Jasmin Bartl, Takatoshi Mori, Peter Riederer, Hiroki Ozawa, Edna Grünblatt
{"title":"哌甲酯促进神经干细胞分化。","authors":"Jasmin Bartl, Takatoshi Mori, Peter Riederer, Hiroki Ozawa, Edna Grünblatt","doi":"10.1186/2049-9256-1-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).</p><p><strong>Findings and conclusion: </strong>We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.</p>","PeriodicalId":73838,"journal":{"name":"Journal of molecular psychiatry","volume":"1 1","pages":"5"},"PeriodicalIF":0.0000,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2049-9256-1-5","citationCount":"12","resultStr":"{\"title\":\"Methylphenidate enhances neural stem cell differentiation.\",\"authors\":\"Jasmin Bartl, Takatoshi Mori, Peter Riederer, Hiroki Ozawa, Edna Grünblatt\",\"doi\":\"10.1186/2049-9256-1-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).</p><p><strong>Findings and conclusion: </strong>We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.</p>\",\"PeriodicalId\":73838,\"journal\":{\"name\":\"Journal of molecular psychiatry\",\"volume\":\"1 1\",\"pages\":\"5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/2049-9256-1-5\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of molecular psychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/2049-9256-1-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2013/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of molecular psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/2049-9256-1-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Background: The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).
Findings and conclusion: We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.
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