Journal of molecular psychiatry最新文献_第3页

Astrocytes reassessment - an evolving concept part one: embryology, biology, morphology and reactivity. 星形胶质细胞的重新评估-一个不断发展的概念第一部分:胚胎学，生物学，形态学和反应性。

Journal of molecular psychiatry Pub Date : 2013-10-24 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-18

Alina Simona Şovrea, Adina Bianca Boşca

引用次数: 17

The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder. 伏隔核:抵抗性重度抑郁症深部脑刺激的目标。

Journal of molecular psychiatry Pub Date : 2013-10-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-17

Cecilia Nauczyciel, Suzanne Robic, Thibaut Dondaine, Marc Verin, Gabriel Robert, Dominique Drapier, Florian Naudet, Bruno Millet

{"title":"The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder.","authors":"Cecilia Nauczyciel, Suzanne Robic, Thibaut Dondaine, Marc Verin, Gabriel Robert, Dominique Drapier, Florian Naudet, Bruno Millet","doi":"10.1186/2049-9256-1-17","DOIUrl":"https://doi.org/10.1186/2049-9256-1-17","url":null,"abstract":"Objective: This review aimed to investigate the therapeutic potential of Deep Brain Stimulation (DBS) for treating resistant Major Depressive Disorder (MDD). We explored the role of Nucleus accumbens (Nac) as a target for treatment.Method: We made a systematic review of all studies examining the mechanisms of action of high frequency brain stimulation and the pathophysiology of MDD. We also reported all the studies exploring the therapeutic potential of DBS in MDD.Results: As a central relay-structure, the Nac seems to play a central role in MDD symptomatology. We investigated its role as a primary target for DBS in depressed patients. Anatomically the Nac is at the centre of the interactions between dopaminergic, serotoninergic and glutamatergic systems. Functionally, the Nac is involved in both normal and abnormal reward processes and in anhedonia and loss of motivation. Due to its central location between the emotional system, the cognitive system and motor control system, the Nac seems to have a central role in mood and feeling regulation.Conclusion: According to encouraging recent studies, DBS seems to be a promising technique in resistant MDD treatment.","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33220529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Matrix metalloproteinases in autism spectrum disorders. 自闭症谱系障碍中的基质金属蛋白酶。

Journal of molecular psychiatry Pub Date : 2013-09-17 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-16

Morsi W Abdallah, Tanja M Michel

{"title":"Matrix metalloproteinases in autism spectrum disorders.","authors":"Morsi W Abdallah, Tanja M Michel","doi":"10.1186/2049-9256-1-16","DOIUrl":"https://doi.org/10.1186/2049-9256-1-16","url":null,"abstract":"Autism Spectrum Disorders (ASD) are group of developmental disabilities with a complex neurobiological basis including putative changes in the immune system. They are characterized by pervasive qualitative abnormalities in social interactions, communication, and stereotyped behaviour. Matrix metalloproteinases (MMPs) represent a group of proteases which play an important role in neuroinflammation and neurodevelopment. Therefore, they possibly have a crucial function in the etiopathology of ASD. In this review, we summarize the plausibility of the hypothesis that MMPs are involved in the neuropathology of ASD. Possible pathways through which MMPs can contribute to the pathogenesis of ASD are discussed including neuroinflammatory mechanisms inclusive of mediating neuropathological effects of infections, the associations between MMPs and other biomarkers such as cytokines, chemokines and neurotrophic factors. Despite sufficient evidence for such an involvement of MMPs in the neuropathology of ASD, they have not yet been extensively studied in this context. Thus, further research in this field is not only urgently needed but also very promising and may also lead to new therapeutic approaches. ","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32824272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure. mGluR2/3阻断可快速、持久地逆转慢性应激暴露引起的快感缺乏。

Journal of molecular psychiatry Pub Date : 2013-09-17 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-15

Jason M Dwyer, Ashley E Lepack, Ronald S Duman

{"title":"mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure.","authors":"Jason M Dwyer, Ashley E Lepack, Ronald S Duman","doi":"10.1186/2049-9256-1-15","DOIUrl":"https://doi.org/10.1186/2049-9256-1-15","url":null,"abstract":"Background: Depression is a prevalent neuropsychiatric disorder that affects an estimated 350 million people worldwide. Currently available treatments for depression are lacking in both speed of onset and efficacy. Recent pharmacological efforts have targeted the glutamatergic neurotransmitter system using the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine to produce rapid and robust antidepressant effects, however the widespread clinical use of ketamine is limited due to side effects and abuse liability. More recently, work evaluating metabotropic mGluR2/3 receptor antagonists has demonstrated many similarities with ketamine.Methods: Male, Sprague-Dawley rats were exposed to a chronic unpredictable stress paradigm, which produces decreased sucrose preference, a measure of anhedonia. Rats were then treated with vehicle or a single injection of the mGluR2/3 antagonist LY341495 (3 mg/kg, i.p.) and tested at 24 hrs, 48 hrs or 10 days after a single treatment.Results: We demonstrate that a single treatment with LY341495 produces a rapid (within 1-2 days) and long-lasting (10 days) reversal of anhedonia caused by chronic unpredictable stress in rats. This model provides a rigorous test of rapid-acting agents as typical antidepressants require several weeks of treatment to produce a response.Conclusions: These data suggest that LY341495 has the ability to produce rapid and robust antidepressant effects similar to ketamine. Together, the results highlight the potential for similar compounds to produce rapid and lasting efficacy for the treatment of depression.","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32823871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 71

Elevated oleic acid serum concentrations in patients suffering from alcohol dependence. 酒精依赖患者血清油酸浓度升高

Journal of molecular psychiatry Pub Date : 2013-08-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-13

Annekatrin Teubert, Johannes Thome, Andreas Büttner, Jörg Richter, Gisela Irmisch

{"title":"Elevated oleic acid serum concentrations in patients suffering from alcohol dependence.","authors":"Annekatrin Teubert, Johannes Thome, Andreas Büttner, Jörg Richter, Gisela Irmisch","doi":"10.1186/2049-9256-1-13","DOIUrl":"https://doi.org/10.1186/2049-9256-1-13","url":null,"abstract":"Background: Alcohol-induced damages such as brain atrophy and fatty liver are closely related to a disturbed lipid metabolism. In animal models, a linkage between chronic alcohol consumption and changes in fatty acid (FA) composition in various organs and cells is well known and there is some indication that this phenomenon could be linked to behavioural alterations associated with alcohol addiction such as craving. However, the influence of ethanol on secretory FA has not been investigated so far. In this study, we therefore aimed at investigating whether there is a significant change of serum FA composition in patients suffering from alcohol dependence. We compared patients before and after treatment (detoxication) with control individuals who did not suffer from addiction. The roles of age, the duration and intensity of alcohol use and lifestyles were considered.Methods: Serum FA was measured in 73 male ethanol dependent patients before and after alcohol withdrawal in an in-patient setting. Additionally, of this group, 45 patients were matched with 45 healthy male volunteers as controls.Results: We found significant differences in the FA composition before and after detoxication as well as between patients and controls. After detoxication, the values changed towards the ones in healthy controls. The main finding during acute alcohol use was an increased oleic acid concentration above the level of the linoleic acid concentration.Conclusions: An elevated oleic/linoleic acid ratio seems to be a state marker for acute alcohol use and may be a relevant trait marker during detoxification and possibly the subsequent therapeutic measures. The results of this pilot study need to be replicated in a larger study also including female patients. Further, the specificity of this potential biomarker needs to be determined.","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32823869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Post-stroke depression and the aging brain. 中风后抑郁和大脑老化。

Journal of molecular psychiatry Pub Date : 2013-08-23 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-14

Gabriel R Cojocaru, Aurel Popa-Wagner, Elena C Stanciulescu, Loredana Babadan, Ana-Maria Buga

引用次数: 15

Neuroregeneration and dementia: new treatment options. 神经再生和痴呆:新的治疗选择。

Journal of molecular psychiatry Pub Date : 2013-07-17 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-12

Smaranda Ioana Mitran, Bogdan Catalin, Veronica Sfredel, Tudor-Adrian Balseanu

引用次数: 8

Genetics and epigenetics of alcohol dependence. 酒精依赖的遗传学和表观遗传学。

Journal of molecular psychiatry Pub Date : 2013-07-11 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-11

Vanessa Nieratschker, Anil Batra, Andreas J Fallgatter

引用次数: 38

Correction: Methylphenidate enhances neural stem cell differentiation. 更正:哌甲酯增强神经干细胞分化。

Journal of molecular psychiatry Pub Date : 2013-06-10 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-10

Jasmin Bartl, Takatoshi Mori, Peter Riederer, Hiroki Ozawa, Edna Grünblatt

引用次数: 3

The amygdala between sensation and affect: a role in pain. 感觉和情感之间的杏仁核:在疼痛中的作用。

Journal of molecular psychiatry Pub Date : 2013-06-05 eCollection Date: 2013-01-01 DOI: 10.1186/2049-9256-1-9

Pierre Veinante, Ipek Yalcin, Michel Barrot

{"title":"The amygdala between sensation and affect: a role in pain.","authors":"Pierre Veinante, Ipek Yalcin, Michel Barrot","doi":"10.1186/2049-9256-1-9","DOIUrl":"https://doi.org/10.1186/2049-9256-1-9","url":null,"abstract":"The amygdala is a structure of the temporal lobe thought to be involved in assigning emotional significance to environmental information and triggering adapted physiological, behavioral and affective responses. A large body of literature in animals and human implicates the amygdala in fear. Pain having a strong affective and emotional dimension, the amygdala, especially its central nucleus (CeA), has also emerged in the last twenty years as key element of the pain matrix. The CeA receives multiple nociceptive information from the brainstem, as well as highly processed polymodal information from the thalamus and the cerebral cortex. It also possesses the connections that allow influencing most of the descending pain control systems as well as higher centers involved in emotional, affective and cognitive functions. Preclinical studies indicate that the integration of nociceptive inputs in the CeA only marginally contributes to sensory-discriminative components of pain, but rather contributes to associated behavior and affective responses. The CeA doesn't have a major influence on responses to acute nociception in basal condition, but it induces hypoalgesia during aversive situation, such as stress or fear. On the contrary, during persistent pain states (inflammatory, visceral, neuropathic), a long-lasting functional plasticity of CeA activity contributes to an enhancement of the pain experience, including hyperalgesia, aversive behavioral reactions and affective anxiety-like states. ","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32823866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 233