{"title":"The Cardiomyocyte as a Source of Cytokines in Cardiac Injury.","authors":"Toshinori Aoyagi, Takashi Matsui","doi":"10.4172/2157-7013.s5-003","DOIUrl":"https://doi.org/10.4172/2157-7013.s5-003","url":null,"abstract":"<p><p>Fibrosis induced by prolonged inflammation is a major pathophysiological feature of adverse left ventricular remodeling after myocardial infarction and pathological cardiac hypertrophy. Recent reports strongly suggest that the interaction between leukocytes, non-myocytes (mainly cardiac fibroblasts) and cardiomyocytes, possibly mediated by cytokine signaling, plays an important role in controlling the inflammatory reaction after cardiac injury. Therefore, controlling cytokine secretion from resident cardiomyocytes is one plausible strategy for preventing tissue damage.</p>","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"2012 S5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594870/pdf/nihms368841.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31307625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shibo Fu, Michael Rivera, Eric C Ko, Andrew G Sikora, Chien-Ting Chen, Ha Linh Vu, David Cannan, Samuel Eisenstein, Barry S Rosenstein, Julio Aguirre-Ghiso, Shu-Hsia Chen, Johnny Kao
{"title":"Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy.","authors":"Shibo Fu, Michael Rivera, Eric C Ko, Andrew G Sikora, Chien-Ting Chen, Ha Linh Vu, David Cannan, Samuel Eisenstein, Barry S Rosenstein, Julio Aguirre-Ghiso, Shu-Hsia Chen, Johnny Kao","doi":"10.4172/2157-7013.s1-002","DOIUrl":"https://doi.org/10.4172/2157-7013.s1-002","url":null,"abstract":"<p><p>Targeting epidermal growth factor receptor (EGFR) is a promising approach to increasing radiosensitivity of head and neck cancers but treatment resistance remains an important clinical problem. We hypothesize that combined EGFR and cyclooxygenase-2 (COX-2) inhibition, using small molecule inhibitors erlotinib and celecoxib, respectively would further increase the antitumor activity of radiotherapy. The effects of combinations of celecoxib, erlotinib and ionizing radiation (IR) on cell growth, cell cycle progression and apoptosis of head and neck cancer cell lines were assessed <i>in vitro</i> by cell viability, clonogenic survival, flow cytometry and Annexin V assays and <i>in vivo</i>. The effects of celecoxib, erlotinib and IR on primary and downstream molecular targets were analyzed by immunoblotting & ELISA assays. Compared to single or double agent approaches, concurrent celecoxib, erlotinib and IR was the most effective regimen at reducing clonogenic survival, increasing apoptosis and inhibiting tumor growth <i>in vivo</i>. Concurrent treatment with celecoxib and erlotinib ± IR inhibited multiple prosurvival proteins including p-ERK1/2, p-EGFR, p-AKT, p-STAT3, COX-2 and PGE-2. The combination of celecoxib, erlotinib and IR is a promising strategy to overcoming resistance to combined EGFR inhibition and IR alone.</p>","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593102/pdf/nihms-354666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31392454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Krishnan Ramanujan, Songyang Ren, Sangyong Park, Daniel L Farkas
{"title":"Non-invasive, Contrast-enhanced Spectral Imaging of Breast Cancer Signatures in Preclinical Animal Models In vivo.","authors":"V Krishnan Ramanujan, Songyang Ren, Sangyong Park, Daniel L Farkas","doi":"10.4172/2157-7013.1000102","DOIUrl":"https://doi.org/10.4172/2157-7013.1000102","url":null,"abstract":"<p><p>We report here a non-invasive multispectral imaging platform for monitoring spectral reflectance and fluorescence images from primary breast carcinoma and metastatic lymph nodes in preclinical rat model in vivo. The system is built around a monochromator light source and an acousto-optic tunable filter (AOTF) for spectral selection. Quantitative analysis of the measured reflectance profiles in the presence of a widely-used lymphazurin dye clearly demonstrates the capability of the proposed imaging platform to detect tumor-associated spectral signatures in the primary tumors as well as metastatic lymphatics. Tumor-associated changes in vascular oxygenation and interstitial fluid pressure are reasoned to be the physiological sources of the measured reflectance profiles. We also discuss the translational potential of our imaging platform in intra-operative clinical setting.</p>","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"1 102","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093534/pdf/nihms247789.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29884281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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