Journal of nanotheranostics最新文献

Paradoxical Roles of Carbon Nanotubes in Cancer Therapy and Carcinogenesis 碳纳米管在癌症治疗和致癌过程中的矛盾作用

Journal of nanotheranostics Pub Date : 2024-07-08 DOI: 10.3390/jnt5030006

Bohan Xu, Shunjie Wu, Yiyang Wang, Yuhe Ji, Shufeng Liang, Chunyan Wang, Xin Tian

{"title":"Paradoxical Roles of Carbon Nanotubes in Cancer Therapy and Carcinogenesis","authors":"Bohan Xu, Shunjie Wu, Yiyang Wang, Yuhe Ji, Shufeng Liang, Chunyan Wang, Xin Tian","doi":"10.3390/jnt5030006","DOIUrl":"https://doi.org/10.3390/jnt5030006","url":null,"abstract":"Carbon nanotubes (CNTs), members of the nanomaterial family, are increasingly being used in consumer products and extensively studied for various biomedical applications. Due to their benign elemental composition, large surface area, and chemical and biological activities, CNTs demonstrate great potential in cancer therapy, including drug delivery, imaging analysis, photothermal therapy, photodynamic therapy, and radiotherapy. However, there is still a major knowledge gap when it comes to transitioning from research to clinical applications. One of the important issues is that the biological toxicity of CNTs, especially in terms of carcinogenesis, and the underlying mechanisms are not fully understood. Therefore, a thorough evaluation of toxicity and the underlying mechanisms of carcinogenesis is essential to enable the wide application of CNTs. In this review, we summarize the recent progress of CNTs as multifunctional therapeutics in cancer therapy. Furthermore, a detailed discussion is provided on the carcinogenesis and potential mechanisms of CNTs. Finally, the review ends with further challenges and prospects for CNTs with the expectation of facilitating their broader utilization.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene Oxide Chemical Refining Screening to Improve Blood Compatibility of Graphene-Based Nanomaterials 通过氧化石墨烯化学提纯筛选改善石墨烯基纳米材料的血液相容性

Journal of nanotheranostics Pub Date : 2024-02-20 DOI: 10.3390/jnt5010002

Fabio Pieretti, Alessandro Moretto, Emanuele Papini, R. Tavano

引用次数: 0

The Role of Fullerenes in Neurodegenerative Disorders 富勒烯在神经退行性疾病中的作用

Journal of nanotheranostics Pub Date : 2024-01-16 DOI: 10.3390/jnt5010001

Daisy L. Wilson, J. Ahlawat, Mahesh Narayan

引用次数: 0

Efficacy of 15 nm Gold Nanoparticles for Image-Guided Gliosarcoma Radiotherapy 15纳米金纳米颗粒在图像引导胶质肉瘤放疗中的疗效

Journal of nanotheranostics Pub Date : 2023-10-26 DOI: 10.3390/jnt4040021

Elette Engels, Michael Lerch, Stéphanie Corde, Moeava Tehei

{"title":"Efficacy of 15 nm Gold Nanoparticles for Image-Guided Gliosarcoma Radiotherapy","authors":"Elette Engels, Michael Lerch, Stéphanie Corde, Moeava Tehei","doi":"10.3390/jnt4040021","DOIUrl":"https://doi.org/10.3390/jnt4040021","url":null,"abstract":"Targeted brain cancer treatments are sorely needed to improve long-term prognosis, particularly for gliosarcoma and glioblastoma patients. Gold nanoparticles (GNPs) have unique properties including high atomic number, biocompatibility, and small size for cancer cell internalization. GNPs are consequently an ideal candidate for improved cancer targeting using image-guided radiotherapy. This work investigated 15 nm AuroVistTM GNPs for image-guided gliosarcoma radiotherapy and identified optimum GNP concentrations. The GNPs were found to be 15–20 nm using optical surface plasmon resonance absorption, with a (41.3 ± 0.3) nm hydrodynamic diameter. Confocal imaging showed that 50–500 µg/mL of the GNPs was well-internalized into the 9L cells within 24–48 h. γ-H2AX assays showed that 50–500 µg/mL of the GNPs radiosensitized the 9L cells irradiated with 125 and 150 kVp X-rays. However, only 500 µg/mL of the GNPs produced significant long-term dose enhancement with 150 kVp X-rays (with a sensitization enhancement ratio at 10% survival of 1.43, and 1.13 with 50 µg/mL) using clonogenic assay. CT imaging of the GNPs in the 9L tumors in Fischer rats further showed that GNP concentrations above 500 µg/mL were required to distinguish the tumor from the brain, and the GNPs were detected 48 h after injection. These promising results indicate that the GNPs can be used for selective gliosarcoma treatment with image-guided X-ray radiotherapy at concentrations above 500 µg/mL.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery 增强抗体在中枢神经系统中的暴露:摄取、清除的机制，以及改善大脑递送的策略

Journal of nanotheranostics Pub Date : 2023-10-02 DOI: 10.3390/jnt4040020

Kelly Schwinghamer, Teruna J. Siahaan

{"title":"Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery","authors":"Kelly Schwinghamer, Teruna J. Siahaan","doi":"10.3390/jnt4040020","DOIUrl":"https://doi.org/10.3390/jnt4040020","url":null,"abstract":"Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs can be generated to have high affinity and specificity to target molecules in the CNS. Unfortunately, only a very small number of mAbs have been specifically developed and approved for neurological indications. This is primarily attributed to their low exposure within the CNS, hindering their ability to reach and effectively engage their potential targets in the brain. This review discusses aspects of various barriers such as the blood–brain barrier (BBB) and blood–cerebrospinal fluid (CSF) barrier (BCSFB) that regulate the entry and clearance of mAbs into and from the brain. The roles of the glymphatic system on brain exposure and clearance are being described. We also discuss the proposed mechanisms of the uptake of mAbs into the brain and for clearance. Finally, several methods of enhancing the exposure of mAbs in the CNS were discussed, including receptor-mediated transcytosis, osmotic BBB opening, focused ultrasound (FUS), BBB-modulating peptides, and enhancement of mAb brain retention.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135829383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Combating Bacterial Infections by Using Hybrid Nano-Systems 利用混合纳米系统对抗细菌感染的最新进展

Journal of nanotheranostics Pub Date : 2023-09-08 DOI: 10.3390/jnt4030019

Unnati Patel, Emily C. Hunt

引用次数: 2

Aptamers as Theranostics in Cardiovascular Diseases 适体作为心血管疾病的Theranos

Journal of nanotheranostics Pub Date : 2023-09-06 DOI: 10.3390/jnt4030018

Manish Ramchandani, Priyanka Kumari, Amit Goyal

引用次数: 0

Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers 纳米技术：乳腺癌和前列腺癌靶向的平台、当前应用和机制

Journal of nanotheranostics Pub Date : 2023-08-10 DOI: 10.3390/jnt4030016

P. Akpa, I. E. Peter, A. M. Onwuka, B. Obi, M. Akunne, C. Nworu, P. Ejikeme, T. Akunne, A. Attama, P. Akah

{"title":"Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers","authors":"P. Akpa, I. E. Peter, A. M. Onwuka, B. Obi, M. Akunne, C. Nworu, P. Ejikeme, T. Akunne, A. Attama, P. Akah","doi":"10.3390/jnt4030016","DOIUrl":"https://doi.org/10.3390/jnt4030016","url":null,"abstract":"Globally, cancer is one of the deadliest diseases, needing a meticulous diagnosis and targeted treatment plan to achieve an initial prognosis, followed by precision and optimization in treatment. Nonselective targeting, difficulty in accurately monitoring treatment end-results, serious drug side-effects, and severity of disease resulting in metastasis are the key flaws of traditional techniques. Nanotechnology and nanoparticles possess special features to completely transform the field of diagnosis and treatment of cancer. A holistic strategy that employs a dual function of diagnosis and therapy while utilizing a nanocarrier is referred to as a nanotheranostic. The nanotheranostic framework was created to surmount a variety of biological and physiological obstacles, effectively delivering the cargo to the intended target location, while simultaneously facilitating therapeutic intervention, surveillance, and validation to demonstrate improved treatment effectiveness. As a result, a nanotheranostic platform can be useful for targeted drug delivery, release, and distribution assessment, in addition to patient classification and survival. Nanotheranostic techniques also lead to reduced drug side-effects compared with conventional therapies. In this review, we outline current studies on nanotheranostics and their advantages over conventional treatment strategies, the applications and challenges/limitations of nanotheranostics, and the mechanisms of targeting in breast and prostate cancers.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45255188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications 智能铂纳米结构：从合成到高级Theranos应用的历程

Journal of nanotheranostics Pub Date : 2023-08-10 DOI: 10.3390/jnt4030017

Akash Kumar, Nabojit Das, R. Rayavarapu

{"title":"Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications","authors":"Akash Kumar, Nabojit Das, R. Rayavarapu","doi":"10.3390/jnt4030017","DOIUrl":"https://doi.org/10.3390/jnt4030017","url":null,"abstract":"A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures are advancing in a plethora of clinical applications as theranostics tools owing to their unique behavior concerning their size, shape, and surface chemistry at the nanoscale regime. Platinum nanostructures are optically active and provide significant potential to the field of theranostics by simplifying diagnosis and therapeutics, thus providing key solutions through nano-enabled technologies. The review emphasizes the potential of platinum nanostructures that have immense potential in vitro and in vivo scenarios as nanocarriers. Still, their potential in terms of photothermal active agents has not been well explored or reported. Nanotheranostics has emerged as a platform where various noble metal nanoparticles are effectively efficient as photothermal agents in bringing precision to therapy and diagnostics. Platinum, as an antioxidant and a stable nanocarrier, will enable them to act as photosensitizers when conjugated to affinity molecules and plays a key role in efficient treatment and diagnosis. The review envisions bringing together the possibilities of the safe-by-design synthesis of platinum nanostructures and their potential role in both in vitro and in vivo applications. A roadmap describing the challenges, pitfalls, and possibilities of influencing platinum nanostructures to overcome the existing biological/targeting barriers is elaborated. This review provides a literature survey on platinum nanostructures in theranostics, providing novel strategies in bio-imaging, diagnostics, and nanomedicine.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44376319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Nanotherapeutic Drug Delivery Options for the Management of Glioblastoma 胶质母细胞瘤管理的纳米治疗药物递送选择综述

Journal of nanotheranostics Pub Date : 2023-08-01 DOI: 10.3390/jnt4030015

W. H. Pentz, Vincenzo J. Pizzuti, Matthew E. Halbert, Tritan J. Plute, P. Lockman, S. Sprowls

{"title":"An Overview of Nanotherapeutic Drug Delivery Options for the Management of Glioblastoma","authors":"W. H. Pentz, Vincenzo J. Pizzuti, Matthew E. Halbert, Tritan J. Plute, P. Lockman, S. Sprowls","doi":"10.3390/jnt4030015","DOIUrl":"https://doi.org/10.3390/jnt4030015","url":null,"abstract":"Glioblastoma is the most common primary, malignant brain tumor that remains uniformly lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance, and recurrence. A major hurdle in therapeutic delivery to brain tumors is the blood–brain barrier (BBB), which is the tightly regulated vascular barrier between the brain parenchyma and systemic circulation that prevents distribution of otherwise beneficial chemotherapeutics to central nervous system tumors. To overcome the obstacle of drug delivery beyond the BBB, nanoparticle formulations have come to the forefront, having demonstrated success in preclinical observations, but have not translated well into the clinical setting. In summary, this review article discusses brain tumors and challenges for drug delivery caused by the BBB, explores the benefits of nanoparticle formulations for brain tumor delivery, describes the characteristics these formulations possess that make them attractive therapeutic strategies, and provides preclinical examples that implement nanoparticles within glioma treatment regimens. Additionally, we explore the pitfalls associated with clinical translation and conclude with remarks geared toward overcoming these issues.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44129897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0