Journal of molecular psychiatry最新文献_第4页

Mass spectrometry for the detection of potential psychiatric biomarkers. 质谱法检测潜在的精神病学生物标志物。

Journal of molecular psychiatry Pub Date : 2013-06-05 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-8

Armand G Ngounou Wetie, Izabela Sokolowska, Kelly Wormwood, Katherine Beglinger, Tanja Maria Michel, Johannes Thome, Costel C Darie, Alisa G Woods

{"title":"Mass spectrometry for the detection of potential psychiatric biomarkers.","authors":"Armand G Ngounou Wetie, Izabela Sokolowska, Kelly Wormwood, Katherine Beglinger, Tanja Maria Michel, Johannes Thome, Costel C Darie, Alisa G Woods","doi":"10.1186/2049-9256-1-8","DOIUrl":"https://doi.org/10.1186/2049-9256-1-8","url":null,"abstract":"The search for molecules that can act as potential biomarkers is increasing in the scientific community, including in the field of psychiatry. The field of proteomics is evolving and its indispensability for identifying biomarkers is clear. Among proteomic tools, mass spectrometry is the core technique for qualitative and quantitative identification of protein markers. While significant progress has been made in the understanding of biomarkers for neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis and Parkinson's disease, psychiatric disorders have not been as extensively investigated. Recent and successful applications of mass spectrometry-based proteomics in fields such as cardiovascular disease, cancer, infectious diseases and neurodegenerative disorders suggest a similar path for psychiatric disorders. In this brief review, we describe mass spectrometry and its use in psychiatric biomarker research and highlight some of the possible challenges of undertaking this type of work. Further, specific examples of candidate biomarkers are highlighted. A short comparison of proteomic with genomic methods for biomarker discovery research is presented. In summary, mass spectrometry-based techniques may greatly facilitate ongoing efforts to understand molecular mechanisms of psychiatric disorders. ","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":"1 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2013-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32823864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Circadian and behavioural responses to shift work-like schedules of light/dark in the mouse. 小鼠的昼夜节律和行为对轮班工作的反应，如光/暗时间表。

Journal of molecular psychiatry Pub Date : 2013-05-29 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-7

Niall M McGowan, Andrew N Coogan

{"title":"Circadian and behavioural responses to shift work-like schedules of light/dark in the mouse.","authors":"Niall M McGowan, Andrew N Coogan","doi":"10.1186/2049-9256-1-7","DOIUrl":"https://doi.org/10.1186/2049-9256-1-7","url":null,"abstract":"Background: Disruption of circadian rhythms is associated with several deleterious health consequences and cognitive impairment. It is estimated that as many as one in five workers are exposed to this risk factor due to experiencing some degree of chronodisruption by way of recurring patterns of shift work. It is not presently clear therefore how efficiently the mammalian circadian system entrains to alternative light/dark cycles such as those found in shift work schedules.Methods: The present study examines male CD-1 mice exposed to three different paradigms of rapidly rotating shift work-like light/dark manipulations compared to control animals maintained on a standard 12:12 h light/dark cycle.Results: Analysis of circadian patterns of behaviour under such conditions reveals that for fast rotating schedules of light/dark there is minimal circadian entrainment. Further, when placed in constant conditions after a period under the \"shift work\" lighting conditions there were changes to circadian period associated with the shift work schedules. In contrast to previous studies the shift work-like conditions did not produce changes in animal body-weight. Behavioural testing suggests possible anxiogenic and hyperactive outcomes dependent on rotation speed as animals displayed open field thigmotaxis and hyperlocomotion.Conclusion: These results indicate that exposure to alternating patterns of light and dark as experienced by millions of shift workers may produce long-lasting changes in both mammalian circadian and neurobehavioural systems.","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":"1 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2013-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32825425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Mass spectrometry as a tool for studying autism spectrum disorder. 质谱法作为研究自闭症谱系障碍的工具。

Journal of molecular psychiatry Pub Date : 2013-05-21 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-6

Alisa G Woods, Armand G Ngounou Wetie, Izabela Sokolowska, Stefanie Russell, Jeanne P Ryan, Tanja Maria Michel, Johannes Thome, Costel C Darie

{"title":"Mass spectrometry as a tool for studying autism spectrum disorder.","authors":"Alisa G Woods, Armand G Ngounou Wetie, Izabela Sokolowska, Stefanie Russell, Jeanne P Ryan, Tanja Maria Michel, Johannes Thome, Costel C Darie","doi":"10.1186/2049-9256-1-6","DOIUrl":"https://doi.org/10.1186/2049-9256-1-6","url":null,"abstract":"Autism spectrum disorders (ASDs) are increasing in incidence but have an incompletely understood etiology. Tools for uncovering clues to the cause of ASDs and means for diagnoses are valuable to the field. Mass Spectrometry (MS) has been a useful method for evaluating differences between individuals with ASDs versus matched controls. Different biological substances can be evaluated using MS, including urine, blood, saliva, and hair. This technique has been used to evaluate relatively unsupported hypotheses based on introduction of exogenous factors, such as opiate and heavy metal excretion theories of ASDs. MS has also been used to support disturbances in serotonin-related molecules, which have been more consistently observed in ASDs. Serotonergic system markers, markers for oxidative stress, cholesterol system disturbances, peptide hypo-phosphorylation and methylation have been measured using MS in ASDs, although further analyses with larger numbers of subjects are needed (as well as consideration of behavioral data). Refinements in MS and data analysis are ongoing, allowing for the possibility that future studies examining body fluids and specimens from ASD subjects could continue to yield novel insights. This review summarizes MS investigations that have been conducted to study ASD to date and provides insight into future promising applications for this technique, with focus on proteomic studies. ","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":"1 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2013-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32825424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Methylphenidate enhances neural stem cell differentiation. 哌甲酯促进神经干细胞分化。

Journal of molecular psychiatry Pub Date : 2013-04-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-5

Jasmin Bartl, Takatoshi Mori, Peter Riederer, Hiroki Ozawa, Edna Grünblatt

引用次数: 12

NRXN1 deletions identified by array comparative genome hybridisation in a clinical case series - further understanding of the relevance of NRXN1 to neurodevelopmental disorders. 通过阵列比较基因组杂交在临床病例系列中鉴定出NRXN1缺失-进一步了解NRXN1与神经发育障碍的相关性

Journal of molecular psychiatry Pub Date : 2013-04-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-4

Sarah Curran, Joo Wook Ahn, Hannah Grayton, David A Collier, Caroline Mackie Ogilvie

{"title":"NRXN1 deletions identified by array comparative genome hybridisation in a clinical case series - further understanding of the relevance of NRXN1 to neurodevelopmental disorders.","authors":"Sarah Curran, Joo Wook Ahn, Hannah Grayton, David A Collier, Caroline Mackie Ogilvie","doi":"10.1186/2049-9256-1-4","DOIUrl":"https://doi.org/10.1186/2049-9256-1-4","url":null,"abstract":"Background: Microdeletions in the NRXN1 gene have been associated with a range of neurodevelopmental disorders, including autism spectrum disorders, schizophrenia, intellectual disability, speech and language delay, epilepsy and hypotonia.Results: In the present study we performed array CGH analysis on 10,397 individuals referred for diagnostic cytogenetic analysis, using a custom oligonucleotide array, which included 215 NRXN1 probes (median spacing 4.9 kb). We found 34 NRXN1 deletions (0.33% of referrals) ranging from 9 to 942 kb in size, of which 18 were exonic (0.17%). Three deletions affected exons also in the beta isoform of NRXN1. No duplications were found. Patients had a range of phenotypes including developmental delay, learning difficulties, attention deficit hyperactivity disorder (ADHD), autism, speech delay, social communication difficulties, epilepsy, behaviour problems and microcephaly. Five patients who had deletions in NRXN1 had a second CNV implicated in neurodevelopmental disorder: a CNTNAP2 and CSMD3 deletion in patients with exonic NRXN1 deletions, and a Williams-Beuren syndrome deletion and two 22q11.2 duplications in patients with intronic NRXN1 deletions.Conclusions: Exonic deletions in the NRXN1 gene, predominantly affecting the alpha isoform, were found in patients with a range of neurodevelopmental disorders referred for diagnostic cytogenetic analysis. The targeting of dense oligonucleotide probes to the NRXN1 locus on array comparative hybridisation platforms provides detailed characterisation of deletions in this gene, and is likely to add to understanding of the importance of NRXN1 in neural development.","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":"1 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32825422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

The origins of molecular psychiatry. 分子精神病学的起源。

Journal of molecular psychiatry Pub Date : 2013-04-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-3

Eric J Nestler

引用次数: 11

The neurobiology of suicide - A Review of post-mortem studies. 自杀的神经生物学——死后研究综述。

Journal of molecular psychiatry Pub Date : 2013-04-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-2

Karolina Furczyk, Barbora Schutová, Tanja M Michel, Johannes Thome, Andreas Büttner

引用次数: 39

Journal of molecular psychiatry. 分子精神病学杂志。

Journal of molecular psychiatry Pub Date : 2013-04-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-1

Johannes Thome

引用次数: 20