Journal of sleep disorders & therapy最新文献

{"title":"Obesity Hypoventilation Syndrome and Pulmonary Hypertension Case withExcessive Daytime Sleepiness","authors":"N. Dursunoğlu","doi":"10.4172/2167-0277.1000259","DOIUrl":"https://doi.org/10.4172/2167-0277.1000259","url":null,"abstract":"Obesity and pulmonary hypertension (PH) are two conditions that frequently coexist in clinical practice and also the association between obesity and hypersomnolence has long been recognized. Pulmonary hypertension is more common (50% vs. 15%) and more severe in patients with OHS than in patients with OSAS. Here, we present an obese man with very severe excessive daytime sleep and very serious pulmonary hypertension, who only gave respond to AVAPS and oxygen treatment.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45060581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into Mechanisms underlying Sleep Deprivation Induced Cognitive Dysfunction","authors":"P. Chanana, Anil Kumar","doi":"10.4172/2167-0277.1000258","DOIUrl":"https://doi.org/10.4172/2167-0277.1000258","url":null,"abstract":"Introduction: Sleep has been found to influence both acquisition and consolidation of memory; therefore, sleep deprivation is often linked to multiple anomalies in cognitive paradigms giving rise cognitive dysfunctions. Objective: The present study has been designed with an aim to decipher plausible mechanistic interplays involved in the induction of cognitive dysfunction as a direct consequence of sleep deprivation. Methods: Male laca mice were sleep deprived for 24-hours using grid suspended over water method on alternate days extended over the total protocol duration of 21 days. Various neurobehavioral memory evaluating parameters followed by biochemical, acetylcholinesterase (AChE) activity, mitochondrial respiratory enzyme complex activities (I-IV) and histopathological examinations of the mice brain were monitored. Results: Sleep deprivation of 24-hours on alternate days for 21 days significantly impaired cognitive performance in both memory evaluating paradigms (Morris water maze test and elevated plus maze test) as compared to naive animals. Additionally animals subjected to sleep deprivation also demonstrated conditions of elevated oxidative stress, impaired mitochondrial enzyme complex activities, increased aceytlcholineestaerase activity, as well as histopathological alterations pertaining to hippocampal and thalamo-cortical regions of mice brain as compared to naive animals. However, chronic piracetam (100 mg/kg) treatment showed significant protective effect against sleep deprivation induced cognitive dysfunction, oxidative damage, mitochondrial respiratory enzyme complex insuffeciencies, increased acetylcholinesterase activity as well as neuromorphological alterations. Conclusion: The present study suggests mechanistic interplay between oxidative stresses; mitochondrial impairment as well as acetylcholineesterase activity may influence hippocampal and cortical neuronal survival and thus lead to precipitation of sleep deprivation induced cognitive deficits.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"6 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0277.1000258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48803767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concepts of Neurophysiological Factors in the Central Regulatory Mechanism of Non-Rapid Eye Movement Sleep: A Review","authors":"B. Ee","doi":"10.4172/2167-0277.1000255","DOIUrl":"https://doi.org/10.4172/2167-0277.1000255","url":null,"abstract":"Objective: It is now fully ascertained that the generation of non-rapid eye movement sleep (NREM) involves vital brain processes achieved through complex interactions of underlying neurophysiological factors, including those of the mechanism for the production of the behavioral expressions of NREM sleep. These central processes in the mechanism of NREM sleep are still far from clear and are subject of much speculations and even controversy. It was the aim of this review to identify and assemble those factors in brain function that informed current research postulations of workers in the subject of the production of NREM sleep. \u0000Methods: Information gathering adopted in this review included, articles and published research works, seminars and conference articles on sleep, information from current textbooks in neuroscience on sleep, lecture notes in behavioral neurophysiology and biology, and articles and reports on sleep accessed from the Internet using search engines such as Google, PubMed etc., were all sources of information consulted. \u0000Results: The significance of specific neurotransmitter systems – Serotonin, GABA and Adenosine, in the proposed central mechanism for the production and behavioral expressions of NREM sleep have been clearly highlighted in this review. Facts noted in this review successfully sensitized the attention of research to the growing profile of the more recently identified Metabolic Energy substrates Drive in the proposed possible central mechanism for the generation of NREM sleep stage. \u0000Conclusion: Research postulations and proposals assembled in this review appear generally to support the notion that different brain processing networks and neurochemical units are probably involved in the production of NREM sleep and other distinct states of sleep. It is therefore concluded from this review that probably different neuronal pathways and systems make up specific vital brain processes for the production and expressions of NREM sleep stage, and these central processes are still far from fully understood with certainty.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"6 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42576307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related Quality of Life in Patients with Sleep-Related Breathing Disorder","authors":"P. Hessmann, J. Heitmann, ra Apelt, M. Balzer‐Geldsetzer, R. Dodel, G. Mayer","doi":"10.4172/2167-0277.1000256","DOIUrl":"https://doi.org/10.4172/2167-0277.1000256","url":null,"abstract":"Background: The aim of this study was to evaluate health-related quality of life (HrQoL) in patients with obstructive sleep apnea (OSA) and to investigate the impact of socio demographic and clinical parameters on HrQoL. \u0000Methods: A total of 627 patients were consecutively recruited in 18 sleep laboratories in the state of Hessen, Germany. Standardized questionnaires were used to assess co-morbid disorders, depressive symptoms (Beck Depression Inventory) and daytime sleepiness (Epworth Sleepiness Scale). HrQoL was evaluated with the generic EuroQol-Instrument (EQ-5D-3L index and EQ VAS). Influencing factors were analyzed using bivariate and multiple linear regression analyses. \u0000Results: The mean EQ-5D-3L index was 0.86 ± 0.19, and the mean EQ VAS score was 66.8 ± 19.3. Patients primarily reported problems in the domains of pain/discomfort (55.5%), anxiety/depression (33.5%), and usual activities (29.5%). Multivariate analyses explained 34.9% and 35.9% of the variance in the EQ VAS and the EQ-5D-3L index, respectively. Relevant predictors of HrQoL were patient age, daytime sleepiness, the presence of medical comorbidities and depression. \u0000Conclusions: The results of our study suggest that depressive disorders and excessive daytime sleepiness have considerable effects on patient HrQoL and should be considered in the treatment of OSA patients to improve HrQoL.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46642678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for severity of obstructive sleep apnea","authors":"Àlex, ru Corlateanu, Victoria Sircu","doi":"10.4172/2167-0277.C1.005","DOIUrl":"https://doi.org/10.4172/2167-0277.C1.005","url":null,"abstract":"","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70798073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Sleep-Monitoring Devices: Bridging the Periodic Limb Movement in Sleep Information Gap","authors":"P. Schramm","doi":"10.4172/2167-0277.1000S1-001","DOIUrl":"https://doi.org/10.4172/2167-0277.1000S1-001","url":null,"abstract":"The prevalence of periodic limb movement in sleep (PLMS) in patients with Restless Legs Syndrome is estimated between 80 to90%, >34% of the population over 60 years of age and 36% of healthy subjects were found to have a PLMS index >5 event per hour of sleep. PLMS can be associated with sleep breathing disorders, insomnia, narcolepsy, and REM Behavior disorder. Its prevalence in the general population is unknown. Home sleep-monitoring devices (HSMD) could be used to derive some consensus on the clinical and non-clinical characteristics of PLMS. There is need to derive age-adjusted normative values for PLMS, assess their clinical significance when presenting as comorbidities, phenotyping the genetic variants and tracking the pathophysiology along a continuum to determine signs and symptom changes from pre-clinical to clinical relevance. This article provides information on why and how HSMD is the logical approach in bridging the clinically relevant information gap associated with PLMS. It discusses future directions to be taken in utilizing HSMD to objectively measure PLMS and determine their effect on sleep quality.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"2015 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0277.1000S1-001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and OSA in Gulf Cooperative Council Countries: Another Gulf War Syndrome","authors":"M. Vats","doi":"10.4172/2167-0277.1000S1-e101","DOIUrl":"https://doi.org/10.4172/2167-0277.1000S1-e101","url":null,"abstract":"With waistlines expanding rapidly in the residents of Gulf cooperative council countries, (GCC) (including UAE, Saudi Arabia, Qatar, Bahrain, Kuwait and Oman) with special thanks to a fast-food culture, sedentary/westernized lifestyles, outdoor weather conditions and complex interplay of many other factors. GCC region can no longer ignore the cost of obesity (indirect and direct) in terms of consequent health problems, healthcare expenditure and human sufferings.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"2015 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0277.1000S1-e101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70798055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive Sleep Apnea among Players in the National Football League: A Scoping Review.","authors":"April J Rogers, Kevin Xia, Kyaw Soe, Azizi Sexias, Felix Sogade, Barbara Hutchinson, Dorice Vieira, Samy I McFarlane, Girardin Jean-Louis","doi":"10.4172/2167-0277.1000278","DOIUrl":"10.4172/2167-0277.1000278","url":null,"abstract":"<p><strong>Objective: </strong>Obstructive sleep apnea (OSA) is a common sleep-disordered breathing condition that has emerged as a significant public health problem given its increased prevalence over the past decade. The high prevalence of obesity and large waist circumference among NFL players are two risk factors that might contribute to the high susceptibility of football players to develop OSA. National Football League linemen might be particularly vulnerable since they tend to have a higher body mass index. In this scoping review, we aim to bring attention to the limited research regarding OSA among National Football League players and highlight the negative consequences of OSA in an attempt to increase awareness of the urgent need for further research in this area.</p><p><strong>Methods: </strong>Search terms associated with obstructive sleep apnea and football were used to examine Google Scholar, EMBASE, CINAHL, PubMed, ProQuest, and Web of Science Plus for relevant studies. All relevant studies were included and documented.</p><p><strong>Results: </strong>Findings included (n=4) studies of interest. All 4 studies revealed a near or slightly above 50% prevalence of OSA in the investigated cohorts (mostly retired NFL linemen). Most participants in the study (active NFL players) showed symptoms associated with a sleep-disorder breathing condition (snoring).</p><p><strong>Conclusion: </strong>OSA requires more attention from the research and medical community. As suggested by results in the 4 studies included in this paper, OSA and associated symptoms are prevalent in the NFL population. Further research is required to investigate the extent of OSA and OSA risk in this population. There is an urgent need to conduct OSA risk surveillance in the athletic community.</p>","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36293415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of the Combination of Body Weight and Minimal Pharyngeal Cross-sectional Area in Assessing Obstructive Sleep Apnea","authors":"R. Hei, J. Qin, Shuhua Li","doi":"10.4172/2167-0277.1000S1-004","DOIUrl":"https://doi.org/10.4172/2167-0277.1000S1-004","url":null,"abstract":"Objectives: The study aims to evaluate the predictive value of a comprehensive index composed of simple biometric parameters in predicting apnea hypopnea index. Subjects and Methods: Ninety-four adult patients with obstructive sleep apnea-hypopnea syndrome were retrospectively reviewed. Pharyngeal axial-computed tomography and polysomnography were applied before surgery. Minimal pharyngeal cross-sectional area, sleep-associated monitoring indices including apnea hypopnea index, and biometric characteristics including body weight were all recorded. Correlations between these parameters were analyzed using correlation and multiple linear regression analyses. Results: Apnea hypopnea index was significantly correlated with minimal pharyngeal cross-sectional area (r=-0.390) and body weight (r=0.553). A notably higher correlation coefficient (r=0.681) was found between apnea hypopnea index and a new comprehensive index composed of minimal pharyngeal cross-sectional area and body weight data. Conclusion: Apnea hypopnea index might be largely influenced by a combined effect of minimal pharyngeal cross-sectional area and body weight. The new comprehensive parameter combining minimal pharyngeal crosssectional area and body weight is an effective indicator for the evaluation of obstructive sleep apnea.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"2015 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Medical and Physical Therapy in Management of Posttraumatic Headaches and Sleep Disturbances in Patients with Post-Concussion Syndrome","authors":"T. Litovchenkoa, I. Iakubenko, I. Kas","doi":"10.4172/2167-0277.1000S1-005","DOIUrl":"https://doi.org/10.4172/2167-0277.1000S1-005","url":null,"abstract":"Some of the main symptoms of mild traumatic brain injury in the long term are headaches and sleep disturbances. The purpose of our study was to investigate the influence of the combination medical and physical treatment using darsonvalization and magnetic therapy on headaches and sleep disturbances in patients with postconcussion syndrome. Methods: We observed 67 patients with the consequences of mild traumatic brain injury. Patients were divided into two groups: the first group consisted of patients who received medical therapy. The second group included patients who received a similar medical therapy, adding physical therapy using the methods of magnetic therapy and darsonvalization. The treatment was controlled by Doppler ultrasound of the carotid arteries as well as by testing the patients according to MOS SF-36 quality of life questionnaire, which were carried out before and after the treatment. Results: The analysis of the data obtained from the first group showed the increase of blood flow velocity by 5.2%. The data obtained from the second group showed the significant increase of blood flow velocity by 14.7%, as well as reducing the indices of vascular resistance (PI and RI) by 39.3%. In second group we saw the positive effect of physical therapy using darsonvalization and magnetic therapy. We observed a significant decrease in autonomic manifestations of the disease, which results in a reduction of headaches (75%), palpitations (57.2%), distal hyperhidrosis (64.7%), normal sleep (72.4%), improved emotional background mood (86.5%). Conclusions: We suppose, that headache in patients with TBI can provoke increased sleep disturbances in turn this sleep disturbances later may lead to increased headache.Combination treatment with physical and medical therapy leads to subjective and objective improvement of the patients’ health. Combination physical and medical therapy is recommended for more effective treatment of the consequences of traumatic brain injury.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":"2015 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0277.1000S1-005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}