ATP和莫西多明联合应用对成年和老年离体大鼠冠脉充分灌注、缺血和再灌注时心脏收缩功能的影响

V. Bezrukov, Liana Kuprush, N. Sykalo, T. Panteleymonova, L. Sharabura, V. Olar
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引用次数: 1

摘要

摘要心血管系统病理在老年人和老年患者的疾病结构中占有重要地位。代谢紊乱是中老年人心肌缺血性损伤的重要原因。因此,具有代谢作用机制的药物在老年心血管疾病的治疗中具有广阔的应用前景。使用具有代谢作用的药物的可行性决定了本研究的相关性,这些药物对心肌细胞的代谢有有益的作用,改善心肌的血供,增加心肌的收缩功能。通过体外实验研究了atp -莫西多明联合用药对不同年龄大鼠心肌收缩力的影响。对成年和老年大鼠离体心脏的实验表明,ATP和莫西多明在不同灌注条件下对成年大鼠离体心脏的收缩性没有显著影响。在老龄大鼠中,atp -莫西多明联合应用对心肌在损伤因素(缺血、再灌注)影响下的收缩功能有积极作用:阻止左心室发育压及其一阶导数(压力上升速度和压力下降速度)的下降,并加速其在再灌注时的生长。在缺血时,ATP和莫西多明对成年大鼠和老年大鼠的心律和再灌注期心率恢复均有积极影响。本研究结果提示atp -莫西多明联合用药对老年大鼠心肌收缩力有积极作用。ATP和莫西多明联合使用对成年和老年动物在损伤因素下的心律均有良好的影响。关键词:ATP;molsidomine;离体大鼠心脏;心肌收缩性;老化
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of ATP and molsidomine combination on contractile function of isolated adult and old rat hearts during adequate coronary perfusion, at ischemia and reperfusion
Abstract. Pathology of the cardiovascular system occupies a major place in the structure of diseases of the elderly and old patients. Metabolic disturbances are very important in ischemic damages of myocardium in the elderly and old people. So, drugі with metabolic mechanism of action is very ppromising in the treatment of elderly patients with cardiovascular diseases. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism of cardiomyocytes, improve blood supply to the myocardium, increase its contractile function. The effect of ATP-molsidomine combination on myocardial contractility in different age animals was stuiesy in vitro experiments. The experiments on the isolated hearts from adult and old rats have shown that combined use of ATP and molsidomine did not significantly affect the contractility of the isolated hearts of adult rats under different perfusion regimes. In old rats, the use of ATP-molsidomine combination had a positive effect on the contractile function of the myocardium under the influence of damaging factors (ischemia, reperfusion): prevented a decrease of left ventricular developing pressure and its first derivative (velocity of pressure rise and velocity of pressure decline) and accelerated its growth during reperfusion. Co-administration of ATP and molsidomine during ischemia had a positive effect on the heart rhythm and restored heart rate at the reperfusion period in adult and old rats. The results of the study indicate a positive effect of the ATP-molsidomine combination on the myocardial contractility in old rats. Combined use of ATP and molsidomine exerted a favourable influence on the heart rhythm under damaging factors both in the adult and old animals. Key words: ATP; molsidomine; isolated rat heart; myocardial contractility; ageing
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