Journal of the National Cancer Institute. Monographs最新文献_第10页

OUP accepted manuscript OUP接受稿件

Journal of the National Cancer Institute. Monographs Pub Date : 2022-01-01 DOI: 10.1093/jncimonographs/lgac010

引用次数: 0

OUP accepted manuscript OUP接受稿件

Journal of the National Cancer Institute. Monographs Pub Date : 2022-01-01 DOI: 10.1093/jncimonographs/lgac012

引用次数: 0

Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects. 大麻素和癌症化疗相关的不良反应。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab007

Sara Jane Ward, Aron H Lichtman, Daniele Piomelli, Linda A Parker

{"title":"Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects.","authors":"Sara Jane Ward, Aron H Lichtman, Daniele Piomelli, Linda A Parker","doi":"10.1093/jncimonographs/lgab007","DOIUrl":"https://doi.org/10.1093/jncimonographs/lgab007","url":null,"abstract":"The use of cannabis is not unfamiliar to many cancer patients, as there is a long history of its use for cancer pain and/or pain, nausea, and cachexia induced by cancer treatment. To date, the US Food and Drug Administration has approved 2 cannabis-based pharmacotherapies for the treatment of cancer chemotherapy-associated adverse effects: dronabinol and nabilone. Over the proceeding decades, both research investigating and societal attitudes toward the potential utility of cannabinoids for a range of indications have progressed dramatically. The following monograph highlights recent preclinical research focusing on promising cannabinoid-based approaches for the treatment of the 2 most common adverse effects of cancer chemotherapy: chemotherapy-induced peripheral neuropathy and chemotherapy-induced nausea and vomiting. Both plant-derived and synthetic approaches are discussed, as is the potential relative safety and effectiveness of these approaches in relation to current treatment options, including opioid analgesics.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848502/pdf/lgab007.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Cannabinoid Cancer Biology and Prevention. 大麻素癌症生物学和预防。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab008

Sean D McAllister, Mary E Abood, Joseph Califano, Manuel Guzmán

{"title":"Cannabinoid Cancer Biology and Prevention.","authors":"Sean D McAllister, Mary E Abood, Joseph Califano, Manuel Guzmán","doi":"10.1093/jncimonographs/lgab008","DOIUrl":"https://doi.org/10.1093/jncimonographs/lgab008","url":null,"abstract":"Plant-based, synthetic, and endogenous cannabinoids have been shown to control a diverse array of biological processes, including regulation of cell fate across cancers. Their promise as broad-based antitumor agents in preclinical models has led to the initiation of pilot clinical trials. Session 5 of the National Cancer Institute's Cannabis, Cannabinoids and Cancer Research Symposium provides an overview of this research topic. Overall, the presentations highlight cannabinoid signal transduction and specific molecular mechanisms underlying cannabinoid antitumor activity. They also demonstrate the broad-based antitumor activity of the plant-based, synthetic, and endogenous cannabinoid compounds. Importantly, evidence is presented demonstrating when cannabinoids may be contraindicated as a treatment for cancer, as in the case of human papilloma virus-meditated oropharynx cancer or potentially other p38 MAPK pathway-driven cancers. Finally, it is discussed that a key to advancing cannabinoids into the clinic is to conduct well-designed, large-scale clinical trials to determine whether cannabinoids are effective antitumor agents in cancer patients.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cannabis Policy in the United States: Implications for Public Health. 美国大麻政策:对公众健康的影响。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab016

Gillian L Schauer

引用次数: 1

Cancer Treatment: Preclinical & Clinical. 癌症治疗:临床前和临床。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab010

Donald I Abrams, Guillermo Velasco, Chris Twelves, Ramesh K Ganju, Gil Bar-Sela

引用次数: 2

The Management of Cancer Symptoms and Treatment-Induced Side Effects With Cannabis or Cannabinoids. 大麻或大麻素对癌症症状和治疗引起的副作用的处理。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab011

Michelle Sexton, Jose M Garcia, Aminah Jatoi, Carey S Clark, Mark S Wallace

{"title":"The Management of Cancer Symptoms and Treatment-Induced Side Effects With Cannabis or Cannabinoids.","authors":"Michelle Sexton, Jose M Garcia, Aminah Jatoi, Carey S Clark, Mark S Wallace","doi":"10.1093/jncimonographs/lgab011","DOIUrl":"https://doi.org/10.1093/jncimonographs/lgab011","url":null,"abstract":"Cannabis and cannabinoids are increasingly being accessed and used by patients with advanced cancer for various symptoms and general quality of life. Specific symptoms of pain, nausea and vomiting, loss of appetite and cachexia, anxiety, sleep disturbance, and medical trauma are among those that have prompted patients with cancer to use cannabis. This conference report from the National Cancer Institute's \"Cannabis, Cannabinoid and Cancer Research Symposium\" on the topic of \"Cancer Symptom/Treatment Side Effect Management\" is an expert perspective of cannabis intervention for cancer and cancer treatment-related symptoms. The purpose of the symposium was to identify research gaps, describe the need for high-quality randomized prospective studies of medical cannabis for palliative care in patients with cancer, and evaluate the impact of medical cannabis on cancer survivors' quality of life. Further, education of clinicians and affiliated health-care providers in guiding cancer patients in using cannabis for cancer care would benefit patients. Together, these steps will further aid in refining the use of cannabis and cannabinoids for symptom palliation and improve safety and efficacy for patients.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848503/pdf/lgab011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Challenges for Clinical Cannabis and Cannabinoid Research in the United States. 美国临床大麻和大麻素研究面临的挑战。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab009

Ziva D Cooper, Donald I Abrams, Steven Gust, Alejandro Salicrup, Douglas C Throckmorton

{"title":"Challenges for Clinical Cannabis and Cannabinoid Research in the United States.","authors":"Ziva D Cooper, Donald I Abrams, Steven Gust, Alejandro Salicrup, Douglas C Throckmorton","doi":"10.1093/jncimonographs/lgab009","DOIUrl":"10.1093/jncimonographs/lgab009","url":null,"abstract":"Significant changes have occurred in the policy landscape surrounding cannabis legalization, production, and use around the globe and across the United States. With widespread availability of novel cannabis and cannabis-based products, there is an urgent need to understand their safety and effectiveness for medical indications. Three primary barriers contribute to the difficulty in initiating research geared toward answering the most pressing public health questions: the US regulatory status of cannabis and cannabinoids, sources for cannabis and cannabinoid study medications, and limited funding and resources to support studies. Despite these hurdles, research is rapidly increasing, and recent changes in the United States have paved the way for exciting new work. Here, challenges and barriers to cannabis and cannabinoid research are described from the perspectives of the National Institute on Drug Abuse, National Institutes of Health; the US Food and Drug Administration; and 2 clinical researchers. Barriers specifically to studying cannabis, cannabinoids, and cancer are emphasized.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783595/pdf/lgab009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Nonmedical Cannabis Use: Patterns and Correlates of Use, Exposure, and Harm, and Cancer Risk. 非医用大麻使用:使用、暴露、危害和癌症风险的模式和相关性。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab006

Amy M Cohn, Benjamin C Blount, Mia Hashibe

引用次数: 5

The National Cancer Institute and Cannabis and Cannabinoids Research. 国家癌症研究所和大麻和大麻素研究所。

Journal of the National Cancer Institute. Monographs Pub Date : 2021-11-28 DOI: 10.1093/jncimonographs/lgab014

Gary L Ellison, L Alejandro Salicrup, Andrew N Freedman, Yali Fu, Sharon Ross, Ronald L Johnson, Alexis Bakos, Jeffrey D White

{"title":"The National Cancer Institute and Cannabis and Cannabinoids Research.","authors":"Gary L Ellison, L Alejandro Salicrup, Andrew N Freedman, Yali Fu, Sharon Ross, Ronald L Johnson, Alexis Bakos, Jeffrey D White","doi":"10.1093/jncimonographs/lgab014","DOIUrl":"https://doi.org/10.1093/jncimonographs/lgab014","url":null,"abstract":"The landscape of both recreational and medicinal cannabis use has changed dramatically over the past decade; however, research examining the risks and benefits of cannabis and cannabinoid use has lagged significantly behind the increased media promotion and their use by the general public and cancer patients. The National Cancer Institute (NCI) has supported cannabis-related research projects and funding opportunity announcements. In addition, NCI organized a virtual symposium on December 15-18, 2020, to discuss recent research findings on the use of cannabis and cannabinoids in relationship to cancer risk, prevention, and care. Specifically, the symposium sought to highlight the state of the science regarding cannabis, including the chemical constituents of cannabis (eg, cannabinoids), and cancer research involving cannabis, including cancer epidemiology, use in cancer patients, cancer biology and prevention, and preclinical and clinical cancer symptom and treatment side effect management with cannabis and cannabinoids as therapeutics. The symposium identified promising areas of future study, current barriers to conducting the research, and strategies to overcome those barriers. The series of papers in this special edition provide a summary of the symposium sessions as well as a synopsis of opportunities and challenges related to conducting research in this area.","PeriodicalId":73988,"journal":{"name":"Journal of the National Cancer Institute. Monographs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783594/pdf/lgab014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2