Susan S Xu, Zhipeng Lei, Ziqing Zhuang, Michael Bergman
{"title":"Numerical Simulations of Exhaled Particles from Wearers of Powered Air Purifying Respirators.","authors":"Susan S Xu, Zhipeng Lei, Ziqing Zhuang, Michael Bergman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In surgical settings, infectious particulate wound contamination is a recognized cause of post-operative infections. Powered air purifying respirators (PAPRs) are worn by healthcare workers for personal protection against contaminated aerosols. Healthcare infection preventionists have expressed concern about the possibility that infectious particles expelled from PAPR exhalation channels could lead to healthcare-associated disease, especially in operative settings where sterile procedural technique is essential. This study used computational fluid dynamics (CFD) modeling to simulate and visualize the distribution of particles exhaled by PAPR wearers. Using CFD simulations, the PAPR inside to outside ratio of particle concentrations was estimated. Also, the effects of particle sizes, supplied-air flow rates, and breathing work rates on outward leakage were evaluated. This simulation study reconstructed a geometrical model of a static median headform wearing a loose-fitting PAPR by capturing a 3D image. We defined a mathematical model for the headform and PAPR system and ran simulations with four particle sizes, three breathing workloads and two supplied-air flow rates (a total 24 configurations; 4×3×2=24) applied on the digital model of the headform and PAPR system. This model accounts for exhaled particles, but not ambient particles. Computed distributions of particles inside and outside the PAPR are displayed. The outward concentration leakage was low at surgical setting, e.g., it was about 9% for a particle size of 0.1 and 1 μm at light breathing and a 205 L/min supplied-air flow rate. The supplied-air flow rates, particle sizes, and breathing workloads had effects on the outward concentration leakage, as the outward concentration leakage increased as particle size decreased, breathing workload increased, and the supplied-air flow rate decreased. The CFD simulations can help to optimize the supplied-air flow rates. When the loose-fitting PAPR is used, exhaled particles with small size (below 1μm), or heavy breathing workloads, may generate a great risk to the sterile field and should be avoided.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"36 2","pages":"66-76"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193200/pdf/nihms-1878287.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Rigidity of Surgical N95 Respirators Using a Manikin-System: A Pilot Study.","authors":"Samy Rengasamy, George Niezgoda","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Surgical N95 respirators are devices certified by the National Institute for Occupational Safety and Health (NIOSH) and also cleared by the Food and Drug Administration (FDA) as a medical device. They are commonly used in healthcare settings to provide protection from infectious aerosols, as well as, bodily fluid sprays and splashes. It is hypothesized based on design, some models may change their shape significantly (i.e., collapse) during heavy breathing, which may allow the device to touch the wearer's face. Concerns have been raised that droplets of infectious biological fluids may reach the inner layer of surgical N95 respirators leading to the transfer of microorganisms to the oronasal facial region upon collapse. Unfortunately, little data currently exists on respirator rigidity testing or its relation to efficacy. The objective of this study was to develop and optimize a manikin-based test system to evaluate respirator rigidity.</p><p><strong>Methods: </strong>Six surgical N95 models of three different designs (cup-shaped, flat fold and trifold) were tested at two different environmental conditions on the NIOSH medium headform. Rigidity evaluation was performed at 50% relative humidity (RH) and 22°C, and at ~100% RH and 33°C at 40, 50, and 60 L/min breathing flow rates. Facial contact secondary to shape change was assessed by coating the inner layer of the surgical N95 respirators with a fluorescent tracer and its transfer to the manikin face.</p><p><strong>Results: </strong>The results showed that the cup-shaped models were rigid and resistant to shape change at both environmental conditions and all flow rates. In contrast, the flat fold models and trifold models showed significant changes with rigidity, at higher breathing flow rates and higher RH and temperature conditions. The flat fold models showed transfer of the fluorescent tracer to the manikin face at higher RH and breathing rates, confirming a change in rigidity.</p><p><strong>Conclusions: </strong>The results from the study suggest that the manikin-based test system designed for the purposes of this study can be used to evaluate respirator rigidity.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"26 1","pages":"18-27"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111508/pdf/nihms-1048433.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37808426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Spelce, Timothy R Rehak, Richard W Metzler, James S Johnson
{"title":"History of U.S. Respirator Approval (Continued) Particulate Respirators.","authors":"David Spelce, Timothy R Rehak, Richard W Metzler, James S Johnson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is the final article in a series of four articles on respirator history. This article continues to follow the history of respirator approval, use, and improvements in the U.S. as discussed in our article entitled, <i>History of U.S. Respirator Approval</i>, published in the ISRP Journal, Vol. 35, No. 1, 2018 (Spelce et al., 2018). This article is entirely about the history of respirators for protection against particulate hazards since the most extensive records available for the United States Bureau of Mines (USBM) approval schedules are for dust/fume/mist respirators.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":" ","pages":"37-55"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307331/pdf/nihms-1588251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38075341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerri Wizner, Lewis Radonovich, Allie Bell, Charles Oke, Mary Yarbrough
{"title":"Feasibility Assessment of a New Surveillance Tool for Respiratory Protective Devices Used in U.S. Healthcare.","authors":"Kerri Wizner, Lewis Radonovich, Allie Bell, Charles Oke, Mary Yarbrough","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Respiratory protective devices (RPDs) are used for infection prevention in healthcare settings during routine patient care and public health emergencies. In recent years, healthcare systems have experienced shortages of RPDs during outbreaks of infectious diseases, in part due to a lack of information about their availability. New tools to track RPD inventories may improve accessibility during an emergency. Investigators at Vanderbilt University have identified four major themes that influence RPD use for infection prevention: hospital preparedness, responsiveness to airborne pathogens, potential exposure outcomes, and infection control practices related to respirator effectiveness. Based on these findings, an RPD surveillance tool (RST) was developed to collect and share near real-time data about RPD supplies in healthcare facilities. The objective of this study was to conduct a feasibility assessment of this RST.</p><p><strong>Methods: </strong>The new online surveillance tool was implemented at four large, urban, acute care U.S. hospitals in January 2014; data was collected about RPD inventory, tracking systems, hospital characteristics, and utility of gathered information.</p><p><strong>Results: </strong>The RST was implemented successfully and without difficulty at hospitals that had 78 to 90 percent occupancy rates. Participating hospitals reported that the RST (1) provided value for benchmarking their RPD supply, (2) promoted understanding about RPD accessibility among hospital systems engaged in infection control, and (3) served as a means to assess RPD program quality.</p><p><strong>Conclusion: </strong>Implementation of this newly developed RST is feasible and appears to have utility in U.S. hospitals for tracking and understanding RPD use for routine healthcare delivery and public health emergencies.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"35 1","pages":"26-35"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145473/pdf/nihms-986035.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36517043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jintuo Zhu, Xinjian He, Steven Guffey, Michael S Bergman, Eun G Lee, Ziqing Zhuang
{"title":"Assessment of Two Personal Breathing Recording Devices in a Simulated Healthcare Environment.","authors":"Jintuo Zhu, Xinjian He, Steven Guffey, Michael S Bergman, Eun G Lee, Ziqing Zhuang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In the field of respiratory protection for healthcare workers (HCWs), few data are available on respiratory airflow rate when HCWs are performing their work activities. The objective of this study was to assess the performance of two wearable breathing recording devices in a simulated healthcare environment.</p><p><strong>Methods: </strong>Breathing recording devices from two different manufactures \"A\" and \"B\" were assessed using 15 subjects while performing a series of simulated healthcare work activities (patient assessment; vitals; IV treatment; changing linen; carrying weight while walking; normal breathing while standing). The minute volume (MV, L/min), mean inhalation flow (MIF, L/min), peak inhalation flow (PIF, L/min), breathing frequency (f, breaths/min), and tidal volume (TV, L/min) measured by each device were analyzed. Bland-Altman method was applied to explore the variability of devices A and B. Duncan's multiple range test was used to investigate the differences among activity-specific inspiratory flow rates.</p><p><strong>Results: </strong>The average MV, MIF and PIF reported by device A were 23, 54, and 82 L/min with 95% upper confidence intervals (CIs) of 25, 60 and 92 L/min; the mean differences of MV, MIF and PIF presented by the two units of device A were 0.9, 1.3, and 2.8 L/min, respectively. The average values and mean differences of MV, MIF and PIF found with device B were significantly higher than device A (P<0.05), showing a high variability. During non-speech activities, the PIF/MV and MIF/MV ratios were >3.14 and >2, while with speech, the ratios increased to >6 and >3. The f during speech (15 breaths/min) was significantly lower than non-speech activities (20-25 breaths/min). Among different simulated work activities, the PIF of \"patient assessment\" was the highest.</p><p><strong>Conclusions: </strong>This study demonstrated a novel approach to characterize respiratory flow for healthcare workers using an innovative wearable flow recording device. Data from this investigation could be useful in the development of future respirator test standards.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"35 2","pages":"98-111"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179815/pdf/nihms-1047288.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Spelce, Timothy R Rehak, Richard W Metzler, James S Johnson
{"title":"History of U.S. Respirator Approval.","authors":"David Spelce, Timothy R Rehak, Richard W Metzler, James S Johnson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article is the second in a series of four articles on respirator history. The discussions presented in this article follow the history of respirator requirements, use, improvements, and certification in America. Included is a discussion of respirator evolution prior to American certification standards and discussion of the need, primarily from the mining industry, for government respirator certification. The reasons for government intervention and the origination of the American respirator certification program are discussed.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"35 1","pages":"35-46"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261008/pdf/nihms-1589584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37991835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flammability of Respirators and other Head and Facial Personal Protective Equipment.","authors":"Samy Rengasamy, George Niezgoda, Ron Shaffer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Personal protective equipment (PPE) is worn by workers in surgical settings to protect them and patients. Food and Drug Administration (FDA) clears some PPE (e.g., surgical masks (SM)) as class II medical devices, and regulates some (e.g. surgical head cover) as class I exempt devices. For respiratory protection, National Institute for Occupational Safety and Health (NIOSH)-approved N95 filtering facepiece respirators (FFRs), and powered air-purifying respirators (PAPRs) are used. One type of PPE, \"surgical N95 respirators\", is a NIOSH-approved FFR that is also cleared by the FDA for use in medical settings. The surgical environment poses unique risks such as the potential for surgical fires. As part of its substantial equivalence determination process, FDA requests testing of flammability and other parameters for SM and surgical N95 respirators. A lack of data regarding flammability of PPE used in healthcare exists. We hypothesize that commonly used PPE, regardless of whether regulated and/or cleared by FDA or not, will pass an industry standard such as the 16 CFR 1610 flammability test.</p><p><strong>Methods: </strong>Eleven N95 FFR models, eight surgical N95 respirator models, seven SM models, five surgical head cover models, and five PAPR hood models were evaluated for flammability with a 45 degree flammability tester using the 16 CFR 1610 method. Three common fabrics were included for comparison.</p><p><strong>Results: </strong>All of the PPE samples regulated/and or cleared by FDA or not, passed the flammability test at class 1 (normal flammability), meaning they are less likely to burn. Only one of the three common fabrics, a cotton fabric at the lowest basis weight, was class 3 (high flammability).</p><p><strong>Conclusions: </strong>The results obtained in the study suggest that NIOSH-approved N95 FFRs would likely pass the 16 CFR 1610 flammability standard. Moreover, results suggest that NIOSH is capable of undertaking flammability testing using the 16 CFR 1610 standard as the flammability results NIOSH obtained for N95 FFRs were comparable to the results obtained by a third party independent laboratory.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"35 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198820/pdf/nihms-991564.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36620770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William P King, Margaret Sietsema, Caitlin McClain, Susan Xu, Helion Dhrimaj
{"title":"Work of Breathing for Respiratory Protective Devices: Method Implementation, Intra-, Inter-Laboratory Variability and Repeatability.","authors":"William P King, Margaret Sietsema, Caitlin McClain, Susan Xu, Helion Dhrimaj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As part of development of performance standards, the International Organization for Standardization (ISO) technical committee, ISO/TC 94/SC 15 Respiratory protective devices (RPD), adopted work of breathing (WOB) to evaluate airflow resistance for all designs (classes) of respiratory protective devices. The interests of the National Institute for Occupational Safety and Health's (NIOSH) National Personal Protective Technology Laboratory (NPPTL) are to compare the proposed WOB method and results for current RPD with those for present resistance methods. The objectives here were to assemble a method to meet the ISO SC15 standards, validate operation and conformance, and assess repeatability of WOB measurements for RPD. WOB method implementation and use followed standards ISO 16900-5:2016 and ISO 16900-12:2016. Volume-averaged total work of breathing (WOB<sub>T</sub>/V<sub>T</sub> where V<sub>T</sub> is tidal volume) determined for standard orifices was analyzed for variation and bias. After fabrication and assembly, the method gave preliminary verification orifice results that met ISO requirements and were equivalent to those from other laboratories. Evaluation of additional results from RPD testing showed tidal volume and frequency determined compliance. Appropriate adjustments reduced average absolute bias to 1.7%. Average coefficient of variation for WOB<sub>T</sub>/V<sub>T</sub> was 2.3%. Over 97% of results obtained during significant use over time met specifications. WOB<sub>T</sub>/V<sub>T</sub> for as-received air-purifying and supplied-air RPD were repeatable (p<0.05). WOB<sub>T</sub>/V<sub>T</sub> for unsealed half mask air-purifying RPD was an average of 31% lower compared to sealed. When experimental parameters were appropriately adjusted, the ISO WOB method implemented by NIOSH NPPTL consistently provided ISO-compliant verification WOB<sub>T</sub>/V<sub>T</sub>. Results for appropriately sealed RPD were reproducible.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"34 2","pages":"81-94"},"PeriodicalIF":0.0,"publicationDate":"2017-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273392/pdf/nihms-1869188.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9708926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jung-Hyun Kim, Raymond J Roberge, Ronald E Shaffer, Ziqing Zhuang, Jeffrey B Powell, Michael Bergman, Andrew J Palmiero
{"title":"Project BREATHE - Prototype Respirator Evaluation Utilizing Newly Proposed Respirator Test Criteria.","authors":"Jung-Hyun Kim, Raymond J Roberge, Ronald E Shaffer, Ziqing Zhuang, Jeffrey B Powell, Michael Bergman, Andrew J Palmiero","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Machine and human subject testing of four prototype filtering facepiece respirators (FFR) and two commercial FFR was carried out utilizing recently proposed respirator test criteria that address healthcare worker-identified comfort and tolerance issues. Overall, two FFR (one prototype, one commercial model) were able to pass all eight criteria and three FFR (two prototypes, one commercial model) were able to pass seven of eight criteria. One prototype FFR was not tested against the criteria due to an inability to obtain satisfactory results on human subject quantitative respirator fit testing. Future studies, testing different models and styles of FFR against the proposed criteria, will be required to gauge the overall utility and effectiveness of the criteria in determining FFR comfort and tolerance issues that may impact user compliance and, by extension, protection.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":"34 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193462/pdf/nihms-1869171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9875595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stella E Hines, Nora Mueller, Marc Oliver, Patricia Gucer, Melissa McDiarmid
{"title":"Qualitative Analysis of Origins and Evolution of an Elastomeric Respirator-based Hospital Respiratory Protection Program.","authors":"Stella E Hines, Nora Mueller, Marc Oliver, Patricia Gucer, Melissa McDiarmid","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Elastomeric respirators (elastomerics) may serve as one alternative to disposable N95 respirator use in healthcare. We explored factors which drove elastomeric adoption and continued use in a large academic medical center. We conducted semi-structured and focus group interviews in 2015 with a) 11 leadership key informants (KIs) with involvement in the respiratory protection program (RPP) when elastomerics were introduced and b) 11 healthcare workers (HCWs) recruited from hospital departments assigned to use elastomerics. Interview transcripts and responses were open-coded to capture emergent themes, which were collapsed into broader categories and iteratively refined. Factors identified by leadership KIs as influencing elastomeric adoption included: 1) N95 shortages during 2009's H1N1 influenza pandemic and 2) the presence of trained, certified safety professionals who were familiar with respiratory protection requirements. Factors identified as influencing ongoing use of elastomerics included: 1) cleaning/decontamination practices, 2) storage, 3) safety culture, 4) HCW respirator knowledge, and 5) risk perception. HCW users expressed dissatisfaction related to breathing, communication and cleaning of elastomerics. Other themes included convenience use of N95s rather than assigned elastomerics, despite perceptions that elastomerics are more protective. Through semi-structured and focus group interviews, we learned that 1) leadership introduced elastomerics due to necessity but now face challenges related to ongoing use, and 2) HCWs were not satisfied with elastomerics for routine care and preferentially used N95s because they were conveniently available at point of use. Although the impetus behind incorporation of elastomerics was clear, the most complex themes related to sustainability of this form of RPP. These themes were used to inform a broader questionnaire and will address the utility of elastomerics as a feasible and acceptable practical alternative to N95s in healthcare.</p>","PeriodicalId":73984,"journal":{"name":"Journal of the International Society for Respiratory Protection","volume":" ","pages":"95-110"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849268/pdf/nihms942991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35920541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}