makoto Hibino MD, PhD, David Spielvogel MD, Faraz Mahmood MD, Daniel M. Spevack MD, Srihari S. Naidu MD, Syed Abbas Haidry MD, Junichi Shimamura MD, Hasan Ahmad MD
{"title":"Percutaneous Mechanical Aspiration of Left-Sided Intracardiac Masses for Prohibitive Surgical Candidates: A Single-Center Experience","authors":"Haris Patail MD, Imran Naeem Aziz MD, MSc, Joshua Anapoell BS, Gabrielle Amar BA, Joshua Goldberg MD, Makoto Hibino MD, PhD, David Spielvogel MD, Faraz Mahmood MD, Daniel M. Spevack MD, Srihari S. Naidu MD, Syed Abbas Haidry MD, Junichi Shimamura MD, Hasan Ahmad MD","doi":"10.1016/j.jscai.2026.105522","DOIUrl":"10.1016/j.jscai.2026.105522","url":null,"abstract":"<div><h3>Background</h3><div>Percutaneous mechanical aspiration (PMA) of intracardiac masses is mostly described for right-sided lesions. Left-sided masses are typically managed medically or surgically, with limited data regarding transcatheter removal. PMA is currently considered off-label; however, it may have advantages to debulk lesions and reduce morbidity in high risk patients.</div></div><div><h3>Methods</h3><div>We performed an observational study of 7, prohibitive surgical candidates who underwent transseptal PMA of mitral valve (MV) masses. Baseline characteristics, echocardiographic findings, procedural details, and in-hospital and short-term outcomes were collected. The primary procedural efficacy end point included procedural success defined by ≥70% mass removal and procedure-related mortality. The primary composite safety end point included in-hospital mortality, cerebrovascular accident, increased valvular regurgitation, and major structural complications.</div></div><div><h3>Results</h3><div>A total of 7 patients were included. The mean age was 77.9 ± 6.1 years; 71% were women, and the median predicted Society of Thoracic Surgery mortality score was 19.5%. All patients had echocardiographic evidence of large (>1 cm) left-sided masses involving the MV or adjacent structures. The primary efficacy end point was seen in 100% of cases. The primary composite outcome was seen in 14.3%, driven by worsening MV regurgitation. Procedure and fluoroscopy durations demonstrated a downward trend with increased experience. All patients survived to discharge and 30-day survival was 85.7%, with 1 noncardiac death.</div></div><div><h3>Conclusions</h3><div>Transseptal PMA is feasible for debulking of MV masses in prohibitive surgical candidates. In this early experience, the technique achieved success with low procedural morbidity and encouraging short-term outcomes. Larger studies are needed to define patient selection criteria and long-term efficacy.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105522"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabina Kumar DO, MS, Milan Seth MS, Mark A. Zainea MD, Brittany Fuller MD, Prasanthi Yelavarthy MD, Eric P. Cantey MD, Elizabeth Pielsticker MD, Ryan D. Madder MD, Devraj Sukul MD MSc
{"title":"Uptake of Intracoronary Imaging-Guided Percutaneous Coronary Intervention Among Female Patients in the State of Michigan: An Analysis of a BMC2 Initiative","authors":"Sabina Kumar DO, MS, Milan Seth MS, Mark A. Zainea MD, Brittany Fuller MD, Prasanthi Yelavarthy MD, Eric P. Cantey MD, Elizabeth Pielsticker MD, Ryan D. Madder MD, Devraj Sukul MD MSc","doi":"10.1016/j.jscai.2026.105524","DOIUrl":"10.1016/j.jscai.2026.105524","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105524"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natali Sorajja MS, Khady N. Fall MD, MPH, Brian K. Courtney MD, Megha Prasad MD, MS
{"title":"Versatility of Hybrid OCT and IVUS Imaging Enhances Contrast-Sparing Management of Eruptive Calcified Nodules","authors":"Natali Sorajja MS, Khady N. Fall MD, MPH, Brian K. Courtney MD, Megha Prasad MD, MS","doi":"10.1016/j.jscai.2026.105497","DOIUrl":"10.1016/j.jscai.2026.105497","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105497"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haytham Allaham MD, C. Michael Gibson MD, Aloke Finn MD, Imad Alhaddad MD, Anuj Gupta MD
{"title":"Sodium-Glucose Cotransporter-2 Inhibitors in Valvular Heart Disease: From Mechanistic Insights to Clinical Application","authors":"Haytham Allaham MD, C. Michael Gibson MD, Aloke Finn MD, Imad Alhaddad MD, Anuj Gupta MD","doi":"10.1016/j.jscai.2026.105568","DOIUrl":"10.1016/j.jscai.2026.105568","url":null,"abstract":"<div><div>Valvular heart disease encompasses a diverse group of hemodynamic disorders that are frequently associated with heart failure, recurrent hospitalizations, and substantial morbidity despite advances in transcatheter and surgical therapies. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a cornerstone of cardiovascular and renal disease management, demonstrating consistent benefits across a broad range of patient populations. Beyond their established effects in heart failure, diabetes mellitus, and chronic kidney disease, accumulating evidence suggests that SGLT2 inhibitors may favorably influence key biological pathways involved in valvular heart disease, including inflammation, oxidative stress, fibrosis, endothelial dysfunction, and adverse cardiac remodeling. Preclinical and translational studies have provided mechanistic support for a potential role of SGLT2 inhibition in modifying valvular and myocardial disease processes. Emerging clinical evidence suggests possible benefits across several forms of valvular heart disease, including degenerative aortic stenosis, functional mitral regurgitation, tricuspid regurgitation, rheumatic mitral stenosis, and bioprosthetic valve degeneration. In addition, growing interest has focused on the integration of SGLT2 inhibitors into contemporary structural heart practice, particularly among patients undergoing transcatheter aortic valve replacement, transcatheter edge-to-edge repair, and other structural interventions. This narrative review summarizes the mechanistic rationale, current clinical evidence, and practical considerations surrounding the use of SGLT2 inhibitors in valvular heart disease and structural heart interventions. We discuss the strengths and limitations of the existing literature, identify important gaps in knowledge, and highlight future directions for research aimed at defining the role of SGLT2 inhibitors as an adjunctive therapy in structural heart disease.</div></div>","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105568"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover","authors":"","doi":"10.1016/S2772-9303(26)01415-8","DOIUrl":"10.1016/S2772-9303(26)01415-8","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105668"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guy Robinson MBBS, Kiyan Heybati MD, MSc, Benjamin Hibbert MD, PhD, Sripal Bangalore MD, MHA, Pete Fong MD, David Zlotnick MD, Brittany Zwischenberger MD, Sameh Sayfo MD, MBA, Stephanie Younes MD, Joseph Ingrassia MD, Muhammad Hammadah MD, Anand Prasad MD, Nadira Hamid MD, Pedro Villablanca MD, MSc, Amir Kaki MD, Mohammed Qintar MD, MSc, Marquand Patton DO, Evin Yucel MD, Pradeep Yadav MD, Andrew Klein MD, Abdallah El Sabbagh MD
{"title":"Device-Specific Outcomes of Percutaneous Mechanical Aspiration in Right-Sided Infective Endocarditis: Insights From the Multicenter CLEAR-IE Registry","authors":"Guy Robinson MBBS, Kiyan Heybati MD, MSc, Benjamin Hibbert MD, PhD, Sripal Bangalore MD, MHA, Pete Fong MD, David Zlotnick MD, Brittany Zwischenberger MD, Sameh Sayfo MD, MBA, Stephanie Younes MD, Joseph Ingrassia MD, Muhammad Hammadah MD, Anand Prasad MD, Nadira Hamid MD, Pedro Villablanca MD, MSc, Amir Kaki MD, Mohammed Qintar MD, MSc, Marquand Patton DO, Evin Yucel MD, Pradeep Yadav MD, Andrew Klein MD, Abdallah El Sabbagh MD","doi":"10.1016/j.jscai.2026.105494","DOIUrl":"10.1016/j.jscai.2026.105494","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105494"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Interventional Cardiology Match: From Milestone to Momentum","authors":"J. Dawn Abbott MD, Douglas E. Drachman MD","doi":"10.1016/j.jscai.2026.105619","DOIUrl":"10.1016/j.jscai.2026.105619","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 9","pages":"Article 105619"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Intelligence–Derived Coronary Physiology Comes of Age—Promises, Precision, and Pragmatism in the Cath Lab","authors":"Jonathan X. Fang MBBS, H.V. (‘Skip’) Anderson MD","doi":"10.1016/j.jscai.2026.105514","DOIUrl":"10.1016/j.jscai.2026.105514","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 8","pages":"Article 105514"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148746487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao-Wei Lee MD, Yoshinobu Onuma MD, PhD, Patrick W. Serruys MD, PhD
{"title":"Letter to the Editor Regarding the Article “High-Definition Intravascular Ultrasound Versus Optical Coherence Tomography: Lumen Size and Plaque Morphology”","authors":"Hao-Wei Lee MD, Yoshinobu Onuma MD, PhD, Patrick W. Serruys MD, PhD","doi":"10.1016/j.jscai.2026.105462","DOIUrl":"10.1016/j.jscai.2026.105462","url":null,"abstract":"","PeriodicalId":73990,"journal":{"name":"Journal of the Society for Cardiovascular Angiography & Interventions","volume":"5 8","pages":"Article 105462"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148745972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}