Advances in Pharmacological Sciences最新文献_第8页

The Influence of Palatable Diets in Reward System Activation: A Mini Review. 美味饮食对奖励系统激活的影响:一个小回顾。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-03-20 DOI: 10.1155/2016/7238679

Isabel Cristina de Macedo, Joice Soares de Freitas, Iraci Lucena da Silva Torres

{"title":"The Influence of Palatable Diets in Reward System Activation: A Mini Review.","authors":"Isabel Cristina de Macedo, Joice Soares de Freitas, Iraci Lucena da Silva Torres","doi":"10.1155/2016/7238679","DOIUrl":"https://doi.org/10.1155/2016/7238679","url":null,"abstract":"The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models. Moreover, palatable high-fat foods (such as those of the cafeteria diet) can induce addiction-like deficits in brain reward function and are considered to be an important source of motivation that might drive overeating and contribute to the development of obesity. The mechanism of neural adaptation triggered by palatable foods is similar to those that have been reported for nondrug addictions and long-term drug use. Thus, this review attempts to describe the potential mechanisms that might lead to highly palatable diets, such as the cafeteria diet, triggering addiction, or compulsion through the reward system. ","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 ","pages":"7238679"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7238679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34469597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 78

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties. 萘普生金属配合物抗痛觉性、抗焦虑性、中枢神经系统抑制剂和降糖性能的药理学评价。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-07-11 DOI: 10.1155/2016/3040724

Md Sharif Hasan, Narhari Das, Zobaer Al Mahmud, S M Abdur Rahman

{"title":"Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties.","authors":"Md Sharif Hasan, Narhari Das, Zobaer Al Mahmud, S M Abdur Rahman","doi":"10.1155/2016/3040724","DOIUrl":"https://doi.org/10.1155/2016/3040724","url":null,"abstract":"Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test. Results. Metal complexes significantly (P < 0.001) reduced the number of abdominal muscle contractions induced by 0.7% acetic acid solution in a dose dependent manner. At the dose of 25 mg/kg body weight p.o. copper, cobalt, and zinc complexes exhibited higher antinociceptive activity having 59.15%, 60.56%, and 57.75% of writhing inhibition, respectively, than the parent ligand naproxen (54.93%). In tail-flick test, at both doses of 25 and 50 mg/kg, the copper, cobalt, silver, and zinc complexes showed higher antinociceptive activity after 90 minutes than the parent drug naproxen. In elevated plus maze (EPM) model the cobalt and zinc complexes of naproxen showed significant anxiolytic effects in dose dependent manner, while the copper, cobalt, and zinc complexes showed significant CNS depressant and hypoglycemic activity. Conclusion. The present study demonstrated that copper, cobalt, and zinc complexes possess higher antinociceptive, anxiolytic, CNS depressant, and hypoglycemic properties than the parent ligand. ","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 ","pages":"3040724"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3040724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34623615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Review of Anti-Inflammatory Herbal Medicines. 消炎草药综述。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-05-10 DOI: 10.1155/2016/9130979

Mona Ghasemian, Sina Owlia, Mohammad Bagher Owlia

引用次数: 163

Drug Efflux Transporters Are Overexpressed in Short-Term Tamoxifen-Induced MCF7 Breast Cancer Cells. 药物外排转运蛋白在短期他莫昔芬诱导的MCF7乳腺癌细胞中过度表达

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-02-14 DOI: 10.1155/2016/6702424

Desak Gede Budi Krisnamurti, Melva Louisa, Erlia Anggraeni, Septelia Inawati Wanandi

{"title":"Drug Efflux Transporters Are Overexpressed in Short-Term Tamoxifen-Induced MCF7 Breast Cancer Cells.","authors":"Desak Gede Budi Krisnamurti, Melva Louisa, Erlia Anggraeni, Septelia Inawati Wanandi","doi":"10.1155/2016/6702424","DOIUrl":"10.1155/2016/6702424","url":null,"abstract":"Tamoxifen is the first line drug used in the treatment of estrogen receptor-positive (ER+) breast cancer. The development of multidrug resistance (MDR) to tamoxifen remains a major challenge in the treatment of cancer. One of the mechanisms related to MDR is decrease of drug influx via overexpression of drug efflux transporters such as P-glycoprotein (P-gp/MDR1), multidrug resistance associated protein (MRP), or BCRP (breast cancer resistance protein). We aimed to investigate whether the sensitivity of tamoxifen to the cells is maintained through the short period and whether the expressions of several drug efflux transporters have been upregulated. We exposed MCF7 breast cancer cells with tamoxifen 1 μM for 10 passages (MCF7 (T)). The result showed that MCF7 began to lose their sensitivity to tamoxifen from the second passage. MCF7 (T) also showed a significant increase in all transporters examined compared with MCF7 parent cells. The result also showed a significant increase of CC50 in MCF7 (T) compared to that in MCF7 (97.54 μM and 3.04 μM, resp.). In conclusion, we suggest that the expression of several drug efflux transporters such as P-glycoprotein, MRP2, and BCRP might be used and further studied as a marker in the development of tamoxifen resistance. ","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":"6702424"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6702424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64486611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

MDMA Impairs Response to Water Intake in Healthy Volunteers. 亚甲二氧基甲基苯丙胺会影响健康志愿者对摄入水分的反应。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-06-14 DOI: 10.1155/2016/2175896

Matthew J Baggott, Kathleen J Garrison, Jeremy R Coyle, Gantt P Galloway, Allan J Barnes, Marilyn A Huestis, John E Mendelson

{"title":"MDMA Impairs Response to Water Intake in Healthy Volunteers.","authors":"Matthew J Baggott, Kathleen J Garrison, Jeremy R Coyle, Gantt P Galloway, Allan J Barnes, Marilyn A Huestis, John E Mendelson","doi":"10.1155/2016/2175896","DOIUrl":"10.1155/2016/2175896","url":null,"abstract":"Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In Study 2, volunteers received MDMA or placebo followed by standardized water intake. MDMA lowered serum sodium but did not increase ADH or copeptin, although the control prazosin did increase ADH. Water loading reduced serum sodium more after MDMA than after placebo. There was a trend for women to have lower baseline serum sodium than men, but there were no significant interactions with drug condition. Combining studies, MDMA potentiated the ability of water to lower serum sodium. Thus, hyponatremia appears to be a significant risk when hypotonic fluids are consumed during MDMA use. Clinical trials and events where MDMA use is common should anticipate and mitigate this risk. ","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 ","pages":"2175896"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34724065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra (L.) Miq.) Leaves Extracts. 丁香槲寄生（Dendrophthoe pentandra (L.) Miq.）叶提取物。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-03-23 DOI: 10.1155/2016/3242698

Vida Elsyana, Maria Bintang, Bambang Pontjo Priosoeryanto

{"title":"Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra (L.) Miq.) Leaves Extracts.","authors":"Vida Elsyana, Maria Bintang, Bambang Pontjo Priosoeryanto","doi":"10.1155/2016/3242698","DOIUrl":"10.1155/2016/3242698","url":null,"abstract":"Clove mistletoe (Dendrophthoe pentandra (L.) Miq.) is a semiparasitic plant that belongs to Loranthaceae family. Clove mistletoe was traditionally used for cancer treatment in Indonesia. In the present study, we examined cytotoxicity of clove mistletoe leaves extracts against brine shrimps and conducted their antiproliferative activity on K562 (human chronic myelogenous leukemia) and MCM-B2 (canine benign mixed mammary) cancer cell lines in vitro. The tested samples were water extract, ethanol extract, ethanol fraction, ethyl acetate fraction, and n-hexane fraction. Cytotoxicity was screened using Brine Shrimp Lethality Test (BSLT). Antiproliferative activity was conducted using Trypan Blue Dye Method and cells were counted using haemocytometer. The results showed that n-hexane fraction exhibited significant cytotoxicity with LC50 value of 55.31 μg/mL. The n-hexane fraction was then considered for further examination. The n-hexane fraction of clove mistletoe could inhibit growth of K562 and MCM-B2 cancer cell lines in vitro. The inhibition activity of clove mistletoe n-hexane fraction at concentration of 125 μg/mL on K562 cancer cell lines was 38.69%, while on MCM-B2 it was 41.5%. Therefore, it was suggested that clove mistletoe had potential natural anticancer activity. ","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 ","pages":"3242698"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34479115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Medicinal Properties of Orientin. 东方藤药用特性研究进展。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-05-19 DOI: 10.1155/2016/4104595

Kit Ying Lam, Anna Pick Kiong Ling, Rhun Yian Koh, Ying Pei Wong, Yee How Say

引用次数: 106

Radical-Scavenging Activity and Ferric Reducing Ability of Juniperus thurifera (L.), J. oxycedrus (L.), J. phoenicea (L.) and Tetraclinis articulata (L.). 苏云杜松（Juniperus thurifera（L.））、氧化木（J.oxidedrus（L.）、凤凰木（J.phoenicea（L.）和牙鲆（Tetraclinis articulata（L.）的清除自由基活性和铁还原能力。

Advances in Pharmacological Sciences Pub Date : 2016-01-01 Epub Date: 2016-05-16 DOI: 10.1155/2016/6392656

Meryem El Jemli, Rabie Kamal, Ilias Marmouzi, Asmae Zerrouki, Yahia Cherrah, Katim Alaoui

{"title":"Radical-Scavenging Activity and Ferric Reducing Ability of Juniperus thurifera (L.), J. oxycedrus (L.), J. phoenicea (L.) and Tetraclinis articulata (L.).","authors":"Meryem El Jemli, Rabie Kamal, Ilias Marmouzi, Asmae Zerrouki, Yahia Cherrah, Katim Alaoui","doi":"10.1155/2016/6392656","DOIUrl":"https://doi.org/10.1155/2016/6392656","url":null,"abstract":"Objective. The aim of this work is to study and compare the antioxidant properties and phenolic contents of aqueous leaf extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus Phoenicea, and Tetraclinis articulata from Morocco. Methods. Antioxidant activities of the extracts were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging ability, Trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP) assays. Also the total phenolic and flavonoids contents of the extracts were determined spectrophotometrically. Results. All the extracts showed interesting antioxidant activities compared to the standard antioxidants (butylated hydroxytoluene (BHT), quercetin, and Trolox). The aqueous extract of Juniperus oxycedrus showed the highest antioxidant activity as measured by DPPH, TEAC, and FRAP assays with IC50 values of 17.91 ± 0.37 μg/mL, 19.80 ± 0.55 μg/mL, and 24.23 ± 0.07 μg/mL, respectively. The strong correlation observed between antioxidant capacities and their total phenolic contents indicated that phenolic compounds were a major contributor to antioxidant properties of these plants extracts. Conclusion. These results suggest that the aqueous extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus phoenicea, and Tetraclinis articulata can constitute a promising new source of natural compounds with antioxidants ability. ","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 ","pages":"6392656"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6392656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34570857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 95

Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey 土耳其三种药用植物的酶抑制特性、抗氧化活性和植物化学特征

Advances in Pharmacological Sciences Pub Date : 2015-12-20 DOI: 10.1155/2015/410675

G. Zengin, G. Guler, A. Aktumsek, R. Ceylan, C. M. N. Picot, M. Mahomoodally

{"title":"Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey","authors":"G. Zengin, G. Guler, A. Aktumsek, R. Ceylan, C. M. N. Picot, M. Mahomoodally","doi":"10.1155/2015/410675","DOIUrl":"https://doi.org/10.1155/2015/410675","url":null,"abstract":"We aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (α-amylase and α-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase). The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays. The total antioxidant capacity (TAC), β-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH•), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts. The half-maximal inhibitory concentrations (IC50) of the extracts on cholinesterase, tyrosinase, and α-amylase were significantly higher than the references, galantamine, kojic acid, and acarbose, respectively. The half-maximal effective concentrations (EC50) of the extracts on TAC, CUPRAC, and FRAP were significantly higher than trolox. The phenol and flavonoid contents of the plant extracts were in the range 20.90 ± 0.190–83.25 ± 0.914 mg gallic acid equivalent/g extract and 1.45 ± 0.200–39.71 ± 0.092 mg rutin equivalent/g extract, respectively. The plants were found to possess moderate antioxidant capacities and interesting inhibitory action against key enzymes.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/410675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64951642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Olive Mill Waste Extracts: Polyphenols Content, Antioxidant, and Antimicrobial Activities 橄榄磨废提取物:多酚含量、抗氧化和抗菌活性

Advances in Pharmacological Sciences Pub Date : 2015-11-29 DOI: 10.1155/2015/714138

Inass Leouifoudi, H. Harnafi, A. Zyad

{"title":"Olive Mill Waste Extracts: Polyphenols Content, Antioxidant, and Antimicrobial Activities","authors":"Inass Leouifoudi, H. Harnafi, A. Zyad","doi":"10.1155/2015/714138","DOIUrl":"https://doi.org/10.1155/2015/714138","url":null,"abstract":"Natural polyphenols extracts have been usually associated with great bioactive properties. In this work, we investigated in vitro antioxidant and antimicrobial potential of the phenolic olive mill wastewater extracts (OWWE) and the olive cake extracts (OCE). Using the Folin Ciocalteux method, OWWE contained higher total phenol content compared to OCE (8.90 ± 0.728 g/L versus 0.95 ± 0.017 mg/g). The phenolic compounds identification was carried out with a performance liquid chromatograph coupled to tandem mass spectrometry equipment (HPLC-ESI-MS). With this method, a list of polyphenols from OWWE and OCE was obtained. The antioxidant activity was measured in aqueous (DPPH) and emulsion (BCBT) systems. Using the DPPH assay, the results show that OWWE was more active than OCE and interestingly the extracts originating from mountainous areas were more active than those produced from plain areas (EC50 = 12.1 ± 5.6 μg/mL; EC50 = 157.7 ± 34.9 μg/mL, resp.). However, when the antioxidant activity was reversed in the BCBT, OCE produced from plain area was more potent than mountainous OCE. Testing by the gel diffusion assay, all the tested extracts have showed significant spectrum antibacterial activity against Staphylococcus aureus, whereas the biophenols extracts showed more limited activity against Escherichia coli and Streptococcus faecalis.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/714138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65113137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81