Journal of orthopaedics and sports medicine最新文献_第3页

Mitochondrial Biogenesis as a Therapeutic Target for Rotator Cuff Tendon Tears. 线粒体生物生成作为肩袖肌腱撕裂的治疗靶点。

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 Epub Date: 2023-12-04 DOI: 10.26502/josm.511500133

Armand N Yazdani, Arian Abdi, Parth Patel, Prathosh Velpuri, Vikrant Rai, Devendra K Agrawal

{"title":"Mitochondrial Biogenesis as a Therapeutic Target for Rotator Cuff Tendon Tears.","authors":"Armand N Yazdani, Arian Abdi, Parth Patel, Prathosh Velpuri, Vikrant Rai, Devendra K Agrawal","doi":"10.26502/josm.511500133","DOIUrl":"10.26502/josm.511500133","url":null,"abstract":"<p><p>Rotator Cuff Injuries (RCI) are highly prevalent and characterized by shoulder pain, restricted shoulder movement, and difficulty with overhead activity, radiating pain in the deltoid muscle, and atrophy of the rotator cuff muscles. Increasing age, hand dominance, smoking, hypertension, hyperlipidemia, and obesity are common risk factors. Chronic inflammation plays a critical role in the underlying pathogenesis. RCI accounts for massive healthcare expenditure costing about $15,000 per repair, and over 4.5 million physician visits per year, however, there is still no therapeutic target to improve clinical outcomes. Mitochondrial biogenesis in response to inflammatory stimuli supports increased cellular energy requirements, cell proliferation, and differentiation. This suggests that mitochondrial biogenesis may play a role in healing RCI by serving as a protective factor against free oxygen species and promoting homeostasis within the rotator cuff. There is evidence highlighting the potential therapeutic benefits of mitochondrial biogenesis in various inflammatory diseases, but no study explored the role of mitochondrial biogenesis in rotator cuff tears. Since hypercholesterolemia is a risk factor for RCI, we investigated the effects of hypercholesterolemia on the expression of PGC-1α, a marker of mitochondrial biogenesis, in rotator cuff muscle. The findings revealed an increased gene and protein expression of inflammatory mediators and PGC-1α, suggesting enhanced inflammation and increased mitochondrial biogenesis due to hypercholesterolemia. Additional studies are warranted to further investigate the chronic effect of hyperlipidemia induced RCI to elucidate the cause of insufficient mitochondrial biogenesis unable to protect the rotator cuff and the therapeutic effect of promoting mitochondrial biogenesis.</p>","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"5 4","pages":"442-449"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence, Severity and Reversibility of Acute Kidney Injury after Elective Hip and Knee Arthroplasty in Patients Receiving Celecoxib Perioperatively as One of the Standard Multimodal Analgesic Protocols 围手术期接受塞来昔布作为标准多模式镇痛方案之一的患者择期髋关节置换术后急性肾损伤的发生率、严重程度和可逆性

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500101

Manson Tak Hei Chan, Timmy Chi Wing Chan, Henry Chi Yeung Mak, Will Shing Him Chan, Stanley Sau Ching Wong, Vincent Kai Chung Wong, Lewis Ping Keung Chan, C. Cheung

{"title":"Incidence, Severity and Reversibility of Acute Kidney Injury after Elective Hip and Knee Arthroplasty in Patients Receiving Celecoxib Perioperatively as One of the Standard Multimodal Analgesic Protocols","authors":"Manson Tak Hei Chan, Timmy Chi Wing Chan, Henry Chi Yeung Mak, Will Shing Him Chan, Stanley Sau Ching Wong, Vincent Kai Chung Wong, Lewis Ping Keung Chan, C. Cheung","doi":"10.26502/josm.511500101","DOIUrl":"https://doi.org/10.26502/josm.511500101","url":null,"abstract":"Background: Acute Kidney Injury (AKI) may complicate up to 10% of primary lower-extremity total joint arthroplasties. However, none of these previous studies evaluated the duration and reversibility of AKI. Moreover, none specifically evaluated the impact of perioperative celecoxib on the incidence and severity of AKI, especially for patients with preexisting renal impairment. This study was to retrospectively review the incidence, severity and duration of AKI with short term perioperative celecoxib. We also aimed to evaluate the impact of perioperative celecoxib on the incidence and severity of AKI in patients with and without preexisting renal impairment. Methods: We retrospectively reviewed 1077 patients at Queen Mary Hospital, Hong Kong, from January 2018 to December 2021. Data were retrieved from the computerized medical records system. Results: One hundred of 1077 patients (9.3%) had postoperative AKI. Eight hundred eighty-eight patients (82.5%) were prescribed perioperative celecoxib, while 189 patients (17.5%) were not. The overall incidence of AKI in those taking perioperative celecoxib was 9.2%, while it was 9.5% in those not taking perioperative celecoxib. There was no statistically significant difference. There was no association between perioperative celecoxib and postoperative AKI. Among those who received perioperative celecoxib, the overall incidence of postoperative AKI in those with and without preexisting renal impairment (normal renal function test) was 9.3% and 9.2%, respectively. This was not statistically significant. The duration of AKI was 4 days for both groups. In both groups, most AKI cases were stage 1. Conclusions: Short term perioperative celecoxib probably had no additional AKI risk even in patients with preexisting renal impairment.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Radiological and Functional Outcome of Proximal Femoral Nail with Helical Blade versus Lag Screw in Intertrochanteric Fractures 螺旋刀片股骨近端钉与拉力螺钉治疗转子间骨折的放射学和功能效果比较

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500078

Kamaldeep Singh, R. K. Aggarwal, A. Dewan, Chandan Jasrotia

{"title":"Comparison of the Radiological and Functional Outcome of Proximal Femoral Nail with Helical Blade versus Lag Screw in Intertrochanteric Fractures","authors":"Kamaldeep Singh, R. K. Aggarwal, A. Dewan, Chandan Jasrotia","doi":"10.26502/josm.511500078","DOIUrl":"https://doi.org/10.26502/josm.511500078","url":null,"abstract":"Introduction: Intertrochanteric fractures are defined as extracapsular fractures of the proximal femur that occur between the greater and lesser trochanter. These fractures occur both in the elderly and the young, but they are more common in the elderly population with osteoporosis due to a low energy mechanism. The female to male ration is between 2:1 and 8:1. Operative management of these fractures is considered urgent, not emergent. This allows the many comorbidities with which patients often present to be optimized preoperatively, to reduce morbidity and mortality. Aim and objectives: Aim of the study is to compare the radiological and functional outcome of proximal femoral nail with helical blade vs. proximal femoral nail with lag screw in intertrochanteric fractures. Materials and methods: Patients fulfilling the inclusion criteria were included in the study and randomly allocated in two groups. Group patients with intertrochanteric fracture were operated with proximal femoral nail using lag screw and group B patients were operated with proximal femoral nail using helical blade.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Ultrasound-Guided Approach for the Management of an Anterior Paralabral Cyst of the Hip 超声引导下治疗髋关节前髌旁囊肿的新方法

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500114

Michael O. Bazzi, Michael A. Downing, David M Civitarese, James R Ross, J. Rothenberg

引用次数: 0

Outcomes Following Capsular Distention for Stage II Adhesive Capsulitis II期粘连性囊炎囊扩张后的结果

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500087

Alyssa Pelak, A. Hassan, Arnav Barve, Antonio Madrazo-Ibarra, Jonathan M. Kirschner, Vijay B. Vad

{"title":"Outcomes Following Capsular Distention for Stage II Adhesive Capsulitis","authors":"Alyssa Pelak, A. Hassan, Arnav Barve, Antonio Madrazo-Ibarra, Jonathan M. Kirschner, Vijay B. Vad","doi":"10.26502/josm.511500087","DOIUrl":"https://doi.org/10.26502/josm.511500087","url":null,"abstract":"Background: There has been many different treatments for adhesive capsulitis explored including physical therapy, manipulation under anesthesia, arthroscopic capsular release, corticosteroid injections, and capsular distention without consensus regarding the most effective treatment. Capsular distention has not been explored in a mid-term study. Therefore, this study aims to investigate the mid-term outcomes of the procedure and analyze the need for a second procedure following initial distention. Methods: This study included 27 patients with average age of 58 diagnosed with stage II adhesive capsulitis. The primary outcome was the rate of second procedures in patients following initial capsular distention, utilizing both electronic medical record and direct patient questions. The secondary outcomes included patient satisfaction rating, range of motion (ROM) limitations, limitations on Activities of Daily Living (ADLs) and time to follow up. Results: At an average follow up of 49 months, 78% of patients did not require a second procedure following capsular distention. The group that required second procedure had a significantly higher percentage of hypothyroid patients and a shorter time to follow up visits. Additionally, 81% of the total cohort reported their outcomes as “good,” 74% had no ROM limitations and 89% had no limitations on ADLs. Conclusion: Capsular distention shows promising results for mid-term follow up with patient reported outcomes and over three quarters of patients not requiring a second procedure. Further research on the use of this treatment is warranted including randomized controlled trials and longer term follow up.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Peroneus Longus Tendon Autograft for Anterior Cruciate Ligament Reconstruction: A Safe and Effective Alternative in Nonathletic Patients 腓长肌腱自体移植物用于前交叉韧带重建:一种安全有效的非运动患者替代方法

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500091

Rahaman Sk, Halder Rc, Tayaba T, Mamun Mba, Islam Ms, K. Mmr, Rahman Mm, Hossain Gmj, Kamruzzaman M

{"title":"Peroneus Longus Tendon Autograft for Anterior Cruciate Ligament Reconstruction: A Safe and Effective Alternative in Nonathletic Patients","authors":"Rahaman Sk, Halder Rc, Tayaba T, Mamun Mba, Islam Ms, K. Mmr, Rahman Mm, Hossain Gmj, Kamruzzaman M","doi":"10.26502/josm.511500091","DOIUrl":"https://doi.org/10.26502/josm.511500091","url":null,"abstract":"Background: The Anterior Cruciate Ligament (ACL) is one of the most vital parts for sustaining knee joint stability. But, the frequency of ACL injuries is increasing alarmingly. The Peroneus Longus Tendon (PLT) is now considered to be a promising graft which is a safe and efficient alternative to other grafting methods. Methods: This was a prospective interventional study conducted at a tertiary care orthopaedic teaching hospital, during the period of March, 2019-August, 2022. The sample size for this study was 64. For statistical analysis, SPSS version 20 was used as a statistical tool. Result: There were 9(14.1%) respondents who were <18 years of age, followed by 22(34.4%) who were aged between 18-20 years, while the remaining 33(51.6%) were aged >20 years. The mean ± SD diameter (mm) was 8.3 ± 0.8, length (mm) was 8.5 ± 0.4, height (cm) was 174.1 ± 8.6, weight (kg) was 76.2 ± 13.2 and BMI was 25.0 ± 3.4. The majority of the patients (50%) were injured 1-3 months prior to the surgery. At the 6-month follow-up period, according to Lachman indicators after the surgery, 59(92.2%) of the respondents were graded 0, and the remaining 5(7.8%) were graded I. At the 12-month follow-up, the majority (93.8%) were graded 0, and 4(6.3%) graded I. At the 18-months follow-up, 59(92.2%) were graded 0 and 5(7.8%) were graded I. At the 6-month follow- up period by KT- 2000 indicators (mm) after the surgery, 57(89.1%) of the respondents were graded 0-2 mm, followed by 7(10.9%) graded 3-5 mm. At 12-months followed up the most 59(92.2%) were graded 0-2 mm and followed by 5(7.8%) graded 3-5 mm at the 18-month followed up, 57(89.1%) graded 0-2 mm, and followed by 7(10.9%) graded 3-5 mm. Conclusion: Peroneus longus tendon autograft in ACL reconstruction is a safe procedure that has a satisfactory result which was proved by the Lachman’s Test and the IKDC (KT-2000) score. PLT can prove to be an effective alternative autograft for ACL reconstruction.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of Musculoskeletal Manifestations Between Diabetes and Hypothyroidism Patients 糖尿病与甲状腺功能减退患者肌肉骨骼表现的比较

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500116

Shaila Sharmin Shahnewaz, Supriya Sarker, Tahmeed Kamal, Naima Akhter Dina

引用次数: 0

Outcomes of Coracoid Bone Graft Positioning During the Latarjet Procedure with Respect to Surgical Approach 在Latarjet手术中喙骨移植物定位与手术入路的关系

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500121

Gary Ulrich MD, Shariff Bishai DO, MS

引用次数: 0

Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury. Karyopherins在细胞外基质重塑中的作用：肌腱损伤的意义。

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 Epub Date: 2023-09-14 DOI: 10.26502/josm.511500122

Connor Diaz, Finosh G Thankam, Devendra K Agrawal

引用次数: 0

Dry Needling as a Treatment for Hallux Valgus – A Case Report 干针治疗拇外翻1例

Journal of orthopaedics and sports medicine Pub Date : 2023-01-01 DOI: 10.26502/josm.511500097

Omri Zilberberg, Dr. Sheehan N MISCP MMedSE PhD, Dr. Sanocka D MD PhD

引用次数: 0