Journal of ageing and longevity最新文献

{"title":"Effect of ATP and molsidomine combination on contractile function of isolated adult and old rat hearts during adequate coronary perfusion, at ischemia and reperfusion","authors":"V. Bezrukov, Liana Kuprush, N. Sykalo, T. Panteleymonova, L. Sharabura, V. Olar","doi":"10.47855/JAL9020-2021-2-2","DOIUrl":"https://doi.org/10.47855/JAL9020-2021-2-2","url":null,"abstract":"Abstract. Pathology of the cardiovascular system occupies a major place in the structure of diseases of the elderly and old patients. Metabolic disturbances are very important in ischemic damages of myocardium in the elderly and old people. So, drugі with metabolic mechanism of action is very ppromising in the treatment of elderly patients with cardiovascular diseases. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism of cardiomyocytes, improve blood supply to the myocardium, increase its contractile function. The effect of ATP-molsidomine combination on myocardial contractility in different age animals was stuiesy in vitro experiments. The experiments on the isolated hearts from adult and old rats have shown that combined use of ATP and molsidomine did not significantly affect the contractility of the isolated hearts of adult rats under different perfusion regimes. In old rats, the use of ATP-molsidomine combination had a positive effect on the contractile function of the myocardium under the influence of damaging factors (ischemia, reperfusion): prevented a decrease of left ventricular developing pressure and its first derivative (velocity of pressure rise and velocity of pressure decline) and accelerated its growth during reperfusion. Co-administration of ATP and molsidomine during ischemia had a positive effect on the heart rhythm and restored heart rate at the reperfusion period in adult and old rats. The results of the study indicate a positive effect of the ATP-molsidomine combination on the myocardial contractility in old rats. Combined use of ATP and molsidomine exerted a favourable influence on the heart rhythm under damaging factors both in the adult and old animals.\u0000Key words: ATP; molsidomine; isolated rat heart; myocardial contractility; ageing","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87799244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative mathematical method for calculating biological age","authors":"A. Pisaruk","doi":"10.47855/jal9020-2021-2-1","DOIUrl":"https://doi.org/10.47855/jal9020-2021-2-1","url":null,"abstract":"Abstract. To eliminate the shortcomings of calculating biological age by the multiple regression method, an alternative mathematical approach is proposed. This method consists in calculating the average value of the ratio of the values of the indicators of the examined person to the average population values of these indicators. Comparison of this method with the regression method on the data set of healthy people showed that it eliminates the disadvantages of the regression method, but gives a slightly lower accuracy in assessing biological age.\u0000Keywords: biological age; mathematical method","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77123012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue 2 2021","authors":"","doi":"10.47855//jal9020-2021-2","DOIUrl":"https://doi.org/10.47855//jal9020-2021-2","url":null,"abstract":"","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73041043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Journal of Ageing and Longevity: Taking a Holistic View of the Human Healthspan","authors":"M. Tully, G. Pawelec","doi":"10.3390/JAL1010001","DOIUrl":"https://doi.org/10.3390/JAL1010001","url":null,"abstract":"It is our pleasure to inaugurate the new open access journal, the Journal of Ageing and Longevity (JAL, ISSN 2673-9259) [...]","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/JAL1010001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48689850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple method for correction of the systematic error in calculating biological age by the multiple regression equation","authors":"A. Pisaruk","doi":"10.47855/JAL9020-2021-1-2","DOIUrl":"https://doi.org/10.47855/JAL9020-2021-1-2","url":null,"abstract":"There was proposed аsimple method of the correction of systematic error of the equation of multiple regression while calculating biological age. The principle of this method is in the vertical transfer of points on the graph \"predicted age -chronologicalage\" on a diagonalline. At the same time, the distances from the points to the regression line are maintained. This correction eliminates the systematic error of the multiple regression equation and increases the accuracyof the biological age model.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"34 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73789179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influense of curcumin on lifespan if it is applied at the larval stage of drosophila melanogaster","authors":"A. Pisaruk, N. Koshel, L. Mekhova, O. Zabuga, S. Ivanov","doi":"10.47855//jal9020-2020-2-5","DOIUrl":"https://doi.org/10.47855//jal9020-2020-2-5","url":null,"abstract":"In this study we have applied the different doses of curcumin at the larval stages of a fruitfly Drosophila melanogaster and subsequently ivestigated its effect on the developmental duration and life expectancy of imago. It has been shown a 2-day delay in the hatching of the flies, which were developing in the medium containing 500 mM of curcumin. Exposure to curcumin significantly influenced on the average and maximum lifespan (ALS and MLS respectively) of all Drosofila in the study: ALS – F=13.01, p<0.001 for males and F=14.3, p<0.001 for females; MLS – F=35.9, p<0.001 for males and F=16.7, p <0.001 for females. Thus, the ALS in the males, which at the larval stage were kept in the medium containing 125 mM, 250 mM and 500 mM of curcumin, was significantly higher (p<0.001) comparing to the control. In females, such kind of significant increase in ALS has been shown at a dose of 500 mM of curcumin (p<0.001) in the medium during the developmental stage comparing to the control. In other words, the ALS of the imago has increased in correlation to the increase in the dose of curcumin applied at the developmental stage in males by 9%, 16%, 13%, and 23% and in females by 0%, 1%, 3%, 16% respectively. There has been also shown the sharp raise in MLS in both males and females, which at the larval stage were kept in the medium containing more than 125 mM of curcumin. To sum up we can assume that in this study consumption of curcumin at the larval stage of fruit flies significantly increased the developmental duration and life span of adult Drosophila, and this may demonstrate the effect of curcumin on the epigenetic programming of pace of life.\u0000Keywords: Development; Life span; Curcumin; Drosophila","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84863839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Express diagnostics of accelerated human aging using the questionnaire","authors":"A. Pisaruk, V. Shatilo, Ivanna Antonuk-Shchehlova, S. Naskalova","doi":"10.47855/jal9020-2020-2-4","DOIUrl":"https://doi.org/10.47855/jal9020-2020-2-4","url":null,"abstract":"Abstract. An express method of diagnosing accelerated aging of a person has been developed with the help of a questionnaire, which includes 15 indications of somatic aging, 12 indications of psychological aging and 10 objective indicators. The Bayesian method is used for the calculation of biological age. The accuracy of the definition for the biological age was 8.3 years. The method developed is notable for its simplicity, ease and accessibility for use in the outpatient and inpatient conditions. This method can be used for pre-selection of the patients with the risk of accelerated aging for the further in-depth studies. \u0000\u0000Keywords: biological age; accelerated aging; indicators of aging; Bayesian formula","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84685210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia resistance among the agedpatients with chronic obstructive lung disease: possibilities of using hypoxic trains","authors":"I. Dyba, E. Asanov, S. Asanova, J. Holubová","doi":"10.47855/jal9020-2020-1-3","DOIUrl":"https://doi.org/10.47855/jal9020-2020-1-3","url":null,"abstract":"Age-related morphological and functional changes in the body lead to the development of arterial hypoxemia, tissue hypoxia and hypoxic changes, which reduces the body's resistance to hypoxia and contributes to the development of lung diseases, in particular chronic obstructive pulmonary disease (COPD) in the elderly. The aim of the study was to clarify the effect of interval normobaric hypoxic training (INHT) on hypoxia resistance in elderly patients with COPD. The survey showed that with an increase in bronchial obstruction, the shifts of blood saturation during hypoxia increase. The course of INHT leads to increased resistance to hypoxia, and also increases the ventilation response to hypoxia in elderly patients with COPD.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87323138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined substance membratonon correction of theindicators of zoo-social behavior of old rats","authors":"T. Panteleymonova, L. Kuprash, L. Sharabura, I. Labunets, N. Sykalo, V. Olar","doi":"10.47855/jal9020-2020-1-2","DOIUrl":"https://doi.org/10.47855/jal9020-2020-1-2","url":null,"abstract":"Brain aging is accompanied by the development of an imbalance of the systems of chemical regulation of cells, a decrease in neurotrophic factors, and disorders of brain plasticity. Important place in the neurotransmitter changes in aging is given to the γ-aminobutyric acid (GABA), represented in the system of both external and internal neurotransmitters. With aging, the activity of GABA systems changes and the content of GABA in brain structures decreases, which is associated with impaired mental function and the development of pathology, in particular, dementia. Given the prevalence of pathology and the rate of population aging, the search for effective and safe means for the prevention and comprehensive metabolic treatment of age-related cognitive and psycho-emotional disorders remains relevant. In experiments on adult (10 months) and old (24 months) Wistar male rats, we investigated the pharmacological activity and age-specificities of the combination, including GABA and magnesium gluconate in the form of a coordination compound (γ-aminobutyro-Mg(II)–gluconate), and pyridoxine hydrochloride (Membraton). Tests \"dark / light camera\" and \"three-chamber activity\" established age differences in the behavior of rats. In older animals, amid increased anxiety, there was a decrease in zoo social interaction, such as communication, novelty preference, and social recognition. Under the influence of the course introduction of Membraton (100 and 500 mg / kg) in old rats, anxiety decreased and social activity increased: motivation and initiation of social contact increased, contact with an unfamiliar partner-stimulus increased, recognition of a familiar and unfamiliar partner was normalized. Under the influence of the remedy, indicators of social behavior of old animals approached the level of young animals. The established effects make it possible to consider Membraton as a promising metabolic therapy for increasing sociality in psycho-emotional disorders associated with age.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80969575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional age and residual working capacity in pensioners","authors":"Olena Tomarevska, O. Poliakov","doi":"10.47855/jal9020-2020-1-7","DOIUrl":"https://doi.org/10.47855/jal9020-2020-1-7","url":null,"abstract":"This investigation is dedicated to clarifying of physiological mechanisms of labor activity in subjects of a different gender and age with the purpose of a theoretical background of rational usage of human residual performance and rehabilitation of his health. When analyzing the tightness of the relationships, there is a stronger relationship between the residual performance and the calendar age than the rate of functional aging and calendar age. The study of concomitant influencing factors throughout life has been shown that the presence of labor or family migration within the region, within and between states; as well as indicators of the length of service, year, age, and reasons for retirement do not have reliable correlation with the rate of aging. Reliable correlation associations were found with continued retirement at the time of the study; with the year of termination of work; and the size of the total income of the examined individuals -associations in comparison with the relationship with the calendar age have a weaker connection with the rate of aging. With indicators of the class of tension and severity, type of work, class of intensity, class for differentiation of labor according to the ILO classification. Muscle strength and endurance in the women have expressed age dynamics. The muscle strength of the women is significantly slashed at 30-35 of years, and the muscle endurance remains stable up to 55-year’s age. For the men the dynamics of the muscle strength and endurance have no obvious age trend, and mostly depend from lifestyle, physical and labor activity. In functionally young subjects the working physical work capacity is 15-20% higher, compared to an average level, observed when the functional and calendar ages coincide. The age-related decline the physical working capacity in the older workers is decelerated owing to the selection of those who are functionally young and the elimination of those who age prematurely. The physiological capabilities that determine 47.54% of the actual performance of people aged 60 -89 years are reliably due to accelerated aging. Studies have shown high information content of using the indicator of residual performance in people over 60 years of age. A study of residual performance in people over 60 years of age showed that close to 57% of elderly people and 96.7% of senile people need ergonomic innovations in work and life to increase physical independence from outside help and compensate for age-related decline of working capacity.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81436029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}