Jaclyn P. Maher, Kourtney Sappenfield, Heidi Scheer, Christine Zecca, D. Hevel, L. Kennedy-Malone
{"title":"Feasibility and Validity of Assessing Low-Income, African American Older Adults’ Physical Activity and Sedentary Behavior Through Ecological Momentary Assessment","authors":"Jaclyn P. Maher, Kourtney Sappenfield, Heidi Scheer, Christine Zecca, D. Hevel, L. Kennedy-Malone","doi":"10.1123/jmpb.2021-0024","DOIUrl":"https://doi.org/10.1123/jmpb.2021-0024","url":null,"abstract":"Ecological momentary assessment (EMA) is a methodological tool that can provide novel insights into the prediction and modeling of physical behavior; however, EMA has not been used to study physical activity (PA) or sedentary behavior (SB) among racial minority older adults. This study aimed to determine the feasibility and validity of an EMA protocol to assess racial minority older adults’ PA and SB. For 8 days, older adults (n = 91; 89% African American; 70% earning <$20,000/year) received six randomly prompted, smartphone-based EMA questionnaires per day and wore an activPAL monitor to measure PA and SB. The PA and SB were also self-reported through EMA. Participants were compliant with the EMA protocol on 92.4% of occasions. Participants were more likely to miss an EMA prompt in the afternoon compared to morning and on weekend days compared to weekdays. Participants were less likely to miss an EMA prompt when engaged in more device-based SB in the 30 min around the prompt. When participants self-reported PA, they engaged in less device-based PA in the 15 min after compared to the 15 min before the EMA prompt, suggesting possible reactance or disruption of PA. EMA-reported PA and SB were positively associated with device-based PA and SB in the 30 min around the EMA prompt, supporting criterion validity. Overall, the assessment of low-income, African American older adults’ PA and SB through EMA is feasible and valid, though physical behaviors may influence compliance and prompting may create reactivity.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79442107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the Polar M430 a Valid Tool for Estimating Maximal Oxygen Consumption in Adult Females?","authors":"K. Miller, T. Kempf, Brian C. Rider, S. Conger","doi":"10.1123/jmpb.2020-0050","DOIUrl":"https://doi.org/10.1123/jmpb.2020-0050","url":null,"abstract":"Background: Previous research studies have found that heart rate monitors that predict maximal oxygen consumption () are valid for males but overestimate in females. Inaccurate self-reported physical activity (PA) levels may affect the validity of the prediction algorithm used to predict . Purpose: To investigate the validity of the Polar M430 in predicting among females with varying PA levels. Methods: Polar M430 was used to predict () for 43 healthy female study participants (26.9 ± 1.3 years), under three conditions: the participant’s self-selected PA category (sPA), one PA category below the sPA (sPA − 1), and one category above the sPA (sPA + 1). Indirect calorimetry was utilized to measure () via a modified Astrand treadmill protocol. Repeated-measures analyses of covariance using age and percentage of body fat as covariates were used to detect differences between groups. Bland–Altman plots were used to assess the precision of the measurement. Results: was significantly correlated with (r = .695, p < .001). The mean values for and were 44.58 ± 9.29 and 43.98 ± 8.76, respectively. No significant differences were found between , , sPA – 1, and sPA + 1 (p = .492). However, the Bland–Altman plots indicated a low level of precision with the estimate. Conclusions: The Polar M430 was a valid method to predict across different sPA levels in females. Moreover, an under/overestimation in sPA had little effect on the predicted .","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84279507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent Validity of ActiGraph GT3X+ and Axivity AX3 Accelerometers for Estimating Physical Activity and Sedentary Behavior","authors":"Leila Hedayatrad, T. Stewart, S. Duncan","doi":"10.1123/jmpb.2019-0075","DOIUrl":"https://doi.org/10.1123/jmpb.2019-0075","url":null,"abstract":"Introduction: Accelerometers are commonly used to assess time-use behaviors related to physical activity, sedentary behavior, and sleep; however, as new accelerometer technologies emerge, it is important to ensure consistency with previous devices. This study aimed to evaluate the concurrent validity of the commonly used accelerometer, ActiGraph GT3X+, and the relatively new Axivity AX3 (fastened to the lower back) for detecting physical activity intensity and body postures when using direct observation as the criterion measure. Methods: A total of 41 children (aged 6–16 years) and 33 adults (aged 28–59 years) wore both monitors concurrently while performing 10 prescribed activities under laboratory conditions. The GT3X+ data were categorized into different physical activity intensity and posture categories using intensity-based cut points and ActiGraph proprietary inclinometer algorithms, respectively. The AX3 data were first converted to ActiGraph counts before being categorized into different physical activity intensity categories, while activity recognition models were used to detect the target postures. Sensitivity, specificity, and the balanced accuracy for intensity and posture category classification were calculated for each accelerometer. Differences in balanced accuracy between the devices and between children and adults were also calculated. Results: Both accelerometers obtained 74–96% balanced accuracy, with the AX3 performing slightly better (∼4% higher, p < .01) for detecting postures and physical activity intensity. Error in both devices was greatest when contrasting sitting/standing, sedentary/light intensity, and moderate/light intensity. Conclusion: In comparison with the GT3X+ accelerometer, AX3 was able to detect various postures and activity intensities with slightly higher balanced accuracy in children and adults.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77557799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent Measurement of Global Positioning System and Event-Based Physical Activity Data: A Methodological Framework for Integration","authors":"Anna M. J. Iveson, M. Granat, B. Ellis, P. Dall","doi":"10.1123/jmpb.2020-0005","DOIUrl":"https://doi.org/10.1123/jmpb.2020-0005","url":null,"abstract":"Objective: Global positioning system (GPS) data can add context to physical activity data and have previously been integrated with epoch-based physical activity data. The current study aimed to develop a framework for integrating GPS data and event-based physical activity data (suitable for assessing patterns of behavior). Methods: A convenience data set of concurrent GPS (AMOD) and physical activity (activPAL) data were collected from 69 adults. The GPS data were (semi)regularly sampled every 5 s. The physical activity data output was presented as walking events, which are continuous periods of walking with a time-stamped start time and duration (to nearest 0.1 s). The GPS outcome measures and the potential correspondence of their timing with walking events were identified and a framework was developed describing data integration for each combination of GPS outcome and walking event correspondence. Results: The GPS outcome measures were categorized as those deriving from a single GPS point (e.g., location) or from the difference between successive GPS points (e.g., distance), and could be categorical, scale, or rate outcomes. Walking events were categorized as having zero (13% of walking events, 3% of walking duration), or one or more (52% of walking events, 75% of walking duration) GPS points occurring during the event. Additionally, some walking events did not have GPS points suitably close to allow calculation of outcome measures (31% of walking events, 22% of walking duration). The framework required different integration approaches for each GPS outcome type, and walking events containing zero or more than one GPS points.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78108962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathalie Berninger, Gregory Knell, Kelley Pettee Gabriel, Guy Plasqui, Rik Crutzen, Gill Ten Hoor
{"title":"Bidirectional Day-to-Day Associations of Reported Sleep Duration With Accelerometer Measured Physical Activity and Sedentary Time Among Dutch Adolescents: An Observational Study.","authors":"Nathalie Berninger, Gregory Knell, Kelley Pettee Gabriel, Guy Plasqui, Rik Crutzen, Gill Ten Hoor","doi":"10.1123/jmpb.2020-0010","DOIUrl":"https://doi.org/10.1123/jmpb.2020-0010","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the bidirectional association of sleep duration with proportions of time spent in physical behaviors among Dutch adolescents.</p><p><strong>Methods: </strong>Adolescents (<i>n</i> = 294, 11-15 years) completed sleep diaries and wore an accelerometer (ActiGraph) over 1 week. With linear mixed-effects models, the authors estimated the association of sleep categories (short, optimal, and long) with the following day's proportion in physical behaviors. With generalized linear mixed models with binomial distribution, the authors estimated the association of physical behavior proportions on sleep categories. Physical behavior proportions were operationalized using percentages of wearing time and by applying a compositional approach. All analyses were stratified by gender accounting for differing developmental stages.</p><p><strong>Results: </strong>For males (number of observed days: 345, <i>n</i> = 83), short as compared with optimal sleep was associated with the following day's proportion spent in sedentary (-2.57%, <i>p</i> = .03, 95% confidence interval [CI] [-4.95, -0.19]) and light-intensity activities (1.96%, <i>p</i> = .02, 95% CI [0.27, 3.65]), which was not significant in the compositional approach models. Among females (number of observed days: 427, <i>n</i> = 104), long sleep was associated with the proportions spent in moderate- to vigorous-intensity physical activity (1.69%, <i>p</i> < .001, 95% CI [0.75, 2.64]) and in sedentary behavior (-3.02%, <i>p</i> < .01, 95% CI [-5.09, -0.96]), which was replicated by the compositional approach models. None of the associations between daytime activity and sleep were significant (number of obs.: 844, <i>n</i> = 204).</p><p><strong>Conclusions: </strong>Results indicate partial associations between sleep and the following day's physical behaviors, and no associations between physical behaviors and the following night's sleep.</p>","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"3 4","pages":"304-314"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica S. Gorzelitz, Chloe Farber, R. Gangnon, L. Cadmus-Bertram
{"title":"Accuracy of Wearable Trackers for Measuring Moderate- to Vigorous-Intensity Physical Activity: A Systematic Review and Meta-Analysis","authors":"Jessica S. Gorzelitz, Chloe Farber, R. Gangnon, L. Cadmus-Bertram","doi":"10.1123/jmpb.2019-0072","DOIUrl":"https://doi.org/10.1123/jmpb.2019-0072","url":null,"abstract":"Background: The evidence base regarding validity of wearable fitness trackers for assessment and/or modification of physical activity behavior is evolving. Accurate assessment of moderate- to vigorous-intensity physical activity (MVPA) is important for measuring adherence to physical activity guidelines in the United States and abroad. Therefore, this systematic review synthesizes the state of the validation literature regarding wearable trackers and MVPA. Methods: A systematic search of the PubMed, Scopus, SPORTDiscus, and Cochrane Library databases was conducted through October 2019 (PROSPERO registration number: CRD42018103808). Studies were eligible if they reported on the validity of MVPA and used devices from Fitbit, Apple, or Garmin released in 2012 or later or available on the market at the time of review. A meta-analysis was conducted on the correlation measures comparing wearables with the ActiGraph. Results: Twenty-two studies met the inclusion criteria; all used a Fitbit device; one included a Garmin model and no Apple-device studies were found. Moderate to high correlations (.7–.9) were found between MVPA from the wearable tracker versus criterion measure (ActiGraph n = 14). Considerable heterogeneity was seen with respect to the specific definition of MVPA for the criterion device, the statistical techniques used to assess validity, and the correlations between wearable trackers and ActiGraph across studies. Conclusions: There is a need for standardization of validation methods and reporting outcomes in individual studies to allow for comparability across the evidence base. Despite the different methods utilized within studies, nearly all concluded that wearable trackers are valid for measuring MVPA.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83302400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Salim, F. Haider, D. Postma, R. V. Delden, D. Reidsma, S. Luz, B. Beijnum
{"title":"Towards Automatic Modeling of Volleyball Players’ Behavior for Analysis, Feedback, and Hybrid Training","authors":"F. Salim, F. Haider, D. Postma, R. V. Delden, D. Reidsma, S. Luz, B. Beijnum","doi":"10.1123/jmpb.2020-0012","DOIUrl":"https://doi.org/10.1123/jmpb.2020-0012","url":null,"abstract":"Automatic tagging of video recordings of sports matches and training sessions can be helpful to coaches and players and provide access to structured data at a scale that would be unfeasible if one were to rely on manual tagging. Recognition of different actions forms an essential part of sports video tagging. In this paper, the authors employ machine learning techniques to automatically recognize specific types of volleyball actions (i.e., underhand serve, overhead pass, serve, forearm pass, one hand pass, smash, and block which are manually annotated) during matches and training sessions (uncontrolled, in the wild data) based on motion data captured by inertial measurement unit sensors strapped on the wrists of eight female volleyball players. Analysis of the results suggests that all sensors in the inertial measurement unit (i.e., magnetometer, accelerometer, barometer, and gyroscope) contribute unique information in the classification of volleyball actions types. The authors demonstrate that while the accelerometer feature set provides better results than other sensors, overall (i.e., gyroscope, magnetometer, and barometer) feature fusion of the accelerometer, magnetometer, and gyroscope provides the bests results (unweighted average recall = 67.87%, unweighted average precision = 68.68%, and κ = .727), well above the chance level of 14.28%. Interestingly, it is also demonstrated that the dominant hand (unweighted average recall = 61.45%, unweighted average precision = 65.41%, and κ = .652) provides better results than the nondominant (unweighted average recall = 45.56%, unweighted average precision = 55.45, and κ = .553) hand. Apart from machine learning models, this paper also discusses a modular architecture for a system to automatically supplement video recording by detecting events of interests in volleyball matches and training sessions and to provide tailored and interactive multimodal feedback by utilizing an HTML5/JavaScript application. A proof of concept prototype developed based on this architecture is also described.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72690957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Small, S. Khalid, P. Dhiman, Shing Chan, D. Jackson, A. Doherty, A. Price
{"title":"Impact of Reduced Sampling Rate on Accelerometer-based Physical Activity Monitoring and Machine Learning Activity Classification","authors":"S. Small, S. Khalid, P. Dhiman, Shing Chan, D. Jackson, A. Doherty, A. Price","doi":"10.1101/2020.10.22.20217927","DOIUrl":"https://doi.org/10.1101/2020.10.22.20217927","url":null,"abstract":"Purpose: Lowering the sampling rate of accelerometer devices can dramatically increase study monitoring periods through longer battery life, however the validity of its output is poorly documented. We therefore aimed to assess the effect of reduced sampling rate on measuring physical activity both overall and by specific behaviour types. Methods: Healthy adults wore two Axivity AX3 accelerometers on the dominant wrist and two on the hip for 24 hours. At each location one accelerometer recorded at 25 Hz and the other at 100 Hz. Overall acceleration magnitude, time in moderate-to-vigorous activity, and behavioural activities were calculated using standard methods. Correlation between acceleration magnitude and activity classifications at both sampling rates was calculated and linear regression was performed. Results: 54 participants wore both hip and wrist monitors, with 45 of the participants contributing >20 hours of wear time at the hip and 51 contributing >20 hours of wear time at the wrist. Strong correlation was observed between 25 Hz and 100 Hz sampling rates in overall activity measurement (r = 0.962 to 0.991), yet consistently lower overall acceleration was observed in data collected at 25 Hz (12.3% to 12.8%). Excellent agreement between sampling rates was observed in all machine learning classified activities (r = 0.850 to 0.952). Wrist-worn vector magnitude measured at 25 Hz (Acc25) can be compared to 100 Hz (Acc100) data using the transformation, Acc100 = 1.038*Acc25 + 3.310. Conclusions: 25 Hz and 100 Hz accelerometer data are highly correlated with predictable differences which can be accounted for in inter-study comparisons. Sampling rate should be consistently reported in physical activity studies, carefully considered in study design, and tailored to the outcome of interest.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90245605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alanna Weisberg, A. M. Campelo, Tanzeel Bhaidani, L. Katz
{"title":"Physical Activity Tracking Wristbands for Use in Research With Older Adults: An Overview and Recommendations","authors":"Alanna Weisberg, A. M. Campelo, Tanzeel Bhaidani, L. Katz","doi":"10.1123/JMPB.2019-0050","DOIUrl":"https://doi.org/10.1123/JMPB.2019-0050","url":null,"abstract":"Traditional physical activity tracking tools, such as self-report questionnaires, are inherently subjective and vulnerable to bias. Physical activity tracking technology, such as activity tracking wristbands, is becoming more reliable and readily available. As such, researchers are employing these objective measurement tools in both observational- and intervention-based studies. There remains a gap in the literature on how to properly select activity tracking wristbands for research, specifically for the older adult population. This paper outlines considerations for choosing the most appropriate wrist-worn wearable device for use in research with older adults. Device features, outcome measures, population, and methodological considerations are explored.","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":"163 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87168200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul R Hibbing, Samuel R LaMunion, Haileab Hilafu, Scott E Crouter
{"title":"Evaluating the Performance of Sensor-based Bout Detection Algorithms: The Transition Pairing Method.","authors":"Paul R Hibbing, Samuel R LaMunion, Haileab Hilafu, Scott E Crouter","doi":"10.1123/jmpb.2019-0039","DOIUrl":"https://doi.org/10.1123/jmpb.2019-0039","url":null,"abstract":"<p><p>Bout detection algorithms are used to segment data from wearable sensors, but it is challenging to assess segmentation correctness.</p><p><strong>Purpose: </strong>To present and demonstrate the Transition Pairing Method (TPM), a new method for evaluating the performance of bout detection algorithms.</p><p><strong>Methods: </strong>The TPM compares predicted transitions to a criterion measure in terms of number and timing. A true positive is defined as a predicted transition that corresponds with one criterion transition in a mutually exclusive pair. The pairs are established using an extended Gale-Shapley algorithm, and the user specifies a maximum allowable within-pair time lag, above which pairs cannot be formed. Unpaired predictions and criteria are false positives and false negatives, respectively. The demonstration used raw acceleration data from 88 youth who wore ActiGraph GT9X monitors (right hip and non-dominant wrist) during simulated free-living. Youth Sojourn bout detection algorithms were applied (one for each attachment site), and the TPM was used to compare predicted bout transitions to the criterion measure (direct observation). Performance metrics were calculated for each participant, and hip-versus-wrist means were compared using paired T-tests (α = 0.05).</p><p><strong>Results: </strong>When the maximum allowable lag was 1-s, both algorithms had recall <20% (2.4% difference from one another, p<0.01) and precision <10% (1.4% difference from one another, p<0.001). That is, >80% of criterion transitions were undetected, and >90% of predicted transitions were false positives.</p><p><strong>Conclusion: </strong>The TPM improves on conventional analyses by providing specific information about bout detection in a standardized way that applies to any bout detection algorithm.</p>","PeriodicalId":73572,"journal":{"name":"Journal for the measurement of physical behaviour","volume":" ","pages":"219-227"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274497/pdf/nihms-1599163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}