Journal of diabetes and clinical research最新文献

{"title":"Epidemiological Characteristics of Diabetic Foot and Affecting Factors for Amputation in China","authors":"Zhao, Zhang-rong Xu, Aihong Wang","doi":"10.33696/diabetes.3.043","DOIUrl":"https://doi.org/10.33696/diabetes.3.043","url":null,"abstract":"With the increased prevalence of diabetes from 0.67% in 1980 to 11.2% in 2017, the prevalence of diabetic foot has been growing in China in recent years. Diabetic foot ulcer (DFU) was one of the most serious complications of diabetes. Complicated general condition, severe infection and poor outcomes were feature characteristics of Chinese DFU patients. The annual incidence of DFU in China was as high as 8.1% in patients with diabetes, which ranked the first among the causes of chronic wounds in hospitalized patients [1-2]. And the recurrence rate of foot ulcers in healed DFU patients over 50-year-old was as high as 31.6% within one year [1].","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44948924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of Peripheral Arterial Disease in People with Type 2 Diabetes Mellitus – A Commentary Article","authors":"Nahid Hashemi-Madani, M. Khamseh","doi":"10.33696/diabetes.3.040","DOIUrl":"https://doi.org/10.33696/diabetes.3.040","url":null,"abstract":"Peripheral arterial disease (PAD) is a prevalent form of atherosclerotic vascular disease in type 2 diabetes mellitus (T2DM). Diagnosis and treatment of PAD is more challenging in these patients. Presence of concomitant neuropathy masks typical pain symptoms, and typical criteria for intermittent claudication are not clearly met [1]. Moreover, PAD often affects the small arteries that makes effective revascularization less successful [2]. Thus, screening and early detection of PAD are of major importance in patients with T2DM.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45311539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Cardiovascular Risk Factors in Osteoarthritis Patients Derived from Primary Care Records: A Systematic Review of Observational Studies.","authors":"Xiaoyang Huang,&nbsp;Ross Wilkie,&nbsp;Mamas A Mamas,&nbsp;Dahai Yu","doi":"10.33696/diabetes.3.042","DOIUrl":"https://doi.org/10.33696/diabetes.3.042","url":null,"abstract":"<p><strong>Background: </strong>People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities for the surveillance of CVD risk factors in the osteoarthritis population. This paper aimed to systematically review evidence of prevalence estimates of CVD risk factors in people with osteoarthritis derived from primary care EHRs.</p><p><strong>Methods: </strong>Eight databases including MEDLINE were systematically searched till January 2019. Observational studies using primary care EHRs data to estimate the prevalence of six CVD risk factors in people with osteoarthritis were included. A narrative review was conducted to summarize study results.</p><p><strong>Results: </strong>Six studies were identified. High heterogeneity between studies prevented the calculation of pooled estimates. One study reported the prevalence of smoking (12.5%); five reported hypertensions (range: 19.7%-55.5%); four reported obesities (range: 34.4%-51.6%); two reported dyslipidemias (6.0%, 13.3%); five reported diabetes (range: 5.2%-18.6%); and one reported chronic kidney disease (1.8%) in people with osteoarthritis. One study reported a higher prevalence of hypertension (Odds Ratio (OR) 1.25, 95% confidence interval (CI) 1.19-1.32), obesity (OR 2.44, 95%CI 2.33-2.55), dyslipidemia (OR 1.24, 95%CI 1.14-1.35) and diabetes (1.11, 95%CI 1.02-1.22) in the osteoarthritis population compared with the matched non-osteoarthritis population.</p><p><strong>Conclusions: </strong>From studies identified in this review that had used primary care EHRs, prevalence estimates of CVD risk factors were higher in people with osteoarthritis compared with those without. These estimates may provide baseline frequency of CVD risk factors in osteoarthritis patients in primary care, although this is limited by the small number of studies and high heterogeneity. Further studies of frequency, using primary care EHRs, will help to answer whether this data source can be used for evaluating approaches to manage CVD risk factors in osteoarthritis patients.</p>","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40569661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons from My Grandmother’s Garden: Intergenerational Learning and Managing Type 2 Diabetes","authors":"J. McConatha, Melina McConatha, N. DiGregorio","doi":"10.33696/diabetes.3.039","DOIUrl":"https://doi.org/10.33696/diabetes.3.039","url":null,"abstract":"Researchers suggest that grandmothers are often the invisible support helping to maintain the health and well-being of the family and community [2]. Studies have explored the important role that grandmothers play in the well-being of families over time [3]. “Learning family” is a concept focused on how family learning, between grandparents and grandchildren, can lead to mutual respect and life-long learning across the generations. During the COVID-19 pandemic, a research project in China has explored ways that family learning activities can lead to skill development for both grandparents and grandchildren [4]. Industrialization has transformed family roles, including those of grandparents. One outcome has been delocalization and a decrease in grandmother’s involvement in extended family learning [5]. During the past year, the COVID-19 pandemic has resulted in a growing interest in traditional sustainable practices in the home. Lockdowns provide an opportunity for informal learning practices associated with food preparation, health promotion, and illness management. While not all elders have an interest in growing food, for those who do, the knowledge and skills they may have gained in early life, can now serve to promote positive intergenerational learning experiences [6]. By adopting the role of keeper of sustainable practices in the home— such as gardening, cooking, fermenting, canning, and more—many grandmothers can take on the vital role of intergenerational teacher and mentor [7].","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41444181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CERT-Dependent Ceramide Transport, A Crucial Process in Cells","authors":"Cécile L. Bandet, E. Hajduch","doi":"10.33696/diabetes.3.036","DOIUrl":"https://doi.org/10.33696/diabetes.3.036","url":null,"abstract":"In mammalian cells, ceramides are central lipids in sphingolipid metabolism and serve both as signaling lipids and as precursors for other bioactive sphingolipids, ranging from complex glycosphingolipids to “simpler” lipids such as ceramide-1-phosphate, sphingomyelin (SM), sphingosine and sphingosine-1-phosphate (S1P). Ceramides are largely distributed in cell membranes where they play an important structural role. In addition, ceramides play also key roles in intracellular signaling, and regulate growth, proliferation, cell migration, apoptosis, and differentiation [1].","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69670316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Technology in the Follow-up of Patients with Diabetes: Is it Possible in a South American Country?","authors":"D. Henao","doi":"10.33696/diabetes.3.035","DOIUrl":"https://doi.org/10.33696/diabetes.3.035","url":null,"abstract":"Despite better treatments and technology available in usual clinical practice, achieving a good glycemic control in patients with diabetes is challenging. In times of SARSCoV-2/COVID-19 infection, chronic diseases like diabetes have been associated with adverse outcomes [1]. Regardless of the limited information, it is known that individuals with diabetes are at risk of respiratory infections [2]. This risk can be reduced by achieving good glycemic control and for this reason, the care of patients with diabetes is a main concern.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69670268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Non-Esterified Fatty Acids (NEFA) in Type 2 Diabetes Mellitus: Evidence on Pathophysiology","authors":"Kailash Chandra, V. Jain, S. Jain","doi":"10.33696/diabetes.3.037","DOIUrl":"https://doi.org/10.33696/diabetes.3.037","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a metabolic dysfunction characterized by elevated levels of blood glucose as well as impaired lipid and protein metabolism [1,2]. The mobilization of fatty acids is augmented in insulin resistance due to the failure of lipolysis inhibition by the hormone that further augments the increase in plasma NEFA levels. This in turn, results in inflammation as well as further insulin resistance [3]. The complementation of insulin resistance with dysfunction of pancreatic islet β-cells leads to hyperglycemia. Insulin resistance may persist unnoticed for several years prior to onset of T2DM. Insulin inhibits lipolysis of stored fat in adipose tissue and gluconeogenesis in liver. It also increases the synthesis of proteins needed for the optimal cellular function, repair, growth, and stimulates the translocation of the GLUT-4 protein leading to increased transport of glucose into the muscle cells [4]. Insulin resistance is a metabolic dysfunction that is often mediated by increased inflammation.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69670326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short Commentary on African Cuisine-Centered Insulin Therapy: Expert Opinion on the Management of Hyperglycaemia in Adult Patients with Type 2 Diabetes Mellitus","authors":"A. Uloko, R. Lamptey, J. Mbanya","doi":"10.33696/diabetes.3.038","DOIUrl":"https://doi.org/10.33696/diabetes.3.038","url":null,"abstract":"Andrew E. Uloko1*, Roberta Lamptey2, Jean Claude Mbanya3 1Department of Medicine, Bayero University Kano / Aminu Kano Teaching Hospital, Kano, Nigeria 2Department of Family Medicine, Korle Bu Teaching Hospital, University of Ghana, Accra, Ghana 3Laboratory of Molecular Medicine and Metabolism, Biotechnology Center, and Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69670371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing Medical Education Rarely Addresses Leading Public Health Problems Including Diabetes and Obesity","authors":"Nicholas A Berry, Nicole Fumo, Bruce B. Berry","doi":"10.33696/DIABETES.1.027","DOIUrl":"https://doi.org/10.33696/DIABETES.1.027","url":null,"abstract":"Medical schools sponsor continuing medical education (CME) to help fulfill their mission of improving the health of the community. CME programs can help physicians stay up-to-date with the best practices associated with disease prevention and treatment. According to the Accreditation Council for Continuing Medical Education (ACCME) there were 1.2 Million (M) hours of accredited CME courses offered in 2018 at a cost of 2.8 Billion (B) dollars, with medical schools receiving $367 M in CME revenue [1]. CME topic offerings are determined by the sponsoring entity and physicians choose which courses they wish to attend.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49354461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the COVID-19 Pandemic Lockdown Measures on Diabetic Retinopathy Services in the East Kent Area of the United Kingdom - A Special Focus on the Pregnant Diabetic","authors":"Alamin Alkundi, R. Momoh","doi":"10.33696/DIABETES.1.022","DOIUrl":"https://doi.org/10.33696/DIABETES.1.022","url":null,"abstract":"75 The COVID-19 pandemic has shaped activities across almost all human endeavours. Changes are still ongoing to accommodate all the challenges it poses. The healthcare sector, working closely with governments of nations and regulatory agencies, has helped to control the impact of this highly contagious virus. The shutdown of nonessential services has been employed in many countries to reduce the burden of infection rates and deaths recorded from the COVID-19 viral infection.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42137361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}