Journal of the National Cancer Institute. Monographs最新文献_第7页

Skeletal muscle omics signatures in cancer cachexia: perspectives and opportunities. 癌症恶病质中的骨骼肌全息特征：前景与机遇。

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI: 10.1093/jncimonographs/lgad006

L Anne Gilmore, Traci L Parry, Gwendolyn A Thomas, Andy V Khamoui

{"title":"Skeletal muscle omics signatures in cancer cachexia: perspectives and opportunities.","authors":"L Anne Gilmore, Traci L Parry, Gwendolyn A Thomas, Andy V Khamoui","doi":"10.1093/jncimonographs/lgad006","DOIUrl":"10.1093/jncimonographs/lgad006","url":null,"abstract":"Cachexia is a life-threatening complication of cancer that occurs in up to 80% of patients with advanced cancer. Cachexia reflects the systemic consequences of cancer and prominently features unintended weight loss and skeletal muscle wasting. Cachexia impairs cancer treatment tolerance, lowers quality of life, and contributes to cancer-related mortality. Effective treatments for cancer cachexia are lacking despite decades of research. High-throughput omics technologies are increasingly implemented in many fields including cancer cachexia to stimulate discovery of disease biology and inform therapy choice. In this paper, we present selected applications of omics technologies as tools to study skeletal muscle alterations in cancer cachexia. We discuss how comprehensive, omics-derived molecular profiles were used to discern muscle loss in cancer cachexia compared with other muscle-wasting conditions, to distinguish cancer cachexia from treatment-related muscle alterations, and to reveal severity-specific mechanisms during the progression of cancer cachexia from early toward severe disease.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition. 癌症治疗药物的药代动力学与能量平衡：饮食摄入、能量消耗和身体组成的作用。

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI: 10.1093/jncimonographs/lgad010

Sarah A Purcell, Dieuwertje E Kok, Tyler Ketterl, Miriam B Garcia, Lenat Joffe, Justin C Brown, Christina M Dieli-Conwright, Grant R Williams

{"title":"Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition.","authors":"Sarah A Purcell, Dieuwertje E Kok, Tyler Ketterl, Miriam B Garcia, Lenat Joffe, Justin C Brown, Christina M Dieli-Conwright, Grant R Williams","doi":"10.1093/jncimonographs/lgad010","DOIUrl":"10.1093/jncimonographs/lgad010","url":null,"abstract":"Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging modalities for measuring body composition in patients with cancer: opportunities and challenges. 测量癌症患者身体成分的成像方式：机遇与挑战。

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI: 10.1093/jncimonographs/lgad001

Urvi A Shah, Tarah J Ballinger, Rusha Bhandari, Christina M Dieli-Cornwright, Kristin A Guertin, Elizabeth A Hibler, Faiza Kalam, Ana Elisa Lohmann, Joseph E Ippolito

{"title":"Imaging modalities for measuring body composition in patients with cancer: opportunities and challenges.","authors":"Urvi A Shah, Tarah J Ballinger, Rusha Bhandari, Christina M Dieli-Cornwright, Kristin A Guertin, Elizabeth A Hibler, Faiza Kalam, Ana Elisa Lohmann, Joseph E Ippolito","doi":"10.1093/jncimonographs/lgad001","DOIUrl":"10.1093/jncimonographs/lgad001","url":null,"abstract":"Body composition assessment (ie, the measurement of muscle and adiposity) impacts several cancer-related outcomes including treatment-related toxicities, treatment responses, complications, and prognosis. Traditional modalities for body composition measurement include body mass index, body circumference, skinfold thickness, and bioelectrical impedance analysis; advanced imaging modalities include dual energy x-ray absorptiometry, computerized tomography, magnetic resonance imaging, and positron emission tomography. Each modality has its advantages and disadvantages, thus requiring an individualized approach in identifying the most appropriate measure for specific clinical or research situations. Advancements in imaging approaches have led to an abundance of available data, however, the lack of standardized thresholds for classification of abnormal muscle mass or adiposity has been a barrier to adopting these measurements widely in research and clinical care. In this review, we discuss the different modalities in detail and provide guidance on their unique opportunities and challenges.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational and transdisciplinary research in energy balance and cancer: past is prologue. 能量平衡与癌症的转化和跨学科研究：前事不忘，后事之师。

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI: 10.1093/jncimonographs/lgad009

Melinda L Irwin, Dorothy D Sears, Jennifer Ligibel

引用次数: 0

Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022. 开展 "能量与癌症跨学科研究"（TREC）的早期职业科学家的知识拓展要点："能量与癌症跨学科研究 "2022 年培训研讨会报告。

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI: 10.1093/jncimonographs/lgad005

Che-Pei Kung, Meghan B Skiba, Erika J Crosby, Jessica Gorzelitz, Mary A Kennedy, Bethany A Kerr, Yun Rose Li, Sarah Nash, Melanie Potiaumpai, Amber S Kleckner, Dara L James, Michael F Coleman, Ciaran M Fairman, Gloria C Galván, David O Garcia, Max J Gordon, Mathilde His, Lyndsey M Hornbuckle, So-Youn Kim, Tae-Hyung Kim, Amanika Kumar, Mélanie Mahé, Karen K McDonnell, Jade Moore, Sangphil Oh, Xinghui Sun, Melinda L Irwin

{"title":"Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022.","authors":"Che-Pei Kung, Meghan B Skiba, Erika J Crosby, Jessica Gorzelitz, Mary A Kennedy, Bethany A Kerr, Yun Rose Li, Sarah Nash, Melanie Potiaumpai, Amber S Kleckner, Dara L James, Michael F Coleman, Ciaran M Fairman, Gloria C Galván, David O Garcia, Max J Gordon, Mathilde His, Lyndsey M Hornbuckle, So-Youn Kim, Tae-Hyung Kim, Amanika Kumar, Mélanie Mahé, Karen K McDonnell, Jade Moore, Sangphil Oh, Xinghui Sun, Melinda L Irwin","doi":"10.1093/jncimonographs/lgad005","DOIUrl":"10.1093/jncimonographs/lgad005","url":null,"abstract":"The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives. Writing groups were formed and collaborated on this summary of the 5 key takeaways from the TREC Workshop. The 2022 TREC Workshop provided a targeted and unique networking opportunity that facilitated meaningful collaborative work addressing research and clinical needs in energetics and cancer. This report summarizes the 2022 TREC Workshop's key takeaways and future directions for innovative transdisciplinary energetics and cancer research.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking social and built environmental factors to leisure-time physical activity in rural cancer survivors. 将社会和建筑环境因素与农村癌症幸存者的闲暇体育活动联系起来。

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI: 10.1093/jncimonographs/lgad004

Courtney J Stevens, Yue Liao, Minxing Chen, Natalia I Heredia, Hannah Arem, Jasmine Sukumar, Lenat Joffe, Kathryn H Schmitz, Scherezade K Mama

{"title":"Linking social and built environmental factors to leisure-time physical activity in rural cancer survivors.","authors":"Courtney J Stevens, Yue Liao, Minxing Chen, Natalia I Heredia, Hannah Arem, Jasmine Sukumar, Lenat Joffe, Kathryn H Schmitz, Scherezade K Mama","doi":"10.1093/jncimonographs/lgad004","DOIUrl":"10.1093/jncimonographs/lgad004","url":null,"abstract":"Background: This study explored associations between social and built environmental factors and leisure-time physical activity (LTPA) in rural cancer survivors (RCS) and whether these associations differed by exercise stage of change (SOC).Method: RCS (n = 219) completed questionnaires assessing LTPA, SOC, and social (social status, connectedness, support) and environmental (home environment, neighborhood environment) factors. Linear regression models examined associations between social and built environmental factors and LTPA and tested for moderation by SOC.Results: Half (50.7%) of RCS were physically active, and 49.3% were not active. Social factors positively associated with LTPA included subjective social status in the community (B = 89.0, P = .014) and in the United States (B = 181.3, P < .001), social connectedness (B = 122.3, P = .024), and social support for physical activity from family (B = 41.9, P < .001) and friends (B = 44.3, P < .001). Environmental factors positively associated with LTPA included the home environment (B = 111.2, P < .001), perceived environmental support for PA (B = 355.4, P = .004), and neighborhood attributes, including bicycling infrastructure (B = 191.3, P = .003), proximity to recreation facilities (B = 140.1, P = .021), traffic safety (B = 184.5, P = .025), and aesthetics (B = 342.6, P < .001). SOC statistically significantly moderated the association between social status in the United States and LTPA (B = 160.3, P = .031).Conclusions: Social and built environmental factors were consistently linked with LTPA and provide context for multilevel interventions promoting LTPA in RCS.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9870254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Enhancing Health Equity Through Cancer Health Economics Research. 修正为:通过癌症健康经济学研究增强健康公平。

Journal of the National Cancer Institute. Monographs Pub Date : 2022-12-15 DOI: 10.1093/jncimonographs/lgac018

引用次数: 0

Integrating Geriatric Assessment Measures into National Cancer Institute Clinical Trials. 将老年评估措施纳入国家癌症研究所临床试验。

Journal of the National Cancer Institute. Monographs Pub Date : 2022-12-15 DOI: 10.1093/jncimonographs/lgac021

Allison Magnuson, Noam Van der Walde, June M McKoy, Tanya M Wildes, Melisa L Wong, Jennifer Le-Rademacher, Richard F Little, Heidi D Klepin

{"title":"Integrating Geriatric Assessment Measures into National Cancer Institute Clinical Trials.","authors":"Allison Magnuson, Noam Van der Walde, June M McKoy, Tanya M Wildes, Melisa L Wong, Jennifer Le-Rademacher, Richard F Little, Heidi D Klepin","doi":"10.1093/jncimonographs/lgac021","DOIUrl":"https://doi.org/10.1093/jncimonographs/lgac021","url":null,"abstract":"To improve the care of older adults with cancer, the traditional approach to clinical trial design needs to be reconsidered. Older adults are underrepresented in clinical trials with limited or no information on geriatric-specific factors, such as cognition or comorbidities. To address this knowledge gap and increase relevance of therapeutic clinical trial results to the real-life population, integration of aspects relevant to older adults is needed in oncology clinical trials. Geriatric assessment (GA) is a multidimensional tool comprising validated measures assessing specific health domains that are more frequently affected in older adults, including aspects related to physical function, comorbidity, medication use (polypharmacy), cognitive and psychological status, social support, and nutritional status. There are several mechanisms for incorporating either the full GA or specific GA measures into oncology therapeutic clinical trials to contribute to the overarching goal of the trial. Mechanisms include utilizing GA measures to better characterize the trial population, define trial eligibility, allocate treatment receipt within the context of the trial, develop predictive models for treatment outcomes, guide supportive care strategies, personalize care delivery, and assess longitudinal changes in GA domains. The objective of this manuscript is to review how GA measures can contribute to the overall goal of a clinical trial, to provide a framework to guide the selection and integration of GA measures into clinical trial design, and ultimately enable accrual of older adults to clinical trials by facilitating the design of trials tailored to older adults treated in clinical practice.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949568/pdf/lgac021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9334188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Preface: Engaging Older Adults in Cancer Clinical Trials Conducted in the National Cancer Institute Clinical Trials Network: Opportunities to Enhance Accrual. 前言:让老年人参与国家癌症研究所临床试验网络进行的癌症临床试验:提高应计收益的机会。

Journal of the National Cancer Institute. Monographs Pub Date : 2022-12-15 DOI: 10.1093/jncimonographs/lgac020

Diane St Germain, Supriya G Mohile

引用次数: 3

Infrastructure to Support Accrual of Older Adults to National Cancer Institute Clinical Trials. 支持老年人参与国家癌症研究所临床试验的基础设施。

Journal of the National Cancer Institute. Monographs Pub Date : 2022-12-15 DOI: 10.1093/jncimonographs/lgac025

Gretchen Kimmick, Mina S Sedrak, Grant Williams, Nadine J McCleary, Ashley E Rosko, Jeffrey L Berenberg, Rachel A Freedman, Mary Lou Smith, Amina Ahmed, Hyman B Muss, Selina Chow, William Dale

{"title":"Infrastructure to Support Accrual of Older Adults to National Cancer Institute Clinical Trials.","authors":"Gretchen Kimmick, Mina S Sedrak, Grant Williams, Nadine J McCleary, Ashley E Rosko, Jeffrey L Berenberg, Rachel A Freedman, Mary Lou Smith, Amina Ahmed, Hyman B Muss, Selina Chow, William Dale","doi":"10.1093/jncimonographs/lgac025","DOIUrl":"10.1093/jncimonographs/lgac025","url":null,"abstract":"As part of ongoing efforts to meaningfully improve recruitment, enrollment, and accrual of older adults into cancer clinical trials, the National Cancer Institute (NCI) sponsored a workshop with experts across the country entitled Engaging Older Adults in the NCI Clinical Trials Network: Challenges and Opportunities. Three working groups, including Study Design, Infrastructure, and Stakeholders, were formed, who worked together to offer synergistic improvements in the system. Here, we summarize the workshop discussions of the Infrastructure Working Group, whose goal was to address infrastructural challenges, identify underlying resources, and offer solutions to facilitate accrual of older adults into cancer clinical trials. Based on preconference work and workshop discussions, four key recommendations to strengthen NCI infrastructure were proposed: 1) further centralize resources and expertise; 2) provide training for clinical research staff; (3) develop common data elements; and 4) evaluate what works and does not work. These recommendations provide a strategy to improve the infrastructure to enroll more older adults in cancer clinical trials.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0