Journal of otorhinolaryngology, hearing and balance medicine最新文献_第4页

Standardized Methodologies to Utilize Exosome Treatment as Potential Nano Substances in Hearing Loss 利用外泌体治疗作为听力损失潜在纳米物质的标准化方法

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2021-06-17 DOI: 10.3390/OHBM2020006

D. Park

{"title":"Standardized Methodologies to Utilize Exosome Treatment as Potential Nano Substances in Hearing Loss","authors":"D. Park","doi":"10.3390/OHBM2020006","DOIUrl":"https://doi.org/10.3390/OHBM2020006","url":null,"abstract":"Recently, studies on the mechanism and clinical application of stem cell-derived exosomes have increased. Although the number of patients with hearing loss is increasing, there is no ideal therapy for the recovery of auditory cells of an independent organ in humans. In this review, we proposed the use of stem cell-derived exosomes for treating hearing loss and summarized the exosome research strategy platform for preclinical studies. It is necessary to select a research direction to assess direct or indirect effects on recipients based on the physiological mechanisms of exosomes that deliver useful molecules (called payloads) to recipient cells or tissues. To apply exosomes in the auditory field, researchers should select a model for assessing the toxicity to the auditory cells and analyzing their mechanisms in the recipient tissue. Such in vitro, ex vivo, and in vivo models have been designed and reported in previous studies. The analytical strategies in various models can evaluate the mechanism of exosomes based on exosome surface markers or the payload, thus helping the researchers in finding evidence regarding the efficacy of exosomes. Here, we propose three strategies for exosome application research in the auditory field.","PeriodicalId":73883,"journal":{"name":"Journal of otorhinolaryngology, hearing and balance medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74620113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vestibular Rehabilitation after Vestibulopathy Focusing on the Application of Virtual Reality 以虚拟现实技术应用为重点的前庭功能康复

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2021-05-17 DOI: 10.3390/OHBM2020005

Masashi Matsumura, T. Murofushi

引用次数: 2

Delayed Speech Perception and Production after Cochlear Implantation in Bilingual Children from Non-Native Families 非母语家庭双语儿童人工耳蜗植入后语言感知和产生的延迟

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2021-03-13 DOI: 10.3390/OHBM2010004

N. Nassif, M. G. Barezzani, L. O. Redaelli de Zinis

{"title":"Delayed Speech Perception and Production after Cochlear Implantation in Bilingual Children from Non-Native Families","authors":"N. Nassif, M. G. Barezzani, L. O. Redaelli de Zinis","doi":"10.3390/OHBM2010004","DOIUrl":"https://doi.org/10.3390/OHBM2010004","url":null,"abstract":"The aim of the study was to evaluate the outcomes of cochlear implantation (CI) in a group of immigrant deaf children living in a foreign language family, following up to 3 years of a personalized habilitation program compared to age-matched Italian CI recipients. Tests of speech perception ability such as the IT-MAIS, the LiP, the CAP, and speech production such as the MUSS have been used before CI and then after 6 months, 1 year, 2 years, and 3 years. Nonparametrical tests were chosen for comparison. Eight bilingual CI recipients were included in the study and matched to 11 Italian CI recipients. The difference between chronological age at implantation, age at diagnosis, hearing age, and verbal age in the two groups of children was not significant. Comparison of the auditory perceptive and linguistic abilities between the two groups showed significant differences only in preoperative MAIS and postoperative CAP (1 to 3 years). In agreement with other studies, we achieved good performances from bilingual children with CI and our personal experience confirm the attitude of promoting bilingualism throughout the rehabilitation process.","PeriodicalId":73883,"journal":{"name":"Journal of otorhinolaryngology, hearing and balance medicine","volume":"2018 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73932789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI Evaluation of Vestibular Endolymphatic Space in Patients with Isolated Cystic Lateral Semicircular Canal Malformation 孤立性囊性外侧半规管畸形患者前庭内淋巴间隙的MRI评价

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2021-01-18 DOI: 10.3390/OHBM2010003

V. Suarez-Vega, P. Dominguez, N. Pérez-Fernández

{"title":"MRI Evaluation of Vestibular Endolymphatic Space in Patients with Isolated Cystic Lateral Semicircular Canal Malformation","authors":"V. Suarez-Vega, P. Dominguez, N. Pérez-Fernández","doi":"10.3390/OHBM2010003","DOIUrl":"https://doi.org/10.3390/OHBM2010003","url":null,"abstract":"Isolated lateral semicircular canal dysplasia (LSCCD) is one of the most frequent malformations of the bony labyrinth. The aim of this study is to depict morphology and size of the vestibular endolymphatic space in patients with isolated LSCCD using a dedicated 3D high resolution MR sequence called 3D inversion recovery with REAL reconstruction (3D-REAL-IR). From January 2018 to February 2020, we reviewed 281 CT and 241 MR temporal bone studies, and 103 MR studies performed for the evaluation of endolymphatic hydrops (EH). Five patients with LSCCD were found, one of them with bilateral malformation. Three patients (four affected ears) underwent specific MR examination for the evaluation of EH, consisting of a heavily T2-weighed cisternography sequence (T2 SPACE) and a 3D inversion-recovery with REAL reconstruction. The endolymphatic volumetric ratio (ELR) was calculated as the total endolymphatic volume divided by the total lymph (vestibular) volume multiplied by 100. Hydrops MR imaging was available in four of the affected ears. ELR ranged from 22% to 81%. Both extremes were present in the same patient, corresponding to a patient with right unilateral Ménière’s syndrome but with bilateral LSCCD. A patient affected with hearing loss had an ELR of 33% and the last patient with unilateral probable Ménière’s syndrome showed an ELR of 42%. Endolymphatic hydrops imaging is feasible and can be performed on patients with inner ear malformations like LSCCD. The endolymphatic volumetric ratio could be a useful and reproducible tool in daily clinical practice.","PeriodicalId":73883,"journal":{"name":"Journal of otorhinolaryngology, hearing and balance medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74968607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

OHBM—International Open Access Journal of Otorhinolaryngology, Hearing and Balance Medicine ohbm -国际耳鼻咽喉、听力和平衡医学开放获取杂志

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2021-01-15 DOI: 10.3390/OHBM2010002

M. Sanna

引用次数: 0

Publisher’s Note: Journal of Otorhinolaryngology, Hearing and Balance Medicine—An International Open Access Journal 出版商注:国际开放获取期刊《耳鼻咽喉、听力和平衡医学杂志》

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2020-07-13 DOI: 10.3390/ohbm2010001

引用次数: 0

Ototoxicity and Noise 耳毒性和噪音

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2018-12-01 DOI: 10.3390/OHBM1020010

A. Behar

引用次数: 1

The Primary Tumor and Regional Lymph Node Clinical Status of Distant Metastasis in Nasopharyngeal Carcinoma 鼻咽癌远处转移的原发肿瘤及局部淋巴结临床状况

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2018-11-14 DOI: 10.3390/OHBM1020009

S. R. Indrasari, K. Sudarman, J. Fedriani

{"title":"The Primary Tumor and Regional Lymph Node Clinical Status of Distant Metastasis in Nasopharyngeal Carcinoma","authors":"S. R. Indrasari, K. Sudarman, J. Fedriani","doi":"10.3390/OHBM1020009","DOIUrl":"https://doi.org/10.3390/OHBM1020009","url":null,"abstract":"Background: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from nasopharyngeal epithelium. NPC characteristic is highly invasive and can metastasize rapidly. The presence of distant metastasis is a major factor in determining the patient’s management and prognosis. The magnitude of radiologic and molecular costs encouraging the need to know the clinical variables associated with distant metastasis of NPC. Methods: Cross-sectional analytical retrospective studies of undifferentiated NPC (WHO type III) patients at initial diagnosis in the ORL-HNS Department of Dr. Sardjito Hospital Yogyakarta from January 2014 to December 2016. Results: At 276 NPC patients with the ratio of 197 men (71.4%) and 79 women (28.6%) was 2.5:1, mean age 48.5 years, distant metastasis was found in 37 patients (13.4%). There was no significant difference in the frequency of sex (p = 0.346), age (p = 0.784), and primary tumor clinical status (p = 0.297) between NPC with distant metastasis and without distant metastasis. There was significant difference in the frequency of regional lymph node clinical status between NPC with distant metastasis and without distant metastasis (p = 0.004; PR = 3.866). Conclusions: There is no statistically significant difference of primary tumor clinical status between NPC with and without distant metastasis. There is statistically significant difference of lymph node clinical status between NPC with and without distant metastasis.","PeriodicalId":73883,"journal":{"name":"Journal of otorhinolaryngology, hearing and balance medicine","volume":"23 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75718765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two Down Syndrome Patients with Bilateral Profound Hearing Loss: Case Report and Literature Review 唐氏综合征合并双侧深度听力损失2例报告并文献复习

Journal of otorhinolaryngology, hearing and balance medicine Pub Date : 2018-09-18 DOI: 10.3390/OHBM1020008

Yu Zheng, Juan‐mei Yang, Meng Zhao, Xiaoqing Qian, F. Chi

引用次数: 0