Journal of ageing and longevity最新文献

{"title":"Effects of combined substance membratonon correction of theindicators of zoo-social behavior of old rats","authors":"T. Panteleymonova, L. Kuprash, L. Sharabura, I. Labunets, N. Sykalo, V. Olar","doi":"10.47855/jal9020-2020-1-2","DOIUrl":"https://doi.org/10.47855/jal9020-2020-1-2","url":null,"abstract":"Brain aging is accompanied by the development of an imbalance of the systems of chemical regulation of cells, a decrease in neurotrophic factors, and disorders of brain plasticity. Important place in the neurotransmitter changes in aging is given to the γ-aminobutyric acid (GABA), represented in the system of both external and internal neurotransmitters. With aging, the activity of GABA systems changes and the content of GABA in brain structures decreases, which is associated with impaired mental function and the development of pathology, in particular, dementia. Given the prevalence of pathology and the rate of population aging, the search for effective and safe means for the prevention and comprehensive metabolic treatment of age-related cognitive and psycho-emotional disorders remains relevant. In experiments on adult (10 months) and old (24 months) Wistar male rats, we investigated the pharmacological activity and age-specificities of the combination, including GABA and magnesium gluconate in the form of a coordination compound (γ-aminobutyro-Mg(II)–gluconate), and pyridoxine hydrochloride (Membraton). Tests \"dark / light camera\" and \"three-chamber activity\" established age differences in the behavior of rats. In older animals, amid increased anxiety, there was a decrease in zoo social interaction, such as communication, novelty preference, and social recognition. Under the influence of the course introduction of Membraton (100 and 500 mg / kg) in old rats, anxiety decreased and social activity increased: motivation and initiation of social contact increased, contact with an unfamiliar partner-stimulus increased, recognition of a familiar and unfamiliar partner was normalized. Under the influence of the remedy, indicators of social behavior of old animals approached the level of young animals. The established effects make it possible to consider Membraton as a promising metabolic therapy for increasing sociality in psycho-emotional disorders associated with age.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80969575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional age and residual working capacity in pensioners","authors":"Olena Tomarevska, O. Poliakov","doi":"10.47855/jal9020-2020-1-7","DOIUrl":"https://doi.org/10.47855/jal9020-2020-1-7","url":null,"abstract":"This investigation is dedicated to clarifying of physiological mechanisms of labor activity in subjects of a different gender and age with the purpose of a theoretical background of rational usage of human residual performance and rehabilitation of his health. When analyzing the tightness of the relationships, there is a stronger relationship between the residual performance and the calendar age than the rate of functional aging and calendar age. The study of concomitant influencing factors throughout life has been shown that the presence of labor or family migration within the region, within and between states; as well as indicators of the length of service, year, age, and reasons for retirement do not have reliable correlation with the rate of aging. Reliable correlation associations were found with continued retirement at the time of the study; with the year of termination of work; and the size of the total income of the examined individuals -associations in comparison with the relationship with the calendar age have a weaker connection with the rate of aging. With indicators of the class of tension and severity, type of work, class of intensity, class for differentiation of labor according to the ILO classification. Muscle strength and endurance in the women have expressed age dynamics. The muscle strength of the women is significantly slashed at 30-35 of years, and the muscle endurance remains stable up to 55-year’s age. For the men the dynamics of the muscle strength and endurance have no obvious age trend, and mostly depend from lifestyle, physical and labor activity. In functionally young subjects the working physical work capacity is 15-20% higher, compared to an average level, observed when the functional and calendar ages coincide. The age-related decline the physical working capacity in the older workers is decelerated owing to the selection of those who are functionally young and the elimination of those who age prematurely. The physiological capabilities that determine 47.54% of the actual performance of people aged 60 -89 years are reliably due to accelerated aging. Studies have shown high information content of using the indicator of residual performance in people over 60 years of age. A study of residual performance in people over 60 years of age showed that close to 57% of elderly people and 96.7% of senile people need ergonomic innovations in work and life to increase physical independence from outside help and compensate for age-related decline of working capacity.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81436029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of quercetin on the functional state of platelets and the viscosity of blood among the aged people with the metabolic syndrome","authors":"S. Naskalova, O. Korkushko, Ivanna Antonuk-Shchehlova, G. Duzhak, O. Bondarenko, O. Grib, V. Shatilo","doi":"10.47855/jal9020-2020-1-5","DOIUrl":"https://doi.org/10.47855/jal9020-2020-1-5","url":null,"abstract":"The purpose of this research was to study the effect of quercetin on the functional state of platelets and blood viscosity among the aged patients with the metabolic syndrome (MS). 110 patients with MS in the age of 60-75 years were divided equally into the main and control groups. The patients of the main group received quercetin for 3 months (drug \"Quertin\", chewable tablets produced by private joint stock company scientific-productional centre \"Borschagovsky chemical pharmaceutical plant\") in dose 80 mg 3 times per day. The examined subjects from the control group were treated with placebo for the same time. Before and after the course of treatment, MS criteria were evaluated, platelet aggregation capacity, blood viscosity, and serum lipid levels were determined. After course treatment with quercetin, the rheological properties of blood were improved: its viscosity, spontaneous and induced aggregation of the platelets were decreased. A statistically significant decrease of total cholesterol and low density lipoprotein (LDL) cholesterol in serum was observed. Correlation analysis showed that the improvement of blood viscosity was due to the favorable changes in the lipid spectrum and a decrease of the aggregation capacity of platelets. Thus, the obtained results indicate that the use of course of quercetin by the aged patients with metabolic syndrome (within 3 months) reduces the manifestation of dyslipidemia, increased spontaneous and induced platelet aggregation, contributes to the increase of erythrocyte deformity index that together lead to a decrease of blood viscosity as one of the risk factors for complications of metabolic syndrome.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84529226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}