Journal of molecular and cellular cardiology plus最新文献

{"title":"10055: Cardiac Disease Occurrences in Primary Aldosteronism patients at Hospital Canselor Tuanku Muhriz UKM: Comparison of Unilateral versus Bilateral Subtype and Medical Treatment versus Adrenalectomy","authors":"Aina Nadheera Abd Rahman, Megan Limbang, Haritha Subba Rau, Hazim Fadzli, Yue Zhen Lim, Adi Syazni Muhammed, Norlela Sukor, Elena Aisha Azizan","doi":"10.1016/j.jmccpl.2024.100177","DOIUrl":"10.1016/j.jmccpl.2024.100177","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10049: Human PSC-based engineered heart tissue platform for disease modeling and investigation of new gene candidates in heart diseases","authors":"Rujie Qi, Roger Foo, Matthew Ackers-Johnson","doi":"10.1016/j.jmccpl.2024.100171","DOIUrl":"10.1016/j.jmccpl.2024.100171","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10020: Identification of a novel enhancer to drive robust cardiac specific gene expression","authors":"Michelle C.E. Mak, Roger S.Y. Foo","doi":"10.1016/j.jmccpl.2024.100142","DOIUrl":"10.1016/j.jmccpl.2024.100142","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10007: Targeting EIF5A hypusination to improve protein synthesis and mitochondrial function during MASH","authors":"Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen, Jin Zhou","doi":"10.1016/j.jmccpl.2024.100129","DOIUrl":"10.1016/j.jmccpl.2024.100129","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased perivascular fibrosis and pro-fibrotic cellular transition in intramyocardial blood vessels in myocardial infarction patients","authors":"Zhu Jiang ,&nbsp;Giulia Sorrentino ,&nbsp;Suat Simsek ,&nbsp;Joris J.T.H. Roelofs ,&nbsp;Hans W.M. Niessen ,&nbsp;Paul A.J. Krijnen","doi":"10.1016/j.jmccpl.2024.100275","DOIUrl":"10.1016/j.jmccpl.2024.100275","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Structural and functional changes in the intramyocardial microcirculation increase the risk of myocardial infarction (MI). This study investigated intramyocardial perivascular fibrosis and pro-fibrotic cellular transitions in deceased acute and subacute MI patients to explore their involvement in the pathogenesis of MI.</div></div><div><h3>Methods</h3><div>Left ventricular tissue (LV) was obtained from the infarction area of autopsied patients with acute-phase MI (3–6 h; <em>n</em> = 24), subacute-phase MI (5–14 days; <em>n</em> = 12), and noninfarcted controls (<em>n</em> = 14). Perivascular fibrosis and fibroblast activation protein (FAP) expression were quantified using (immuno)histochemistry. Fibroblast-like transitioning of vascular smooth muscle cells (VSMC) and endothelial cells (EC) was quantified using immunofluorescent microscopy.</div></div><div><h3>Results</h3><div>Perivascular fibrosis was elevated in acute-phase (77.69 %) and subacute-phase (72.19 %: border zone 95.18 %: infarct core) MI patients (<em>p</em> &lt; 0.0001) compared to controls (61.03 %). FAP expression was higher in both acute-phase (1.46 %) and subacute-phase (18.01 %: border zone 5.67 %: infarct core) compared to controls (0.46 %) (<em>p</em> &lt; 0.05). VSMC fibroblast-like cellular transition (SMA + S100A4+ vessels fraction) was higher in acute-phase (31.96 %) and subacute-phase (21.90 %: border zone; 37.25 %: infarct core) MI compared to controls (8.95 %) (<em>p</em> &lt; 0.05). Similarly, EC fibroblast-like cellular transition (CD31 + S100A4+ area fraction) was increased in acute-phase MI (10.14 %) and subacute-phase MI (8.31 %: border zone 10.15 %: infarct core) compared to controls (2.67 %) (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Increased perivascular fibrosis, fibroblast activation and vascular cellular transition in intramyocardial blood vessels of MI patients may contribute to MI development. Further increases of FAP expression and perivascular fibrosis, particularly in subacute-phase infarct cores, suggest MI itself exacerbates fibroblast activation and perivascular fibrosis, theoretically increasing reinfarction risk.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100275"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex steroid hormones and atrial electrophysiology: Vive la difference!","authors":"Elise S. Bisset ,&nbsp;Susan E. Howlett","doi":"10.1016/j.jmccpl.2024.100087","DOIUrl":"10.1016/j.jmccpl.2024.100087","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10012: Spatially Resolved Atlas of Transplanted Human Cardiac Progenitors Reveals Post-Infarct Cardiac Regeneration and Cellular Maturation","authors":"Swarnaseetha Adusumalli PhD,&nbsp;Samantha Lim MSc,&nbsp;Vincent Ren MD. PhD,&nbsp;Li Yen Chong Msc,&nbsp;Clarissa Tan Msc,&nbsp;Roy Tham B.Sc,&nbsp;Kye Siong Leong B.Sc,&nbsp;Min En Cheng,&nbsp;Ye Lei MD. PhD,&nbsp;Yibin Wang PhD,&nbsp;Enrico Petretto PhD,&nbsp;Karl Tryggvason MD. PhD,&nbsp;Lynn Yap PhD","doi":"10.1016/j.jmccpl.2024.100134","DOIUrl":"10.1016/j.jmccpl.2024.100134","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10017: Mitochondrial cristae instability drives ageing-related inflammation and heart failure","authors":"Francesco Paolo Ruberto,&nbsp;Chang Jie Mick Lee,&nbsp;Pooja Sridharan,&nbsp;Mathew Ackers-Johnson,&nbsp;Prasanna Vidyasekar,&nbsp;Leroy Pakki,&nbsp;Wu Lik Hang,&nbsp;Goh Ling Xuan,&nbsp;Erielle Villanueva,&nbsp;Zhe Li,&nbsp;Tuan Luu,&nbsp;Lena Ho,&nbsp;Chester Drum,&nbsp;Roger SY Foo","doi":"10.1016/j.jmccpl.2024.100139","DOIUrl":"10.1016/j.jmccpl.2024.100139","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10029: An RNA-targeted Platform Technology for Therapeutics","authors":"Permeen Yusoff,&nbsp;Annadory Lavenniah,&nbsp;Erica M. Wee,&nbsp;Bhav Harshad Parikh,&nbsp;Xinyi Su,&nbsp;Roger Foo Sy","doi":"10.1016/j.jmccpl.2024.100151","DOIUrl":"10.1016/j.jmccpl.2024.100151","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10034: Identification of Long Non-coding RNA Regulators of Cardiac Specification Using CRISPRi Screening","authors":"Ryan Fan Ruiming,&nbsp;Chang Jie Mick Lee,&nbsp;Roger Foo Sik Yin","doi":"10.1016/j.jmccpl.2024.100156","DOIUrl":"10.1016/j.jmccpl.2024.100156","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}