JACC advances最新文献

{"title":"Ventricular Arrhythmia Catheter Ablation Following Anthracycline Exposure","authors":"Narut Prasitlumkum MD, Joerg Hermann MD, Nicholas Y. Tan MD, MS","doi":"10.1016/j.jacadv.2025.101817","DOIUrl":"10.1016/j.jacadv.2025.101817","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101817"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease","authors":"Peter D. Mark MD, PhD ,&nbsp;Jakob Schroder MD ,&nbsp;Andreas K. Jensen MD ,&nbsp;Timothy C.R. Prickett PhD ,&nbsp;Eva Prescott MD, DMSc ,&nbsp;Jens P. Goetze MD, DMSc","doi":"10.1016/j.jacadv.2025.101859","DOIUrl":"10.1016/j.jacadv.2025.101859","url":null,"abstract":"<div><h3>Background</h3><div>Circulating C-type natriuretic peptides (CNPs) predict adverse outcome in women presenting with ST-elevation myocardial infarction.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to determine the prognostic impact of a high proCNP concentration in women with angina pectoris but no obstructive coronary artery disease (ANOCA).</div></div><div><h3>Methods</h3><div>In a prospective cohort of women with ANOCA, we assessed the baseline associations between proCNP concentrations in plasma and clinical data. Moreover, we performed exploratory partial least squares regression (PLS) analyses for correlation patterns of proCNP with 185 cardiovascular plasma markers. We included 1,508 women in baseline/follow-up analyses and 1,598 women in PLS analyses. Follow-up analyses included all-cause death and a composite endpoint of cardiovascular events, where we calculated HR estimates from crude and adjusted (age, creatinine) Cox proportional hazards models.</div></div><div><h3>Results</h3><div>A high proCNP concentration (223 women) was associated with hypertension (<em>P</em> = 0.001), diabetes mellitus (<em>P</em> &lt; 0.001), and postmenopausal status (<em>P</em> &lt; 0.001) but not age (<em>P</em> = 0.13). PLS analyses showed that proCNP concentrations were positively associated with atherosclerotic markers and negatively associated with pro-inflammatory markers. For high proCNP, we found an increased risk of all-cause mortality (HR_crude: 1.73 [95% CI: 1.10-2.73]; <em>P</em> = 0.02 and HR_adjusted: 1.57 [95% CI: 0.99-2.49]; <em>P</em> = 0.06), whereas hazard rates of cardiovascular events were comparable (HR_crude: 1.08 [95% CI: 0.72-1.62]; <em>P</em> = 0.71 and HR_adjusted: 1.03 [95% CI: 0.68-1.56]; <em>P</em> = 0.90).</div></div><div><h3>Conclusions</h3><div>In women with ANOCA, a high circulating proCNP concentration is associated with a distinct cardiovascular risk profile beyond pro-inflammatory biomarkers and an increased risk of all-cause mortality.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101859"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Left Ventricular Dysfunction After Spontaneous Coronary Artery Dissection","authors":"Stanislav Henkin MD, MPH ,&nbsp;Malissa J. Wood MD ,&nbsp;Sahar Naderi MD ,&nbsp;Heather L. Gornik MD ,&nbsp;Daniella Kadian-Dodov MD ,&nbsp;Anna Grodzinsky MD ,&nbsp;Gerald Chi MD ,&nbsp;C. Michael Gibson MD ,&nbsp;Katherine K. Leon MS ,&nbsp;Esther S.H. Kim MD, MPH","doi":"10.1016/j.jacadv.2025.101854","DOIUrl":"10.1016/j.jacadv.2025.101854","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101854"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Race and Ethnicity With Stroke and Mortality Outcomes in Atrial Fibrillation","authors":"Utibe R. Essien MD, MPH ,&nbsp;Jasmyn J. Tang MPH ,&nbsp;Nadejda Kim MA ,&nbsp;Leslie R.M. Hausmann PhD, MS ,&nbsp;Donna L. Washington MD, MPH ,&nbsp;Maria K. Mor PhD ,&nbsp;Valerie P. Nguyen MPH ,&nbsp;Jared W. Magnani MD, MSc ,&nbsp;Walid F. Gellad MD, MPH ,&nbsp;Michael J. Fine MD, MSc","doi":"10.1016/j.jacadv.2025.101860","DOIUrl":"10.1016/j.jacadv.2025.101860","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is associated with stroke and mortality. Research has demonstrated racial and ethnic disparities in AF outcomes, yet our understanding of the determinants of these disparities is limited.</div></div><div><h3>Objectives</h3><div>The authors compared stroke and mortality by race and ethnicity for AF patients in the Veterans Health Administration.</div></div><div><h3>Methods</h3><div>We identified Veterans Health Administration patients with incident AF from January 1, 2014, to December 31, 2021, with follow-up through May 31, 2022. Our independent variables were race (American Indian/Alaska Native (AI/AN), Asian, Black, and White) and ethnicity (Hispanic). Our primary outcomes were stroke and mortality incidence. Cox proportional hazard models assessed the association between race, ethnicity, and our outcomes, adjusting for sociodemographic, clinical, and facility factors.</div></div><div><h3>Results</h3><div>Our cohort included 157,332 patients with AF; mean age 72.9 ± 10.5 years, 97.8% male and 2.2% female. Overall, 22,628 (14.7%) patients developed stroke (46.3 per 1,000 person-years), and 52,288 (33.2%) patients died (96.1 per 1,000 person-years). The adjusted HR (aHR) for stroke was higher for Black (aHR: 1.14; 95% CI: 1.09-1.20) than White patients, with no differences observed between AI/AN, Asian, or Hispanic and White patients. Mortality was lower for Asian (aHR: 0.85; 95% CI: 0.78-0.93), Black (aHR: 0.92; 95% CI: 0.89-0.95), and Hispanic (aHR: 0.82; 95% CI: 0.77-0.87) than White patients, with no difference observed for AI/AN patients.</div></div><div><h3>Conclusions</h3><div>In a nationwide cohort of AF patients, we found significantly higher stroke rates for Black than White patients. Conversely, we observed significantly lower mortality rates for Asian, Black, and Hispanic patients than for White patients. Interventions to address factors associated with these disparities are essential.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101860"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Outcomes of Semaglutide vs Dulaglutide in Nonobese Type II Diabetes Patients With HFpEF","authors":"Patrick A. Kwaah MBChB ,&nbsp;Samuel A. Mensah MBChB ,&nbsp;Abraham Carboo MBChB, MPH ,&nbsp;Hamza A. Rashid MBBS ,&nbsp;Emmanuel A. Agyemang MBChB ,&nbsp;Grace Appah MBChB ,&nbsp;Smith K. Frimpong MD","doi":"10.1016/j.jacadv.2025.101857","DOIUrl":"10.1016/j.jacadv.2025.101857","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101857"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Risk Stratification in Apical Hypertrophic Cardiomyopathy","authors":"Arif Albulushi MD ,&nbsp;Noora Alhajri MD ,&nbsp;Mosaad Alhussein MD","doi":"10.1016/j.jacadv.2025.101867","DOIUrl":"10.1016/j.jacadv.2025.101867","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101867"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Psychological Health Into Maternal Cardiovascular Care","authors":"Zaroon Mazhar MBBS ,&nbsp;Muiz Khan Tareen MD ,&nbsp;Muhammad Ahmad Qureshi MD","doi":"10.1016/j.jacadv.2025.101810","DOIUrl":"10.1016/j.jacadv.2025.101810","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 7","pages":"Article 101810"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Frailty and Cardiometabolic Disease","authors":"Wenjie Wang MD ,&nbsp;Kexin Wang MD ,&nbsp;Guangyuan Chen MD ,&nbsp;Jialong Niu MD ,&nbsp;Yixuan Liu MD ,&nbsp;Zhongke Wang MD ,&nbsp;Hailong Ge MD","doi":"10.1016/j.jacadv.2025.101782","DOIUrl":"10.1016/j.jacadv.2025.101782","url":null,"abstract":"<div><h3>Background</h3><div>Cardiometabolic diseases (CMD) include coronary heart disease, stroke, and diabetes. Patients who have ≥2 CMD are defined as cardiometabolic multimorbidity (CMM). CMD and CMM have been associated with frailty, but studies are limited.</div></div><div><h3>Objectives</h3><div>The aim of this study was to examine the association between frailty index (FI), changes in frailty, and risks of CMD and CMM.</div></div><div><h3>Methods</h3><div>Data were obtained from the China Health and Retirement Longitudinal Study. Frailty status was classified into 3 categories: robust (FI ≤0.1), pre-frail (FI 0.1-0.25), and frail (FI ≥0.25). Total FI and change in FI (ΔFI) were divided into 3 tertiles. Mendelian randomization was used to clarify the relationship between FI and CMD from a genetic perspective.</div></div><div><h3>Results</h3><div>A total of 10,022 patients were included (female: 54.0%, median age: 57 years). Robust subjects who progressed to pre-frail/frail status had significantly increased risks of CMD (HR: 1.67, 95% CI: 1.46-1.92) and CMM (HR: 1.80, 95% CI: 1.30-2.50). Participants in the tertile 2 (HR: 1.48, 95% CI: 1.31-1.66) and tertile 3 of the total FI group (HR: 2.11, 95% CI: 1.87-2.37) had increased risks of developing CMD, compared with tertile 1. Participants in the upper tertile of the ΔFI group had higher risks of CMD (HR: 1.61, 95% CI: 1.44-1.80) and CMM (HR: 2.07, 95% CI: 1.61-2.66) than those in the first tertile.</div></div><div><h3>Conclusions</h3><div>Progression of frailty status elevates CMD and CMM risks. Higher total FI and ΔFI were also related to increased risks of CMD and CMM.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101782"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic Disparities in Obesity Prevalence Among Adults Aged 20-59 Years Between 2017 and 2023","authors":"Olayinka J. Agboola MD, MPH ,&nbsp;Ryan P. Chang BA ,&nbsp;Madelyn Hurwitz BA ,&nbsp;Erica S. Spatz MD, MHS ,&nbsp;Tiffany M. Powell-Wiley MD, MPH ,&nbsp;Michael J. Blaha MD ,&nbsp;Garima Sharma MD ,&nbsp;Michael D. Shapiro DO, MCR ,&nbsp;Jared A. Spitz MD","doi":"10.1016/j.jacadv.2025.101798","DOIUrl":"10.1016/j.jacadv.2025.101798","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101798"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Systolic Blood Pressure Time in Target Range and Cardiovascular Disease in Individuals With Hypertension","authors":"Zhenyu Huo MD ,&nbsp;Shouling Wu MD ,&nbsp;Liuxin Li MD ,&nbsp;Jingdi Zhang MD ,&nbsp;Yang Liu MD ,&nbsp;Xu Han MD ,&nbsp;Shuohua Chen MD ,&nbsp;Guodong Wang MD ,&nbsp;Yun Li PhD ,&nbsp;Shunming Zhang PhD ,&nbsp;Yan Borné PhD ,&nbsp;Tingting Geng PhD ,&nbsp;Zhe Huang MD","doi":"10.1016/j.jacadv.2025.101702","DOIUrl":"10.1016/j.jacadv.2025.101702","url":null,"abstract":"<div><h3>Background</h3><div>Previous post hoc analyses of clinical trials have suggested that a higher percentage of systolic blood pressure time in target range (SBP-TTR) was associated with a decreased risk of cardiovascular disease (CVD). However, there is limited evidence from large prospective cohort studies on the relationship between long-term SBP-TTR and the risk of CVD.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to assess the association between long-term SBP-TTR and the risk of CVD in adults with hypertension.</div></div><div><h3>Methods</h3><div>This study included 26,929 hypertensive patients (mean age 52.8 ± 10.7 years; 83.1% males), free of CVD at baseline from the Kailuan Study. Blood pressure was measured biennially from 2006 to 2012, and the SBP target range was defined as 120 to 140 mm Hg. SBP-TTR was calculated by the Rosendaal linear interpolation method. Incident CVD events were ascertained via the linkage of electronic health record data.</div></div><div><h3>Results</h3><div>During a median follow-up of 8.6 years, 2,565 CVD, including 472 myocardial infarction and 2,151 stroke cases were documented. Comparing the high SBP-TTR (75%-100%) with the low SBP-TTR (0%-25%) group, the multivariable HRs were 0.67 (95% CI: 0.59-0.76) for CVD, 0.76 (95% CI: 0.56-1.02) for myocardial infarction, and 0.64 (95% CI: 0.56-0.74) for stroke. In addition, the association between SBP-TTR and CVD risk was stronger among individuals aged &lt;65 years than their older counterparts (<em>P</em> for interaction &lt;0.001).</div></div><div><h3>Conclusions</h3><div>A greater percentage of SBP-TTR was associated with a lower risk of CVD among patients with hypertension. These findings underscore the importance of maintaining SBP within the target range for the prevention of CVD among hypertensive individuals.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101702"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}