Journal of blood disorders & transfusion最新文献_第2页

Stem cell transplantation: Donors as research objects, the donor search process and beyond 干细胞移植:供体作为研究对象，供体搜索过程及以后

Journal of blood disorders & transfusion Pub Date : 2019-04-04 DOI: 10.4172/2155-9864-c1-040

S. Morsch

引用次数: 0

Haemophilia a carrier detection among Sudanese families: DNA linkage analysis approaches 血友病携带者检测苏丹家庭:DNA连锁分析方法

Journal of blood disorders & transfusion Pub Date : 2019-04-04 DOI: 10.4172/2155-9864-C1-041

pRayan Elsheikh, Eltaher Khalilp

引用次数: 0

Heparin Induced Thrombocytopenia in a Patient with Antiphospholipid Syndrome 抗磷脂综合征患者肝素诱导的血小板减少症

Journal of blood disorders & transfusion Pub Date : 2019-01-01 DOI: 10.4172/2155-9864.1000411

R. Ahmad, S. Chaudhry

引用次数: 0

Evaluation of Blood Lead Level as a Risk Factor in Children with Autism Spectrum Disorder: A Case Control Study 评估血铅水平作为自闭症谱系障碍儿童的危险因素:一项病例对照研究

Journal of blood disorders & transfusion Pub Date : 2019-01-01 DOI: 10.4172/2155-9864.1000415

Ali Ms, Begum Ba, Akhter S, N. K, Uddin Ukm, Akter S, Jolly Yn

{"title":"Evaluation of Blood Lead Level as a Risk Factor in Children with Autism Spectrum Disorder: A Case Control Study","authors":"Ali Ms, Begum Ba, Akhter S, N. K, Uddin Ukm, Akter S, Jolly Yn","doi":"10.4172/2155-9864.1000415","DOIUrl":"https://doi.org/10.4172/2155-9864.1000415","url":null,"abstract":"The present study deals with the Evaluation of Blood lead (Pb) level as a risk factor in Autistic Children and to determine the association between blood lead level (BLL) and Autism Spectrum Disorder (ASD). It was a casecontrol study. Blood samples were collected from both case (25 of 3-16 years) and control (25 of 3-16 years) groups by vein puncture for the determination of blood lead levels using Energy Dispersive X-ray Fluorescence (EDXRF) technique. Predesigned questionnaires were completed for each case and control group by interviewing the parents or care-givers. The present study revealed that there was a significant difference between mean ages of mother at child’s birth in both case and control group. Significantly more children in case group had parents with higher educational levels and came from families with higher socioeconomic status. Significantly more children in ASD group came from urban areas than rural area. The risk of exposure to air pollution in case group was 14 times more than the control group which is represented by the proximity of child’s residence to high traffic roads. History of pica was exclusively present in case group (p value 0.001) indicating that children in ASD group had more exposure to lead than those of control group. The mean blood levels were 44.18 and 29.22 μg/dl for case and control group respectively. In case group 48% of the children had blood lead level ≥ 10 μg/dl compared to 24% in the control group.","PeriodicalId":73627,"journal":{"name":"Journal of blood disorders & transfusion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70322889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Some Hematologic Parameters of Blood Donors at the National Blood Transfusion Service (NBTS), Jos, Nigeria 尼日利亚乔斯国家输血中心献血者的一些血液学参数

Journal of blood disorders & transfusion Pub Date : 2019-01-01 DOI: 10.4172/2155-9864.1000416

Lugos, Okoh Jb, Polit Uy, V. Ny, Ofojekwu Mjn, Nnanna Ou, Damen Jg, Iheanacho Cu, Ntuhun Bd, Damulak Od

{"title":"Some Hematologic Parameters of Blood Donors at the National Blood Transfusion Service (NBTS), Jos, Nigeria","authors":"Lugos, Okoh Jb, Polit Uy, V. Ny, Ofojekwu Mjn, Nnanna Ou, Damen Jg, Iheanacho Cu, Ntuhun Bd, Damulak Od","doi":"10.4172/2155-9864.1000416","DOIUrl":"https://doi.org/10.4172/2155-9864.1000416","url":null,"abstract":"Introduction: A blood donor is expected to be a healthy individual who donates his or her blood for the medical treatment of patients. World Health Organisation (WHO) recommends that only those with good health status should be accepted as blood donors. Full blood count is a standard haematology test that evaluates a blood sample for a variety of basic parameters and partly applicable in the general screening of health. Normal haemoglobin level is one of the requirements for blood donor suitability. Normal haemoglobin alone does not connote normalcy of other haematologic variables. The full blood count of blood donors may reveal other blood measurements that may contribute to the better assessment of donors and standardisation of blood donor selection.Aim: This research is aimed to evaluate some haematological parameters of assumingly healthy volunteer blood donors at the NBTS (National Blood Transfusion Service), in Jos, Plateau State.Methods: A total of 102 potential healthy blood donors from Jos City and Du Village participated in the study. We obtained 2.5 ml of venous blood aseptically from each donor into an EDTA container and mixed. The full blood counts of the samples were all analysed. The values gotten were subjected to statistical analysis using the SPSS version 23 software.Results: The packed cell volume (PCV), total and differential white blood cell counts and platelet count were significantly different compared to local reference ranges. Further, evaluation of the parameters between genders, locations, age groups and occupations of donors, the platelet, PCV and eosinophil counts differed significantly (p=0.042, 0.00 and 0.029 respectively). The average white blood cells (WBC) count was lower among donors in the rural area (p=0.000).Conclusion: There may be a significant number of apparently healthy blood donors with abnormal haematologic parameters. Full blood count should be included in evaluating blood donors to ensure blood and donor safety.","PeriodicalId":73627,"journal":{"name":"Journal of blood disorders & transfusion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70322516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Prevalence/Incidence of Hereditary and Acquired Thrombophilia Markers among Egyptian Females with Recurrent Pregnancy Loss or IVF Failure 埃及女性复发性流产或体外受精失败的遗传和获得性血栓标志物的患病率/发病率

Journal of blood disorders & transfusion Pub Date : 2019-01-01 DOI: 10.4172/2155-9864.1000412

A. V., Issa H, R. A

引用次数: 0

A Rare Presentation of ph Chromosome: idic der (22q11) in Blast Crisis Chronic Myeloid Leukemia 细胞危象慢性髓系白血病中罕见的ph染色体:idic der (22q11)

Journal of blood disorders & transfusion Pub Date : 2019-01-01 DOI: 10.4172/2155-9864.1000414

P. Kumari, M. Mangalagowri, Kavitha Bl, C. ObulaReddy, S. Shanthala, M. Mahadavaprasad, Madhumathi Ds, Govinda Bk

引用次数: 0

CALR and CD47: An Insight into Their Roles in the Disease Progression of MDS and MPN CALR和CD47在MDS和MPN疾病进展中的作用

Journal of blood disorders & transfusion Pub Date : 2018-11-20 DOI: 10.4172/2155-9864.1000413

K. Boasman, M. Simmonds, C. Rinaldi

{"title":"CALR and CD47: An Insight into Their Roles in the Disease Progression of MDS and MPN","authors":"K. Boasman, M. Simmonds, C. Rinaldi","doi":"10.4172/2155-9864.1000413","DOIUrl":"https://doi.org/10.4172/2155-9864.1000413","url":null,"abstract":"Myelodysplastic syndrome and myeloproliferative neoplasms are clonal myeloid disorders arising from haematopoietic stem cells that have the tendency to progress into acute myeloid leukaemia. Multiple prognostic scoring systems have been proposed and utilised in clinical practice to predict disease evolution, however none of them can predict treatment response. In solid tumours, the relationship between the pro-phagocytic calreticulin and the anti-phagocytic CD47 is repeatedly investigated. Overexpression of calreticulin has been documented to produce a pro-phagocytic signal in solid tumour and it is often counteracted by a concomitant expression of the anti-phagocytic CD47 as they act in response to one another, reflecting an apoptosis vs survival mechanism in response to chemotherapy. The role of both calreticulin and CD47 are currently poorly understood in myeloid malignancies including myelodysplastic syndrome and myeloproliferative neoplasms. The aim of this review is to elaborate on the current understanding round the roles and implications of calreticulin and CD47 signalling with in solid and haematological cancers, discuss potential roles for calreticulin and CD47 expression in transformation of myeloid cells in patients with MDS or MPN into AML and how these advances are starting to be used to design new therapeutic strategies to determine disease progression and treatment response in both solid cancer and myeloid malignancies.","PeriodicalId":73627,"journal":{"name":"Journal of blood disorders & transfusion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49285544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Binding of Factor VIII to Lipid Nanodiscs Increases its Clotting Function in a Mouse Model of Hemophilia A. 在血友病a小鼠模型中，因子VIII与脂质纳米盘的结合增加了其凝血功能。

Journal of blood disorders & transfusion Pub Date : 2015-12-01 DOI: 10.4172/2155-9864.1000325

Keri Csencsits-Smith, Krill Grushin, Svetla Stoilova-McPhie

{"title":"Binding of Factor VIII to Lipid Nanodiscs Increases its Clotting Function in a Mouse Model of Hemophilia A.","authors":"Keri Csencsits-Smith, Krill Grushin, Svetla Stoilova-McPhie","doi":"10.4172/2155-9864.1000325","DOIUrl":"https://doi.org/10.4172/2155-9864.1000325","url":null,"abstract":"Background: Hemophilia A is a congenital bleeding disorder caused by defective or deficient factor VIII (FVIII). The active form of FVIII is the co-factor for the serine protease factor IXa (FIXa) in the membrane-bound intrinsic tenase (FVIIIa-FIXa) complex. The assembly of the FVIIIa-FIXa complex on the activated platelet surface is critical for successful blood clotting.Objectives: To characterize the role of lipid nanodiscs (ND) for on FVIII function in vivo and test the lipid ND as a delivery system for FVIII. To evaluate the potential of binding recombinant FVIII to ND as improved treatment for Hemophilia A.Methods: Recombinant porcine FVIII (rpFVIII) was expressed and characterized in solution, and when bound to ND. The rpFVIII, ND and rpFVIII-ND complexes were characterized via transmission electron microscopy. Functional studies were carried out using aPTT tests and time resolved tail snip studies of hemophilic mice.Results: Functional rpFVIII was successfully assembled on lipid ND. When injected in hemophilic mice, the rpFVIII-ND complexes showed a pronounced pro-coagulant effect, which was stronger than that of rpFVIII alone. While injection of the ND alone showed a pro-coagulant effect this effect was not additive, implying that the rpFVIII-ND complexes have a synergistic effect on the clotting process in hemophilic mice.Conclusions: Binding of rpFVIII to ND prior to its injection in hemophilic mice significantly improves the therapeutic function of the protein. This represents a meaningful step towards a new approach to modulate blood coagulation at the membrane-bound FVIII level and the assembly of the intrinsic tenase complex.","PeriodicalId":73627,"journal":{"name":"Journal of blood disorders & transfusion","volume":"6 6","pages":"325"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2155-9864.1000325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Characterization of Bone Marrow-Derived Dendritic Cells Developed in Serum-Free Media and their Ability to Prevent Type 1 Diabetes in Nonobese Diabetic Mice 无血清培养基中培养的骨髓来源树突状细胞的特性及其在非肥胖糖尿病小鼠中预防1型糖尿病的能力

Journal of blood disorders & transfusion Pub Date : 2014-03-22 DOI: 10.4172/2155-9864.1000206

Benjamin M. Looney, Anna V. Chernatynskaya, M. Clare-Salzler, C. Xia

引用次数: 5