JAR life最新文献

{"title":"Associations Between Multidomain Lifestyle Interventions and Intrinsic Capacity Domains During Aging: A Narrative Review.","authors":"M Fourteau,&nbsp;K Virecoulon Giudici,&nbsp;Y Rolland,&nbsp;B Vellas,&nbsp;P de Souto Barreto","doi":"10.14283/jarlife.2020.6","DOIUrl":"https://doi.org/10.14283/jarlife.2020.6","url":null,"abstract":"<p><strong>Background: </strong>Recently, the World Health Organization defined five domains of intrinsic capacity (IC), composed of physical and mental capacities linked to body functions, and that contribute to healthy aging: locomotion, cognition, psychological, vitality and sensorial. In the past decade, studies investigating the effects of concomitant lifestyle interventions (also called multidomain interventions) on one or several IC domains have been developed. The aim of this study is to synthetize the scientific literature about the associations between multidomain lifestyle interventions and IC domains.</p><p><strong>Methods: </strong>We conducted a narrative review of randomized controlled trials examining the effects of multidomain lifestyle interventions on at least one IC domain among older people. Multidomain intervention was defined as the presence of at least two of the following lifestyle interventions: physical activity/exercise, nutrition, cognitive stimulation, and management of cardiovascular risk factors (eg, smoking, alcohol consumption).</p><p><strong>Results: </strong>Multidomain interventions were associated with improvements on locomotion (as measured by performance-based tests of lower-limb function) and vitality (as measured by handgrip strength); benefits on cognitive function were also found, in particular among populations at increased risk of dementia and when operationalizing strong multidomain interventions (eg, using regular exercise training instead of physical activity advices). No study investigated the effects of multidomain lifestyle interventions on the sensorial domain (hearing and/or vision). The modalities composing the multidomain interventions and intervention length, as well as study population, substantially varied across studies; the most common combination of interventions was physical activity- and nutritional-related interventions.</p><p><strong>Conclusion: </strong>Available evidence is still limited, but literature suggests a positive effect of multidomain lifestyle interventions on IC domains, in particular locomotion. Further studies are still needed on this topic, in particular, studies exploring the effects of multidomain lifestyle interventions on the sensorial domain, as well as on a composite measurement of all IC domains.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"9 ","pages":"16-25"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002877/pdf/jarlife-9-016.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9119887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MALNUTRITION POINT-PREVALENCE FROM 2012 TO 2019 AND ASSOCIATED HEALTH-OUTCOMES IN ADULT PATIENTS IN RURAL HOSPITALS","authors":"Eloisa Lopez, M. Banbury, E. Isenring, Skye Marshall","doi":"10.14283/jarcp.2019.16","DOIUrl":"https://doi.org/10.14283/jarcp.2019.16","url":null,"abstract":"Background: Malnutrition negatively impacts hospitalised patients and the healthcare system. Objectives: 1) report point-prevalence of hospital malnutrition from 2012 to 2019; and 2) determine if there was an association between nutrition status and health-related outcomes. Design: Point-prevalence of malnutrition was determined by three (2012, 2014, and 2019) cross-sectional studies. Health-related outcomes, assessed by a prospective cohort study in 2014, were length of stay, in-hospital mortality, hospital readmission, infection, falls, fractures, and pressure wounds. Setting: three Australian rural hospitals. Participants: Adult inpatients. Measurements: Nutrition status was assessed with the Subjective Global Assessment (SGA) tool. Results: Malnutrition point prevalence was 39% in 2012 (n=62), 48% in 2014 (n=128), and 28% in 2019 (n=96); where the prevalence in 2019 was significantly lower than in 2014 (p<0.017). The 2019 (median age 70 years) sample was younger than the 2012 (median age 80 years) and 2014 (median age 78 years) samples (p<0.05). Mortality and falls rate were higher in the severely malnourished participants (p=<0.05); and severe malnutrition may predict mortality (Adjusted OR: 3.47 (95%CI: 0.94, 12.78] p=0.061). Conclusions: Nutrition status did not predict other health-related outcomes. The rate of malnutrition in rural hospitals was consistently high and may increase the risk of in-hospital mortality.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41713095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADEQUACY OF CURRENT AND FUTURE INCOME AND ASSETS AND THE RISK OF MORTALITY IN A COHORT OF OLDER MEN – THE MANITOBA FOLLOW-UP STUDY","authors":"P. S. St John, R. Tate","doi":"10.14283/jarcp.2019.14","DOIUrl":"https://doi.org/10.14283/jarcp.2019.14","url":null,"abstract":"Background: Income security is a determinant of health in most populations, but there is less evidence in very old men. Objective: To determine if self-reported current income adequacy or future expectation of income adequacy predicts death amongst older men. Design and Setting: We conducted an analysis of a prospective cohort of 3 983 men who have been followed since 1948. In 2006, 1001 men were alive, of whom 807 completed the annual survey without assistance. Two items in the 2006 survey were: “How well do you think your income and assets satisfy your current needs?” and “How well do you think your income and assets will satisfy your needs in the future?” We considered the categories: “very adequate, adequate and inadequate.” Time to death over the next 11 years was examined with the Cox proportional hazards models, and adjusted for age, marital status, and functional status. Results: The mean age in 2006 was 85 years old. The median follow-up time was 6.1 years, and 664 of the participants died. Satisfaction with current income did not predict mortality. Those with an expectation of inadequate future income had a higher risk of death: Hazard Ratio of 1.37 [(95%CI) 1.02, 1.84)] for “Not adequate” relative to “Very Adequate”. In models adjusted for age, marital status and functional status, this association was only marginally statistically significant (p=0.07). Conclusions: Perceived adequacy of future income predicts mortality in very old men. The effect may be confounded or mediated by functional decline.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66885877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NUTRITIONAL ADEQUACY AND ORAL NUTRITIONAL SUPPLEMENTATION IN OLDER COMMUNITY-DWELLING ADULTS","authors":"L. McKeever, I. Farrar, S. Sulo, J. Partridge, Patricia M Sheean, M. Fitzgibbon","doi":"10.14283/jarcp.2019.2","DOIUrl":"https://doi.org/10.14283/jarcp.2019.2","url":null,"abstract":"Background: Older adults (65 years and older) comprise a high-risk group that are susceptible to the development of malnutrition. Dietary intake and diet quality represent key modifiable risk factors to help prevent and to treat declines in nutrition status, with oral nutritional supplements (ONS) often being a cost-effective therapy for many to increase protein and caloric intake. The DETERMINE Checklist offers a series of questions capable of mapping the initial landscape of contextual factors that influence the dietary patterns of the at-risk populations. Objectives: To examine independent predictors of inadequate dietary intake and poor diet quality amongst a multi-ethnic sample of urban community-dwelling older adults in an effort to identify target groups of participants that could benefit most from an ONS intervention. Design: Cross-sectional. Participants: Chicago, Illinois, United States urban residents greater than 55 years of age who self-reported to be non-Hispanic White, non-Hispanic Black, or Hispanic. Methods: Telephone surveys were conducted to obtain basic demographic information. The DETERMINE Checklist was administered to (1) characterize participants’ nutritional risk, and (2) identify participants with inadequate intake and/or poor diet quality. Predictors of inadequate intake, defined as any participant who reported either to eat less than two meals per day and/or poor diet quality, defined as any participant who reported to eat few fruits, vegetables or dairy were used to identify groups of participants who could benefit most from ONS consumption. Mantel-Hanzel chi square, Breslow-day tests, and logistic regressions were conducted. Results: 1001 ethnically diverse participants were interviewed (37% non-Hispanic White, 37% non-Hispanic Black, and 26% Hispanic). Respondents were predominantly female (69%) with a mean age of 66.9 (± 6.4) years. The majority were found to be at either moderate or high nutrition risk (78.7%). Domains of the DETERMINE Checklist that predicted either inadequate dietary intake or poor diet quality included social isolation, lower levels of educational attainment, food insecurity, limitations in activities of daily living (ADL), polypharmacy, or three or more alcoholic drinks per day. Of the participants who met the criteria as those who would benefit from ONS, less than 50% had reported consuming ONS in the past six months. Conclusion: Older community-dwelling adults living in an urban setting, especially those with social isolation, lower levels of education, food insecurity, limitations with ADLs, polypharmacy, and those reporting heavy alcohol intake represent a population who could benefit from consuming ONS. Efforts should be made towards further understanding these contextual factors and providing nutrition education along with an ONS intervention that could be beneficial to supplement dietary inadequacies in this population.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66886310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KNOWLEDGE OF COMMONLY PRESCRIBED MEDICATIONS TO OCTOGENARIANS","authors":"T. V. N. Didone, D. Melo, E. Ribeiro","doi":"10.14283/jarcp.2019.12","DOIUrl":"https://doi.org/10.14283/jarcp.2019.12","url":null,"abstract":"Eighty outpatients aged 80 years or more were face-to-face interviewed in order to assess the appropriate recall of six items of information about the 19 most commonly prescribed medications by means of a questionnaire cross-culturally adapted into Brazilian Portuguese. In some cases, the caregiver was interviewed instead. The frequency of medications whose information was appropriately recalled ranged from 36% to 100%, 36% to 100%, 18% to 90%, 9% to 63%, 0 to 25%, and 0 to 10% for respectively the following items dosage, form of administration, indication, storage, side effects, and precautions and warnings, indicating poor overall knowledge. The lowest frequency of dosage and form of administration was seen for alendronic acid (36% each), and the highest frequency of side effects was found for donepezil (25%). Octagenarians and their caregivers should be constantly counseled on medication information.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66885635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VALIDITY OF MALNUTRITION UNIVERSAL SCREENING TOOL (MUST) IN GERIATRIC PATIENTS: APPROPRIATE SCREENING TOOL IN HOSPITAL; MUST OR FULL-MNA?","authors":"S. Hormozi, M. Alizadeh-Khoei, F. Sharifi, M. Chehrehgosha, R. Esmaeili, F. Rezaie-Abhari, R. Aminalroaya, Z. Madadi","doi":"10.14283/jarcp.2019.13","DOIUrl":"https://doi.org/10.14283/jarcp.2019.13","url":null,"abstract":"Background: Since malnutrition of geriatric hospitalized patients has an impact on treatment and care management, the aim was to define the accuracy of Malnutrition Universal Screening Test (MUST) for malnutrition screening in the Iranian hospitalized elderly. Methods: In this cross-sectional study elderly 60 ≥ years (N= 192) were selected from two hospitals, anthropometric measures (BMI, MAC, and CC), laboratory test (Albumin), and nutrition tool (Full-MNA) applied and analyzed at P<0.05 level. Results: Elderly participants had a mean age of 68.86 ± 7.46 years and BMI 24.08± 4.64. Elderly patients (28%) lost their weight (>10%) in the last six months and loss of appetite observed in (33.4%) participants. In MUST tool rating, high-risk elderly patients for malnutrition were 33.3%. The AUC for MUST, according to Full-MNA was obtained 90.41%, with sensitivity 90.0% and specificity 73.25%. The MUST showed the strongest correlation with Full-MNA (r = -0.7) and BMI (r = - 0.51); but, the lowest correlation observed with Alb (r= -0.274). Most AUC was belonging to weight loss (0.96) and BMI (0.94). NConclusion: The MUST tool like full-MNA could diagnose malnutrition in geriatric patients in the hospital setting.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66885782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOLERABILITY, COMPLIANCE, AND PRODUCT EVALUATION OF A PRE-THICKENED ORAL NUTRITIONAL SUPPLEMENT FOR DISEASE RELATED MALNUTRITION IN PATIENTS WITH DYSPHAGIA","authors":"T. Dennehy, F. Veldkamp, M. Lansink, R. Schulz","doi":"10.14283/jarcp.2019.15","DOIUrl":"https://doi.org/10.14283/jarcp.2019.15","url":null,"abstract":"Background: Oropharyngeal dysphagia is a prevalent risk factor for malnutrition in older patients and both conditions are related to poor outcome. For the management of (risk of) malnutrition in patients with oropharyngeal dysphagia pre-thickened oral nutritional supplements are available. Objective: The objective of the study is to describe tolerance parameters (stool frequency and incidence and intensity of gastrointestinal symptoms), study product intake (compliance), product appreciation and product properties of a pre-thickened oral nutritional supplement compared to a manually-thickened standard oral nutritional supplement. Design: A randomized, open label, controlled, parallel group study. Setting: participants were recruited through nine general practices in Ireland, one nursing home in The Netherlands, and one hospital in Germany. Participants: Fifty patients requiring oral nutritional support (twenty-four of fifty cases (48%) with dysphagia) were divided into two groups: test group (N = 27) and control group (N = 23). Intervention: During four weeks the test group received a ready-to-use, low volume (125 mL), and energy dense pre-thickened oral nutritional supplement, and the control group a manually-thickened iso-caloric oral nutritional supplement (200 mL) with a similar viscosity. Measurements: Compliance and stool frequency were recorded daily, evaluation of the product appreciation and properties and gastrointestinal tolerability were assessed with questionnaires. Results: Incidence and intensity of gastrointestinal symptoms was not statistically different between groups. Pre-thickened oral nutritional supplement scored significantly better on compliance in week 4 (p = 0.019), on thickness appreciation by patients (day 14, p = 0.035) and on product properties evaluation by carers (appearance, preparation time, ease of preparation and change in thickness, all p < 0.001) compared to the manually-thickened ONS. Conclusion: These results substantiate the use of pre-thickened oral nutritional supplement for the dietary management of patients in need of nutritional support and with oropharyngeal dysphagia.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66886234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMYLOIDß, APP, AND DISCOVERIES IN THE TREATMENT OF ALZHEIMER’S DISEASE","authors":"G. Webb, T. Clemons","doi":"10.14283/jarcp.2019.5","DOIUrl":"https://doi.org/10.14283/jarcp.2019.5","url":null,"abstract":"","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66886481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF ß-HYDROXY-ß-METHYLBUTYRATE (HMB) ON MUSCLE STRENGTH IN OLDER ADULTS WITH LOW PHYSICAL FUNCTION","authors":"K. Kinoshita, S. Satake, Y. Matsui, S. Kawashima, H. Arai","doi":"10.14283/JARCP.2019.1","DOIUrl":"https://doi.org/10.14283/JARCP.2019.1","url":null,"abstract":"Objectives: To evaluate the effects of β-hydroxy-β-methylbutyrate (HMB) on muscle strength, physical performance, and muscle mass without additional exercise training in older adults with low physical function. Design: Randomized, controlled trial (Open-label study). Setting: Outpatients. Participants: 34 senior outpatients with low physical function who do not exercise regularly. Intervention: 2.4 g of HMB (3.0 g of calcium β-hydroxy-β-methylbutyrate [CaHMB]) per day was given for 60 days, and subjects in the control group were asked to engage in daily activities as normal. Measurements: Weakness or low function was defined by the Asian Working Group for Sarcopenia criteria, then the participants were assigned to the HMB group or the control group. All participants underwent several evaluations such as grip strength, the timed up and go test, the 5-times chair stand test (5CS), and skeletal muscle mass index by the bioimpedance method at baseline and at the end of intervention or control period. Results: An intragroup comparison of pre- to post-treatment values showed significant improvement in grip strength and the 5CS in the HMB group (grip strength: HMB, 16.6±6.1 kg to 18.2±6.4 kg, P=.001; control, 16.5±4.3 kg to 16.7±4.7 kg, P=.729; 5CS: HMB, 11.0 [8.8-13.0] s to 10.1 [8.5-12.6] s, P=.011; control, 11.1 [8.6-13.8] s to 10.0 [8.8-11.3] s, P=.246). Two-way repeated measures analysis of variance (ANOVA) used to compare the HMB and control groups showed a significant improvement in grip strength in the HMB group compared with the control group (P=.029). Conclusion: A supplementation of HMB without additional exercise may improve muscle strength in older patients with low muscle strength.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66885847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSING THE IMPACT OF A NUTRITION-FOCUSED QUALITY IMPROVEMENT PROGRAM IN CARDIOPULMONARY PATIENTS","authors":"M. Costanzo, S. Kozmic, S. Sulo, F. Dabbous, B. Warren, J. Partridge, Alan S. Brown, K. Sriram","doi":"10.14283/jarcp.2019.11","DOIUrl":"https://doi.org/10.14283/jarcp.2019.11","url":null,"abstract":"Background: Patients with cardiopulmonary diagnoses are at high risk for hospital readmissions and prolonged hospitalizations. Nutrition-focused quality improvement programs (QIPs) can improve the care of malnourished hospitalized patients. Objectives: Data collected previously was analyzed to evaluate the impact of a nutrition-focused QIP on health outcomes in patients with cardiopulmonary diseases. Design: The QIP consisted of malnutrition risk screening, prompt initiation of oral nutritional supplements (ONS), and nutrition education. Setting: A total of 4 hospitals implemented the QIP–2 teaching hospitals and 2 community hospitals. Participants: Eligible QIP participants were hospitalized patients with any diagnosis, 18 years of age or older, at risk for malnutrition at admission, and able to consume food and beverages orally. Measurements: Data collected from the QIP patients was compared to data from historical controls to assess differences in readmission rates and length of stay (LOS). Results: Patients were mainly older adults (66 ± 17.4 years) and non-obese (85%). Univariate analysis showed significant reductions in 30-day readmission rates for the QIP group when compared with the controls (13.9% for QIP vs. 26.4% for controls), with the QIP group experiencing a 55% reduction in the odds of being readmitted (OR = 0.45, p = 0.006). Similarly, a significant reduction in LOS was reported for the QIP group (5.4 ± 5.7 days for QIP vs. 6.8 ± 5.7 days for controls) corresponding to a relative risk reduction (RR) of 20% (RR = 0.80, p = 0.0085). Logistic regression adjusting for patient characteristics showed that the QIP patients were 33% less likely to be readmitted (p = 0.33), and had a 6% RR (RR = 0.94, p = 0.55) in LOS versus controls. Conclusions: Malnourished hospitalized cardiopulmonary patients participating in a nutrition-focused QIP experienced fewer readmissions and improved LOS compared to controls. These results underscore the importance of nutrition-focused interventions as a key part of treatment for cardiopulmonary patients.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66885575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}