Journal of nanotheranostics最新文献_第4页

Recent Advances in Gold Nanomaterials for Photothermal Therapy 光热治疗用金纳米材料的研究进展

Journal of nanotheranostics Pub Date : 2022-06-01 DOI: 10.3390/jnt3020008

Y. Chuang, Hsin-Lun Lee, J. Chiou, L. Lo

{"title":"Recent Advances in Gold Nanomaterials for Photothermal Therapy","authors":"Y. Chuang, Hsin-Lun Lee, J. Chiou, L. Lo","doi":"10.3390/jnt3020008","DOIUrl":"https://doi.org/10.3390/jnt3020008","url":null,"abstract":"Gold nanoparticle (AuNPs)-mediated photothermal therapy (PTT) has attracted increasing attention both in laboratory research and clinical applications. Due to its easily-tuned properties of irradiation light and inside-out hyperthermia ability, it has demonstrated clear advantages in cancer therapy over conventional thermal ablation. Despite this great advancement, the therapeutic efficacy of AuNPs mediated PTT in tumor treatment remains compromised by several obstacles, including low photothermal conversion efficiency, tissue penetration limitation of excitation light, and inherent non-specificity. In view of the rapid development of AuNPs mediated PTT, we present an in-depth review of major breakthroughs in the advanced development of gold nanomaterials for PTT, with emphasis on those from 2010 to date. In particular, the current state of knowledge for AuNPs based photothermal agents within a paradigm of key structure-optical property relationships is presented in order to provide guidance for the design of novel AuNP based photothermal agents to meet necessary functional requirements in specific applications. Furthermore, potential challenges and future development of AuNP mediated PTT are also elucidated for clinical translation. It is expected that AuNP mediated PTT will soon constitute a markedly promising avenue in the treatment of cancer.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46154007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Simultaneous Thermal and Spectroscopic Screening of Morphologically Complex Theranostic Gold Nanoparticles 形貌复杂Theranostic金纳米粒子的同时热筛选和光谱筛选

Journal of nanotheranostics Pub Date : 2022-05-26 DOI: 10.3390/jnt3020007

S. Chavva, Namratha Bhat, A. M. T. San Juan, Siddhant Jaitpal, S. Mabbott

{"title":"Simultaneous Thermal and Spectroscopic Screening of Morphologically Complex Theranostic Gold Nanoparticles","authors":"S. Chavva, Namratha Bhat, A. M. T. San Juan, Siddhant Jaitpal, S. Mabbott","doi":"10.3390/jnt3020007","DOIUrl":"https://doi.org/10.3390/jnt3020007","url":null,"abstract":"Gold nanoparticles absorb light energy and convert it to thermal energy that transfers to the surrounding environment, making them potentially useful for the hyperthermic treatments well known as photothermal therapy (PTT). Further, it is well documented that noble metal nanoparticles are capable of significantly enhancing the Raman scattering of molecules attached to their surfaces, a technique which is termed surface-enhanced Raman scattering (SERS). SERS combined with PTT has the ability to locate nanoparticles at depth and trigger heat production, providing an effective methodology to both seek and destroy diseased tissues. While PTT and SERS are often used in tandem and there are several ways of individually measuring SERS and thermal output, there is currently no method available that pre-screens both properties prior to in vitro or in vivo application. In this work, we have designed a 3D printed platform capable of coupling a commercially available Raman probe to a sample cuvette for SERS and heat output to be monitored simultaneously. We have compared the performance of morphologically complex gold nanoparticles, nanostars (AuNSs) and nanoplates (AuNPLs), which are both well utilized in SERS and photothermal experiments; and measured the SERS activity originating from common Raman reporter analytes 4-mercaptobenzoic acid (MBA) and 1,4-benzenedithiol (BDT). We were able to show that the system effectively measures the thermal output and SERS activity of the particles and can evaluate the effect that multiple irradiation cycles have on the SERS signal.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48728931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipid Nanoparticles as Platforms for Theranostic Purposes: Recent Advances in the Field 脂质纳米颗粒作为治疗目的的平台:该领域的最新进展

Journal of nanotheranostics Pub Date : 2022-05-05 DOI: 10.3390/jnt3020006

N. Naziris, C. Demetzos

{"title":"Lipid Nanoparticles as Platforms for Theranostic Purposes: Recent Advances in the Field","authors":"N. Naziris, C. Demetzos","doi":"10.3390/jnt3020006","DOIUrl":"https://doi.org/10.3390/jnt3020006","url":null,"abstract":"Lipid nanoparticles (LNPs) are the first approved nanomedicines and the most well-studied class of nanocarriers for drug delivery. Currently, they are in the frontline of the pandemic fight as vaccine formulations and therapeutic products. However, even though they are so well-studied, new materials and new modifications arise every day that can improve their properties. Their dynamic nature, especially the liquid crystal state of membranes, is under constant investigation and it is that which many times leads to their complex biological behavior. In addition, newly discovered biomaterials and nanoparticles that possess promising effects and functionalities, but also toxicity and/or poor pharmacokinetics, can be combined with LNPs to ameliorate their properties. As a result, many promising theranostic applications have emerged during the past decade, proving the huge potential of LNPs in the field. In the present review, we summarize some of the most prominent classes of LNPs for nanotheranostic purposes, and present state-of-the-art research examples, with emphasis on the utilized biomaterials and the functionality that they confer to the resultant supramolecular nanosystems, in relation to diagnostic and therapeutic modalities. Although there has been unprecedented progress in theranostics, the translational gap between the bench and the clinic is undeniable. This issue must be addressed by experts in a coordinated way, in order to fully exploit these nanomedicines for the benefit of the society.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44902275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Exosomes for Regulation of Immune Responses and Immunotherapy 调节免疫反应和免疫治疗的外泌体

Journal of nanotheranostics Pub Date : 2022-03-16 DOI: 10.3390/jnt3010005

Md Walid Akram Hussain, Sarah Jahangir, Bikona Ghosh, F. Yesmin, Afnan Anis, Sabikun Nahar Satil, Faizan Anwar, M. Rashid

引用次数: 11

Implantable Devices for the Treatment of Breast Cancer. 用于治疗乳腺癌的植入式装置。

Journal of nanotheranostics Pub Date : 2022-03-01 DOI: 10.3390/jnt3010003

Mohammad Mohtasim Hamid Pial, Asahi Tomitaka, Nezih Pala, Upal Roy

引用次数: 1

In Silico, Combined Plasmonic Photothermal and Photodynamic Therapy in Mice 等离子体光热和光动力联合治疗小鼠的实验研究

Journal of nanotheranostics Pub Date : 2022-02-28 DOI: 10.3390/jnt3010004

G. Kareliotis, Eleni Chronopoulou, M. Makropoulou

{"title":"In Silico, Combined Plasmonic Photothermal and Photodynamic Therapy in Mice","authors":"G. Kareliotis, Eleni Chronopoulou, M. Makropoulou","doi":"10.3390/jnt3010004","DOIUrl":"https://doi.org/10.3390/jnt3010004","url":null,"abstract":"Plasmonic photothermal and photodynamic therapy (PPTT and PDT, respectively) are two cancer treatments that have the potential to be combined in a synergistic scheme. The aim of this study is to optimize the PPTT treatment part, in order to account for the PDT lack of coverage in the hypoxic tumor volume and in cancer areas laying in deep sites. For the needs of this study, a mouse was modeled, subjected to PDT and its necrotic area was estimated by using the MATLAB software. The same procedure was repeated for PPTT, using COMSOL Multiphysics. PPTT treatment parameters, namely laser power and irradiation time, were optimized in order to achieve the optimum therapeutic effect of the combined scheme. The PDT alone resulted in 54.8% tumor necrosis, covering the upper cancer layers. When the PPTT was also applied, the total necrosis percentage raised up to 99.3%, while all of the surrounding studied organs (skin, heart, lungs and trachea, ribs, liver and spleen) were spared. The optimized values of the PPTT parameters were 550 mW of laser power and 70 s of irradiation time. Hence, the PPTT–PDT combination shows great potential in achieving high levels of tumor necrosis while sparing the healthy tissues.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45232295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Acknowledgment to the Reviewers of the Journal of Nanotheranostics in 2021 感谢《纳米肿瘤学杂志》2021年审稿人

Journal of nanotheranostics Pub Date : 2022-02-02 DOI: 10.3390/jnt3010002

引用次数: 0

Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations 混合纳米粒子作为治疗胶质母细胞瘤的Theranos平台：光治疗和X射线相位对比断层扫描研究

Journal of nanotheranostics Pub Date : 2022-01-20 DOI: 10.3390/jnt3010001

Loredana Ricciardi, S. Chatterjee, G. Palermo, Elisabeta I. Szerb, A. Sanna, F. Palermo, N. Pieroni, M. Fratini, R. Bartolino, A. Cedola, Massimo La Deda, G. Strangi

引用次数: 0

The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury 纳米技术研究人员使用创伤性脑损伤动物模型指南

Journal of nanotheranostics Pub Date : 2021-12-01 DOI: 10.3390/jnt2040014

Brandon Z. McDonald, Connor C. Gee, Forrest M. Kievit

{"title":"The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury","authors":"Brandon Z. McDonald, Connor C. Gee, Forrest M. Kievit","doi":"10.3390/jnt2040014","DOIUrl":"https://doi.org/10.3390/jnt2040014","url":null,"abstract":"Traumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually. Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanism and frequency of injury. Previous literature has investigated this relationship through the development of animal models and behavioral tasks. However, recent advancements in these methods may provide insight into the translation of therapeutics into a clinical setting. In this review, we characterize various animal models and behavioral tasks to provide guidelines for evaluating the therapeutic efficacy of treatment options in TBI. We provide a brief review into the systems utilized in TBI classification and provide comparisons to the animal models that have been developed. In addition, we discuss the role of behavioral tasks in evaluating outcomes associated with TBI. Our goal is to provide those in the nanotheranostic field a guide for selecting an adequate TBI animal model and behavioral task for assessment of outcomes to increase research in this field.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47469353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prospects of Extracellular Vesicles in Otorhinolaryngology, Head and Neck Surgery 细胞外囊泡在耳鼻咽喉头颈外科的应用前景

Journal of nanotheranostics Pub Date : 2021-11-28 DOI: 10.3390/jnt2040013

Metka Sluga, S. Battelino, Domen Vozel

{"title":"Prospects of Extracellular Vesicles in Otorhinolaryngology, Head and Neck Surgery","authors":"Metka Sluga, S. Battelino, Domen Vozel","doi":"10.3390/jnt2040013","DOIUrl":"https://doi.org/10.3390/jnt2040013","url":null,"abstract":"The diagnostic and therapeutic potential of extracellular vesicles (EVs) has been recognised in many fields of medicine for several years. More recently, it has become a topic of increasing interest in otorhinolaryngology, head and neck surgery (ORL-HNS). With this narrative review, we have aspired to determine different aspects of those nanometrically sized theranostic particles, which seem to have promising potential as biomarkers in some of the most common diseases of the ORL-HNS by being available via less invasive diagnostic methods. At the same time, a better understanding of their activity provides us with new possibilities for developing specific target treatments. So far, most research has been oriented towards the role of EVs in the progression of head and neck cancer, notably head and neck squamous cell cancer. Nonetheless, some of this research has focused on chronic diseases of the ears, nose and paranasal sinuses. However, most research is still in the preclinical or experimental phase. It therefore requires a further and more profound understanding of EV content and behaviour to utilise their nanotheranostic capacities to their fullest potential.","PeriodicalId":73846,"journal":{"name":"Journal of nanotheranostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42649976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0