JAACAP open最新文献

{"title":"Scope","authors":"","doi":"10.1016/S2949-7329(24)00025-5","DOIUrl":"10.1016/S2949-7329(24)00025-5","url":null,"abstract":"","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Page A1"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732924000255/pdfft?md5=c54401da0830f05acfa5386f384eb05d&pid=1-s2.0-S2949732924000255-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population","authors":"Cees J. Weeland MD, PhD ,&nbsp;Chris Vriend PhD ,&nbsp;Henning Tiemeier PhD ,&nbsp;Odile A. van den Heuvel MD, PhD ,&nbsp;Tonya White MD, PhD","doi":"10.1016/j.jaacop.2023.11.003","DOIUrl":"10.1016/j.jaacop.2023.11.003","url":null,"abstract":"<div><h3>Objective</h3><p>Cross-sectional studies in children with obsessive-compulsive disorder (OCD) have found larger thalamic volume, which is not found at later ages. We previously found that 9- to 12-year-old children from the general population with clinical-level obsessive-compulsive symptoms (OCS) also have a larger thalamus. Thus, using a longitudinal design, we studied the relationship among thalamic volume, cortical maturation, and the course of OCS.</p></div><div><h3>Method</h3><p>Children from the population-based Generation R Study underwent 1 or 2 (N = 2,552) magnetic resonance imaging (MRI) scans between the age of 9 and 16 years (baseline 9-12 years, follow-up 13-16 years). OCS were assessed with the Short Obsessive-Compulsive Disorder Screener (SOCS) questionnaire using both continuous and clinical cut-off measures to identify children with “probable OCD.” We applied linear regression models to investigate the cross-sectional relationship between brain morphology and OCS at age 13 to 16 years. Linear mixed-effect models were fitted to model the bidirectional longitudinal relationship between thalamus and OCS and the thalamus and cortical morphology.</p></div><div><h3>Results</h3><p>Thalamic volume was not different between probable OCD cases and controls at age 13 to 16 years. Higher baseline thalamic volume predicted a relative persistence of OCS and a flatter slope of thinning in 12 cortical regions.</p></div><div><h3>Conclusion</h3><p>Larger thalamic volume may be a subtle biomarker for persistent OCS symptoms. The persistence of OCS and cortical thickness in relation to earlier larger thalamic volume may reflect being at an earlier stage in neurodevelopment. Longitudinal designs with repeated multimodal brain imaging are warranted to improve our understanding of the neurodevelopmental processes underlying OCS and OCD.</p></div><div><h3>Plain language summary</h3><p>In this study utilizing Generation R data, 2,552 children from the general population underwent brain scans and assessment of obsessive-compulsive symptoms on 2 occasions between the ages of 10 and 16 years. The brain scans were used to measure the size and shape of various brain regions, including the thalamus and cortical morphology. Although there were no case-control differences, larger baseline thalamic volume predicted persistence of obsessive compulsive symptoms and a flatter slope of thinning of 12 cortical regions. These findings suggest that brain anatomy, and the thalamus in particular, may be a subtle biomarker for persistent symptoms that occur in obsessive-compulsive disorder.</p></div><div><h3>Study preregistration information</h3><p>Relationship between obsessive-compulsive symptoms and brain morphology in school-aged children in the general population; <span>https://osf.io/</span><svg><path></path></svg>; y6vs2.</p></div>","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 126-134"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732923000650/pdfft?md5=f4337315042b4c6a17b006663d8ff094&pid=1-s2.0-S2949732923000650-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Newly Diagnosed Psychotic Symptoms in Youth Receiving Medications for Attention-Deficit/Hyperactivity Disorder","authors":"Rana Elmaghraby MD ,&nbsp;Andrew Pines MD, MA ,&nbsp;Jennifer R. Geske MS ,&nbsp;Brandon J. Coombes PhD ,&nbsp;Jonathan G. Leung PharmD ,&nbsp;Paul E. Croarkin DO, MS ,&nbsp;Matej Markota MD ,&nbsp;William V. Bobo MD, MPH","doi":"10.1016/j.jaacop.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.jaacop.2024.01.003","url":null,"abstract":"<div><h3>Objective</h3><p>Epidemiological studies suggest that patients with attention-deficit/hyperactivity disorder (ADHD) treated with amphetamines have an increased risk of newly diagnosed psychosis. This risk in youth is poorly understood. This investigation studied the potential risk of newly diagnosed psychotic symptoms associated with exposure to 4 classes of ADHD medications.</p></div><div><h3>Method</h3><p>This retrospective study used a medical records–linkage system from a cohort of youth (age 6-18 years) with diagnosed ADHD who were prescribed amphetamines, methylphenidate, atomoxetine, or α-2 agonists. Cohort members with any diagnosis of psychosis before their first ADHD medication were excluded. The primary outcome was newly diagnosed psychotic symptoms. The risk for psychotic symptoms for each medication (vs the remaining medication classes combined) was estimated using a multivariable time-varying covariate Cox proportional hazard regression model that adjusted for sex and age at ADHD diagnosis.</p></div><div><h3>Results</h3><p>Of 5,171 youth (68.6% male), 134 (2.6 %) had newly diagnosed psychotic symptoms. Exposure to amphetamine (vs amphetamine nonexposure, hazard ratio 1.41, 95% CI 1.15-2.26) and atomoxetine (vs atomoxetine nonexposure, hazard ratio 2.01, 95% CI 1.38-2.92) was associated with increased risk of newly diagnosed psychotic symptoms. Secondary analysis showed that the frequency of newly diagnosed psychotic symptoms was higher with atomoxetine/stimulant lifetime combination therapy (12.5% with amphetamines, 7.7% with methylphenidate) than atomoxetine monotherapy (1.2%).</p></div><div><h3>Conclusion</h3><p>Risk of newly diagnosed psychotic symptoms was low. These results suggest that cumulative exposure to amphetamines or atomoxetine/stimulant lifetime combination therapy may be associated with an increased risk of newly diagnosed psychotic symptoms in youth with ADHD.</p></div><div><h3>Plain language summary</h3><p>This retrospective study, using the Rochester Epidemiology Project, looked at the risk of developing newly diagnosed psychotic symptoms in youth (n = 5,171 between 6- to 18-years-old) with attention-deficit/hyperactivity disorder (ADHD) treated with 4 different classes of US FDA approved medications. The authors found that the overall absolute risk of psychosis was low. The risk of newly diagnosed psychotic symptoms was higher in youth treated with amphetamines and atomoxetine. In addition, this risk was observed when atomoxetine was combined with methylphenidate, amphetamine, or both. Authors suggest that this association may be related to attentional difficulties presenting as a prodromal symptom of psychosis or related to polypharmacy in youth with treatment-resistant ADHD.</p></div><div><h3>Diversity &amp; Inclusion Statement</h3><p>We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepare","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 135-144"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732924000103/pdfft?md5=e6cbebe3333d6e9647bcf26ba50687fb&pid=1-s2.0-S2949732924000103-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent Contributions of Callous-Unemotional Behaviors and Quantitative Autistic Traits to Aggression in Early Childhood","authors":"Kristen Lineback BS ,&nbsp;Holly C. Baer BA Candidate ,&nbsp;Yi Zhang MS ,&nbsp;David Hartenbach BA Candidate ,&nbsp;W. Roger Mills-Koonce PhD ,&nbsp;Michael T. Willoughby PhD ,&nbsp;Anne L. Glowinski MD, MPE ,&nbsp;John N. Constantino MD ,&nbsp;Natasha Marrus MD, PhD","doi":"10.1016/j.jaacop.2023.12.005","DOIUrl":"10.1016/j.jaacop.2023.12.005","url":null,"abstract":"<div><h3>Objective</h3><p>Callous-unemotional (CU) behaviors and quantitative autistic traits (QATs), heritable domains implicated in social development, are both associated with reduced prosocial behavior and increased aggression at their clinical extremes. However, they are hypothesized to contribute to aggression through separate mechanisms. This study tested whether CU behaviors and QATs exhibited distinct profiles of heritable influences as well as independent contributions to early childhood aggression in a general population sample with enhanced sensitivity to clarify these relationships.</p></div><div><h3>Method</h3><p>Parents of 3- to 4-year-old epidemiologically representative twins ascertained from birth records (N = 113 pairs) completed questionnaires measuring CU behaviors, QATs, and aggression. Correlation coefficients indexed overlap across behaviors. Intraclass correlations were compared between monozygotic and dizygotic twins to characterize relative genetic and environmental influences. Generalized estimating equations tested contributions of CU subdomains, verified via factor analysis, and QATs to aggression.</p></div><div><h3>Results</h3><p>Total CU scores strongly correlated with QATs (<em>r</em> = 0.54) and aggression (<em>r</em> = 0.55), while QATs correlated moderately with aggression (<em>r</em> = 0.38). Among 3 identified CU factors, the uncaring factor strongly correlated with QATs (<em>r</em> = 0.52), while unemotional and callous factors showed small correlations (<em>r</em> = 0.25 and <em>r</em> = 0.16, respectively). QATs, aggression, and all CU factors except the callous factor showed heritable influences. Uncaring and callous factors as well as QATs demonstrated unique and shared contributions to aggression, with the callous factor being moderated by sex.</p></div><div><h3>Conclusion</h3><p>Partially overlapping relations support distinct mechanisms whereby CU behaviors, in particular the callous factor, and QATs contribute to early aggression. In-depth social developmental assessment may enhance personalized intervention for aggression in early childhood.</p></div><div><h3>Plain language summary</h3><p>In this cross-sectional dimensional approach, authors evaluated the extent to which callous unemotional behaviors and quantitative autistic traits showed independent contributions to aggression at age 3 to 4 years based on heritable and environmental influences that set the stage for future outcomes. In 224 preschool-aged twins, callous-unemotional behaviors and quantitative autistic traits were independently associated with reduced prosocial behavior and increased aggression, accounting for almost 30% of the variance in aggression and evidence of some shared genetic influences. Callous-unemotional behaviors accounted for a greater unique contribution to variation in aggression than autistic traits. Callous behavior is also strongly influenced by environmental factors and showed a stronger relationship with aggress","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 100-111"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732923000674/pdfft?md5=ee50f41e088faa5f55b9e7fc183b6cfd&pid=1-s2.0-S2949732923000674-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Learning and Preferences in Adolescents With Conduct Problems and Varying Levels of Callous-Unemotional Traits","authors":"Anne Gaule PhD ,&nbsp;Leonardo Bevilacqua PhD ,&nbsp;Lucas Molleman PhD ,&nbsp;Wouter van den Bos PhD ,&nbsp;Anna C. van Duijvenvoorde PhD ,&nbsp;Ruth Roberts PhD ,&nbsp;Christopher R. Pease PhD ,&nbsp;Eamon McCrory DClinPsy, PhD ,&nbsp;Essi Viding PhD","doi":"10.1016/j.jaacop.2023.12.008","DOIUrl":"10.1016/j.jaacop.2023.12.008","url":null,"abstract":"<div><h3>Objective</h3><p>Learning to successfully navigate the social world, in particular when to trust others and how to work together with them, is crucial to well-adjusted social development. This is especially the case during adolescence, when individuals are undergoing significant biological and social changes. Adolescents with conduct problems (CP) tend to have difficulties in social relationships and to display aggressive behaviors as well as reduced cooperation with others. This pattern appears to be particularly pronounced in adolescents with CP and high callous-unemotional traits (CP/HCU). However, very little is currently known about the mechanisms that might drive reduced cooperative behaviors in adolescent CP, and whether these differ for individuals with high vs low levels of CU traits.</p></div><div><h3>Method</h3><p>We used a series of economic games to assess how adolescents with CP/HCU (n = 46), CP, and lower levels of CU traits (CP/LCU) (n = 46), and typically developing adolescents (TD) (n = 59) interacted with social (human) and non-social (computer) partners that varied in their degree of cooperation (trustworthy vs untrustworthy and friendly vs unfriendly), and whether this related to group differences in social preferences (aversion to inequality) and prior beliefs.</p></div><div><h3>Results</h3><p>Adolescents with CP (both HCU and LCU) had more difficulty than TD adolescents in differentiating between trustworthy and untrustworthy social environments in our task. Adolescents with CP/LCU also had more difficulty coordinating with friendly and unfriendly social partners to produce rewarding outcomes than TD adolescents. Surprisingly, we saw no relationship between participants’ inequality aversion or prior beliefs and social learning in our games.</p></div><div><h3>Conclusion</h3><p>These findings indicate that, under controlled experimental conditions, adolescents with CP have more difficulty learning to differentiate between social environments that vary in cooperation, particularly adolescents with CP/LCU. These findings were not explained by inequality aversion or prior beliefs. Our findings also raise important questions regarding methods used to understand the mechanisms underlying social behaviors in adolescents with CP.</p></div><div><h3>Plain language summary</h3><p>In this interesting study of 151 boys between the ages of 11 and 16 years, authors used economic games to investigate how adolescents with conduct problems learn to cooperate with social (human) and nonsocial (computer) partners under various social environments. The authors found that, relative to peers without any conduct problems, adolescents with conduct problems had difficulty gauging trustworthiness in social environments and coordinating with social partners to achieve rewarding outcomes. These findings were not explained by social preferences or prior beliefs. Adolescents with conduct problems and conduct problems with low callous unemotional ","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 79-89"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732924000012/pdfft?md5=1725b7f2fa63ca983c7d5ba253f5bc55&pid=1-s2.0-S2949732924000012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139537754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive, Proactive, Relational, and Slow Dissipation of Aggression in Children","authors":"Daniel A. Waschbusch PhD ,&nbsp;Susan D. Mayes PhD ,&nbsp;James G. Waxmonsky MD ,&nbsp;Dara E. Babinski PhD ,&nbsp;Raman Baweja MD, MS","doi":"10.1016/j.jaacop.2023.12.007","DOIUrl":"10.1016/j.jaacop.2023.12.007","url":null,"abstract":"<div><h3>Objective</h3><p>This study investigated the associations between aggression subtypes (reactive, proactive, relational, and slow dissipation of aggression), callous-unemotional traits (CU), irritability (IRR), and sex among children.</p></div><div><h3>Method</h3><p>The sample included 508 children 5 to 12 years of age, rated by their mothers.</p></div><div><h3>Results</h3><p>A 4-factor model of aggression subtypes (reactive, proactive, relational, slow dissipation) provided a good fit to the data. Correlations between aggression subtypes and demographic variables were generally nonsignificant, except for a unique association between relational aggression and sex, with girls exhibiting higher scores, and proactive aggression was associated with younger age. Both CU and IRR correlated positively with all types of aggression. Slow dissipation of aggression showed a unique association with IRR, whereas reactive aggression was uniquely associated with both CU and IRR. Regressions showed an interaction between CU, IRR, and sex for slow dissipation and relational aggression. Interactions showed that boys with high levels of both CU and IRR demonstrated slower dissipation of aggression, indicating a tendency to hold grudges, and that sex differences in relational aggression depended on the co-occurrence of CU and IRR.</p></div><div><h3>Conclusion</h3><p>This study sheds light on the interplay among aggression subtypes, CU, IRR, and sex in children. Findings emphasize the need for psychiatrists and other mental health professionals to consider the multifaceted nature of aggressive behavior and the role of CU and IRR when assessing aggressive children or developing treatment plans for them. Further research is warranted to examine these relationships longitudinally and across diverse populations.</p></div><div><h3>Plain language summary</h3><p>In this study of 508 children between age 5 to 12, maternal ratings were used to distinguish 4 different types of aggression in their children: reactive (like hitting back when teased), proactive (starting fights), relational (spreading rumors), and slow to cool down (holding grudges). Girls were found to be more relational aggressors, and proactive aggression was more common in younger children. Results also showed that children with certain emotional traits (callous and irritable) were more likely to show all types of aggression, and boys who were both callous and irritable held onto their anger. All 4 types of aggression were associated with externalizing disorders: attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder.</p></div><div><h3>Clinical guidance</h3><p></p><ul><li><span>•</span><span><p>Recognize the different types of aggression: Look beyond angry outbursts and consider reactive, proactive, relational, and slow dissipation of aggression to target intervention.</p></span></li><li><span>•</span><span><p>Emotional traits matter: Assess for callous-unemotiona","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 90-99"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732923000698/pdfft?md5=e09491164564f200660bb2dd2c6451c6&pid=1-s2.0-S2949732923000698-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Childhood Aggression in Autistic and Non-Autistic Preschoolers: Prevalence, Topography, and Relationship to Emotional Reactivity","authors":"Shalini Sivathasan PhD ,&nbsp;Safaa Eldeeb PhD ,&nbsp;Jessie B. Northrup PhD ,&nbsp;Ligia Antezana PhD ,&nbsp;Amy Ionadi PhD ,&nbsp;Lauren S. Wakschlag PhD ,&nbsp;Carla A. Mazefsky PhD","doi":"10.1016/j.jaacop.2023.12.003","DOIUrl":"10.1016/j.jaacop.2023.12.003","url":null,"abstract":"<div><h3>Objective</h3><p>Despite heightened rates of aggressive behaviors among older autistic youth relative to non-autistic peers, less is known about these behaviors during early childhood. This study included 3 objectives to address this gap: (1) to establish the prevalence and topography (frequency, severity, type, context) of aggressive behaviors in a large sample of preschool-aged children using a developmentally sensitive parent-report measure; (2) to identify clinical correlates of aggression; and (3) to investigate whether different subgroups of autistic children can be identified based on their profiles of aggression, emotional reactivity, and autism traits.</p></div><div><h3>Method</h3><p>Data were analyzed from parents of 1,199 children 2 to 5 years of age (n = 622 autistic children) who completed the Multidimensional Assessment Profiles Scales (MAPS) aggression subscale and the Emotion Dysregulation Inventory–Young Child (EDI-YC) reactivity subscale.</p></div><div><h3>Results</h3><p>Autistic preschoolers had 2 to 6 times higher odds of experiencing frequent aggression (more days than not) compared with non-autistic preschoolers. Hierarchical multiple regression analyses revealed that autism diagnosis, traits, and suspected and diagnosed attention-deficit/hyperactivity disorder (ADHD) were positively associated with aggression; however, heightened emotional reactivity explained the greatest degree of added variance in aggression total scores. Machine learning clustering techniques revealed 3 distinct subgroups of autistic preschoolers, with cluster membership driven primarily by aggression and reactivity scores, and less so by autism traits.</p></div><div><h3>Conclusion</h3><p>Autistic preschoolers display more frequent parent-reported aggressive behaviors, and emotional reactivity may play an important role in aggressive behavior presentation. Future developmental screening and early intervention tailoring for aggression may benefit from assessing reactivity early in development.</p></div><div><h3>Plain language summary</h3><p>In this study of 1,199 children aged 2 to 5 years of age (n = 622 autistic children), parents completed validated questionnaires quantifying disruptive behaviors and emotion dysregulation to evaluate prevalence and topography of aggressive behaviors, identifying clinical correlates of aggression, and determining distinct subgroups of children with autism based on patterns of aggression, reactivity, and autism traits. The authors found that preschoolers with autism had higher rates of frequent aggressive behaviors compared to non-autistic children. Although more aggression was associated with having an autism diagnosis, greater levels of autism traits, and attention-deficit/hyperactivity disorder, high levels of aggression were most strongly associated with heightened emotional reactivity. Subgroups of preschoolers with autism emerged principally on their aggression and emotional reactivity scores, rather than","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 112-125"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732923000649/pdfft?md5=b348c2c45d9a36bff92d3ae1375a0979&pid=1-s2.0-S2949732923000649-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138991182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Follow-Up of Adolescents With and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort Longitudinal Assessments","authors":"Jader Piccin MD ,&nbsp;Anna Viduani MSc ,&nbsp;Claudia Buchweitz MA ,&nbsp;Rivka B. Pereira BA ,&nbsp;Aline Zimerman BA ,&nbsp;Guilherme R. Amando MSc ,&nbsp;Victor Cosenza BS ,&nbsp;Leonardo Z. Ferreira PhD ,&nbsp;Natália A.G. McMahon HSD ,&nbsp;Ramásio F. Melo PhD ,&nbsp;Danyella Richter BA ,&nbsp;Frederico D.S. Reckziegel HSD ,&nbsp;Fernanda Rohrsetzer MSc ,&nbsp;Laila Souza MD ,&nbsp;André C. Tonon MD, PhD ,&nbsp;Marina Tuerlinckx Costa-Valle PhD ,&nbsp;Zuzanna Zajkowska PhD ,&nbsp;Ricardo Matsumura Araújo PhD ,&nbsp;Tobias U. Hauser PhD ,&nbsp;Alastair van Heerden PhD ,&nbsp;Christian Kieling MD, PhD","doi":"10.1016/j.jaacop.2023.11.002","DOIUrl":"10.1016/j.jaacop.2023.11.002","url":null,"abstract":"<div><h3>Objective</h3><p>To present the protocol and methods for the prospective longitudinal assessments—including clinical and digital phenotyping approaches—of the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo) study, which comprises Brazilian adolescents stratified at baseline by risk of developing depression or presence of depression.</p></div><div><h3>Method</h3><p>Of 7,720 screened adolescents aged 14 to 16 years, we recruited 150 participants (75 boys, 75 girls) based on a composite risk score: 50 with low risk for developing depression (LR), 50 with high risk for developing depression (HR), and 50 with an active untreated major depressive episode (MDD). Three annual follow-up assessments were conducted, involving clinical measures (parent- and adolescent-reported questionnaires and psychiatrist assessments), active and passive data sensing via smartphones, and neurobiological measures (neuroimaging and biological material samples). Retention rates were 96% (Wave 1), 94% (Wave 2), and 88% (Wave 3), with no significant differences by sex or group (<em>p</em> &gt; .05). Participants highlighted their familiarity with the research team and assessment process as a motivator for sustained engagement.</p></div><div><h3>Discussion</h3><p>This protocol relied on novel aspects, such as the use of a WhatsApp bot, which is particularly pertinent for low- to-middle-income countries, and the collection of information from diverse sources in a longitudinal design, encompassing clinical data, self-reports, parental reports, Global Positioning System (GPS) data, and ecological momentary assessments. The study engaged adolescents over an extensive period and demonstrated the feasibility of conducting a prospective follow-up study with a risk-enriched cohort of adolescents in a middle-income country, integrating mobile technology with traditional methodologies to enhance longitudinal data collection.</p></div><div><h3>Plain language summary</h3><p>This article details the study protocol and methods used in the longitudinal assessment of 150 Brazilian teenagers with depression and at risk for depression as part of the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo). Over 3 years, the authors collected clinical and digital data using innovative mobile technology, including a WhatsApp bot. Most adolescents participated in all the study phases, showing feasibility of prospective follow-up in a middle-income country. This approach allowed for a deeper understanding of depression in young populations, particularly in areas where mental health research is scarce.</p></div>","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"2 2","pages":"Pages 145-159"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949732923000613/pdfft?md5=fbcaf765dc1658f9e6341b74451411a2&pid=1-s2.0-S2949732923000613-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139016747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parent/Guardian- and Self-Report Versions of the Irritability Domain of the Concise Associated Symptom Tracking Scale: Evaluation of Psychometric Properties and Potential Clinical Utility in the Texas Youth Depression and Suicide Research Network","authors":"M. Jha, Abu T. Minhajuddin, Regina B. Baronia, Joseph C. Blader, T. Mayes, Michaella A. Petrosky, Holli M. Slater, Sarah M. Wakefield, Madhukar H. Trivedi","doi":"10.1016/j.jaacop.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.jaacop.2024.04.002","url":null,"abstract":"","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141037904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative Review: A Neurobiological Perspective on Resilience in Youth","authors":"Kiran Khalid, Huma Baqir, Hanna E. Stevens","doi":"10.1016/j.jaacop.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.jaacop.2024.05.001","url":null,"abstract":"","PeriodicalId":73525,"journal":{"name":"JAACAP open","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}