Journal of diabetes and clinical research最新文献

{"title":"The Clinical Utility of Outpatient Continuous Glucose Monitoring in Establishing Insulinoma Diagnosis in a Patient with Impaired Nocturnal Hypoglycemia Awareness","authors":"Aundrea E. Loftley, Christopher Woody, Colin A Russell","doi":"10.33696/diabetes.1.005","DOIUrl":"https://doi.org/10.33696/diabetes.1.005","url":null,"abstract":"Aundrea E. Loftley1, Christopher Woody2, Colin Russell3 1Department of Medicine, Division of Endocrinology, Medical University of South Carolina, Charleston, SC, USA 2College of Medicine, Medical University of South Carolina, Charleston, SC, USA 3Department of Medicine, Medical University of South Carolina, Charleston, SC, USA *Correspondence should be addressed to Aundrea E. Loftley, easona@musc.edu","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69669847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Profiling and Role of miRNAs in Diabetes Mellitus.","authors":"Michael Kim,&nbsp;Xiaokan Zhang","doi":"10.33696/diabetes.1.003","DOIUrl":"https://doi.org/10.33696/diabetes.1.003","url":null,"abstract":"<p><p>Diabetes mellitus (DM), a complex metabolic disease, has become a global threat to human health worldwide. Over the past decades, an enormous amount of effort has been devoted to understand how microRNAs (miRNAs), a class of small non-coding RNA regulators of gene expression at the post-transcriptional level, are implicated in DM pathology. Growing evidence suggests that the expression signature of a specific set of miRNAs has been altered in the progression of DM. In the present review, we summarize the recent investigations on the miRNA profiles as novel DM biomarkers in clinical studies and in animal models, and highlight recent discoveries on the complex regulatory effect and functional role of miRNAs in DM.</p>","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":"5-23"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9345174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Community Diabetes Model: Future of Diabetes Services and Way Forward?","authors":"P. De","doi":"10.33696/diabetes.1.001","DOIUrl":"https://doi.org/10.33696/diabetes.1.001","url":null,"abstract":"Prevalence of diabetes is increasing. Diabetes is more prevalent in the socially deprived, ethnic minority population (based on continuing rise in elderly population, growing obesity and BME groups). Compliance is a major stumbling block in the management of most long-term conditions including diabetes. The impact on primary care is significant with difficulty in managing the above increasing numbers, reducing HbA1c, other complications and maintaining skills in diabetes. As a result, diabetes care is full of gaps and duplication in service – there is inability to build capacity and capability in primary care and to progress towards better management of diabetes patients.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69669749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cut-off Value of Random Blood Glucose among Asian Indians for Preliminary Screening of Persons with Prediabetes and Undetected Type 2 Diabetes Defined by the Glycosylated Haemoglobin Criteria.","authors":"Priscilla Susairaj,&nbsp;Chamukuttan Snehalatha,&nbsp;Arun Raghavan,&nbsp;Arun Nanditha,&nbsp;Ramachandran Vinitha,&nbsp;Krishnamoorthy Satheesh,&nbsp;Desmond G Johnston,&nbsp;Nicholas J Wareham,&nbsp;Ambady Ramachandran","doi":"10.33696/diabetes.1.009","DOIUrl":"https://doi.org/10.33696/diabetes.1.009","url":null,"abstract":"<p><strong>Aim: </strong>The increased morbidity and mortality due to type 2 diabetes can be partly due to its delayed diagnosis. In developing countries, the cost and unavailability of conventional screening methods can be a setback. Use of random blood glucose (RBG) may be beneficial in testing large numbers at a low cost and in a short time in identifying persons at risk of developing diabetes. In this analysis, we aim to derive the values of RBG corresponding to the cut-off values of glycosylated hemoglobin (HbA1c) used to define prediabetes and diabetes.</p><p><strong>Methods: </strong>Based on their risk profile of developing diabetes, a total of 2835 individuals were screened for a large diabetes prevention study. They were subjected to HbA1c testing to diagnose prediabetes and diabetes. Random capillary blood glucose was also performed. Correlation of RBG with HbA1c was computed using multiple linear regression equation. The optimal cut-off value for RBG corresponding to HbA1c value of 5.7% (39 mmol/mol), and ≥ 6.5% (48 mmol/mol) were computed using the receiver operating curve (ROC). Diagnostic accuracy was assessed from the area under the curve (AUC) and by using the Youden's index.</p><p><strong>Results: </strong>RBG showed significant correlation with HbA1c (r=0.40, p<0.0001). Using the ROC analysis, a RBG cut-off value of 140.5 mg/dl (7.8 mmol/L) corresponding to an HbA1c value of 6.5% (48mmol/mol) was derived. A cut-off value could not be derived for HbA1c of 5.7% (39 mmol/mol) since the specificity and sensitivity for identifying prediabetes were low.</p><p><strong>Conclusion: </strong>Use of a capillary RBG value was found to be a simple procedure. The derived RBG cut-off value will aid in identifying people with undiagnosed diabetes. This preliminary screening will reduce the number to undergo more cumbersome and invasive diagnostic testing.</p>","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 2","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37707441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Mellitus and Dengue","authors":"V. Wiwanitkit","doi":"10.33696/diabetes.1.004","DOIUrl":"https://doi.org/10.33696/diabetes.1.004","url":null,"abstract":"Diabetes mellitus is a common metabolic disorder that present with abnormal glucose metabolism. This metabolic disease is prevalent in many countries, worldwide. It is no doubt there might be a chance that diabetes mellitus might co-occur with other medical problems. In tropical world, the concurrence between diabetes mellitus and tropical infection is interesting. In this specific editorial article, the interrelationship between diabetes mellitus and dengue is summarized and discussed.","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69669805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Quell Childhood Obesity: The Pacific Ending Childhood Obesity Network’s Response","authors":"A. Ravuvu, S. Tin, S. Bertrand, E. Na'ati, I. Kubuabola","doi":"10.33696/diabetes.3.034","DOIUrl":"https://doi.org/10.33696/diabetes.3.034","url":null,"abstract":"The need to accelerate collective and concerted action to combat Non-Communicable Diseases (NCDs) and childhood obesity is particularly relevant in the Pacific context. In October 2017, the country-driven Pacific Ending Childhood Obesity Network (Pacific ECHO) was established1, and all twenty-two Pacific Island countries and territories (PICTs) became members of the Network. Several regional and international plans and strategies have outlined key proven populations-based measures to address this epidemic including the WHO Report of the Commission on Ending Childhood Obesity (ECHO) [1], the Global Action Plan for the Prevention and Control of NCDs 2013-2020 [2], the Comprehensive Implementation Plan on Maternal, Infant and Young Child Nutrition 2012 [3] and the UN Decade of Action on Nutrition 2016-2025 [4].","PeriodicalId":73706,"journal":{"name":"Journal of diabetes and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69670234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}