JACC advances最新文献

{"title":"Stroke Prevention With Oral Anticoagulants in High-Risk Atrial Fibrillation in an Aging Population","authors":"Ken Okumura MD, PhD ,&nbsp;Masaharu Akao MD, PhD ,&nbsp;Shinya Suzuki MD, PhD ,&nbsp;Takeshi Yamashita MD, PhD","doi":"10.1016/j.jacadv.2025.101757","DOIUrl":"10.1016/j.jacadv.2025.101757","url":null,"abstract":"<div><div>Aging societies will pose unique health challenges in the near future. Elderly and very elderly patients often have complex medical needs, including comorbidities and polypharmacy. Contributing to this, atrial fibrillation (AF) is common among elderly patients. Direct oral anticoagulants are widely used to prevent stroke in patients with AF. However, patients in randomized controlled trials tend to be younger than many patients with AF and may not have the complicating factors that can influence treatment decisions. In this review, we summarize what is currently known about direct oral anticoagulants in elderly (age 65-79 years) and very elderly (age ≥80 years) patients with AF, and highlight the remaining gaps in the literature. Although further randomized controlled trials are needed, the ELDERCARE-AF (Edoxaban Low-Dose for Elder Care Atrial Fibrillation Patients) trial may have contributed to filling these gaps.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101757"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic Tissue Characterization Using Radiomics in Patients With Transthyretin-Related Cardiac Amyloidosis","authors":"Sara Mori MD ,&nbsp;Noemi Montobbio MSc ,&nbsp;Maria Pia. Sormani MSc, PhD ,&nbsp;Cristina Campi MSc, PhD ,&nbsp;Carlotta Mazzoni MD ,&nbsp;Alessia Argirò MD, PhD ,&nbsp;Giulia Elena Mandoli MD ,&nbsp;Francesca Rubina Ginetti MD ,&nbsp;Margherita Zanoletti MD ,&nbsp;Pier Filippo Vianello MD ,&nbsp;Valeria Rella MD ,&nbsp;Lia Crotti MD, PhD ,&nbsp;Michele Piana MSc, PhD ,&nbsp;Matteo Cameli MD, PhD ,&nbsp;Francesco Cappelli MD, PhD ,&nbsp;Italo Porto MD, PhD ,&nbsp;Luigi Paolo Badano MD, PhD ,&nbsp;Marco Canepa MD, PhD","doi":"10.1016/j.jacadv.2025.101755","DOIUrl":"10.1016/j.jacadv.2025.101755","url":null,"abstract":"<div><h3>Background</h3><div>Transthyretin-related cardiac amyloidosis (ATTR-CA) is often diagnosed at an advanced stage. Emerging evidence suggests that radiomics applied to echocardiographic images (ie, ultrasonomics) can detect early myocardial texture changes in ATTR-CA.</div></div><div><h3>Objectives</h3><div>This study aimed to develop a radiomic model for characterizing ATTR-infiltrated myocardium via echocardiography.</div></div><div><h3>Methods</h3><div>Echocardiographic images in parasternal long-axis and apical 4-chamber views from ATTR-CA and control patients were collected across 4 Italian centers. A region of interest (ROI) within the interventricular septum was delineated. Ninety-four radiomic features were extracted and classified into 2 categories for analysis, based on whether they were ROI-dependent or independent. Five logistic regression models analyzed data from 3 centers (229 ATTR-CA, 224 controls) to assess diagnostic accuracy and area under the curve (AUC) of different sets of radiomic features, with external validation conducted on patients from a fourth center (32 ATTR-CA, 32 controls).</div></div><div><h3>Results</h3><div>Models analyzing the entire ROI using both ROI-dependent and ROI-independent features demonstrated high cross-validated accuracies (93%-95%) and AUC values (0.97-0.99). Using a fixed-size 0.5 × 0.5 cm ROI, these values decreased to 85% and 0.91, respectively, highlighting previous models' dependence on ROI size. The fifth model used 73 ROI-independent features on the entire ROI and demonstrated significantly better accuracy and AUC (92% and 0.97, respectively, <em>P</em> &lt; 0.001), confirmed in the external validation cohort (87% and 0.95, respectively). Removing the least informative features slightly improved the model, achieving 90% accuracy and 0.95 precision.</div></div><div><h3>Conclusions</h3><div>This study showcases ultrasonomics potential to differentiate ATTR-CA and control patients by capturing disease-specific textural features independent of ROI dimensions.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101755"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aldosterone-Related Cardiovascular Disease and Benefits of Mineralocorticoid Receptor Antagonists in Clinical Practice","authors":"Maria Alfarano MD, PhD ,&nbsp;Giulia Marchionni MD ,&nbsp;Jacopo Costantino MD ,&nbsp;Federico Ballatore MD ,&nbsp;Romina Verardo PhD ,&nbsp;Fabio Miraldi MD ,&nbsp;Francesco Luigi Ciciarello MD ,&nbsp;Luigi Petramala MD ,&nbsp;Claudio Letizia MD ,&nbsp;Andrea Frustaci MD ,&nbsp;Cristina Chimenti MD, PhD","doi":"10.1016/j.jacadv.2025.101762","DOIUrl":"10.1016/j.jacadv.2025.101762","url":null,"abstract":"<div><div>High levels of aldosterone are associated with vascular and cardiac remodeling, myocardial fibrosis, and endothelial dysfunction with consequent increased risk of cardiovascular events and cardiovascular mortality. Indeed, mineralcorticoid receptor antagonists (MRAs) are recommended in the treatment of arterial hypertension, heart failure, alone or associated with chronic kidney disease. Nevertheless, molecular pathways underlying aldosterone-induced cardiac remodeling are poorly investigated. High levels of aldosterone induce reactive oxygen species with consequent oxidative stress and mitochondrial dysfunction. Moreover, aldosterone induces myocardial hypertrophy through increase of sarcomere mass mediated by pro-hypertrophic effect mediated by a G protein-coupled receptor kinase 5 cytosolic signaling and retention of ions and water regulated by aquaporins. Aim of this review is to report the data from the literature regarding excessive aldosterone signaling in mediating cardiovascular disease, also highlighting the morphostructural and molecular pathways correlated to myocardial damage and the role of MRAs in clinical practice.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101762"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of De Novo Postpartum Hypertension","authors":"Ukachi N. Emeruwa MD, MPH ,&nbsp;Ana Çapi MD ,&nbsp;Marni B. Jacobs PhD ,&nbsp;Louise C. Laurent MD, PhD ,&nbsp;Natalie A. Bello MD, MPH ,&nbsp;Cynthia Gyamfi-Bannerman MD, MS","doi":"10.1016/j.jacadv.2025.101756","DOIUrl":"10.1016/j.jacadv.2025.101756","url":null,"abstract":"<div><h3>Background</h3><div>Individuals developing hypertensive disorders of pregnancy face a 2- to 5-fold risk of long-term cardiovascular disease. Limited data exist on de novo postpartum hypertension (dnPPHTN), where those normotensive during pregnancy develop hypertension immediately postpartum. Under-recognition of dnPPHTN can lead to severe morbidity due to delayed or absent treatment and missed opportunities for mitigating long-term cardiovascular disease risk.</div></div><div><h3>Objectives</h3><div>The aim of the study was to estimate the incidence of dnPPHTN and identify demographic and clinical risk factors for its development.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 506 postpartum individuals delivering at a tertiary care institution over 1 month. Participants were classified as: 1) normotensive; or 2) dnPPHTN, defined as systolic blood pressure (BP) ≥140 mm Hg and/or diastolic BP ≥90 mm Hg on at least 2 occasions up to 6 weeks postpartum after a normotensive pregnancy. We excluded those with prepregnancy or antepartum hypertensive disorders. Demographic and clinical characteristics were compared using adjusted logistic regression models.</div></div><div><h3>Results</h3><div>Of 389 included participants, 35 (9.0%) developed dnPPHTN. Of these, 5.7% had pregestational diabetes compared to 0.6% of normotensive individuals (<em>P</em> = 0.042; adjusted OR: 11.3; 95% CI: 1.8-73.1). Early prenatal diastolic BP was higher in the dnPPHTN group (72.2 vs 68.4 mm Hg, <em>P</em> = 0.008), though this difference did not persist after adjustment. Medication-dependent gestational diabetes mellitus (ie, A2GDM) was associated with dnPPHTN (adjusted OR: 6.1; 95% CI: 1.2-30.1).</div></div><div><h3>Conclusions</h3><div>Pregestational diabetes and A2GDM are associated with dnPPHTN. Closer follow-up for BP monitoring postpartum and more urgent transitions of care for ongoing medical management may reduce long-term cardiovascular risk.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101756"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HDL Cholesterol Is Remarkably Cardioprotective Against Coronary Artery Disease in Native Hawaiians and Pacific Islanders","authors":"Austin Szatrowski BS ,&nbsp;Zane Maggio BS ,&nbsp;Bohdan Khomtchouk PhD","doi":"10.1016/j.jacadv.2025.101741","DOIUrl":"10.1016/j.jacadv.2025.101741","url":null,"abstract":"<div><h3>Background</h3><div>High-density lipoprotein cholesterol (HDL-C) is inversely associated with cardiometabolic risk and exhibits nonlinear effects at extreme levels. Cardiometabolic diseases are a leading cause of death and are particularly prevalent among Native Hawaiian and Pacific Islanders (NHPIs).</div></div><div><h3>Objectives</h3><div>This study characterizes HDL-C’s association with coronary artery disease (CAD), major adverse cardiovascular events (MACE), and type 2 diabetes (T2D) in NHPIs compared to the general population.</div></div><div><h3>Methods</h3><div>Using electronic health record data from the National Institutes of Health All of Us Research Program, we applied Cox proportional hazards models to compare HDL-C’s protective effects on CAD, MACE, and T2D between 261 NHPIs and the remaining cohort (n = 188,802). Models were adjusted for key confounders, and restricted cubic splines were used to assess nonlinear risk dynamics.</div></div><div><h3>Results</h3><div>Tracking individuals across 10,534,661 person-years (mean age 55.7 ± 15.8 years, 38% male), HDL-C was more strongly associated with reduced CAD risk in NHPIs (HR: 0.32; 95% CI: 0.19-0.54) than in the general cohort (HR: 0.57; 95% CI: 0.56-0.58). A marginally stronger association was observed for MACE (NHPI HR: 0.40; 95% CI: 0.23-0.71 vs general HR: = 0.54; 95% CI: 0.53-0.56), while T2D associations were similar. Spline analysis indicated that low HDL-C increases risk for both CAD and T2D in NHPIs.</div></div><div><h3>Conclusions</h3><div>HDL-C’s protective role against cardiometabolic diseases is more pronounced in NHPIs, particularly for CAD. These findings support further investigation into tailored clinical assessments for this population.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101741"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Quantification of Tricuspid Regurgitation With Echocardiography vs 4D Flow Cardiac Magnetic Resonance","authors":"Agata Sularz MB BChir ,&nbsp;Ahmed S. Negm MD ,&nbsp;Alejandra Chavez Ponce MD ,&nbsp;Ahmed El Shaer MD ,&nbsp;Chia-Hao Liu MD ,&nbsp;Jared Bird MD ,&nbsp;Jae Oh MD ,&nbsp;Sorin V. Pislaru MD, PhD ,&nbsp;Jeremy D. Collins MD ,&nbsp;Mohamad Alkhouli MD, MBA","doi":"10.1016/j.jacadv.2025.101759","DOIUrl":"10.1016/j.jacadv.2025.101759","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac magnetic resonance (CMR) is a valuable tool in the assessment of valvular disease. However, its utilization in tricuspid regurgitation (TR) evaluation has been limited.</div></div><div><h3>Objectives</h3><div>The authors sought to compare TR grading with 4D-CMR and transthoracic echocardiography (TTE).</div></div><div><h3>Methods</h3><div>We prospectively recruited patients with ≥ moderate TR on TTE to undergo multiparametric CMR with integrated cardiac function and 4D flow assessments using a 1.5-T scanner (Siemens Somatom Aera). Patients with other severe valvulopathy, end-stage renal disease, or pacemakers were excluded. TR was graded severe on CMR when TR volume ≥45 mL and/or TR fraction ≥50%. The weighted kappa test was used to assess the agreement in overall TR grading on TTE and CMR.</div></div><div><h3>Results</h3><div>Fifty-two patients were enrolled (mean age 78.5 ± 7.6 years, 53.8% men). The median interval between CMR and TTE was 2 days (Q1-Q3: 1-37 days). The agreement between TTE and CMR-derived TR volume was fair (kappa = 0.28, 95% CI: 0.13-0.45), with only 10 of 31 patients (32%) with ≥ severe TR on TTE meeting severe TR volume criterion on CMR (TR volume ≥45 mL). There was no agreement between TTE and CMR-derived TR fraction (kappa = 0.04, 95% CI: 0.13-0.46), with only 3 of 31 patients (13%) with ≥ severe TR on TTE meeting severe TR criterion on CMR (TR fraction ≥50%).</div></div><div><h3>Conclusions</h3><div>Grading of TR was frequently discordant between TTE and 4D magnetic resonance imaging. Further studies are needed to elucidate the clinical impact of concordant/discordant TR grading on multimodality imaging.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101759"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric Heart Valves","authors":"Dominique Vervoort MD, MPH, MBA ,&nbsp;Mimi X. Deng MD ,&nbsp;Jacques Kpodonu MD","doi":"10.1016/j.jacadv.2025.101761","DOIUrl":"10.1016/j.jacadv.2025.101761","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101761"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-Level Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in the United States, 2011 to 2023","authors":"Ryan Chang BA ,&nbsp;Tarang Parekh PhD, MBBS ,&nbsp;Kobina K. Hagan MBChB, MPH ,&nbsp;Zulqarnain Javed MD, PhD, MBBS, MPH ,&nbsp;John W. Ostrominski MD","doi":"10.1016/j.jacadv.2025.101754","DOIUrl":"10.1016/j.jacadv.2025.101754","url":null,"abstract":"","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 6","pages":"Article 101754"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future of Stroke Prevention: 7 Updates in the 2024 AHA/ASA Primary Prevention of Stroke Guideline.","authors":"Alexander C Razavi, Aaron L Troy, Jaideep Patel, Laxmi S Mehta, Jared A Spitz, Donald Lloyd-Jones, Seamus P Whelton, Michelle C Johansen, Roger S Blumenthal","doi":"10.1016/j.jacadv.2025.101724","DOIUrl":"https://doi.org/10.1016/j.jacadv.2025.101724","url":null,"abstract":"<p><p>Approximately 9 to 10 million adults (4%) have experienced a stroke in the United States. While stroke incidence has generally declined, progress has been less pronounced among young individuals, and such trends have underlined the importance of focusing on the primary prevention of stroke. In 2024, the American Heart Association and American Stroke Association released new guidelines for the primary prevention of stroke. Here, we review major updates in 7 domains: dietary modification, glucagon-like peptide-1 receptor agonists, blood pressure targets, lipid-lowering medications, antithrombotic agents, colchicine therapy, and sex-specific preventive risk assessment. Through this process, we review important randomized controlled trial evidence contributing to guideline updates and provide key perspectives on the incorporation of lifestyle and pharmacotherapy for personalized stroke prevention.</p>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":" ","pages":"101724"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults","authors":"Winok Lapidaire PhD ,&nbsp;Afifah Mohamed DPhil ,&nbsp;Wilby Williamson DPhil ,&nbsp;Odaro J. Huckstep DPhil ,&nbsp;Maryam Alsharqi DPhil ,&nbsp;Cheryl M.J. Tan DPhil ,&nbsp;Samuel Burden PhD ,&nbsp;Cameron Dockerill PhD ,&nbsp;William Woodward BSc ,&nbsp;Annabelle McCourt MSc ,&nbsp;Holger Burchert DPhil ,&nbsp;Yvonne Kenworthy BSc ,&nbsp;Luca Biasiolli DPhil ,&nbsp;Helen Dawes PhD ,&nbsp;Charlie Foster PhD ,&nbsp;Paul Leeson MB, PhD ,&nbsp;Adam J. Lewandowski DPhil","doi":"10.1016/j.jacadv.2025.101721","DOIUrl":"10.1016/j.jacadv.2025.101721","url":null,"abstract":"<div><h3>Background</h3><div>People born preterm (&lt;37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation.</div></div><div><h3>Objectives</h3><div>The authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic exercise intervention.</div></div><div><h3>Methods</h3><div>We conducted a randomized controlled trial in 203 adults (aged 18-35 years) with elevated blood pressure or stage 1 hypertension. Participants were randomized 1:1 to a 16-week aerobic exercise intervention or to a control group. In a prespecified cardiovascular magnetic resonance imaging (CMR) substudy, CMR was performed at 3.0-Tesla to assess left and right ventricular (LV and RV) structure and function before and after intervention.</div></div><div><h3>Results</h3><div>A total of 100 participants completed CMR scans at baseline and after the 16-week intervention, with n = 47 in the exercise intervention group (n = 26 term-born; n = 21 preterm-born) and n = 53 controls (n = 32 term-born; n = 21 preterm-born). In term-born participants, LV mass to end-diastolic volume ratio decreased (−3.43; 95% CI: −6.29 to −0.56; interaction <em>P</em> = 0.027) and RV stroke volume index increased (5.53 mL/m²; 95% CI: 2.60, 8.47; interaction <em>P</em> = 0.076) for those in the exercise intervention group vs controls. No significant effects were observed for cardiac structural indices in preterm-born participants. In preterm-born participants, LV basal- and mid-ventricular circumferential strain increased (−1.33; 95% CI: −2.07 to −0.60; interaction <em>P</em> = 0.057 and −1.54; 95% CI: −2.46 to −0.63; interaction <em>P</em> = 0.046, respectively) and RV global longitudinal strain increased (1.99%; 95% CI: −3.12 to −0.87; interaction <em>P</em> = 0.053) in the exercise intervention group vs controls. No significant effects were observed for myocardial deformation parameters in term-born participants.</div></div><div><h3>Conclusions</h3><div>Aerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 5","pages":"Article 101721"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}