Journal of cancer immunology最新文献_第5页

Quantifying Neural Stem Cell-Derived Extracellular Vesicle Uptake Using Imaging Flow Cytometry 用成像流式细胞术定量神经干细胞来源的细胞外小泡摄取

Journal of cancer immunology Pub Date : 2021-11-05 DOI: 10.33696/cancerimmunol.3.049

Taylor J. Ellison, B. Jurgielewicz, S. Stice, Yao Yao

{"title":"Quantifying Neural Stem Cell-Derived Extracellular Vesicle Uptake Using Imaging Flow Cytometry","authors":"Taylor J. Ellison, B. Jurgielewicz, S. Stice, Yao Yao","doi":"10.33696/cancerimmunol.3.049","DOIUrl":"https://doi.org/10.33696/cancerimmunol.3.049","url":null,"abstract":"Nanomedicine, which includes nanoparticles and other nanomaterials for diagnosis and therapeutic delivery to treat numerous diseases, is making advances [1]. Utilizing engineered nanomaterials as delivery shuttles for therapeutics provides an opportunity to increase targeting specificity for treatments of certain disorders, as well as provide intrinsic benefits to cell systems of interest [2,3]. However, it is important to understand the functional properties of materials in pre-clinical studies. Proper selection of nanomaterials could be enhanced by recent studies in the field of cellular uptake of nanomaterials. The study of EVs is an expanding field within nanomedicine and are one such example of nanomaterials as a drug delivery shuttle. EVs are lipid-bound vesicles ranging in size from 40-1000 nm that mediate intercellular communication through shuttling nucleic acids, protein and lipids between cells. Once thought to be the secreted waste of cells, EVs have been engineered as drug delivery vectors due to multiple intrinsic benefits such as biocompatibility of genetic materials, therapeutic potentials, low immunogenicity and toxicity, ability to cross bio-barriers and for repeated dosing, various routes of administration [4-6]. Previous work from our group and others indicates that the therapeutic potential and Abstract","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44974744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-PD1 Therapy in Lynch Syndrome-associated Recurrent Glioblastoma 抗pd1治疗Lynch综合征相关复发性胶质母细胞瘤

Journal of cancer immunology Pub Date : 2021-11-05 DOI: 10.33696/cancerimmunol.3.051

Wendy J. Sherman

引用次数: 0

Profiling the Energy Metabolism at the Cell Subpopulation Level 在细胞亚群水平上分析能量代谢

Journal of cancer immunology Pub Date : 2021-11-05 DOI: 10.33696/cancerimmunol.3.050

K. Benihoud, C. Brenner

引用次数: 0

Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too? 多环芳烃与乳腺癌风险:肥胖也有关系吗?

Journal of cancer immunology Pub Date : 2021-10-27 DOI: 10.33696/cancerimmunol.3.052

Lydia Lichtiger, Janelle A. Rivera, Debashish Sahay, Rachel L. Miller

{"title":"Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too?","authors":"Lydia Lichtiger, Janelle A. Rivera, Debashish Sahay, Rachel L. Miller","doi":"10.33696/cancerimmunol.3.052","DOIUrl":"https://doi.org/10.33696/cancerimmunol.3.052","url":null,"abstract":"Breast cancer risk remains incompletely explained, and higher incidence rates of breast cancer over recent times and in urban and industrialized areas suggest environmental causes. Polycyclic aromatic hydrocarbons (PAH) are ubiquitous in the environment and epidemiological and rodent studies have shown associations between exposure to PAH and breast cancer incidence as well as mammary tumorigenesis. In addition, in vitro and rodent studies have implicated alterations in estrogen receptor alpha (Erα) signaling pathways following PAH exposure in limited experimental studies. However, our understanding of these mechanisms is incomplete. Sahay et al. addressed this gap by examining the effect of PAH exposure on epigenetic and transcriptional regulation of genes in the Erα pathway in a mouse cohort exposed to aerosolized PAH at proportions measured in urban air. In addition to alterations in the Erα signaling pathway in the pregnant mice and in their offspring and grandoffspring, the investigators observed higher body weights in mice exposed to PAH compared to the control. Given that associations between mammary tissue adiposity, systemic adiposity, and breast cancer risk have been observed previously, the finding of higher body weight in the PAH exposure group raises the possibility that body weight might influence the association between PAH exposure and breast cancer risk. Along with new analyses, we discuss the possibility that body weight may modify the association between PAH exposure, mammary cellular proliferation, and mammary gland ductal hyperplasia in offspring and grandoffspring mice and future research that may be needed to delineate these associations.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":"3 1","pages":"154 - 162"},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42372088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Relevance of Neuropilin 1 and Neuropilin 2 Targeting for Cancer Treatment Neuropilin 1和Neuropilin 2靶向治疗癌症的相关性

Journal of cancer immunology Pub Date : 2021-06-30 DOI: 10.33696/cancerimmunol.3.046

A. Dumond, Gilles Pagès

引用次数: 2

Dose-dependent Effects of Vitamin C on Cancer Regulation: A Review 维生素C在癌症调节中的剂量依赖性研究进展

Journal of cancer immunology Pub Date : 2021-06-30 DOI: 10.33696/cancerimmunol.3.048

F. Hadi, T. Maqbool, Saira Aftab, Muhammad Tahir, S. Ramzan, K. Kiran, A. Malik, S. Akhtar

引用次数: 0

Emerging Roles of Pseudogene RNAs in Antitumor and Antiviral Immunity 假基因RNA在抗肿瘤和抗病毒免疫中的新作用

Journal of cancer immunology Pub Date : 2021-06-30 DOI: 10.33696/cancerimmunol.3.045

Yoo Jane Han, Michaela U. Gack, O. Olopade

引用次数: 0

Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too? 多环芳烃与乳腺癌风险:肥胖也有关系吗?

Journal of cancer immunology Pub Date : 2021-01-01

Lydia Lichtiger, Janelle Rivera, Debashish Sahay, Rachel L Miller

{"title":"Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too?","authors":"Lydia Lichtiger, Janelle Rivera, Debashish Sahay, Rachel L Miller","doi":"","DOIUrl":"","url":null,"abstract":"Breast cancer risk remains incompletely explained, and higher incidence rates of breast cancer over recent times and in urban and industrialized areas suggest environmental causes. Polycyclic aromatic hydrocarbons (PAH) are ubiquitous in the environment and epidemiological and rodent studies have shown associations between exposure to PAH and breast cancer incidence as well as mammary tumorigenesis. In addition, in vitro and rodent studies have implicated alterations in estrogen receptor alpha (Erα) signaling pathways following PAH exposure in limited experimental studies. However, our understanding of these mechanisms is incomplete. Sahay et al. addressed this gap by examining the effect of PAH exposure on epigenetic and transcriptional regulation of genes in the Erα pathway in a mouse cohort exposed to aerosolized PAH at proportions measured in urban air. In addition to alterations in the Erα signaling pathway in the pregnant mice and in their offspring and grandoffspring, the investigators observed higher body weights in mice exposed to PAH compared to the control. Given that associations between mammary tissue adiposity, systemic adiposity, and breast cancer risk have been observed previously, the finding of higher body weight in the PAH exposure group raises the possibility that body weight might influence the association between PAH exposure and breast cancer risk. Along with new analyses, we discuss the possibility that body weight may modify the association between PAH exposure, mammary cellular proliferation, and mammary gland ductal hyperplasia in offspring and grandoffspring mice and future research that may be needed to delineate these associations.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":" ","pages":"154-162"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39842277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenic Cell Death: A Step Ahead of Autophagy in Cancer Therapy. 免疫性细胞死亡：自噬在癌症治疗中的领先一步

Journal of cancer immunology Pub Date : 2021-01-01 DOI: 10.33696/cancerimmunol.3.041

Gourab Gupta, Kristina Borglum, Hexin Chen

{"title":"Immunogenic Cell Death: A Step Ahead of Autophagy in Cancer Therapy.","authors":"Gourab Gupta, Kristina Borglum, Hexin Chen","doi":"10.33696/cancerimmunol.3.041","DOIUrl":"10.33696/cancerimmunol.3.041","url":null,"abstract":"Immunogenic cell death (ICD) plays a major role in providing long lasting protective antitumor immunity by the chronic exposure of damage associated molecular patterns (DAMPs) in the tumor microenvironment (TME). DAMPs are essential for attracting immunogenic cells to the TME, maturation of DCs, and proper presentation of tumor antigens to the T cells so they can kill more cancer cells. Thus for the proper release of DAMPs, a controlled mechanism of cell death is necessary. Drug induced tumor cell killing occurs by apoptosis, wherein autophagy may act as a shield protecting the tumor cells and sometimes providing multi-drug resistance to chemotherapeutics. However, autophagy is required for the release of ATP as it remains one of the key DAMPs for the induction of ICD. In this review, we discuss the intricate balance between autophagy and apoptosis and the various strategies that we can apply to make these immunologically silent processes immunogenic. There are several steps of autophagy and apoptosis that can be regulated to generate an immune response. The genes involved in the processes can be regulated by drugs or inhibitors to amplify the effects of ICD and therefore serve as potential therapeutic targets.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":"3 1","pages":"47-59"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39185136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Expression of TIM 3 and Galectin 9 on Immunohistochemistry Staining of Tumor Specimen at Diagnosis in Pediatric Patients with Ewing Sarcoma. TIM 3和凝集素9在儿童尤文氏肉瘤诊断时肿瘤标本免疫组化染色中的高表达。

Journal of cancer immunology Pub Date : 2021-01-01 DOI: 10.33696/cancerimmunol.3.053

Stephanie J Si, Gerald B Wertheim, David M Barrett

引用次数: 0