Journal of nanotheranostics最新文献_第5页

Surface Adsorption of the Alpha-Emitter Astatine-211 to Gold Nanoparticles Is Stable In Vivo and Potentially Useful in Radionuclide Therapy α发射体Astatine-211对金纳米粒子的表面吸附在体内是稳定的，并有可能用于放射性核素治疗

Journal of nanotheranostics Pub Date : 2021-10-01 DOI: 10.3390/jnt2040012

Emanuel Sporer, C. Poulie, S. Lindegren, Emma Aneheim, H. Jensen, T. Bäck, P. Kempen, A. Kjaer, M. Herth, A. I. Jensen

{"title":"Surface Adsorption of the Alpha-Emitter Astatine-211 to Gold Nanoparticles Is Stable In Vivo and Potentially Useful in Radionuclide Therapy","authors":"Emanuel Sporer, C. Poulie, S. Lindegren, Emma Aneheim, H. Jensen, T. Bäck, P. Kempen, A. Kjaer, M. Herth, A. I. Jensen","doi":"10.3390/jnt2040012","DOIUrl":"https://doi.org/10.3390/jnt2040012","url":null,"abstract":"Targeted α-therapy (TAT) can eradicate tumor metastases while limiting overall toxicity. One of the most promising α-particle emitters is astatine-211 (211At). However, 211At-carbon bonds are notoriously unstable in vivo and no chelators are available. This hampers its adoption in TAT. In this study, the stability of 211At on the surface of gold nanoparticles (AuNPs) was investigated. The employed AuNPs had sizes in the 25–50 nm range. Radiolabeling by non-specific surface-adsorption in >99% radiochemical yield was achieved by mixing 211At and AuNPs both before and after polyethylene glycol (PEG) coating. The resulting 211At-AuNPs were first challenged by harsh oxidation with sodium hypochlorite, removing roughly 50% of the attached 211At. Second, incubation in mouse serum followed by a customized stability test, showed a stability of >95% after 4 h in serum. This high stability was further confirmed in an in vivo study, with comparison to a control group of free 211At. The AuNP-associated 211At showed low uptake in stomach and thyroid, which are hallmark organs of uptake of free 211At, combined with long circulation and high liver and spleen uptake, consistent with nanoparticle biodistribution. These results support that gold surface-adsorbed 211At has high biological stability and is a potentially useful delivery system in TAT.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49285467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Dissecting the Inorganic Nanoparticle-Driven Interferences on Adhesome Dynamics 无机纳米粒子驱动的对成体动力学的干扰

Journal of nanotheranostics Pub Date : 2021-09-02 DOI: 10.3390/jnt2030011

Vladimir Mulens-Arias

{"title":"Dissecting the Inorganic Nanoparticle-Driven Interferences on Adhesome Dynamics","authors":"Vladimir Mulens-Arias","doi":"10.3390/jnt2030011","DOIUrl":"https://doi.org/10.3390/jnt2030011","url":null,"abstract":"Inorganic nanoparticles have emerged as an attractive theranostic tool applied to different pathologies such as cancer. However, the increment in inorganic nanoparticle application in biomedicine has prompted the scientific community to assess their potential toxicities, often preventing them from entering clinical settings. Cytoskeleton network and the related adhesomes nest are present in most cellular processes such as proliferation, migration, and cell death. The nanoparticle treatment can interfere with the cytoskeleton and adhesome dynamics, thus inflicting cellular damage. Therefore, it is crucial dissecting the molecular mechanisms involved in nanoparticle cytotoxicity. This review will briefly address the main characteristics of different adhesion structures and focus on the most relevant effects of inorganic nanoparticles with biomedical potential on cellular adhesome dynamics. Besides, the review put into perspective the use of inorganic nanoparticles for cytoskeleton targeting or study as a versatile tool. The dissection of the molecular mechanisms involved in the nanoparticle-driven interference of adhesome dynamics will facilitate the future development of nanotheranostics targeting cytoskeleton and adhesomes to tackle several diseases, such as cancer.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41346483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies 纳米粒子介导的光激活疗法的治疗应用

Journal of nanotheranostics Pub Date : 2021-08-03 DOI: 10.3390/jnt2030009

Shalini Sharma, A. Zvyagin, I. Roy

{"title":"Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies","authors":"Shalini Sharma, A. Zvyagin, I. Roy","doi":"10.3390/jnt2030009","DOIUrl":"https://doi.org/10.3390/jnt2030009","url":null,"abstract":"Nanoparticle-mediated light-activated therapies, such as photodynamic therapy and photothermal therapy, are earnestly being viewed as efficient interventional strategies against several cancer types. Theranostics is a key hallmark of cancer nanomedicine since it allows diagnosis and therapy of both primary and metastatic cancer using a single nanoprobe. Advanced in vivo diagnostic imaging using theranostic nanoparticles not only provides precise information about the location of tumor/s but also outlines the narrow time window corresponding to the maximum tumor-specific drug accumulation. Such information plays a critical role in guiding light-activated therapies with high spatio-temporal accuracy. Furthermore, theranostics facilitates monitoring the progression of therapy in real time. Herein, we provide a general review of the application of theranostic nanoparticles for in vivo image-guided light-activated therapy in cancer. The imaging modalities considered here include fluorescence imaging, photoacoustic imaging, thermal imaging, magnetic resonance imaging, X-ray computed tomography, positron emission tomography, and single-photon emission computed tomography. The review concludes with a brief discussion about the broad scope of theranostic light-activated nanomedicine.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41748173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nanoscale Carbon-Polymer Dots for Theranostics and Biomedical Exploration 纳米尺度碳聚合物点用于治疗和生物医学探索

Journal of nanotheranostics Pub Date : 2021-07-29 DOI: 10.3390/jnt2030008

S. Sharker, Minjae Do

引用次数: 8

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization 十二烷基硫酸钠稳定金纳米棒生物相容性的改进

Journal of nanotheranostics Pub Date : 2021-07-16 DOI: 10.3390/jnt2030010

Rossana Terracciano, A. Zhang, Mathieu L. Simeral, D. Demarchi, J. Hafner, Carly S. Filgueira

{"title":"Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization","authors":"Rossana Terracciano, A. Zhang, Mathieu L. Simeral, D. Demarchi, J. Hafner, Carly S. Filgueira","doi":"10.3390/jnt2030010","DOIUrl":"https://doi.org/10.3390/jnt2030010","url":null,"abstract":"Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis, limits their clinical translation. We report a facile method to improve GNR biocompatibility through the presence of sodium dodecyl sulfate (SDS). GNRs (120 × 40 nm) were synthesized through a seed-mediated approach, using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to direct the growth of nanorods and stabilize the particles. Post-synthesis, SDS was used as an exchange ligand to modify the net surface charge of the particles from positive to negative while maintaining rod stability in an aqueous environment. GNR cytotoxic effects, as well as the mechanisms of their cellular uptake, were examined in two different cancer cell lines, Lewis lung carcinoma (LLC) and HeLa cells. We not only found a significant dose-dependent effect of GNR treatment on cell viability but also a time-dependent effect of GNR surfactant charge on cytotoxicity over the two cell lines. Our results promote a better understanding of how we can mediate the undesired consequences of GNR synthesis byproducts when exposed to a living organism, which so far has limited GNR use in cancer theranostics.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43148855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Deciphering Exhaled Aerosol Fingerprints for Early Diagnosis and Personalized Therapeutics of Obstructive Respiratory Diseases in Small Airways 解读呼气气溶胶指纹用于小型航空公司阻塞性呼吸道疾病的早期诊断和个性化治疗

Journal of nanotheranostics Pub Date : 2021-06-22 DOI: 10.3390/jnt2030007

X. Si, J. Xi

{"title":"Deciphering Exhaled Aerosol Fingerprints for Early Diagnosis and Personalized Therapeutics of Obstructive Respiratory Diseases in Small Airways","authors":"X. Si, J. Xi","doi":"10.3390/jnt2030007","DOIUrl":"https://doi.org/10.3390/jnt2030007","url":null,"abstract":"Respiratory diseases often show no apparent symptoms at their early stages and are usually diagnosed when permanent damages have been made to the lungs. A major site of lung pathogenesis is the small airways, which make it highly challenging to detect using current techniques due to the diseases’ location (inaccessibility to biopsy) and size (below normal CT/MRI resolution). In this review, we present a new method for lung disease detection and treatment in small airways based on exhaled aerosols, whose patterns are uniquely related to the health of the lungs. Proof-of-concept studies are first presented in idealized lung geometries. We subsequently describe the recent developments in feature extraction and classification of the exhaled aerosol images to establish the relationship between the images and the underlying airway remodeling. Different feature extraction algorithms (aerosol density, fractal dimension, principal mode analysis, and dynamic mode decomposition) and machine learning approaches (support vector machine, random forest, and convolutional neural network) are elaborated upon. Finally, future studies and frequent questions related to clinical applications of the proposed aerosol breath testing are discussed from the authors’ perspective. The proposed breath testing has clinical advantages over conventional approaches, such as easy-to-perform, non-invasive, providing real-time feedback, and is promising in detecting symptomless lung diseases at early stages.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/jnt2030007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49500579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cellular Investigations on Mechanistic Biocompatibility of Green Synthesized Calcium Oxide Nanoparticles with Danio rerio 绿色合成氧化钙纳米颗粒与微生物相容性的细胞研究

Journal of nanotheranostics Pub Date : 2021-03-09 DOI: 10.3390/JNT2010004

Rashke Eram, P. Kumari, P. Panda, Sonal Singh, B. Sarkar, M. Mallick, S. Verma

{"title":"Cellular Investigations on Mechanistic Biocompatibility of Green Synthesized Calcium Oxide Nanoparticles with Danio rerio","authors":"Rashke Eram, P. Kumari, P. Panda, Sonal Singh, B. Sarkar, M. Mallick, S. Verma","doi":"10.3390/JNT2010004","DOIUrl":"https://doi.org/10.3390/JNT2010004","url":null,"abstract":"The utility of calcium oxide nanoparticles in the biomedical and physical fields has instigated their biocompatible synthesis and production. Moreover, it is important to investigate their biocompatibility at the molecular level for biomedical and ecotoxicological concern. This study explores the green synthesis of calcium oxide nanoparticles (CaONP) using Crescentia cujete leaf extract. The synthesized CaONP were found to have a size of 62 ± 06 nm and a hydrodynamic diameter of 246 ± 12 nm, as determined by FE-SEM and dynamic light scattering (DLS). CaONP was stable in fish medium with a zeta potential of −23 ± 11 mV. The biocompatibility of the CaONP was investigated with adult zebrafish bearing an LC50 of 86.32 µg/mL. Cellular and molecular investigation revealed the mechanism of biocompatibility as a consequence of elicited reactive oxygen species leading to apoptosis, due to accumulation and internalization of CaONP in exposed zebrafish. The study provided detailed information about the mechanistic biocompatibility and a defined horizon of green synthesis of CaONP for biomedical and ecological purposes.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/JNT2010004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44736544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

An Assessment of InP/ZnS as Potential Anti-Cancer Therapy: Quantum Dot Treatment Increases Apoptosis in HeLa Cells InP/ZnS作为潜在抗癌疗法的评估:量子点治疗增加HeLa细胞的凋亡

Journal of nanotheranostics Pub Date : 2021-01-20 DOI: 10.3390/JNT2010002

V. Davenport, Cullen Horstmann, Rishi B. Patel, Qi-Hui Wu, Kyoungtae Kim

{"title":"An Assessment of InP/ZnS as Potential Anti-Cancer Therapy: Quantum Dot Treatment Increases Apoptosis in HeLa Cells","authors":"V. Davenport, Cullen Horstmann, Rishi B. Patel, Qi-Hui Wu, Kyoungtae Kim","doi":"10.3390/JNT2010002","DOIUrl":"https://doi.org/10.3390/JNT2010002","url":null,"abstract":"InP/ZnS quantum dots (QDs) are an emerging option in QD technologies for uses of fluorescent imaging as well as targeted drug and anticancer therapies based on their customizable properties. In this study we explored effects of InP/ZnS when treated with HeLa cervical cancer cells. We employed XTT viability assays, reactive oxygen species (ROS) analysis, and apoptosis analysis to better understand cytotoxicity extents at different concentrations of InP/ZnS. In addition, we compared the transcriptome profile from the QD-treated HeLa cells with that of untreated HeLa cells to identify changes to the transcriptome in response to the QD. RT-qPCR assay was performed to confirm the findings of transcriptome analysis, and the QD mode of action was illustrated. Our study determined both IC50 concentration of 69 µg/mL and MIC concentration of 167 µg/mL of InP/ZnS. It was observed via XTT assay that cell viability was decreased significantly at the MIC. Production of superoxide, measured by ROS assay with flow cytometry, was decreased, whereas levels of nitrogen radicals increased. Using analysis of apoptosis, we found that induced cell death in the QD-treated samples was shown to be significantly increased when compared to untreated cells. We conclude InP/ZnS QD to decrease cell viability by inducing stress via ROS levels, apoptosis induction, and alteration of transcriptome.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/JNT2010002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49002095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Nanomaterial-Mediated Theranostics for Vascular Diseases 纳米材料介导的血管疾病治疗

Journal of nanotheranostics Pub Date : 2020-12-22 DOI: 10.3390/jnt2010001

S. Agrawal, S. Nooti, Harbinder Singh, Vikrant Rai

{"title":"Nanomaterial-Mediated Theranostics for Vascular Diseases","authors":"S. Agrawal, S. Nooti, Harbinder Singh, Vikrant Rai","doi":"10.3390/jnt2010001","DOIUrl":"https://doi.org/10.3390/jnt2010001","url":null,"abstract":"Nanotechnology could offer a new complementary strategy for the treatment of vascular diseases including coronary, carotid, or peripheral arterial disease due to narrowing or blockage of the artery caused by atherosclerosis. These arterial diseases manifest correspondingly as angina and myocardial infarction, stroke, and intermittent claudication of leg muscles during exercise. The pathogenesis of atherosclerosis involves biological events at the cellular and molecular level, thus targeting these using nanomaterials precisely and effectively could result in a better outcome. Nanotechnology can mitigate the pathological events by enhancing the therapeutic efficacy of the therapeutic agent by delivering it at the point of a lesion in a controlled and efficacious manner. Further, combining therapeutics with imaging will enhance the theranostic ability in atherosclerosis. Additionally, nanoparticles can provide a range of delivery systems for genes, proteins, cells, and drugs, which individually or in combination can address various problems within the arteries. Imaging studies combined with nanoparticles helps in evaluating the disease progression as well as the response to the treatment because imaging and diagnostic agents can be delivered precisely to the targeted destinations via nanocarriers. This review focuses on the use of nanotechnology in theranostics of coronary artery and peripheral arterial disease.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/jnt2010001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47351041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) via Multiple Imaging Modalities and Modifications to Reduce Cytotoxicity: An Educational Review 使用超顺磁性氧化铁纳米颗粒(SPIONs)通过多种成像方式和修改，以减少细胞毒性:教育综述

Journal of nanotheranostics Pub Date : 2020-12-09 DOI: 10.3390/jnt1010008

Nicholas R. Nelson, J. Port, M. Pandey

引用次数: 34