Journal of nutritional biology最新文献

{"title":"Biochemical Composition and Heavy Metal Content in the Mussels of Kadiyapattinam, Kanyakumari distrct, South West Coast of India","authors":"K ImmaculateJeyasanta, S. Wilson, N. Sathish, J. Patterson","doi":"10.18314/JNB.V4I2.1417","DOIUrl":"https://doi.org/10.18314/JNB.V4I2.1417","url":null,"abstract":"Samples of the green mussel, Perna viridis, the brown mussel Perna perna and the parrot mussel were collected from Kadiyapattinam of Kanyakumari coast and their biochemical composition and the levels of heavy metal contamination were analyzed. The results of this study showed that the biochemical composition of the mussels did not very much. The specimens of all the three species of mussels were found to be good aquatic invertebrates for human consumption. P. viridis contained higher proportion of protein than Perna perna and the parrot mussel. Perna perna and the parrot mussel contained more lipid, ash, carbohydrate, and fibre; and their caloric values were also more than that of Perna viridis. Perna perna had the highest moisture content (78.21%) followed by the parrotmussel (19.47%) and Perna viridis (20.30%). Concentrations of the heavy metals (Cd, Cu, Pb, Cr, As, Ni and Se) in the edible portions of the samples were within the values recommended by the WHO. Mercury was not detected and so these mussels are safe for the consumers. The order of concentrations of minerals found in the mussel samples was: K > Na > P > Ca > Mg > Fe > Zn > Mn. Potassium content was more than the other elements. It was evident from the study that in the soft tissue of all Perna species the concentration of essential minerals was higher than the nonessential metals. Kadiyapattinam mussels are a rich source not only of protein but also of all the other micro and macro minerals. The soft tissues of all the mussels had low levels of heavy metal concentration, and this indicates a comparatively lower heavy metal contamination of Kadiyapattinam coast. Mussels are also a rich source of nutritional components and could be used as human diet in place of other fish so as to reduce the pressure on sea foods.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42246148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Properties and Antimicrobial Activity of Natural Colorant Extracted from Mesocarp and Exocarp of Cocos nucifera","authors":"R. Hassan, Nur Asma Fhadhila Zulrushdi, A. M. Yusoff, Nurhafizah Ibrahim, Norakma Mohd Nor","doi":"10.18314/jnb.v4i2.1251","DOIUrl":"https://doi.org/10.18314/jnb.v4i2.1251","url":null,"abstract":"Phytochemical analysis was carried out on the natural colorant extracted using the microwave-assisted extraction which performed at a microwave power of 300 watts for 2 minutes. The pigment compound was extracted from mesocarp and mesocarp of Cocos nucifera by using 0.1 M NaOH as extracting agent. The qualitative analysis that was carried out for these natural colorants confirmed that flavonoids, terpenoids, cardiac glycosides and phenol/tannins were present in both plant parts (mesocarp and exocarp) tested whereas alkaloids, saponins, steroids and anthraquinone were not detected. Quantitative analysis showed that tannin content was significantly (p < 0.05) higher (134.82 mg TAE/g) in the mesocarp extract compared to the exocarp extract (33.90 mg TAE/g). The amount of flavonoids was low in both extracts (mesocarp: 15.48 mg QE/g and exocarp: 28.45 mg QE/g, respectively). The antimicrobial study discovered that the mesocarp and the exocarp extract were not effective as antibacterial agents.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41839357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Nutritional Supplementation with Vitamin B12 and Folic Acid on Serum Homocysteine Levels of Deep Vein Thrombosis","authors":"S. Kharb, A. Khandelwal, K. Singh, M. Vashist","doi":"10.18314/JNB.V4I2.1183","DOIUrl":"https://doi.org/10.18314/JNB.V4I2.1183","url":null,"abstract":"Deep vein thrombosis is a common vascular disorder and association of Homocysteine with DVT is known. Evidence of decrease B12 and folic acid levels in DVT with Hyperhomocysteinemia has also been reported. Scanty data is available regarding role of folate and vitamin B12 on Homocysteine levels in DVT patients. The present study was undertaken in 100 patients. Study group comprised of 50 patients who had clinical features suggestive of DVT and 50 patients, who did not have clinical features suggestive of any venous or arterial disorder, were labelled as control group. All the patients of study group were given vitamin B12 and folic acid treatment along with standard treatment of DVT. Serum Homocysteine, folate, vitamin B12 were measured in all the patients in both the groups and estimated by chemiluminescence technology. After 12 weeks of vitamin B12 and folic acid therapy, serum Homocysteine levels, folic acid levels and vitamin B12 levels of study group were again estimated. The collected records and data was analysed statistically by Student t-test and Chi-square test. Mean Homocysteine level in study group was significantly higher as compared to control group (19.63 ± 19.14 µmol/mL vs. 7.0 ± 4.94 µmol/mL). Mean Homocysteine levels before treatment were 19.63 ± 19.14 µmol/mL and after treatment they were significantly reduced. Hyperhomocysteinemia is a risk factor for deep vein thrombosis. Folic acid and B12 therapy reduced the level of Homocysteine suggesting that this may decrease the chances of recurrence of DVT.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49183271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D: Controversy Cancer and Beyond","authors":"C. Rosales, D. Bandyopadhyay","doi":"10.18314/JNB.V4I2.1374","DOIUrl":"https://doi.org/10.18314/JNB.V4I2.1374","url":null,"abstract":"Vitamins are an essential part to wellbeing. This was not something always known however, as the Germ theory was the accepted thesis of the 18th century. It was found that certain accessory factors helped mitigate and even cure these diseases such as beriberi, scurvy, and rickets. Accessory factors, later coined vitamins by Casimir Funk, are an essential constituent of the human diet. Vitamin D is technically not a vitamin but functions as a steroid hormone whose most well-known purpose is calcification of the human skeleton. This helps prevent osteomalacia in adults and rickets, a serious problem in children due to their developmental stages. But besides its well-known role, vitamin D also has other important non-calcification purposes, including being a possible anticancer agent. Calcitriol (1,25 dihydroxycholecalciferol, vitamin D3) has found to treat certain cancers in various ways: from the VDR-RXR complex to analogs being able to decrease tumor growth, lowering expression of stem cell marker genes, and inhibition of the Wnt pathway. Although there is promise in its effectiveness based on studies of squamous cell carcinoma, prostate, breast, colon, and ovarian cancer; hypercalcemia, lack of consistent data, and insufficient clinical trials are serious issues that constantly get in the way of progression of vitamin D’s legitimacy as a solution.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44637338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balanced Essential Micronutrients during Pregnancy: High Concern","authors":"Srilatha Bashetti, Kumar SaiSailesh, A. Varma, R. Vijayaraghavan","doi":"10.18314/jnb.v4i2.1373","DOIUrl":"https://doi.org/10.18314/jnb.v4i2.1373","url":null,"abstract":"Nutrition and epigenetic changes is the emerging topic of interest in the present scenario to understand the effects of increased supplementation of micronutrients like Folic Acid (FA). The study is taken up in the public health interest, to evaluate the importance of balancing the different micronutrients in the diet to avoid unbalanced nutritional disorders and other health complications later in life. It has been hypothesized that disease risks after birth or later in life can be determined by paternal or maternal diet. This raised an interest to study in-utero effects of environmental exposures like air pollution, toxins, nutrition, etc. It had been assumed that during embryonic period most of the dividing tissues get exposed to the environmental insults and that change results in predisposition of cancer or other health outcomes. There could be the possibility of maternal exposures like nutrition may alter the intrauterine one-carbon metabolism or the precursor milieu and may be involved in the disruption of one-carbon metabolism in developing offspring. Modification in methyl me of offspring with subsequent changes in phenotypes has been noted in the preliminary studies with increased folic acid (FA) supplementation during pregnancy. Maternal folate deficiency has been implicated as a cause of prematurity and both folate deficiency and cobalamin deficiency have been implicated in recurrent fetal loss and neural tube defects. Folic acid supplementation at the time of conception and in the first 12 weeks of pregnancy is expected to reduce by 70% the incidence of neural tube defects (NTDs) (meningomyelocele, encephalocele and spina bifida) in the fetus. Most of the protective effect can be achieved by taking folic acid, 0.4 mg daily at the time of conception. However there is no clear relationship between maternal folatestatus and the fetal abnormalities. It has been observed that, the lower the maternal folate, the greater the risk to the fetus. On the other hand maternal cobalamin status is a strong predictor of vitamin B12 in breastfed infants up to at least 6 months of age. Because of the transfer from mother to offspring during pregnancy and lactation, maternal requirements during this period are increased and deficiency may occur. The influence of low vitamin B12 during pregnancy may have cognitive ability of children later in life. Hypothyroidism is caused by insufficient production of thyroid hormones by the thyroid gland. In females, hypothyroidism is associated mainly with oligomenorrhea.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44323131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Education Household’s Wealth and Child Mortality in Rural Nigeria","authors":"Ashagidigbi Waheed M, Adewumi Oluwatosin B, Olagunju Kehinde O, Ogunniyi Adebayo I","doi":"10.18314/jnb.v4i2.1347","DOIUrl":"https://doi.org/10.18314/jnb.v4i2.1347","url":null,"abstract":"Poverty, maternal literacy and child mortality has been a policy issue in Nigeria, most especially in rural areas.Studies have established their individual effects on households. However, the need to establish the link between the three welfare indicators is of great economic and social importance. The study aimed at investigating the linkage and effect of maternal education and household wealth on incidence of child mortality in rural Nigeria. The study made use of data obtained from the 2013 Nigeria Demographic and Health Survey (NDHS2013). Logit, probit and Principal Component Analysis models were the analytical techniques adopted. The findings revealed that mothers residing in the north-west recorded the highest percentage of no formal education (54%). Also, asset deprivation (poverty rate) is 63%, though higher in the northern divide than in the south. About 44 percent of the rural households recorded child mortality, with north-west households having the highest. The results revealed that maternal education improves households’ wealth; also, households with low level of maternal education and wealth index have the likelihood of recording higher child mortality rate in rural Nigeria. If the Sustainable Development Goals of ending extreme poverty, achieving good health, and ensuring gender equality in relation to female education are to be achieved, maternal human capital development and households’ welfare improvement should be the areas of focus in rural Nigeria.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67530464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where the Pendulum of Knowledge Stands Now: Is Circulating Albumin a Marker of Inflammation or of Malnutrition? How to Manage Hypoalbuminemia by Nutrition?","authors":"F. Dioguardi","doi":"10.18314/JNB.V4I2.1285","DOIUrl":"https://doi.org/10.18314/JNB.V4I2.1285","url":null,"abstract":"Low plasma albumin levels have been historically associated with insufficient nutritional nitrogen support.Recently, linked to the poor response of actual therapies and available supplements to manage this alteration, the role of this alteration has been attributed to the vast ensemble of modifications referred generally as consequent to inflammation. On the contrary, as recently it has been reported that life based on introduction of mainly essential amino acids is possible, and life span is improved when compared to standard diets, it is possible to hypothesize that by normal foods or by actually most widely diffused supplements insufficient amounts of essential amino acids to match with real needs of hypoalbuminemic patients are not provided. Peculiarly, some non essential amino acids provided in excess by diets may mislead clinicians by suggesting achievement of sufficient nitrogen intake if urea syntheses is used as reference of sufficient nutrition, while syntheses of liver proteins is not sufficiently implemented. Studies suitable to understand if some innovative therapy would be efficient in implementing albumin syntheses and thus prognosis in hypoalbuminemic patients are necessary.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42217317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting Therapy versus Standard Weight Reduction Diet Combined with Naturopathic Complex Treatment in Patients with Overweight and Obesity","authors":"K. Wiebelitz, D. Wessely, Lena Elisabeth Ismar, Tanja Pötschke, Beate Weidner, A. Beer","doi":"10.18314/jnb.v4i2.1007","DOIUrl":"https://doi.org/10.18314/jnb.v4i2.1007","url":null,"abstract":"Background: Overweight and obesity are major risk factors for many chronic diseases in modern societies. A retrospective follow-up study showed an advantage of weight reduction diet (WRD) to fasting therapy  concerning long-term weight loss.Objective: Prospective comparison of WRD to fasting therapy concerning long-term weight loss. Methods: From 08/2007 to 02/2009 90 patients with overweight or obesity were observed with a follow-up period of 6 months, who received either a fasting therapy or a WRD in the context of naturopathic complex in-patient treatment including physical activity.Results: During the in-patient treatment the fasting patients loosed significantly more weight than the WRD patients, but regained weight during the follow-up, while the weight loss of the WRD patients persisted. 32% of the fasting and 81% of the WRD patients achieved a 5% weight loss after 6 months. Total and LDL-cholesterol were significantly more reduced, controlled eating habits, physical leisure activity and tendentially physical quality of life increased more after 6 months in the WRD group, while the systolic blood pressure declined more in the fasting patients.Conclusion: Weight loss and improvement of obesity-associated parameters were long-term significantly inferior in fasting patients compared to patients treated with a WRD. The reduced success of the fasting patients is probably caused by the minor lifestyle modification.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41952418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with Herbal Mouthwash Mediates Improvement of Symptoms in Xerostomia and Oral Mucositis patients","authors":"J. Berrout, S. Dahlbeck, Gianluca Rotino, D. Nguyen, J. Figueroa","doi":"10.18314/jnb.v4i2.1060","DOIUrl":"https://doi.org/10.18314/jnb.v4i2.1060","url":null,"abstract":"Oral discomfort and pain are frequent side-effects of many popular prescription medications. Over 500 prescription drugs are known to result in the development of adverse oral conditions. In fact, approximately 40% of patients suffer from xerostomia and oral mucositis, as a result of cancer medications. The number of affected individuals is expected to continue to rise, given that the incidence of major cancers is predicted to grow over the next decade. Regrettably, there are currently lacks of treatments available to effectively improve xerostomia and oral mucositis symptoms. Interestingly, the use of several herbal ingredients (such as chamomile, cinnamon, and peppermint oil) has been reported to effectively improve pain and oral dryness. For this reason, we examined the effectiveness of an herbal mouthwash, Nature’s Herbal (a blend of cinnamon oil, chamomile, cranberry, and peppermint extract), to alleviate symptoms of oral pain and dry mouth exhibited by patients diagnosed with oral mucositis and xerostomia. Daily treatment with the mouthwash induced a 53% ± 6% and 33.2% ± 3.8% improvement in the severity of symptom, for the oral mucositis and xerostomia patients groups, respectively. Overall, the herbal mouthwash induced an improvement in 91% of oral mucositis and 83% of xerostomia patients.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46345930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Receptor Levels Regulated by the Receptor- Associated Protein Progesterone Receptor Membrane Component 1 (PGRMC1)","authors":"R. Craven, Kaia K. Hampton","doi":"10.18314/jnb.v4i2.1081","DOIUrl":"https://doi.org/10.18314/jnb.v4i2.1081","url":null,"abstract":"As of 2014, 29.1 million Americans suffer from diabetes, creating a severe socioeconomic and medical burdenon society. Impaired insulin signaling is key to the development of type 2 diabetes, presenting a unique therapeutic challenge. Obese individuals demonstrate decreased insulin binding due to a reduction in IR levels, without an alteration in ligand-receptor binding affinity. The progesterone receptor membrane component 1 (PGRMC1) is an endosomal protein that promotes cellular signaling via altered receptor trafficking. A recent translational study determined that PGRMC1 was decreased in patients with insulin-resistant disease, suggesting a role in insulin signaling. In the present study, we hypothesized that PGRMC1 affects the levels of IR? (insulin receptor-? sub-unit) in adipocytes. Indeed, we show that treatment with PGRMC1 ligands significantly increase IR? protein levels in fully differentiated human subcutaneous adipocytes. Protein levels are likely affected through the direct interaction of PGRMC1 and IR?, as we demonstrate their co immunoprecipitation in differentiated 3T3-L1 cells. Notably, PGRMC1 ligand treatment significantly reduced IR? protein levels in two rodent model systems, indicating a pharmacological difference across species.","PeriodicalId":73868,"journal":{"name":"Journal of nutritional biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45628402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}