Journal of surgery and research最新文献_第9页

Novel Recognition of HER2 Amplification in Enteroblastic Colonic Adenocarcinoma. Diagnostic Clues and Future Perspectives 小肠母细胞结肠腺癌中HER2扩增的新识别。诊断线索和未来展望

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020256

Leoncini Giuseppe, Sabella Giovanna, Milione Massimo

{"title":"Novel Recognition of HER2 Amplification in Enteroblastic Colonic Adenocarcinoma. Diagnostic Clues and Future Perspectives","authors":"Leoncini Giuseppe, Sabella Giovanna, Milione Massimo","doi":"10.26502/jsr.10020256","DOIUrl":"https://doi.org/10.26502/jsr.10020256","url":null,"abstract":"Enteroblastic differentiation in sporadic colonic adenocarcinoma was a rare event that lacks to be fully elucidated. It was characterized by an aggressive biological behavior, with early metastatic spread and poor prognosis. Diagnostic clues and molecular features were not completely elucidated so far. Histological features including tubulo-papillary architecture, cleared neoplastic cells, fetal oncoproteins expression were diagnostic requirements. We describe a new case of enteroblastic colonic adenocarcinoma (CAED) in the sigmoid, exhibiting small intestinal phenotype, higher stage at diagnosis and early liver metastases. At molecular level, CAED shared both TP53 gene mutation and beta-catenin nuclear translocation with conventional colonic adenocarcinoma. Altered human epidermal growth factor receptor (HER) 2 signaling has been described in a small subset of conventional colonic adenocarcinoma. At best of our knowledge our report represents the first immunohistochemical recognition of HER2 gene amplification in CAED. Given its aggressive clinical behavior, clinicians should be aware of the possible HER2 amplification, that could point toward further treatment options.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87289188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-shaped Uterus, Other Studies are Needed But What Can We Do in The Meantime? t型子宫，需要其他研究，但同时我们能做些什么?

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020252

L. Marin, G. Ambrosini, Simone Antonio Laganà, G. Capobianco, F. Dessole, A. Andrisani

引用次数: 0

The Stage III Melanoma in Cervical Region, Prognostic Impact of The Lymph Node Ratio of The Neck Dissections 颈部III期黑色素瘤，颈部淋巴结比例对预后的影响

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020235

Quiriny M, Shall F, M. M, Willemse E, Sales F, A. G., Digonnet A

引用次数: 0

A Comparative Study Between Fine Needle Aspiration Cytology and Core Needle Biopsy in the Diagnosis of Palpable Breast Lumps 细针穿刺细胞学与核心针活检诊断可触及乳腺肿块的比较研究

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020215

Sharang S Kulkarni, S. Murchite, A. Patil

{"title":"A Comparative Study Between Fine Needle Aspiration Cytology and Core Needle Biopsy in the Diagnosis of Palpable Breast Lumps","authors":"Sharang S Kulkarni, S. Murchite, A. Patil","doi":"10.26502/jsr.10020215","DOIUrl":"https://doi.org/10.26502/jsr.10020215","url":null,"abstract":"A Comparative Study Between Fine Needle and Core Biopsy in the Palpable Abstract Background Breast carcinoma is a frequently diagnosed cancer in women worldwide. An effective diagnosis is necessary to manage this cancer in its preliminary stages. After a radiological examination of the palpable breast lumps, a core needle biopsy (CNB) or fine needle aspiration cytology (FNAC), is performed. The study focuses on comparing the accuracy and efficacy of FNAC and CNB in diagnosing palpable breast lumps. Design A randomized, open-labeled, comparative research. Setting selected The randomization technique was used to divide patients into two groups, i.e., undergoing FNAC or CNB. The results thus obtained were compared the post-operative histopathological Biostatistical parameters such as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy. Results The sensitivity of CNB and FNAC was 92.8% and 86.6% respectively, whereas the specificity and positive predictive value of both the tests were 100%. NPV of CNB was 95%, and that of FNAC was 90%. The accuracy of CNB was 96.96% and that of FNAC was 93.90%. Conclusion Better cellularity, the possibility of immunohistochemical analysis and better characterization of specimens make core needle biopsy more efficacious than FNAC. It is more sensitive and accurate than FNAC. Core needle biopsy provides a more dependable preoperative diagnosis which can help in creating a prudent algorithm for management of a palpable breast lump, thereby more often leading to definitive surgical treatment.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79018365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Anterior Mediastinal Mass Requiring Awake Veno-Venous Extracorporeal Membrane Oxygenation Therapy: Case Report and Review of the Literature 巨大前纵隔肿块需要清醒的静脉-静脉体外膜氧合治疗:病例报告和文献复习

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020230

Dichtwald Sara, M. Avraham, Gorfil Dan M, Ifrach Nisim

引用次数: 0

Heterogeneous Population of Immune cells Associated with Early Thrombosis in Arteriovenous Fistula. 与动静脉瘘早期血栓形成相关的异质免疫细胞群。

Journal of surgery and research Pub Date : 2022-01-01 Epub Date: 2022-07-07 DOI: 10.26502/jsr.10020237

Gunimat Samra, Vikrant Rai, Devendra K Agrawal

{"title":"Heterogeneous Population of Immune cells Associated with Early Thrombosis in Arteriovenous Fistula.","authors":"Gunimat Samra, Vikrant Rai, Devendra K Agrawal","doi":"10.26502/jsr.10020237","DOIUrl":"https://doi.org/10.26502/jsr.10020237","url":null,"abstract":"<p><p>End-Stage Renal Disease (ESRD) is a growing cause of morbidity and mortality in the practice of modern medicine. Advances in medicine have elongated the average life span and subsequently made chronic diseases prevalent. Hemodialysis is the main treatment that is used to treat ESRD and is a clinical procedure that is being re-imagined with novel approaches to improve patient and clinic practicality and effectiveness. Arteriovenous Fistulas (AVF) are now used in place of catheters due to their higher success and lower co-morbidities. The main drawback of AVF is the time gap that is needed from the surgical creation of AVF to its use. During this time, the AVF is susceptible to thrombosis and occlusion rendering the fistula ineffective for treatment. Immune cells play a major role in vascular pathologies and macrophages, dendritic cells, and T-regulatory cells are the main cells seen during the inflammatory and anti-inflammatory phases. However, the role of immune response and immune cells in AVF maturation is poorly understood. This study aimed to investigate the immune response and immune cell expression in femoral vessels after AVF creation in a miniswine model of AVF using immunohistochemistry and qRT-PCR. The results of this study revealed an increased expression of immune cells in AVF vessels and suggest an association of immune response with AVF creation and maturation.</p>","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":" ","pages":"423-434"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354142/pdf/nihms-1823003.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40593598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Double-Crossed Knotless Suture Anchor Repair of Quadriceps Tendon Rupture 双交叉无结缝合锚钉修复股四头肌肌腱断裂

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020210

W. Ali, J. Iqbal, Talat Z. Mahmood, Liam Leonard, P. O’grady

{"title":"Double-Crossed Knotless Suture Anchor Repair of Quadriceps Tendon Rupture","authors":"W. Ali, J. Iqbal, Talat Z. Mahmood, Liam Leonard, P. O’grady","doi":"10.26502/jsr.10020210","DOIUrl":"https://doi.org/10.26502/jsr.10020210","url":null,"abstract":"Quadriceps tendon rupture is an uncommon injury but may result in long term disability if not adequately repaired. Many techniques are described for repair of acute quadriceps tendon rupture, including tendon-totendon repair, trans-osseous tunnels, synthetic augmentation, tendon plasty and the use of suture anchors. There is no single accepted surgical treatment. This study's objective was to assess the efficacy of a double-crossed suture anchor repair in the management of quadriceps tendon rupture. Materials and methods 85 patient attended our institute for surgical management of quadriceps tendon rupture over eight years (2012-2019). Twenty patients were treated with the use of a double-crossed suture anchor fixation. These patients were allowed to weight bear in a hinged knee brace for six weeks following surgery. Eighteen out of twenty patients had one or more predisposing comorbidities, including obesity, diabetes, renal failure, quinolone and steroid use. Results Clinical and functional outcomes were recorded during follow up visits prospectively for a mean of one year (10-14 months). The mean knee flexion was 124 degree (120-130). All patients were able to return to activities of daily living (ADL) with a mean of 2 J Surg Res 2022; 5 (1): 173-184 DOI: 10.26502/jsr.10020210 Journal of Surgery and Research Vol. 5 No. 1 March 2022. [ISSN 2640-1002] 174 months (1.5-3 months) and return to work at a mean of 6 months (4-8 months). The mean Tegner, Cincinnati and Lysholm score at the latest follow up were 2.8 (05), 79.2 (60-88) and 90 (70-100), respectively. There were no early complications. There was no re-tear reported at the latest follow up. Conclusion The double-crossed suture anchor fixation is a safe and effective treatment option in managing quadriceps tendon ruptures.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76463237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinico Pathological Analysis of Nodular Goiter: A Retrospective Study 结节性甲状腺肿的临床病理分析:回顾性研究

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020203

Talukder Mih, Naher N, Karim Smr, Hasan Km, Khan Si, Rahman Akms

引用次数: 1

Predicting Screening Factors for an Obesity Team’s Decision: A large Retrospective Cohort study 预测肥胖小组决策的筛选因素:一项大型回顾性队列研究

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020199

Lodewijks Y, de Zoete JP, Van der Ven R, Schiffer A, Nienhuijs S

引用次数: 0

Fecal Microbial Profiling of Young Hirschsprung Disease Children After Pull-Through Operation 幼童先天性巨结肠手术后粪便微生物特征分析

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020261

Kanokrat Thaiwatcharamas, W. Loilome, S. Chusilp, Patchareeporn Tanming, P. Klanrit, Jutarop Phetcharaburanin

{"title":"Fecal Microbial Profiling of Young Hirschsprung Disease Children After Pull-Through Operation","authors":"Kanokrat Thaiwatcharamas, W. Loilome, S. Chusilp, Patchareeporn Tanming, P. Klanrit, Jutarop Phetcharaburanin","doi":"10.26502/jsr.10020261","DOIUrl":"https://doi.org/10.26502/jsr.10020261","url":null,"abstract":"Introduction: This study aimed to characterize and compare the fecal microbial profiles between post pull-through Hirschsprung disease patients and healthy children aged younger than five years. Method: Fresh fecal samples were collected from 10 post pull-through Hirschsprung disease patients and age range-matched 10 healthy children. Bacterial DNA obtained from fecal samples were analyzed using 16S rRNA Illumina MiSeq platform. Results: Our findings demonstrated the significantly increased Firmicutes in Hirschsprung disease group compared to the healthy group (corrected p-value=0.007) at the phylum level. In addition, the Firmicutes/ Bacteroidetes ratio in Hirschsprung disease group was 4.8 times higher than that of its control counterpart. Bacilli were also significantly increased (corrected p-value=0.004), while Erysipelotrichi and Actinobacteria were significantly decreased in Hirschsprung disease patients (corrected p-value=0.04 and 0.03, respectively) at the class level. Moreover, functional analysis demonstrated that 20 enzymes and 18 Kyoto Encyclopedia of Genes and Genomes pathways were significantly different between groups (corrected p-value<0.01). Conclusion: A distinct dysbiosis even when the aganglionic segment had already been removed was remarkably evident in young children with Hirschsprung disease, with a significant increase in Firmicutes and a nearly five-fold increase in proportion of Firmicutes/Bacteroidetes which may potentially be employed as the dysbiosis-related biological indicator.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"302 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90489583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0