Journal of surgery and research最新文献_第10页

Neoadjuvant Chemotherapy for Breast Cancer: Evolution of Clinical Practice in a French Cancer Center Over 16 Years and Pathologic Response Rates According to Tumor Subtypes and Clinical Tumor Size: Retrospective Cohort Study. 乳腺癌的新辅助化疗:法国癌症中心16年来临床实践的演变和根据肿瘤亚型和临床肿瘤大小的病理反应率:回顾性队列研究。

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020251

Gilles Houvenaeghel, Alexandre de Nonneville, Monique Cohen, Frédéric Viret, Sandrine Rua, Laura Sabiani, Max Buttarelli, Emmanuelle Charaffe, Audrey Monneur, Aurélie Jalaguier-Coudray, Marie Bannier, Renaud Sabatier, Anthony Gonçalves

{"title":"Neoadjuvant Chemotherapy for Breast Cancer: Evolution of Clinical Practice in a French Cancer Center Over 16 Years and Pathologic Response Rates According to Tumor Subtypes and Clinical Tumor Size: Retrospective Cohort Study.","authors":"Gilles Houvenaeghel, Alexandre de Nonneville, Monique Cohen, Frédéric Viret, Sandrine Rua, Laura Sabiani, Max Buttarelli, Emmanuelle Charaffe, Audrey Monneur, Aurélie Jalaguier-Coudray, Marie Bannier, Renaud Sabatier, Anthony Gonçalves","doi":"10.26502/jsr.10020251","DOIUrl":"https://doi.org/10.26502/jsr.10020251","url":null,"abstract":"<p><p>We examined characteristics trends in early breast cancer patients receiving neoadjuvant chemotherapy (NAC) over a 16-year period. Our primary objective was to analyze variations in tumor stage and subtype over time. Secondary objectives included analyses of type of surgery and pathological response, from January 2005 to May 2021, 1623 patients receiving NAC were identified. Three periods were determined: 2005-2009 (P1), 2010-2014 (P2), 2015-2021 (P3). Correlations between periods and patient features with cT stage, pathological breast and axillary node response, pathological complete response (pCR), and type of surgery were assessed in univariate and multivariate analyses. We observed a significant increase in cT0-1 and N0 stages with periods (from 6.8% at P1 to 21.2% at P3, and from 43.2% at P1 to 55.9% at P3, respectively) and in the proportion of HER2+ and triple negative (TN) subtypes. In a multivariate analysis, a decrease of cT2-3-4 tumors during P3 was observed for HER2+ (OR:0.174; p=0.004) and TN tumors (OR:0.287; p=0.042). In-breast pCR and pCR were observed in 40.8% and 34.4% of all patients, respectively, with strong association with tumor subtypes, but not with tumor size in multivariate analysis (37.0% pCR for cT0-1 tumors, 36.4% for cT2 tumors, 29.1% for cT3 tumors (cT0-1 versus cT≥2; p=0.222)). pCR was negatively associated with cN1 stage (OR:1.499; p<0.001 for cN1 patients compared to cN0). We observed an increase in the proportion of small cT0-1 and N0 stages treated with NAC, especially in HER2+ and TN subtypes. No significant impact of tumor size on pCR rates was found.</p>","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"5 3","pages":"511-525"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10646830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of the SARS-COV2 on Surgical Treatment of Acute Appendicitis: A Retrospective Cohort Multi-Centre Study SARS-COV2对急性阑尾炎手术治疗的影响:一项回顾性队列多中心研究

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020221

Jeremi Bedard Ginchereau, M. Bellavance, Anthonie Hamel, Nicolas Tassé, S. Drolet

引用次数: 1

Chylothorax after Excision of The Right Broad Ligament Mass of The Uterus was Diagnosed Lymphangiomyomatosis A Case Report and Literature Review 右子宫宽韧带肿块切除后乳糜胸诊断为淋巴管肌瘤病1例报告并文献复习

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020233

Liwan Dai, Tao Chen, Jinxing Wu

{"title":"Chylothorax after Excision of The Right Broad Ligament Mass of The Uterus was Diagnosed Lymphangiomyomatosis A Case Report and Literature Review","authors":"Liwan Dai, Tao Chen, Jinxing Wu","doi":"10.26502/jsr.10020233","DOIUrl":"https://doi.org/10.26502/jsr.10020233","url":null,"abstract":"Lymphangioleiomyomatosis (LAM) is a rare disease frequently (often) occurs in women of childbearing age. It is a multi-systemic disorder characterized by the proliferation, metastasis, and infiltration of smooth muscle cells in the lung and other tissues. We will report a case of a patient diagnosed with LAM who presented with chylothorax after hysterectomy of broad ligament. of etiology of this but the this the this We will a case of a patient diagnosed with LAM who presented with chylothorax after broad ligament developed dyspnea after surgical treatment. Chest CT found bilateral pleural effusion and multiple cystic lesions in both lungs. The pleural fluid Chyle test was positive, subsequent postoperative pathology confirmed LAM. The patient was treated by Sirolimus with Ideal therapeutic effect. However the presence of chylothorax after adnexal occupying resection has not been reported. Conclusions The pathogenesis of LAM is not completely clear, but the clinical manifestations of this patient seem to confirm the hypothesis that LAM originates from the female reproductive system. LAM should be considered in the differential diagnosis of female reproductive system tumors, we suggested to improve chest CT before surgery to be vigilant against the possibility of LAM if multiple cystic changes occur in pulmonary.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87921319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retroperitoneal Sarcoma Mimicking a Testicular Malignancy 模拟睾丸恶性肿瘤的腹膜后肉瘤

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020211

Girish Bakhshi, A. Dutt, Sushrut Baligar, R. V., Chettubattina Ravi Teja, Sampada V. Joshi, Madhulika Jha

引用次数: 1

Spontaneous Pneumothorax in Post COVID-19 Patients - A Case Series COVID-19后患者自发性气胸-病例系列

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020200

G. Wadhawan, Konark Thakkar, Ravdeep Singh

引用次数: 2

Operative Prognostic Scores for Pelvic Exenterations for Gynecological Cancer: When Should we Operate? 妇科癌症盆腔切除手术预后评分:何时该手术?

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020241

L. Sabiani, S. Knight, G. Blache, C. Jauffret, M. Buttarelli, E. Lambaudie, G. Houvenaeghel

{"title":"Operative Prognostic Scores for Pelvic Exenterations for Gynecological Cancer: When Should we Operate?","authors":"L. Sabiani, S. Knight, G. Blache, C. Jauffret, M. Buttarelli, E. Lambaudie, G. Houvenaeghel","doi":"10.26502/jsr.10020241","DOIUrl":"https://doi.org/10.26502/jsr.10020241","url":null,"abstract":"Purpose: Pelvic exenteration (PE) for locally advanced gynecological cancer or local recurrence is in some cases the only option. Because of the impact of this major surgery, our objective was to identify prognostic factors in order to establish an operative prognostic score. Methods: Patients were characterized by age, type of PE (anterior, posterior, total, atypical, preservation of pelvic floor and perineal excision, extended or not to other structures), indication, curative or palliative surgery and prior radiation therapy. Results: Over 30 years, 277 patients were included. 3 and 5-years overall survival was 36.8% and 32.3%. The rate of non curative resection was significantly correlated with posterior PE (OR: 2.29), tumors extending to the lateral pelvic wall (OR: 2.91), PE requiring enlargement (OR: 2.61) and lack of radiotherapy or <45 Gy (OR: 1.73). In multivariate analysis, factors significantly impacting survival were: total PE (HR: 2.04, p <0.0001), extended PE (HR: 1.56, p=0.017) and lack of radiotherapy or <45 Gy (HR: 1.40; p=0.033). Based on these factors, we created 4 different groups in order to establish a pre and post-operative prognostic score. Overall 5-years survival for each group was respectively 48.7%, 29.0%, 28.7% and 14.8% (p <0.0001). A preoperative high score was a strong negative predictive predictor of overall survival (HR=3.01, p <0.0001). Conclusion: These scores could help to predict overall survival and help decide when to perform this surgery.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82414743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Maxillary Radicular Cyst Excision and Reconstruction with Concentrated Bone Marrow Aspirate Cells Mixed with Xenograft - Case Report with 7-Year Follow-up 上颌神经根囊肿的切除与骨髓抽吸细胞混合移植重建- 7年随访1例

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020259

R. Jadach, Karolina Osypko

引用次数: 0

Dorsal Second and Third Carpometacarpal Joint Dislocation: A Case Report 第二、第三掌背关节脱位1例

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020227

Charalampos Pitsilos, Theofylaktos Kyriakidis, Konstantinos Chitas, K. Ditsios

{"title":"Dorsal Second and Third Carpometacarpal Joint Dislocation: A Case Report","authors":"Charalampos Pitsilos, Theofylaktos Kyriakidis, Konstantinos Chitas, K. Ditsios","doi":"10.26502/jsr.10020227","DOIUrl":"https://doi.org/10.26502/jsr.10020227","url":null,"abstract":"Background Carpometacarpal joint dislocations are uncommon hand injuries occurring in less than 1% of hand trauma. On routine postero-anterior view, asymmetry at the carpometacarpal joints should raise suspicion of possible subtle injury, which can be confirmed with CT scan. In literature, there is a scarcity of published cases and the optional treatment is controversial. Case report A 28-year-old man presented with dorsal dislocation of the second and third carpometacarpal joints. After initial closed reduction, the computerized tomography scan revealed residual dorsal subluxation. The patient was successfully treated with closed reduction under fluoroscopy and percutaneous pinning. In the followup full range of motion was gained and there were no recurrence or signs of degenerative changes. Conclusion Closed reduction of traumatic dorsal second and third carpometacarpal dislocation may be associated with incomplete reduction. Reduction under fluoroscopy and percutaneous pinning may be more suitable for the J Surg Res 2022; 5 (2): 346-351 DOI: 10.26502/jsr.10020227 Journal of Surgery and Research Vol. 5 No. 2 June 2022. [ISSN 2640-1002] 347 treatment of these injuries. Level of Evidence: V","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86489437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fraser syndrome: About A Case and Review of the Literature 弗雷泽综合征:关于一个病例和文献回顾

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020263

Laouali Laminou, O. Habou, M. Amadou, Abba Kaka Yakoura Hadjia, Amza Abdou

引用次数: 0

External Validation of Models to Predict Unsuccessful Endometrial Ablation: A Retrospective Study 预测子宫内膜消融失败模型的外部验证:一项回顾性研究

Journal of surgery and research Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020232

Stevens Kelly Yvonne Roger, Müller Iris, Houterman Saskia, Weyers Steven, Schoot Benedictus

引用次数: 0