{"title":"Improving ISOMAP Efficiency with RKS: A Comparative Study with t-Distributed Stochastic Neighbor Embedding on Protein Sequences","authors":"Sarwan Ali, Murray Patterson","doi":"10.3390/j6040038","DOIUrl":"https://doi.org/10.3390/j6040038","url":null,"abstract":"Data visualization plays a crucial role in gaining insights from high-dimensional datasets. ISOMAP is a popular algorithm that maps high-dimensional data into a lower-dimensional space while preserving the underlying geometric structure. However, ISOMAP can be computationally expensive, especially for large datasets, due to the computation of the pairwise distances between data points. The motivation behind this study is to improve efficiency by leveraging an approximate method, which is based on random kitchen sinks (RKS). This approach provides a faster way to compute the kernel matrix. Using RKS significantly reduces the computational complexity of ISOMAP while still obtaining a meaningful low-dimensional representation of the data. We compare the performance of the approximate ISOMAP approach using RKS with the traditional t-SNE algorithm. The comparison involves computing the distance matrix using the original high-dimensional data and the low-dimensional data computed from both t-SNE and ISOMAP. The quality of the low-dimensional embeddings is measured using several metrics, including mean squared error (MSE), mean absolute error (MAE), and explained variance score (EVS). Additionally, the runtime of each algorithm is recorded to assess its computational efficiency. The comparison is conducted on a set of protein sequences, used in many bioinformatics tasks. We use three different embedding methods based on k-mers, minimizers, and position weight matrix (PWM) to capture various aspects of the underlying structure and the relationships between the protein sequences. By comparing different embeddings and by evaluating the effectiveness of the approximate ISOMAP approach using RKS and comparing it against t-SNE, we provide insights on the efficacy of our proposed approach. Our goal is to retain the quality of the low-dimensional embeddings while improving the computational performance.","PeriodicalId":73524,"journal":{"name":"J","volume":"64 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of AI-Based Techniques on Moody’s Diagram for Predicting Friction Factor in Pipe Flow","authors":"Ritusnata Mishra, Chandra Shekhar Prasad Ojha","doi":"10.3390/j6040036","DOIUrl":"https://doi.org/10.3390/j6040036","url":null,"abstract":"The friction factor is a widely used parameter in characterizing flow resistance in pipes and open channels. Recently, the application of machine learning and artificial intelligence (AI) has found several applications in water resource engineering. With this in view, the application of artificial intelligence techniques on Moody’s diagram for predicting the friction factor in pipe flow for both transition and turbulent flow regions has been considered in the present study. Various AI methods, like Random Forest (RF), Random Tree (RT), Support Vector Machine (SVM), M5 tree (M5), M5Rules, and REPTree models, are applied to predict the friction factor. While performing the statistical analysis (root-mean-square error (RMSE), mean absolute error (MAE), squared correlation coefficient (R2), and Nash–Sutcliffe efficiency (NSE)), it was revealed that the predictions made by the Random Forest model were the most reliable when compared to other AI tools. The main objective of this study was to highlight the limitations of artificial intelligence (AI) techniques when attempting to effectively capture the characteristics and patterns of the friction curve in certain regions of turbulent flow. To further substantiate this behavior, the conventional algebraic equation was used as a benchmark to test how well the current AI tools work. The friction factor estimates using the algebraic equation were found to be even more accurate than the Random Forest model, within a relative error of ≤±1%, in those regions where the AI models failed to capture the nature and variation in the friction factor.","PeriodicalId":73524,"journal":{"name":"J","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135301750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-Destructive Discrimination of Blue Inks on Suspected Documents through the Combination of Raman Spectroscopy and Chemometric Analysis","authors":"Sruthi Thiraviam Saravanan, Jaysiva Ganesamurthi, Shen-Ming Chen, Tse-Wei Chen, Chun-Jung Chen, Keseven Lakshmanan, Partheeban Chinnamuthu, Xiaoheng Liu, Ramachandran Balaji","doi":"10.3390/j6040035","DOIUrl":"https://doi.org/10.3390/j6040035","url":null,"abstract":"Increasingly sophisticated techniques for falsifying and forging legal documents demand non-destructive and accurate analysis methods. Researchers have extensively investigated ink discrimination through an interdisciplinary analysis involving Raman spectroscopy and chemometrics, which is now regarded as a leading forensic document analysis approach. In this study, a groundbreaking method was developed to identify the specific origin of blue-ink pens used in written documents. By employing Raman spectroscopy in conjunction with principal component analysis (PCA), we successfully differentiated between 45 different blue-ink pens used on various documents. The Raman spectroscopy analysis provided a visual examination of each blue ink’s unique Raman signature, and PCA was then applied to the processed spectral data. Moreover, we successfully distinguished highly similar ink types in documents through the combined use of Raman spectroscopy, Pearson’s correlation analysis, and a statistical approach (PCA).","PeriodicalId":73524,"journal":{"name":"J","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134961005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JPub Date : 2023-09-01Epub Date: 2023-08-08DOI: 10.3390/j6030031
Rajvi N Thakkar, Ivelina P Kioutchoukova, Ian Griffin, Devon T Foster, Pratiksha Sharma, Eduardo Molina Valero, Brandon Lucke-Wold
{"title":"Mapping the Glymphatic Pathway Using Imaging Advances.","authors":"Rajvi N Thakkar, Ivelina P Kioutchoukova, Ian Griffin, Devon T Foster, Pratiksha Sharma, Eduardo Molina Valero, Brandon Lucke-Wold","doi":"10.3390/j6030031","DOIUrl":"10.3390/j6030031","url":null,"abstract":"<p><p>The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e.g., Alzheimer's disease), traumatic brain injury, and subarachnoid hemorrhage. Thus, understanding the function and structure of this system can play a key role in researching the progression and prognoses of these diseases. In this review article, we discuss the current ways to map the glymphatic system and address the advances being made in preclinical mapping. As mentioned, the concept of the glymphatic system is relatively new, and thus, more research needs to be conducted in order to therapeutically intervene via this system.</p>","PeriodicalId":73524,"journal":{"name":"J","volume":"6 3","pages":"477-491"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shervin Assari, Shanika Boyce, Mohsen Bazargan, Cleopatra H Caldwell, Ron Mincy
{"title":"Maternal Education at Birth and Youth Breakfast Consumption at Age 15: Blacks' Diminished Returns.","authors":"Shervin Assari, Shanika Boyce, Mohsen Bazargan, Cleopatra H Caldwell, Ron Mincy","doi":"10.3390/j3030024","DOIUrl":"https://doi.org/10.3390/j3030024","url":null,"abstract":"<p><strong>Background: </strong>Based on the Marginalization-related Diminished Returns (MDRs) framework, high socioeconomic status (SES) such as parental education shows weaker effects for Blacks than Whites. For example, high SES Black individuals report a high level of depression, anxiety, suicide, chronic disease, smoking, and mortality. Limited knowledge exists on MDRs of parental education on dietary behavior.</p><p><strong>Aims: </strong>Built on the MDRs framework, we tested the hypothesis of whether the effect of parental education on eating breakfast differs for Black compared to White families. We hypothesized that there is an association between mothers' educational attainment and eating breakfast and compared Blacks and Whites for the effect of mothers' educational attainment on the frequency of eating breakfast.</p><p><strong>Methods: </strong>The Fragile Families and Child Wellbeing Study is a 15-year follow up study of a random sample of births in cities larger than 200,000 population. The predictor was parental education at birth. The outcome was the frequency of eating breakfast at age 15. Linear regression was used for data analysis.</p><p><strong>Results: </strong>Maternal educational attainment at birth was positively associated with youth frequency of eating breakfast among Whites, not Blacks. We also found a significant interaction between maternal educational attainment at birth and race, suggesting that the association between maternal education and youth frequency of eating breakfast at age 15 was weaker for Black than White families.</p><p><strong>Conclusions: </strong>Diminished returns of maternal educational attainment on healthy youth diet may contribute to the racial disparities in poor health of high SES Black families. That is, a smaller protective effect of maternal education on changing health behaviors for Black than White youth may be one of the mechanisms by which health is worse than expected in high SES Black families. The health disparities are not only due to racial differences in SES but also the diminishing returns of socioeconomic status indicators such as education for racial minorities. Research should study contextual and structural factors that reduce Black families' ability to mobilize their human capital and secure health outcomes in urban settings.</p>","PeriodicalId":73524,"journal":{"name":"J","volume":"3 3","pages":"313-323"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/j3030024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9703801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Riluzole Oral Suspension for the Treatment of Amyotrophic Lateral Sclerosis: Texture and Compatibility with Food Thickeners Evaluation","authors":"G. Colombo, R. Artico, D. Barbareschi","doi":"10.3390/j3030021","DOIUrl":"https://doi.org/10.3390/j3030021","url":null,"abstract":"Riluzole 5 mg/mL oral suspension is the only licensed liquid medicine to treat Amyotrophic Lateral Sclerosis (ALS) orally. As more than 80% of ALS patients develop dysphagia, an oral liquid formulation provides an important therapeutic option. The Riluzole 5 mg/mL oral suspension is administered by means of the graduated oral dosing syringe included in the medicine package. Its concentration (5 mg/mL) is consistent with a small and easy to measure volume (10 mL) to deliver the prescribed 50-mg dose twice daily. This work had a dual objective. The first was to evaluate the texture of the Riluzole 5 mg/mL oral suspension according to the International Dysphagia Diet Standardisation Initiative (IDDSI) flow test. Results of this experiment indicated that Riluzole 5 mg/mL oral suspension would basically fall under the “mildly thick” IDDSI descriptors. This is an important feature because thick fluids facilitate a safer swallow in patients with dysphagia. As a second objective, we evaluated for scientific purposes the compatibility of Riluzole 5 mg/mL oral suspension with some of the most common food thickeners available on the market. Intimate mixtures of the Riluzole 5 mg/mL oral suspension with thickeners were evaluated for appearance, pH, Riluzole assay and Riluzole related substances immediately after preparation and after two hours at room temperature. Riluzole 5 mg/mL oral suspension resulted to be compatible with all the marketed thickeners tested.","PeriodicalId":73524,"journal":{"name":"J","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/j3030021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44222554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Real-Time Sensing and Control of Integrative Horticultural Lighting Systems","authors":"D. Durmus","doi":"10.3390/j3030020","DOIUrl":"https://doi.org/10.3390/j3030020","url":null,"abstract":"Optical radiation, including light, plays a crucial role in the structural development of plants through photomorphogenesis and the response to environmental changes. However, plant sensitivity to optical radiation widely varies across species. While research efforts are currently underway to discover the fundamentals of plant physiology, light sources with preprogrammed light settings (light recipes) are offered to clients to expedite plant growth. Since horticultural lighting research is in its infancy, prescribed lighting conditions are not likely to address every plants’ needs in terms of the spatial and spectral distribution, intensity, and duration of the light sources. However, it is possible to imagine an intelligent horticultural lighting system that can diagnose plants through sensors, and adjust the light intensity, the spatial and spectral distribution for the specific plant species with active feedback. Such an advanced real-time horticultural lighting system would consist of sensors to detect physiological markers from plants and environmental factors and an artificial intelligence algorithm to adjust the output. While the underlying technology for a real-time optimization system exists, the implementation and training would require further research.","PeriodicalId":73524,"journal":{"name":"J","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/j3030020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42620016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Factors that Influence Human Resources on Affordable Housing Delivery within Restraint of Budget","authors":"I. Akinyede, J. Fapohunda, R. Haldenwang","doi":"10.3390/j3030019","DOIUrl":"https://doi.org/10.3390/j3030019","url":null,"abstract":"The study aims to establish the factors influencing human resources on cost, since the construction cost of housing delivery is often above budgeted cost. The challenges occurred due to unsustainable practices in the use of human resources, design-related issues, matching resources availability with cost and time frame problems. The methodology used is a sequential mixed method to achieve the aim and objective of the study, for this purpose, construction managers and stakeholders were considered as research respondents. Data collected was analysed on SPSS software version 25, with the application of a descriptive statistics analysis technique. Findings deduced are involvement of all team members in the planning and implementation process will enhance mutual relationships, less conflict and fewer controversies on design, while documenting delivery roles and responsibilities among construction team members will increase the satisfaction of interest and efficient resources utilisation. This study establishes “factors regulating human resources management on construction cost and “strong component factors influencing human resources on cost”. The study then assembles the factors to develop an operational framework that will control construction resources management on cost, as a guide to improve competency and sustainable techniques for affordable housing delivery within the income limit of the poor people in South Africa.","PeriodicalId":73524,"journal":{"name":"J","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/j3030019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45256621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physicochemical and Bacteriological Quality of Public Swimming Pools in the Tamale Metropolis, Ghana","authors":"U. Mustapha, Seth Mensah Abobi, G. Quarcoo","doi":"10.3390/j3020018","DOIUrl":"https://doi.org/10.3390/j3020018","url":null,"abstract":"The study focused on the physicochemical and bacteriological quality of public swimming pools in the Tamale Metropolis. Physicochemical properties such as pH, temperature, and conductivity, and bacteria counts—including total coliform, faecal coliform, Escherichia coli (E. coli), Staphylococcus aureus, and total heterotrophic bacteria—were analyzed for their conformity with required health standards. The results obtained were analyzed using Student t test and compared with World Health Organization (WHO) and Environmental Protection Agency (EPA) standards for safe recreational and drinking water. The highest and the lowest temperatures were recorded in April (32.53 °C) and February (28.16 °C), respectively. The lowest and the highest mean pH values were 4.04 and 6.13, which were below acceptable standards. The conductivity level varied from 469.1563 µS cm−1 to 928.1563 µS cm−1. While the pH did not conform to acceptable standards, temperature and conductivity were within the EPA and/or the WHO acceptable limits. The total coliform (TC) expressed in colony-forming units per 100 mL ranged from 0 to 397 (cfu/100 mL), faecal coliform (FC) 0 to196 cfu/100 mL, E. coli 0 to 52 cfu/100 mL, Staphylococcus aureus (S. aureus) 8 to 27 cfu/100 mL, and Total Heterotrophic Bacteria (THB) 44 to 197 (cfu/mL). TC, FC, E. coli, S. aureus, and THB counts in most of the samples complied with the bacteriological standards. However, the bacterial loads increased and exceeded the WHO and/or EPA standards as the number of bathers increased. Besides, there were positive correlations between physicochemical parameters such as temperature, pH, and bacterial loads. Most parameters studied met the acceptable standards of recreational water stipulated by the WHO and EPA. However, the presence of pathogenic organisms in the recreational waters at any point in time should be treated as a public health concern, and hence a call for routine monitoring and inspection of public swimming pools in the Tamale Metropolis.","PeriodicalId":73524,"journal":{"name":"J","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/j3020018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48589676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Mozumdar, G. Hagelaar, Gerben van der Velde, S. Omta
{"title":"Determinants of the Business Performance of Women Entrepreneurs in the Developing World Context","authors":"L. Mozumdar, G. Hagelaar, Gerben van der Velde, S. Omta","doi":"10.3390/j3020017","DOIUrl":"https://doi.org/10.3390/j3020017","url":null,"abstract":"Resource-based theory posits the deployment of resources by entrepreneurs to achieve performance without questioning the possibility of deploying these resources. The question, however, remains how resources are deployed in developing countries that constrain the choice in the deployment of resources. To answer this, we analyse the factors determining the business performance of women entrepreneurs in a developing country context. Data were collected through a survey sent to 211 Bangladeshi women entrepreneurs engaged in handicraft businesses. Results from hierarchical multiple regression analyses show that (1) the social environment in terms of socio-cultural norms and customs hinders the performance; (2) the entrepreneurial orientation (EO) dimensions, namely, combined Innovative–proactive EO and Risk-taking EO, and the business trainings positively affect the performance; and (3) the social ties negatively influence the performance, which may be due to the excessive presence of strong ties in a personal social network. Based on results, we suggest that environment (context) is a contingent factor for the way personal traits such as EO, human, and social capital can be used by women entrepreneurs to achieve performance in a developing world context.","PeriodicalId":73524,"journal":{"name":"J","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/j3020017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47039670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}