Journal of cancer science and clinical therapeutics最新文献_第8页

Estimation of the Fractal Dimension of Thyroid Nodules as a Complementary Diagnostic Tool for Predicting Malignancy 甲状腺结节分形维数的估计作为预测恶性肿瘤的辅助诊断工具

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079141

Lothaire P, Uzureau P, Boudjelta Kz, Nagy N, Michiels C, C. T.

引用次数: 0

Comparison of Different Schedules of Rituximab and Chlorambucil in Previously Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of Krohem 不同方案的利妥昔单抗和氯霉素治疗未经治疗的慢性淋巴细胞白血病的比较:Krohem的回顾性研究

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079128

S. Bašić-Kinda, I. Hude, E. Ranković, Slobodanka Ostojić-Kolonić, V. Pejsa, I. Radman, Martina Bogeljic-Patekar, O. Jakšić, K. Dubravčić, Ivana Franić-Šimić, I. Aurer

{"title":"Comparison of Different Schedules of Rituximab and Chlorambucil in Previously Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of Krohem","authors":"S. Bašić-Kinda, I. Hude, E. Ranković, Slobodanka Ostojić-Kolonić, V. Pejsa, I. Radman, Martina Bogeljic-Patekar, O. Jakšić, K. Dubravčić, Ivana Franić-Šimić, I. Aurer","doi":"10.26502/jcsct.5079128","DOIUrl":"https://doi.org/10.26502/jcsct.5079128","url":null,"abstract":"Due to age and comorbidities many patients with CLL receive chlorambucil as front-line treatment. Doses and schedules of this drug vary widely but it is not clear whether this affects outcomes. We performed this retrospective analysis to compare the efficacy and toxicity of continuous high-dose chlorambucil (12-20 mg daily until response or toxicity) (cHD-Clb-R) and intermittent high dose chlorambucil (8-10 mg/m2 daily for 7 days q 4 wk) (iClb-R) in combination with rituximab (375 mg/m2/cycle for 8 cycles) in previously untreated CLL patients. Thirtysix patients received cHD-Clb-R and 32 iClb-R. Median age was 66 years (range 41-80); 24 were women and 44 men; 24 had Binet stage A, 27 B and 17 C; 5 had del(17p). Most common severe adverse events were granulocytopenia, occurring in 14; and infections in 7 patients, one of whom died. One patient stopped treatment due to hepatotoxicity. Both schedules resulted in similar toxicity and efficacy (cHD-Clb-R vs. iClb-R overall survival, progression-free survival and survival without next treatment at 30 mo. 70% vs. 83%, 49% vs. 55% and 67% vs. 75% respectively). Combinations of rituximab and chlorambucil are well tolerated and effective treatments for patients ineligible for fludarabine-based regimens. Outcomes seem to be related more to total drug doses than schedules.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Squamous Cell Carcinoma of Thyroid 原发性甲状腺鳞状细胞癌

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079142

Burkan Nasr, A. Al-tamimi, M. Issa, A. Amri, Yasser A Obadiel, M. Qubati, Anwar Al_junaeed, M. Al-Shehari, Saeed Al Bahlooli

{"title":"Primary Squamous Cell Carcinoma of Thyroid","authors":"Burkan Nasr, A. Al-tamimi, M. Issa, A. Amri, Yasser A Obadiel, M. Qubati, Anwar Al_junaeed, M. Al-Shehari, Saeed Al Bahlooli","doi":"10.26502/jcsct.5079142","DOIUrl":"https://doi.org/10.26502/jcsct.5079142","url":null,"abstract":"Background: Primary squamous cell carcinoma (PSCC) is a rare thyroid cancer that is difficult to diagnose and differentiate before pathology changes observed, poor prognosis, aggressive malignancy associated with locally advanced disease and frequent metastases to regional lymph nodes and distant sites. Case Presentation: A 76-year-old female patient complained about a rapidly growing anterior neck mass and a change in her voice. Based on the patient's symptoms, clinical examination, neck and thyroid ultrasound with fine needle aspiration cytology, the patient was initially diagnosed with suspicious thyroid nodule thereafter, total thyroidectomy with left neck node dissection. However, her J Cancer Sci Clin Ther 2022; 6 (1): 16-24 DOI: 10.26502/jcsct.5079142 Journal of Cancer Science and Clinical Therapeutics 17 disease was finally diagnosed according to the histopathology result as Primary squamous cell cancer (PSCC). Conclusion: Primary squamous cell cancer (PSCC) of thyroid are poor prognosis when associated with locally tissue infiltration and infected necrosis, the proper history, good neck and thyroid examination support by neck sonography help full to diagnosis the thyroid malignancy in general, the best treatment for Primary squamous cell cancer (PSCC) was total thyroidectomy with or without lymph node dissection followed by radiochemotherapy.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction between Physical Activity and Socioeconomic Determinants among Cancer Patients: A Systematic Mapping Review 癌症患者身体活动与社会经济决定因素之间的相互作用:一项系统的制图回顾

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079132

Jean-Marie Nguyen, Abdou Yacoubou Omorou, C. Rotonda, C. Tarquinio, S. Gendarme, C. Martin-Krumm, Aurélie Van Hoye

{"title":"Interaction between Physical Activity and Socioeconomic Determinants among Cancer Patients: A Systematic Mapping Review","authors":"Jean-Marie Nguyen, Abdou Yacoubou Omorou, C. Rotonda, C. Tarquinio, S. Gendarme, C. Martin-Krumm, Aurélie Van Hoye","doi":"10.26502/jcsct.5079132","DOIUrl":"https://doi.org/10.26502/jcsct.5079132","url":null,"abstract":"Socioeconomic factors and physical activity (PA), have been recognized as key factors affecting survival and quality of life of cancer patients. Nevertheless, less is known about their interactions among cancer patients. A mapping systematic review was undertaken to identify gaps in the literature regarding the interactions of socioeconomic factors and PA and the identification of theoretical model to define this relationship. A search for peer-reviewed English articles published between January 2010 and March 2020 in Medline, PsycINFO, Web of Science and SportDiscus databases was realized using three keywords: physical activity, cancer, socioeconomic. Cancer location and time, socioeconomic factor measurement, PA measurement, intervention and theoretical model were analyzed. Of the J Cancer Sci Clin Ther 2021; 5 (4): 468-495 DOI: 10.26502/jcsct.5079132 Journal of Cancer Science and Clinical Therapeutics 469 5163 articles found, 90 were included (86 observational studies and 4 interventions). While many studies evaluate socioeconomic factors and PA, authors often do not consider their interactions, but test them separately. Socioeconomic factors identified in the studies ranged among 12 categories (age, sex, ethnicity, education, income, occupation, residence, green space exposure, marital status, household, social support, Health insurance). A high diversity of measurements within each category led to a huge variation in the definition of socioeconomic factors and refrained comparison between studies. Similar conclusions could be drawn with regard to the diversity of PA measurements. Only few studies mobilized theoretical models, without considering the interactions between socioeconomic factors and PA. The definition of socioeconomic factors as well as theoretical modeling of how socioeconomic factors interact with PA among cancer patients needs to be clarified.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case of Using Wet Healing Theory for Wound Bed Preparation Care for A Patient with Breast Cancer Wounds 湿愈合理论在乳腺癌创面准备护理中的应用

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079137

Wenli D, Yaping S, H. X, Ying Y

引用次数: 0

Impact of COVID-19 on Breast Cancer Treatment: A Tertiary Referral Centre Experience COVID-19对乳腺癌治疗的影响:三级转诊中心的经验

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079125

K. Balachandran, Jennet Williams, David C. Bell, Anna Brown, P. Hurhangee, R. Ramakrishnan, S. Cleator, R. Coombes, O. Hatcher, F. Rehman, J. Stebbing, L. Kenny

{"title":"Impact of COVID-19 on Breast Cancer Treatment: A Tertiary Referral Centre Experience","authors":"K. Balachandran, Jennet Williams, David C. Bell, Anna Brown, P. Hurhangee, R. Ramakrishnan, S. Cleator, R. Coombes, O. Hatcher, F. Rehman, J. Stebbing, L. Kenny","doi":"10.26502/jcsct.5079125","DOIUrl":"https://doi.org/10.26502/jcsct.5079125","url":null,"abstract":"Background: The effect of the COVID-19 on breast cancer treatment is unknown. The pandemic’s impact on treatment delivery was assessed in patients undergoing chemotherapy treatment at a major London oncology centre. Methods: Treatment and medical records for all patients attending the chemotherapy unit and on outpatient treatment for breast cancer over an 8 week period (during first lockdown; 23rd March-17th May 2020) were compared to a similar time period in 2019. Results: Breast cancer diagnosis referrals fell by 38% mainly due to screening services halting which had a knock-on effect on patient numbers starting their first treatment (reduced by 34%). Neoadjuvant, adjuvant, and palliative patients were all affected, mostly at the start of lockdown. On-site chemotherapy and supportive treatments fell by 39% compared to 2019, mainly due to fewer number of bone-modifying agents. Towards the end of 8 week period, treatment numbers had nearly returned to normal. The system adapted by modifying treatment regimens, using telemedicine, increased use of supportive medications and less frequent blood tests. Conclusion: COVID-19’s global impact has significantly reduced breast cancer treatments given during the first lockdown. Whilst recovery is now evident, cancer services, patients, and clinical cancer research must be prioritised in future waves.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69367565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Management of Delayed Onset Cramps Related to Irinotecan during Oncological Treatment 肿瘤治疗中与伊立替康相关的迟发性痉挛的处理

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079130

J. van Heerden, N. Moes, Katleen Balliauw, Elien Romaen, J. Verlooy, M. van den Akker, K. Norga

{"title":"The Management of Delayed Onset Cramps Related to Irinotecan during Oncological Treatment","authors":"J. van Heerden, N. Moes, Katleen Balliauw, Elien Romaen, J. Verlooy, M. van den Akker, K. Norga","doi":"10.26502/jcsct.5079130","DOIUrl":"https://doi.org/10.26502/jcsct.5079130","url":null,"abstract":"Background: Irinotecan-induced gastro-intestinal side effects are well described in the literature. The pathophysiology and treatment of diarrhea, especially acute onset, is the most understood. Yet delayed onset cramps and management have not been sufficiently documented. J Cancer Sci Clin Ther 2021; 5 (4): 448-458 DOI: 10.26502/jcsct.5079130 Journal of Cancer Science and Clinical Therapeutics 449 Materials: A case report of a nine-year-old girl diagnosed with rhabdomyosarcoma who was treated with irinotecan in the relapse setting, is presented. A limited literature review was done based on the challenges experienced during the management of a patient with delayed onset irinotecaninduced cramps. The pathophysiology of delayed onset irinotecan induced cramps is based on cholinergic, inflammatory and enzymatic factors as well as neural damage. Treatment was based on the etiology described in the literature with a positive result. Conclusion: Delayed onset irinotecan related cramps are part of a multifactorial etiology that should be approached systematically, especially when first line treatment does not yield an adequate response.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Impact of Mastectomy on Self-Concept and Social Life: Decisional Conflicts for Breast Reconstruction 乳房切除术对自我概念和社会生活的影响:乳房重建的决定性冲突

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079133

Hessa A Alsanad, Lama A Alrasheed, Reem R Alkharji, Nur Khadijah Mohd Zin, Abdulrahman A Alzahrani, Alaa T Alshareeda

{"title":"The Impact of Mastectomy on Self-Concept and Social Life: Decisional Conflicts for Breast Reconstruction","authors":"Hessa A Alsanad, Lama A Alrasheed, Reem R Alkharji, Nur Khadijah Mohd Zin, Abdulrahman A Alzahrani, Alaa T Alshareeda","doi":"10.26502/jcsct.5079133","DOIUrl":"https://doi.org/10.26502/jcsct.5079133","url":null,"abstract":"Background: Having a mastectomy affects a woman psychosocially, especially to adapt to the changes of her body. It is important to understand women's motivation for breast reconstruction surgery (BRS) to reconcile themselves J Cancer Sci Clin Ther 2021; 5 (4): 496-511 DOI: 10.26502/jcsct.5079133 Journal of Cancer Science and Clinical Therapeutics 497 with their own beliefs and desires. This study explored the factors that affect women's decision to have BRS after the mastectomy, the level of awareness of the available BRS options and their suggestions to improve the acceptance of BRS. Materials and methods: A questionnaire was distributed to patients diagnosed with BC in Saudi Arabia. Results: A total of 352 women were recruited for this cross-sectional study. Age and high educational attainment were significantly associated with a positive decision for BRS. Physical appearance and self-confidence were essential factors in the decision-making for BRS. The main barriers were the surgical risks and strong religious beliefs. Interestingly, both breasts removed affect women’s social life positively compared to those who had one breast removed. The majority (70%) of the sample did not know of the educational campaigns held by the Ministry of Health. The main suggestion to increase interest in BRS is the presence of clinicians throughout the treatment journey. Conclusion: Women diagnosed with BC should be involved in a personalized care plan, especially the group at a higher risk of developing negative body image feelings associated with a mastectomy.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative Treatment of NMSC Recurrent with NILS NMSC复发与NILS的替代治疗

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/jcsct.5079126

Aferdita Stroka Koka, Laver Stroka, B. Çela, Ronny Khadra, A. Guy, F. Hyseni, J. Musa

{"title":"Alternative Treatment of NMSC Recurrent with NILS","authors":"Aferdita Stroka Koka, Laver Stroka, B. Çela, Ronny Khadra, A. Guy, F. Hyseni, J. Musa","doi":"10.26502/jcsct.5079126","DOIUrl":"https://doi.org/10.26502/jcsct.5079126","url":null,"abstract":"Throughout 2018 in the \"STROKA\" clinic in Tirana, are presented for alternative treatment 28 patients with recurrent non melanoma skin cancer (NMSC) after standard treatment with surgery, radiotherapy or together for one or more lesions. All patients are diagnosed with Basal Cell Carcinoma and Squamous Cell Carcinoma, and are treated with NILS which contains extracts of some Albanian plants such as Allium sativum, Juglans regia and Laurus nobilis. According to a certain methodology, the treatment of patients lasts from one to three months until the complete destruction of the tumor and the regeneration of the area below and around it. From the first session, the measure of the tumor was reduce and all the surface that has absorbed the Nils, was turn in a cruste. The crustes falls one after another until the tumor mass has end and the sound layer was reached. At this point, we stoped the sessions of treatment, because the process of regeneration starts. NILS solution is J Cancer Sci Clin Ther 2021; 5 (3): 405-413 DOI: 10.26502/jcsct.5079126 Journal of Cancer Science and Clinical Therapeutics 406 applied topically and the number of sessions varied from 314 in our 28 patients. After complete recovery, all are advised for periodic check-ups after 1, 2, 3, 6, 12, 18, 24, 30 and 36 months, without limiting them further.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69367588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aspects on the International Commission on Non-Ionizing Radiation Protection (ICNIRP) 2020 Guidelines on Radiofrequency Radiation 国际非电离辐射防护委员会(ICNIRP) 2020年《射频辐射指南》的各个方面

Journal of cancer science and clinical therapeutics Pub Date : 2021-01-01 DOI: 10.26502/JCSCT.5079117

L. Hardell, Mona Nilsson, T. Koppel, M. Carlberg

引用次数: 15