Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique最新文献

{"title":"Intense pulsed light versus benzoyl peroxide.","authors":"Mohammad J Al Abdullah,&nbsp;Yasameen Gheni Mahdi","doi":"10.47750/jptcp.2022.856","DOIUrl":"https://doi.org/10.47750/jptcp.2022.856","url":null,"abstract":"<p><p>The intense pulsed light (IPL) therapy has three mechanisms of action in acne vulgaris: photochemical, photoimmunological, and photothermal. In this clinical trial, 47 patients with facial inflammatory acne lesions, ages ranging from 15 to 40 years, were enrolled. Patients were categorized into two groups: (a) 20 patients in Group A treated with IPL for 3 sessions, 3 weeks apart, (b) and 27 patients in Group B treated with benzoyl peroxide (BPO) 2.5% gel daily at night for 9 weeks. Follow up was done at 3 weeks after the end of treatment. The effect of treatment was evaluated objectively according to total lesion counting and digital photographic assessment and subjectively according to the patients' satisfaction. IPL is an effective and well-tolerated method for the treatment of inflammatory facial acne like BPO. Therefore, the IPL can be used as a standard therapy for inflammatory acne vulgaris.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"28 2","pages":"e54-e61"},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39833258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practice of self-medication.","authors":"Mais Najah Razak Al Shibly,&nbsp;Lamyaa Ali Hasan,&nbsp;Ashwaq Ridha Abdulsada","doi":"10.47750/jptcp.2022.863","DOIUrl":"https://doi.org/10.47750/jptcp.2022.863","url":null,"abstract":"<p><strong>Background: </strong>Self-medication (SM) is the usage of medicines to resolve self-identified health issues, and it is quite common in many countries. The current study aimed to assess the knowledge and practices of SM among attendants at an outpatient clinic of a Baghdad teaching hospital at Baghdad Medical City as well as to determine association of SM practice with some socio-demographic factors.</p><p><strong>Subjects and methods: </strong>The current cross-sectional study was conducted with about 460 people attending outpatients at Baghdad teaching hospital from January 1, 2019 to June 30, 2019.</p><p><strong>Results: </strong>The highest proportion of participants, 176 (44%), was found in the age group of 18-30 years, with 290 (72.5%) females representing the study sample. Around two-thirds (266) of participants were married, and a higher proportion of participants, 218 (54.5%), were government employees; in all, 77 (19%) of participants were either unemployed or housewives. A total of 241 (60%) participants of the study sample were graduates and 74 (18.5%) postgraduates. Considering monthly income, 140 (35%) participants were earning below <i>Iraqi Dinar</i> 5,00,000. Of all the participants, 12 (43%) of them were concerned about the side effects of taking medicines, and 9 of them (32%) due to require medical experiences, 5 of them (18%) due to the risk of missing a diagnosis, and another 4 of them (14%) and 100 of them (27%) of participants used medicine leaflets, 86 (23%) of them used previous prescription, while 67 (18%) of study participants asking the nurse or health assistant, and reminder 41 (11%) used the mass media as a source of information about medicines. The majority of participants, 331 (89%), depended on private pharmacies and only 37 (10%) of them depended on paramedics. About half of the participants, 167 (45%), mentioned name of the medicine while requesting, and 115 (31%) participants mentioned symptoms of the disease to pharmacist, and only 90 (24%) purchased the drug container (bottles, boxes, etc.).</p><p><strong>Conclusion: </strong>SM is a common healthcare practice among the attendants outpatients at Baghdad teaching hospital with different socio-demographic characteristic. SM is more prevalent in young age group and among low-income people, hence there was a significant association between age and SM practice, as elderly people practice less SM because of chronic diseases and their use of multiple medicines. In addition, SM practice has increased due to the availability of medicines and their easy access from pharmacies.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"28 2","pages":"e62-e70"},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial activity of cinnamon and clove oil against wound pathogens.","authors":"P Anandhi,&nbsp;M Tharani,&nbsp;S Rajeshkumar,&nbsp;T Lakshmi","doi":"10.47750/jptcp.2022.871","DOIUrl":"https://doi.org/10.47750/jptcp.2022.871","url":null,"abstract":"<p><p>A wound is a complicated health issue, and it severely affects the injured area because of the growth of many pathogenic microorganisms. Cinnamon and clove oil exhibit antibacterial activity against wound pathogens like <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Klebsiella pneumoniae</i> were identified by the disc diffusion method. Cinnamon and clove oils are effective antibacterial agents because of their importance in reducing virulence and pathogenicity of drug-resistant bacteria in vivo. The increased frequency in clinically observed cases of antibiotic resistance has been attributed to many factors, such as the misuse and overuse of antibiotics. In some countries, antibiotics are sold over the counter without a prescription; hence, this study aimed to investigate the antimicrobial effect of clove and cinnamon on clinically isolated resistant strains of P. aeruginosa, E. coli, and K. pneumoniae.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"28 2","pages":"e41-e46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39812777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on plant-mediated selenium nanoparticles and its applications.","authors":"Jayapriya Johnson,&nbsp;Rajeshkumar Shanmugam,&nbsp;Thangavelu Lakshmi","doi":"10.47750/jptcp.2022.870","DOIUrl":"https://doi.org/10.47750/jptcp.2022.870","url":null,"abstract":"<p><p>Nanotechnology explores a variety of promising approaches in the field of biomedical sciences. For biogenesis of selenium (Se) nanoparticles different parts of a plant are used as they contain metabolites such as alkaloids, flavonoids, phenols, proteins, and other phytochemicals which act as reducing agent to produce and stabilize nanoparticles. Nanotechnology is also widely practiced in medicine, agriculture, and many other technologies. This review is focused on green synthesis and its latest developments for the fabrication of Se nanoparticles. This research article also summarizes Se nanoparticles and different plants individually and combined along with their characterizations, using techniques such as ultraviolet-visible spectroscopy, transmission electron microscopy, and scanning electron microscopy, which specified the range, shape, size, and other specifications to easily identify and explore the studies further.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"28 2","pages":"e29-e40"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39812776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical decision-making in managing deep carious lesions in primary teeth based on clinical experience among pediatric dentists-A cross-sectional study.","authors":"Sunil Babu Kotha,&nbsp;Haifa A Binhuwaishel,&nbsp;Rayyanah N Almuhaydib,&nbsp;Lujain Y Alzeghaibi,&nbsp;Maram A Alhajri","doi":"10.47750/jptcp.2022.860","DOIUrl":"https://doi.org/10.47750/jptcp.2022.860","url":null,"abstract":"<p><strong>Objective: </strong>To explore the different treatment methods employed in managing deep carious lesions (DCL) of vital primary teeth among pediatric dentists practic.ing in Saudi Arabia. We also want to find out whether the experience of pediatric dentists has any influence on clinical decision-making in managing DCL in primary teeth.</p><p><strong>Methods: </strong>This online questionnaire-based cross-sectional study was carried out among pediatric dentists practicing in Saudi Arabia. We used a self-administered questionnaire consisting of five sections: demographic data, clinical decisions in managing DCL, clinical protocols, and dentist's knowledge about allowing carious dentin to remain under a restoration. The questionnaire was administrated electronically via SurveyMonkey.</p><p><strong>Results: </strong>A total of 216 pediatric dentists participated in the study, in which nearly 60% were males. Most dentists reported that they preferred partial caries removal (63%), and the Hall technique (68%) was the mostly practiced method in managing DCL. Nearly 93.5% of the dentists reported performing indirect pulp capping before placing a permanent restoration, and the most preferred liner was Dycal (60%). About 47.2% of senior dentists reported practicing complete caries removal. Multivariate logistic regression analysis revealed that younger dentists (5-10 years) preferred practiced partial caries excavation two times more often than senior dentists (>10 years).</p><p><strong>Conclusions: </strong>Pediatric dentists should focus on minimally invasive approaches such as partial caries excavation for DCL treatment. Pediatric dentists, especially senior practitioners, should be educated and trained to adopt minimally invasive strategies in managing DCL, reducing unnecessary risks such as iatrogenic pulpal damage.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"28 2","pages":"e17-e28"},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39674591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Favipiravir on liver enzyme among patients with mild to moderate COVID-19 infection: A prospective cohort study.","authors":"Ahmed Hamza Al-Shammari,&nbsp;Mohammed Abd Ali Shahadha","doi":"10.15586/jptcp.2022.967","DOIUrl":"https://doi.org/10.15586/jptcp.2022.967","url":null,"abstract":"<p><p>Teratogenicity and hyperuricemia are considered as the major adverse effects of favipiravir, but less is known about other possible side effects which includes drug-induced liver damage and renal injury. In the current research, assessment of favipiravir-induced liver injury was performed by evaluating liver enzymes among patients with mild to moderate COVID-19 infection. A prospective cohort study was conducted on 66 patients diagnosed with mild to moderate COVID-19 infection who were treated with favipiravir for 5 days. During this period, a baseline assessment of liver enzymes (aspartate aminotransferase - AST, alanine transaminase - ALT and alkaline phosphatase - ALP) in addition to bilirubin before initiation of therapy and after 1 day of completion of therapy were carried out. The comparison of all measured parameters among all patients before and after receiving the treatment showed that non-significant differences were obtained in their levels. It was noticed that COVID-19 patients demonstrated high AST levels in which only 16 patients out of the all-subjected cases (66 patients) had AST levels of less than 45 U/L whereas the majority of patients showed normal ALT, ALP, and bilirubin levels. It was concluded that 5 days administration of favipiravir in mild to moderate COVID-19 patients who had no previous liver diseases did not affect the liver enzymes significantly and only transient elevations were occurred.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 4","pages":"e46-e54"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovation of new clinical concepts in the correction of facial deformity of patients with post-traumatic condylar hyperplasia condition.","authors":"Sabah Hassan","doi":"10.47750/jptcp.2022.890","DOIUrl":"https://doi.org/10.47750/jptcp.2022.890","url":null,"abstract":"Post traumatic condylar hyperplasia condition is an increase in the total number of cells due to increased activity, which exist only as long as the activity or the stimulus is applied. When it is removed, the tissue returns to the normal state; however, a secondary structural alteration in the general architecture due to accompanying degeneration may render a complete return to the normal state impossible. Mandibular asymmetry following condylar injury is poorly documented as a cause of facial asymmetry. leFort1 (low-level fracture) osteotomies and bilateral sagittal mandibular osteotomies, which are comprehensive surgical plans, correct the facial deformity together with the occlusion. An innovation of new clinical concepts has been used in the correction of facial deformity in 11 patients with post-traumatic condylar hyperplasia condition (syndrome) by applying a new modified allo plastic material (subperiosteal acrylic implant).","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"13 1","pages":"e82-e86"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72883568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Angiotensin-converting Enzyme 2 Gene (rs1514283) Polymorphism with the Incidence of COVID-19.","authors":"H. H. H. Al-Fattli, T. S. Abd-Alraoof","doi":"10.47750/jptcp.2022.922","DOIUrl":"https://doi.org/10.47750/jptcp.2022.922","url":null,"abstract":"It has been a busy year for coronaviruses, with the most recent one causing severe coronavirus illness in 2019 (COVID-19). It is broadly distributed in many human tissues and organs as the potential SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2). ACE2 provides homeostatic modulation of circulation angiotensin II levels by acting as a physiological counterbalance to ACE. They have been linked to COVID-19 disease acquisition, progression, and severity. As a result, we investigated how ACE2 variations and epigenetic variables affect SARS-CoV-2 infection susceptibility and infection outcomes in terms of age, gender, and ethnicity. Debates raged over the etiology of this occurrence. It is important to note that further research is required to demonstrate the efficacy of human recombinant ACE2 and ACE2-derived peptides in fighting SARSCoV-2 variants. Better recognition of a host genetic, as well as the function of the properties of ACE2 variations, would assist in explaining clinical disparities of infection between individuals and contribute to the development of remedies and managing future SARS-CoV-2 epidemics, an essential function for ACE2 in essential hypertension (EH). We wanted to see how ACE2 gene polymorphisms and enzyme activity correlated with COVID-19 incidence in the Iraqi province of Al-Diwaniya. A total of 63 COVID-19 patients and 70 (NT) controls were genotyped using Sequenom Mass-ARRAY RS1000 for ACE2. Participants' ACE2 rs1514283 SNP was linked to COVID-19.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"17 1","pages":"e122-e141"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86508384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disability caused by hip joint injuries among the adult population of Moscow in for the period of 2013-2019.","authors":"M. Kovrizhnykh, N. Zapariy, E. Achkasov, V. Solovev, A. Samusenko","doi":"10.47750/jptcp.2022.889","DOIUrl":"https://doi.org/10.47750/jptcp.2022.889","url":null,"abstract":"The study found that the 2013-2019 period saw a decrease in the incidence of primary disability caused by hip joint injuries among the adult population of Moscow. The level of primary disability averaged 0.09 ± 0.03 per 10,000 adult population. In the structure of disability caused by injuries of the lower limbs, hip joint injuries accounted for 10.5% over the studied period. The age structure was dominated by disabled people above the working age with a tendency to decrease their share. In the nosological structure, people disabled as a result of femoral neck fractures (46.2%) and femur fractures (29.3%) prevailed. In the structure of people who were first recognized as disabled, disabled people of groups II and III prevailed (with a large proportion of disabled people of group III and a lower share of disabled people of group II). The proportion of people with disabilities in group I is the smallest, and it tends to decrease over the studied period. Among people above the working age, the disabled people of groups I and II prevailed while among people of the working age, the disabled people of groups II and III prevailed.The incidence of repeated disability of this contingent was also characterized by a downward trend. The level of repeated disability averaged 0.11 per 10,000 population. The share of people repeatedly recognized as disabled due to injuries of the lower limbs was 8.5%. The structure was dominated by people with disabilities caused by femoral neck and femur fractures. The period saw an increase in the proportion of disabled people of the working age. The disabled people of group III with a tendency to increase their share and the disabled people of group II with a tendency to decrease their share prevailed, and the number of disabled people of group I decreased.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"21 1","pages":"e71-e81"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82769722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development model of integrated development post for non-communicable diseases in West Java of Indonesia.","authors":"Wuri Ratna Hidayani,&nbsp;Siti Utami Dewi,&nbsp;Prasanti Adriani,&nbsp;Roslin E M Sormin,&nbsp;Maria Kanan,&nbsp;Sofa Qurrata A'yun,&nbsp;Setiana Andarwulan","doi":"10.47750/jptcp.2022.999","DOIUrl":"https://doi.org/10.47750/jptcp.2022.999","url":null,"abstract":"<p><p>Data from the West Java Health Office in 2013 stated that the prevalence of non-communicable diseases (NCD), one of which is diabetes Mellitus, was 4.2% with pre-diabetes at 7.8% and 144 cases in the work area of the Singaparna Puskesmas.¹ Empowerment of Posbindu cadres with NCD (PTM) ) to reduce cases of PTM. The purpose of this research is to develop a model of empowerment of Posbindu PTM by increasing the role and skills of the Posbindu PTM cadres. This study uses a combined or collaborative method approach, namely qualitative and quantitative. Sampling by stratified random sampling from August to November 2019 consisted of four government stakeholders as research informants, and 16 Posbindu PTM cadres. Collecting data using questionnaires, in-depth interviews, and Focus Group Discussions (FGD). Analysis using thematic content analysis and Wilcoxon Test. Results shows in qualitative research that cadres have knowledge about the role of cadres, but do not yet know the main tasks and functions of cadres and do not have cadre skills. The quantitative analysis showed that there were differences in the knowledge and skills of cadres after training compared to before training <i>p</i> = 0.000 (<i>p</i> < 0.05). In conclusion, Cadres know the role of cadres through training. There were differences in the knowledge and skills of cadres after training compared to before training.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 4","pages":"e177-e187"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10473332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}