Heparin Induced Thrombocytopenia in a Patient with Antiphospholipid Syndrome

Abstract

Heparin-induced thrombocytopenia (HIT) is a less commonly encountered adverse reaction of heparin characterized by formation of heparin complex with platelet factor 4 due to formation of autoantibody. HIT is reported in about 2% of all patients receiving heparin, out of which 35% develop thrombosis. In Antiphospholoipid syndrome autoantibodies are generated to phospholipid binding proteins which are risk factors for thrombosis and pregnancy complications. In this report we present case of a patient with recurrent venous thromboembolism receiving heparin and was found to develop HIT with coexistence of Antiphospholipid syndrome.