Journal of cell science & therapy最新文献

Activators of G-Protein Signaling 3 (AGS3) Puncta: Potential Novel Biomolecular Condensates in Signal Transduction. G 蛋白信号激活因子 3 (AGS3) Puncta：信号转导中潜在的新型生物分子凝聚体。

Journal of cell science & therapy Pub Date : 2024-01-01 Epub Date: 2024-06-14

Ali Vural

引用次数: 0

Impact of Needle Selection on Survival of Muscle-Derived Cells When Used for Laryngeal Injections. 用于喉部注射时针头选择对肌肉衍生细胞存活率的影响

Journal of cell science & therapy Pub Date : 2023-01-01 Epub Date: 2022-12-09

Oluwaseyi Awonusi, Zachary J Harbin, Sarah Brookes, Lujuan Zhang, Samuel Kaefer, Rachel A Morrison, Sharlé Newman, Sherry Voytik-Harbin, Stacey Halum

{"title":"Impact of Needle Selection on Survival of Muscle-Derived Cells When Used for Laryngeal Injections.","authors":"Oluwaseyi Awonusi, Zachary J Harbin, Sarah Brookes, Lujuan Zhang, Samuel Kaefer, Rachel A Morrison, Sharlé Newman, Sherry Voytik-Harbin, Stacey Halum","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To describe how differing injector needles and delivery vehicles impact Autologous Muscle-Derived Cell (AMDC) viability when used for laryngeal injection.Methods: In this study, adult porcine muscle tissue was harvested and used to create AMDC populations. While controlling cell concentration (1 × 107 cells/ml), AMDCs including Muscle Progenitor Cells (MPCs) or Motor Endplate Expressing Cells (MEEs) were suspended in either phosphate-buffered saline or polymerizable (in-situ scaffold forming) type I oligomeric collagen solution. Cell suspensions were then injected through 23- and 27-gauge needles of different lengths at the same rate (2 ml/min) using a syringe pump. Cell viability was measured immediately after injection and 24- and 48-hours post-injection, and then compared to baseline cell viability prior to injection.Results: The viability of cells post-injection was not impacted by needle length or needle gauge but was significantly impacted by the delivery vehicle. Overall, injection of cells using collagen as a delivery vehicle maintained the highest cell viability.Conclusion: Needle gauge, needle length, and delivery vehicle are important factors that can affect the viability of injected cell populations. These factors should be considered and adapted to improve injectable MDC therapy outcomes when used for laryngeal applications.","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian Potency Spectrum in Light-Adapted Humans. 适应光的人类的昼夜节律效谱。

Journal of cell science & therapy Pub Date : 2022-01-01

Martin Moore-Ede, Anneke Heitmann

引用次数: 0

GRK4, A Potential Link between Hypertension and Breast Cancer. GRK4:高血压和乳腺癌之间的潜在联系

Journal of cell science & therapy Pub Date : 2022-01-01 Epub Date: 2022-03-15

Wei Yue, John J Gildea, Peng Xu, Robin A Felder

引用次数: 0

Application of a Successful Germ Cell Tumor Paradigm to the Challenges of Common Adult Solid Cancers 一种成功的生殖细胞肿瘤模式在常见成人实体癌挑战中的应用

Journal of cell science & therapy Pub Date : 2021-07-25 DOI: 10.35248/2157-7013.21.12.301

S. Tu, M. Campbell, A. Shah, C. Logothetis

{"title":"Application of a Successful Germ Cell Tumor Paradigm to the Challenges of Common Adult Solid Cancers","authors":"S. Tu, M. Campbell, A. Shah, C. Logothetis","doi":"10.35248/2157-7013.21.12.301","DOIUrl":"https://doi.org/10.35248/2157-7013.21.12.301","url":null,"abstract":"When we aspire to cure cancer, we may need to search no further than a curable cancer, such as Germ Cell Tumor of the Testis (TGCT). After all, a germ cell is a primordial stem cell. Importantly, TGCT provides a classic stem cell model of cancer that teaches us some invaluable lessons about curing other intractable solid tumors. The intrinsic intratumoral heterogeneity of TGCT alludes to its stem-ness origin and nature. Which implicates the existence of putative lethal TGCT subtypes-the identification and detection of which may further enhance the cure rate and improve the therapeutic ratio of TGCT. In this Mini review, we discuss about the role of biologic insights, clinical lessons, and therapeutic strategies in drug and therapy development. We illustrate some clinical pearls and perils when it concerns drug versus therapy development in the cure and care of patients with TGCT. In many respects, we have cured more TGCT patients when we apply multimodal therapy rather than targeted therapy and integrated medicine rather than precision medicine. In principle and in practice, this is the implication of therapy versus drug development in improving the overall outcome and cure rate of patients with cancer.","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42385627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Application of a Successful Germ Cell Tumor Paradigm to the Challenges of Common Adult Solid Cancers. 成功的生殖细胞肿瘤范例在成人常见实体癌挑战中的应用。

Journal of cell science & therapy Pub Date : 2021-01-01

Shi-Ming Tu, Matthew Campbell, Amishi Shah, Christopher J Logothetis

{"title":"Application of a Successful Germ Cell Tumor Paradigm to the Challenges of Common Adult Solid Cancers.","authors":"Shi-Ming Tu, Matthew Campbell, Amishi Shah, Christopher J Logothetis","doi":"","DOIUrl":"","url":null,"abstract":"When we aspire to cure cancer, we may need to search no further than a curable cancer, such as Germ Cell Tumor of the Testis (TGCT). After all, a germ cell is a primordial stem cell. Importantly, TGCT provides a classic stem cell model of cancer that teaches us some invaluable lessons about curing other intractable solid tumors. The intrinsic intratumoral heterogeneity of TGCT alludes to its stem-ness origin and nature. Which implicates the existence of putative lethal TGCT subtypes-the identification and detection of which may further enhance the cure rate and improve the therapeutic ratio of TGCT. In this Mini review, we discuss about the role of biologic insights, clinical lessons, and therapeutic strategies in drug and therapy development. We illustrate some clinical pearls and perils when it concerns drug versus therapy development in the cure and care of patients with TGCT. In many respects, we have cured more TGCT patients when we apply multimodal therapy rather than targeted therapy and integrated medicine rather than precision medicine. In principle and in practice, this is the implication of therapy versus drug development in improving the overall outcome and cure rate of patients with cancer.","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"12 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39293250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Hedgehog Pathway in Uterine Leiomyosarcoma. Hedgehog通路在子宫平滑肌肉瘤中的作用。

Journal of cell science & therapy Pub Date : 2021-01-01 Epub Date: 2021-08-23

Natalia Garcia, Mara Ulin, Ayman Al-Hendy, Qiwei Yang

引用次数: 0

Commentary on NNT Mediates Redox-Dependent Pigmentation via a UVB-And MITF-Independent Mechanism. NNT通过不依赖uvb和mitf的机制介导氧化还原依赖性色素沉着。

Journal of cell science & therapy Pub Date : 2021-01-01 Epub Date: 2021-09-20

Jennifer Allouche, Inbal Rachmin, David E Fisher, Elisabeth Roider

引用次数: 0

The translation of fundamental research discoveries into cell and gene based medicinal products 将基础研究成果转化为基于细胞和基因的医药产品

Journal of cell science & therapy Pub Date : 2019-04-03 DOI: 10.4172/2157-7013-c2-052

F. Farzaneh

引用次数: 0

Rat Bone Marrow-Derived Mononuclear Cells Outperform Folic Acid in the Treatment of Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats 大鼠骨髓来源的单核细胞在治疗链脲佐菌素诱导的糖尿病大鼠糖尿病周围神经病变方面优于叶酸

Journal of cell science & therapy Pub Date : 2019-01-01 DOI: 10.35248/2157-7013.19.10.291

Manal H Al-Badawi, Basma S. Abd El-Hay, S. A. Fareed, M. H. Mohamed

{"title":"Rat Bone Marrow-Derived Mononuclear Cells Outperform Folic Acid in the Treatment of Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats","authors":"Manal H Al-Badawi, Basma S. Abd El-Hay, S. A. Fareed, M. H. Mohamed","doi":"10.35248/2157-7013.19.10.291","DOIUrl":"https://doi.org/10.35248/2157-7013.19.10.291","url":null,"abstract":"Background: Diabetes mellitus is the most common cause of peripheral neuropathy, which itself is mediated in part via oxidative stress. Recent studies have used stem-cell-based therapies to regenerate nerve tissues following diabetic neuropathy. Folic acid supplementation promotes neuronal development and protection in some neurological diseases. Aim: This study aims to compare the effects of bone marrow-mononuclear cells (BM-MNCs) and folic acid (FA) in the treatment of peripheral neuropathy in streptozotocin-induced diabetic rats. Methods: Forty adult male albino rats were randomly divided into five groups: Group I (healthy control group); Group II, diabetic group (a single intraperitoneal streptozotocin injection); Group III, diabetic rats that received BM-MNCs; Group IV, diabetic rats that were treated with FA (10 mg/kg/day intraperitoneal injection) for 4 weeks and Group V (FA): Folic Acid-treated group. Random blood sugar was measured for all groups. The animals were euthanized, and the right sciatic nerve was carefully extracted to measure sciatic nerve conduction velocity and processed for histopathological, immunohistochemical (CD68), electron microscopic and morphometric studies. Results: The diabetic group showed progressive histological changes characteristic of neuropathy in the sciatic nerve. Also increased number of CD68-immunopositive cells were detected. In BM-MNC transplantation group, the sciatic nerve sections showed improved histological changes characteristic of neuropathy with a decreased number of CD68-immunopositive cells. The diabetic group treated with FA showed less histological results relative to diabetic rats treated with BM-MNCs. Conclusion: Diabetic rats treated with BM-MNC showed better improvement in diabetic neuropathy than diabetic rats treated with folic acid.","PeriodicalId":73642,"journal":{"name":"Journal of cell science & therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69971819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0