JACC advances最新文献

{"title":"Higher-Risk Localized Prostate Cancer Is Associated With Increased Coronary Artery Calcium and Coronary Plaque Burden","authors":"Adithya K. Yadalam MD, MSc , Carlotta Onnis MD , Marly van Assen PhD , Carlo N. DeCecco MD, PhD , Stephanie M. Cantu MD , Anant Mandawat MD , Sagar A. Patel MD, MSc","doi":"10.1016/j.jacadv.2025.101973","DOIUrl":"10.1016/j.jacadv.2025.101973","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101973"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupting the Echoes of the Past","authors":"Cole Howie MD , Jason F. Deen MD","doi":"10.1016/j.jacadv.2025.101969","DOIUrl":"10.1016/j.jacadv.2025.101969","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101969"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Related Differences in Outcomes According to Surgical Treatment Approach in Degenerative Mitral Regurgitation","authors":"Jérémy Bernard PhD ,&nbsp;Solenn Dal Soglio MD ,&nbsp;Bin Zhang MD ,&nbsp;Erwan Salaun MD, PhD ,&nbsp;Jonathan Beaudoin MD ,&nbsp;Éric Charbonneau MD ,&nbsp;Éric Dumont MD ,&nbsp;Dimitri Kalavrouziotis MD ,&nbsp;Siamak Mohammadi MD ,&nbsp;Philippe Pibarot DVM, PhD ,&nbsp;François Dagenais MD ,&nbsp;Marie-Annick Clavel DVM, PhD","doi":"10.1016/j.jacadv.2025.101897","DOIUrl":"10.1016/j.jacadv.2025.101897","url":null,"abstract":"<div><h3>Background</h3><div>Sex differences in degenerative mitral regurgitation (DMR) are poorly described, especially according to surgical treatment approach (ie, mitral valve repair [MVr] vs replacement [MVR]).</div></div><div><h3>Objectives</h3><div>We aimed to assess sex differences in presentation, treatment, and outcomes of patients surgically treated for DMR and identify sex-specific predictors of mortality.</div></div><div><h3>Methods</h3><div>Consecutive patients treated by MVr or MVR between 2002 and 2019 were included (n = 1,804), and all data were prospectively collected. To account for confounders between men and women, the inverse probability weighting method was used in total population and within each treatment approach singly. The study endpoints were short-term postoperative (ie, ≤30 days) outcomes and long-term mortality.</div></div><div><h3>Results</h3><div>Preoperatively, women (n = 661; 37%) presented more atrial fibrillation, higher values of brain natriuretic peptides, higher indexed values of left atrial and ventricular dimensions, and pulmonary pressure and were more symptomatic (all <em>P</em> ≤ 0.006). After inverse probability weighting, women were at higher risk of early stroke. They presented higher long-term mortality than men after MVr (HR: 1.62 [95% CI: 1.14-2.30], <em>P</em> = 0.007), whereas mortality was similar between sexes after MVR (HR: 0.91 [95% CI: 0.71-1.17], <em>P</em> = 0.47). Independent predictors of long-term mortality were mainly the presence of mitral annulus calcification in men, and left ventricular ejection fraction and DMR severity in women (all <em>P</em> ≤ 0.04).</div></div><div><h3>Conclusions</h3><div>In this large series of patients surgically treated for DMR, women had worse preoperative presentation, higher early postoperative rates of stroke, and higher long-term risk of mortality when treated by MVr.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101897"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Evaluating Post-TAVR Antithrombotic Strategies in Nonanticoagulated Patients","authors":"Ioannis Skalidis MD, PhD,&nbsp;Thomas Hovasse MD,&nbsp;Francesca Sanguinetti MD,&nbsp;Philippe Garot MD,&nbsp;Mariama Akodad MD","doi":"10.1016/j.jacadv.2025.101983","DOIUrl":"10.1016/j.jacadv.2025.101983","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101983"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Pre-Participation Cardiac Screening in Athletes","authors":"Raghav T. Bhatia MBBS, PhD ,&nbsp;Sanjay Sharma BSc, MBChB, MD ,&nbsp;Michael Papadakis MBBS, MD(Res) ,&nbsp;Peter N. Dean MD ,&nbsp;Hamish MacLachlan MBBS, MD(Res) ,&nbsp;Aneil Malhotra MB BChir, MA (Cantab), MSc, PhD ,&nbsp;Katie Stewart MS, NP ,&nbsp;Eugene H. Chung MD, MPH ,&nbsp;Jonathan H. Kim MD, MSc ,&nbsp;Matthew W. Martinez MD ,&nbsp;ACC Sports and Exercise Council","doi":"10.1016/j.jacadv.2025.101943","DOIUrl":"10.1016/j.jacadv.2025.101943","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101943"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes","authors":"John E. Brush Jr. MD ,&nbsp;Chungsoo Kim PharmD, PhD ,&nbsp;Yuntian Liu MPH ,&nbsp;Xin Xin MS ,&nbsp;Chenxi Huang PhD ,&nbsp;Iris J. Lundy BSN ,&nbsp;Jordan R. Asher MD, MS ,&nbsp;Mitsuaki Sawano MD ,&nbsp;Patrick Young PhD ,&nbsp;Jacob McPadden MD ,&nbsp;Mark Anderson AS ,&nbsp;John S. Burrows MBA ,&nbsp;Harlan M. Krumholz MD, SM ,&nbsp;Yuan Lu ScD","doi":"10.1016/j.jacadv.2025.101912","DOIUrl":"10.1016/j.jacadv.2025.101912","url":null,"abstract":"<div><h3>Background</h3><div>Neighborhood-level social vulnerability is associated with hypertension prevalence and severity and with cardiovascular complications in conditions other than hypertension, but its association with cardiovascular complications in patients with hypertension is understudied.</div></div><div><h3>Objectives</h3><div>The aim of the study was to examine how the neighborhood-level social vulnerability index (SVI) influences cardiovascular outcomes in a large, diverse cohort of patients with hypertension.</div></div><div><h3>Methods</h3><div>We used electronic health data to examine the association between census tract-level rankings for the SVI with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke.</div></div><div><h3>Results</h3><div>In a longitudinal cohort of 330,972 patients with hypertension followed for a median of 6.6 years, the neighborhood-level SVI was significantly associated with the composite endpoint after adjustment for demographics, baseline body mass index and blood pressure (BP), and comorbidities (HR for quartile 4 [most disadvantaged group] vs quartile 1 = 1.31 [95% CI: 1.25-1.38], <em>P</em> &lt; 0.001). Patients living in quartile 4 SVI areas had a significantly lower BP control rate compared with patients living in quartile 1 SVI areas (70.3% vs 74.8%, <em>P</em> &lt; 0.001). Patients living in SVI quartile 4 areas were disproportionately Black (53.8%). Compared with the White race, the Black race was negatively associated with the composite outcome after adjustment for the SVI quartile, and other clinical factors (HR: 0.89 [95% CI: 0.86-0.92], <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Neighborhood-level social vulnerability was strongly associated with adverse cardiovascular outcomes and poorer BP control and may be a driver of racial disparities in hypertension. These findings highlight the potential of leveraging social vulnerability indices for tailored interventions in hypertension management.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101912"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Children and Adolescents With Hypertrophic Cardiomyopathy","authors":"Gabrielle Norrish PhD ,&nbsp;Kimberley Hall BSc ,&nbsp;Ella Field MSc ,&nbsp;Elena Cervi MD ,&nbsp;Olga Boleti MD ,&nbsp;Lidia Ziółkowska MD ,&nbsp;Iacopo Olivotto MD ,&nbsp;Sylvia Passantino MD ,&nbsp;Diala Khraiche MD ,&nbsp;Giuseppe Limongelli MD ,&nbsp;Robert G. Weintraub MD ,&nbsp;Aris Anastasakis MD ,&nbsp;Elena Biagini MD ,&nbsp;Luca Ragni MD ,&nbsp;Georgia Sarquella-Brugada MD ,&nbsp;Sergi Cesar MD ,&nbsp;Terrence Prendiville MD ,&nbsp;Karen McLeod MD ,&nbsp;Maria Ilina MD ,&nbsp;Anwar Baban MD ,&nbsp;Juan Pablo Kaski MD","doi":"10.1016/j.jacadv.2025.101907","DOIUrl":"10.1016/j.jacadv.2025.101907","url":null,"abstract":"<div><h3>Background</h3><div>Sex differences have been described in adults with hypertrophic cardiomyopathy (HCM), but it is unknown if similar differences exist in childhood-onset disease.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the influence of biological sex on the clinical characteristics and outcomes of children with HCM.</div></div><div><h3>Methods</h3><div>An international retrospective cohort of patients diagnosed with nonsyndromic HCM ≤16 years was formed. Sex differences in baseline characteristics and clinical outcomes were investigated. Primary outcome was all-cause mortality or cardiac transplantation. Secondary outcomes include major arrhythmic cardiac event and heart failure event.</div></div><div><h3>Results</h3><div>Of 1,433 patients diagnosed at a median age of 11 years (IQR: 6-14), 471 (33.0%) were female. Although there were no sex differences in phenotype in preadolescent patients (&lt;12 years), adolescent female patients were more likely to have heart failure symptoms (n = 53 [31.9%] vs n = 86 [22.5%]; <em>P</em> = 0.019). Adolescent female patients had larger left atrial size (1.4 <em>z</em>-score [±2.3] vs 2.1 <em>z</em>-score [±2.5]; <em>P</em> = 0.0056) but there was no difference in degree of hypertrophy or proportion with obstructive disease. Over a median follow-up of 5.3 years (IQR: 2.9, 8.0) annual incidence of all-cause mortality or cardiac transplantation, major arrhythmic cardiac event or heart failure events did not vary by sex.</div></div><div><h3>Conclusions</h3><div>Young female patients with HCM are more likely to experience heart failure symptoms and have echocardiographic features of diastolic impairment. Despite differences in phenotype, outcomes during childhood and young adulthood are not different. Further studies are required to explore the underlying mechanisms for these observed differences.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101907"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis","authors":"Jonathan Hourmozdi MD, MSAI, MA ,&nbsp;Nicholas Easton MSAI ,&nbsp;Simon Benigeri MSAI ,&nbsp;James D. Thomas MD ,&nbsp;Akhil Narang MD ,&nbsp;David Ouyang MD ,&nbsp;Grant Duffy BS ,&nbsp;Ross Upton PhD ,&nbsp;Will Hawkes PhD ,&nbsp;Ashley Akerman PhD ,&nbsp;Ike Okwuosa MD ,&nbsp;Adrienne Kline MD, PhD ,&nbsp;Abel N. Kho MD ,&nbsp;Yuan Luo PhD ,&nbsp;Sanjiv J. Shah MD ,&nbsp;Faraz S. Ahmad MD, MS","doi":"10.1016/j.jacadv.2025.101901","DOIUrl":"10.1016/j.jacadv.2025.101901","url":null,"abstract":"<div><h3>Background</h3><div>Delays in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) contribute to the significant morbidity of the condition, especially in the era of disease-modifying therapies. Screening for ATTR-CM with artificial intelligence and other algorithms may improve timely diagnosis, but these algorithms have not been directly compared.</div></div><div><h3>Objectives</h3><div>The aim of this study was to compare the performance of 4 algorithms for ATTR-CM detection in a heart failure population and assess the risk for harms due to model bias.</div></div><div><h3>Methods</h3><div>We identified patients in an integrated health system from 2010 to 2022 with ATTR-CM and age- and sex-matched them to controls with heart failure to target 5% prevalence. We compared the performance of a claims-based random forest model (Huda et al model), a regression-based score (Mayo ATTR-CM), and 2 deep learning echo models (EchoNet-LVH and EchoGo Amyloidosis). We evaluated for bias using standard fairness metrics.</div></div><div><h3>Results</h3><div>The analytical cohort included 176 confirmed cases of ATTR-CM and 3,192 control patients with 79.2% self-identified as White and 9.0% as Black. The Huda et al model performed poorly (AUC: 0.49). Both deep learning echo models had a higher AUC when compared to the Mayo ATTR-CM Score (EchoNet-LVH 0.88; EchoGo Amyloidosis 0.92; Mayo ATTR-CM Score 0.79; DeLong <em>P</em> &lt; 0.001 for both). Bias auditing met fairness criteria for <em>equal opportunity</em> among patients who identified as Black.</div></div><div><h3>Conclusions</h3><div>Deep learning, echo-based models to detect ATTR-CM demonstrated best overall discrimination when compared to 2 other models in external validation with low risk of harms due to racial bias.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101901"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Electrocardiographic Approach for Accurate Diagnosis of Prior Inferior Myocardial Infarction","authors":"Hailei Liu MD ,&nbsp;Thien Tan Tri Tai Truyen MD ,&nbsp;Harpriya Chugh MSHS ,&nbsp;Kyndaron Reinier PhD ,&nbsp;Ashkan Ehdaie MD ,&nbsp;Eugenio Cingolani MD ,&nbsp;Archana Ramireddy MD ,&nbsp;Eric D. Braunstein MD ,&nbsp;Michael Shehata MD ,&nbsp;Xunzhang Wang MD ,&nbsp;Sumeet S. Chugh MD","doi":"10.1016/j.jacadv.2025.101968","DOIUrl":"10.1016/j.jacadv.2025.101968","url":null,"abstract":"<div><h3>Background</h3><div>The accuracy of diagnosing prior inferior wall myocardial infarction (IMI) on the 12-lead electrocardiogram (ECG) remains limited.</div></div><div><h3>Objectives</h3><div>The aim of the study was to use predictive model building to select the optimal ECG criteria specific to the diagnoses of true-IMI.</div></div><div><h3>Methods</h3><div>From an ongoing health system-based cohort study (n = 382,121), all consecutive subjects with ECG-based diagnoses of prior IMI (n = 9,676; 2019-2023) were assessed. Subjects with at least 1 cardiac imaging test performed were identified (n = 5,924). Discovery (2019-2022, n = 329) and validation (2023, n = 185) subgroups were identified by random sampling. Subjects with true- vs pseudo-IMI were identified from a combination of ECG and imaging. Logistic regression was used in the discovery cohort to identify ECG parameters associated with true-IMI, and optimal cutoff values were determined using the Youden Index.</div></div><div><h3>Results</h3><div>In the discovery sample, 209 subjects (63.5%) were identified as pseudo-IMI. A combination of lead II Q-wave duration &gt;20 ms and/or amplitude ratio &gt;0.2, derived from logistic regression and selected to optimize diagnostic performance while minimizing false negatives, improved sensitivity and specificity to 100.0% and 96.7%. The positive and negative predictive values were 94.5% and 100.0%, respectively. Findings were consistent in the validation cohort.</div></div><div><h3>Conclusions</h3><div>Using the prevailing definition for electrocardiographic diagnosis of prior IMI had a significantly high rate of pseudo-IMI. Refinement using simple ECG lead II criteria substantially improved the accuracy of the ECG-based diagnosis. These findings have potential implications for clinical practice and highlight the need for large, multicenter studies to further define the optimal criteria for the ECG diagnosis of structural heart disease.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101968"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiologists' Perceptions of Cardiogenetic Testing and Management","authors":"W.H. Wilson Tang MD ,&nbsp;Quan M. Bui MD ,&nbsp;Allison L. Cirino MS, CGC ,&nbsp;Lisa Dellefave-Castillo MS, CGC ,&nbsp;Brendan J. Floyd MD, PhD, MEd ,&nbsp;Alejandra Guerchicoff PhD ,&nbsp;Marianna Guerchicoff MD ,&nbsp;Amit V. Khera MD, MSc ,&nbsp;Joshua W. Knowles MD, PhD ,&nbsp;Kristen Lafayette MPP ,&nbsp;Andrew P. Landstrom MD, PhD ,&nbsp;Daria W. Ma MS, LCGC, MSHS ,&nbsp;Ana Morales MS, CGC ,&nbsp;Kate M. Orland MS, CGC ,&nbsp;Daniel E. Pineda-Alvarez MD ,&nbsp;Siddharth K. Prakash MD, PhD ,&nbsp;Paul Theriot BSBA ,&nbsp;Melissa Dempsey MS, CGC","doi":"10.1016/j.jacadv.2025.101910","DOIUrl":"10.1016/j.jacadv.2025.101910","url":null,"abstract":"<div><h3>Background</h3><div>Cardiogenetic testing has become clinically relevant as genetic insights increasingly contribute to the understanding and management of cardiovascular diseases of genetic origin. However, utilization of cardiogenetic testing remains variable and underutilized.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to assess cardiologists' perceptions of cardiogenetic testing and identify relevant barriers, facilitators, educational needs, and clinical applications.</div></div><div><h3>Methods</h3><div>We surveyed 161 cardiologists using the American College of Cardiology CardioSurve Panel between March and April 2024.</div></div><div><h3>Results</h3><div>Among respondents, 80% reported that they have directly ordered or facilitated a referral for cardiogenetic testing for their patients. Generally, cardiologists from our testing group felt confident identifying and referring patients for testing, but only 40% confidently ordering tests and only 31% were confident interpreting results. A substantial portion of respondents (40%) had not received any training in cardiogenetic testing. Furthermore, 76% of those who had never ordered testing did not receive relevant education in cardiogenetic testing. The majority (59%) had access to genetic counselors though this was limited for those less familiar with testing. Common barriers included perceived high cardiogenetic testing costs (60%), limited access to genetic counselors (59%), and lack of confidence in interpreting results (43%). Respondents had substantial variability in perceived insurance coverage. Guidelines and resources from professional societies were top educational tools, whereas most cardiologists (91%) expressed interest in further education in patient selection, testing procedures, and results interpretation.</div></div><div><h3>Conclusions</h3><div>The survey suggest that improved access to genetic counselors and professionals, clearer guidelines, and expanded education could boost cardiogenetic testing adoption and integration into cardiovascular care.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 8","pages":"Article 101910"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}