Ramadan Abouomar, Zameer Hussain Shah, David P Rivas, Sudipta Mallick, Luisa Palmese, Sai S Patkar, Kristi L Kiick, Sambeeta Das
{"title":"FABRICATION OF PATTERNED HYDROGELS WITH CONTROLLED MECHANICAL PROPERTIES USING CHEMICALLY MODIFIED RLPS.","authors":"Ramadan Abouomar, Zameer Hussain Shah, David P Rivas, Sudipta Mallick, Luisa Palmese, Sai S Patkar, Kristi L Kiick, Sambeeta Das","doi":"10.1115/IMECE2025-164092","DOIUrl":"10.1115/IMECE2025-164092","url":null,"abstract":"<p><p>In our study, we created hydrogels containing selectively polymerized regions with distinct mechanical properties by photopolymerizing chemically modified resilin-like polypeptides (RLPs) under a variety of conditions. To promote the formation of microstructures, we utilized a poly(ethylene glycol) crosslinker and employed Digital Micromirror Display (DMD) techniques to pattern the hydrogel. The microstructures of the hydrogels were analyzed using various methods, such as confocal microscopy and scanning electron microscopy, while the local mechanical properties were determined through atomic force microscopy (AFM) measurements. Overall, our work demonstrates a versatile approach for creating hydrogels with spatially varying mechanical properties. The mechanical properties, both inside and outside the illuminated region, can furthermore be adjusted by adding a crosslinker. We find that the microstructure of the hydrogel is different when the hydrogel is crosslinked via DMD compared to a UV lamp, providing an additional method for material property control. These results have potential applications in various fields, including tissue engineering and drug delivery, where the ability to precisely control mechanical properties and microstructures is critical for achieving desired outcomes.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13211947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EFFECT OF SURFACE MODIFICATION ON LONG-TERM MECHANICAL AND TRIBOLOGICAL PERFORMANCE OF BIOMEDICAL POLYMERS.","authors":"Ravi Chandra Madasani, Mohammad Motaher Hossain","doi":"10.1115/imece2025-166637","DOIUrl":"10.1115/imece2025-166637","url":null,"abstract":"<p><p>Long-term mechanical durability of biomedical polymers is essential for their effectiveness in hip and knee joint replacement prostheses, where materials experience various stress situations in the presence of physiological fluids. However, prolonged exposure to physiological fluids can accelerate moisture absorption, leading to mechanical degradation of the polymers. This can significantly reduce the lifespan of polymers used in various biomedical applications, such as total joint replacement prostheses applications. Surface modification can improve hydrophobicity, which can delay moisture absorption and enhance the resistance to mechanical degradation. Among the various surface modification techniques, surface texturing has drawn significant attention as it does not alter the chemical properties of the material. This study investigates the role of surface texturing in improving the long-term mechanical and tribological performance of Ultrahigh Molecular Weight Polyethylene (UHMWPE) and High-Density Polyethylene (HDPE). UHMWPE and HDPE samples with square, cylindrical, and hemispherical micro-protrusions and microcavities were submerged in deionized (DI) water and compared against the mechanical properties of flat samples. Scratch and wear testing was done on flat and textured polymer samples under dry and boundary lubrication scenarios to investigate the effect of surface modification on tribological behavior of polymers. Relationships between long-term mechanical behavior and tribological performance under dry and boundary lubrication scenarios were sought. The findings highlight the crucial role of surface texturing in preserving mechanical and tribological performance under physiological conditions.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"2025 Volume 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IMPACT OF SURFACE TEXTURE ON MOISTURE ABSORPTION AND LONG-TERM MECHANICAL PERFORMANCE OF BIOMEDICAL POLYMERS.","authors":"Ravi Chandra Madasani, Mohammad Motaher Hossain","doi":"10.1115/IMECE2024-145742","DOIUrl":"https://doi.org/10.1115/IMECE2024-145742","url":null,"abstract":"<p><p>Mechanical integrity over time is a crucial factor for various biomedical polymers used in numerous applications, including total joint replacement prostheses applications. However, moisture absorption can significantly affect the long-term mechanical behavior of these polymers, leading to potential degradation and failure. This research investigates how surface texture influences the long-term mechanical behavior of two biomedical polymers, High Density Polyethylene (HDPE) and Ultrahigh Molecular Weight Polyethylene (UHMWPE). A comprehensive analysis is conducted by comparing the mechanical performance of flat/smooth and textured HDPE and UHMWPE specimens subjected to moisture exposure over an extended period. A combination of laser engraving and hot-pressing techniques is used to introduce textures, with variation in geometry and dimension, on the surfaces of model polymers. Tensile tests are performed on both flat/smooth and textured specimens stored under dry condition and in moisture environment for up to 90 days. Effects of moisture absorption on mechanical properties are studied and compared for the flat/smooth samples as well as among different textured samples with varying geometries and dimensions. The results demonstrate that the introduction of surface texture delays moisture absorption compared to flat/smooth samples. This delayed moisture absorption enhances the long-term mechanical durability of polymers under moisture environment. Dynamic mechanical analysis (DMA) is conducted to understand the molecular mechanisms responsible for the observed long-term mechanical behavior. The findings highlight the critical role surface texture plays in mitigating moisture-induced degradation, thereby enhancing the long-term mechanical performance of biomedical polymers in moisture environments.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IMPROVING THE LONG-TERM DURABILITY OF POLYMERS USED IN BIOMEDICAL APPLICATIONS.","authors":"Mohammad Motaher Hossain, Ravi Chandra Madasani","doi":"10.1115/IMECE2023-112796","DOIUrl":"10.1115/IMECE2023-112796","url":null,"abstract":"<p><p>Hydrophobic surfaces can improve the long-term mechanical response of polymers by delaying their degradation caused by moisture absorption over time. This improvement in long-term mechanical performance can significantly increase the lifespan of polymers used in various biomedical applications, such as total joint replacement prostheses applications. Although a number of surface modification techniques have been developed over the years, such as introduction of various textures on the surface; their specific influences on hydrophobicity enhancement as well as long-term mechanical performance are yet to be fully understood. In this study, surface textures, with variation in type and geometry, are introduced on model Ultrahigh Molecular Weight Polyethylene (UHMWPE) and High Density Polyethylene (HDPE) surfaces to study the effect of surface modification on hydrophobicity and long-term mechanical performance under environmental conditions. The results show that introduction of surface textures significantly improves the hydrophobicity of model polymers. Texture length or diameter significantly affects the improvement in hydrophobicity. However, texture spacing does not have significant influence on the improvement in hydrophobicity. How this improvement in hydrophobicity facilitates improving the long-term mechanical performance under environmental conditions is investigated. The study provides useful guidelines to improve the long-term mechanical response of polymers for various applications, including biomedical applications.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"2023 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HYDROPHOBICITY IMPROVEMENTS OF POLYMERS USED IN BIOMEDICAL APPLICATIONS.","authors":"Mohammad Motaher Hossain, Vinay Reddy Lokasani","doi":"10.1115/IMECE2022-95610","DOIUrl":"10.1115/IMECE2022-95610","url":null,"abstract":"<p><p>Improvement in hydrophobicity is important for polymers used in various applications such as biomedical applications, as it can delay their degradation due to long-term exposure to moisture environments. Although a number of surface modification techniques have been developed over the years to improve hydrophobicity, their specific influences on hydrophobicity enhancement as well as long-term mechanical and tribological performances are yet to be fully understood. In this study, surface textures, with variation in type and geometry, are introduced on Ultrahigh Molecular Weight Polyethylene (UHMWPE) and High Density Polyethylene (HDPE) surfaces to study the effect of surface modification on hydrophobicity and long-term mechanical and tribological performances. Based on the theoretical study using Wenzel and Cassie-Baxter models, surface textures of various types and dimension are introduced on UHMWPE and HDPE surfaces. The results show that introduction of surface textures significantly improves the hydrophobicity of polymers. Specific relationship between texture type and geometry, and improvement in hydrophobicity is explored. Based on the comparison between experimental results and theoretical models, transition state modeling seems to be more suitable in describing the change in hydrophobicity with the addition of surface texture. The study provides useful guidelines to improve hydrophobicity of polymers for biomedical applications.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"2022 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205070/pdf/nihms-1897956.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guanyun Liu, Yanzhou Wang, Gang Li, Kevin Cleary, Iulian Iordachita
{"title":"EVALUATION OF NEEDLE DRIVER DESIGNS FOR ROBOT-ASSISTED NEEDLE INSERTIONS UNDER MRI GUIDANCE.","authors":"Guanyun Liu, Yanzhou Wang, Gang Li, Kevin Cleary, Iulian Iordachita","doi":"10.1115/IMECE2022-96678","DOIUrl":"10.1115/IMECE2022-96678","url":null,"abstract":"<p><p>This paper presents the evaluation of two detachable MR-Conditional needle driver designs for our 4-degree-of-freedom (DOF) robotic platform for MRI-guided spinal injections. Compared to their predecessor, the new designs open up the possibility of intraoperative needle driver attachment, and in order to evaluate the feasibility of such an approach, force and torque requried during the needle driver attachment process are captured to evaluate which of the two designs are better suited for such purpose. A simulated clinical scenario is also carried out to measure the possible position change of the 4-DOF robot with respect to the patient due to intraoperative tool attachment, thus providing future guidance to the proposed clinical workflow in the framework of body-mounted robotic surgical devices.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321559/pdf/nihms-1861315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9859820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DEMONSTRATION AND EXPERIMENTAL VALIDATION OF PLASTIC-ENCASED RESONANT ULTRASONIC PIEZOELECTRIC ACTUATOR FOR MRI-GUIDED SURGICAL ROBOTS.","authors":"P. Carvalho, K. Gandomi, C. Nycz, G. Fischer","doi":"10.1115/IMECE2018-87963","DOIUrl":"https://doi.org/10.1115/IMECE2018-87963","url":null,"abstract":"Intra-operative medical imaging based on magnetic resonance imaging (MRI) coupled with robotic manipulation of surgical instruments enables precise feedback-driven procedures. Electrically powered non-ferromagnetic motors based on piezoelectric elements have shown to be well suited for MRI robots. However, even avoiding ferrous materials, the high metal content on commercially available motors still cause distortions to the magnetic fields. We construct semi-custom piezoelectric actuators wherein the quantity of conductive material is minimized and demonstrate that the distortion issues can be partly addressed through substituting several of these components for plastic equivalents, while maintaining motor functionality. Distortion was measured by assessing the RMS change in position of 49 centroid points in a 12.5mm square grid of a gelatin-filled phantom. The metal motor caused a distortion of up to 4.91mm versus 0.55mm for the plastic motor. An additional SNR drop between motor off and motor spinning of approximately 20% was not statistically different for metal versus plastic (p=0.36).","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75691456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amirhossein Farvardin, Mahsan Bakhtiari Nejad, Michael Pozin, M. Armand
{"title":"A BIOMECHANICAL AND THERMAL ANALYSIS FOR BONE AUGMENTATION OF THE PROXIMAL FEMUR.","authors":"Amirhossein Farvardin, Mahsan Bakhtiari Nejad, Michael Pozin, M. Armand","doi":"10.1115/IMECE2018-88583","DOIUrl":"https://doi.org/10.1115/IMECE2018-88583","url":null,"abstract":"In this study, we aim to create and validate a Finite Element (FE) model to estimate the bone temperature after cement injection and compare the simulation temperature results with experimental data in three key locations of the proximal femur. Simulation results suggest that the maximum temperature-rise measured at the bone surface is 10°C which occurs about 12 minutes after the injection. Temperature profiles measured during the experiment showed an agreement with those of the simulation with an average error of 1.73°C Although additional experiments are required to further validate the model, results of this study suggest that this model is a promising tool for bone augmentation planning to lower the risk of thermal necrosis.","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79851267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pengfei Dong, David Prabhu, David L Wilson, Hiram G Bezerra, Linxia Gu
{"title":"OCT-BASED THREE DIMENSIONAL MODELING OF STENT DEPLOYMENT.","authors":"Pengfei Dong, David Prabhu, David L Wilson, Hiram G Bezerra, Linxia Gu","doi":"10.1115/IMECE2017-72146","DOIUrl":"https://doi.org/10.1115/IMECE2017-72146","url":null,"abstract":"<p><p>Stent deployment has been widely used to treat narrowed coronary artery. Its acute outcome in terms of stent under expansion and malapposition depends on the extent and shape of calcifications. However, no clear understanding as to how to quantify or categorize the impact of calcification. We have conducted ex vivo stenting characterized by the optical coherence tomography (OCT). The goal of this work is to capture the ex vivo stent deployment and quantify the effect of calcium morphology on the stenting. A three dimensional model of calcified plaque was reconstructed from ex vivo OCT images. The crimping, balloon expansion and recoil process of the Express stent were characterized. Three cross-sections with different calcium percentages were chosen to evaluated the effect of the calcium in terms of stress/strain, lumen gains and malapposition. Results will be used to the pre-surgical planning.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/IMECE2017-72146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35967677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A MULTISCALE COMPUTATIONAL MODEL FOR THE GROWTH OF THE CRANIAL VAULT IN CRANIOSYNOSTOSIS.","authors":"Chanyoung Lee, Joan T Richtsmeier, Reuben H Kraft","doi":"10.1115/IMECE2014-38728","DOIUrl":"https://doi.org/10.1115/IMECE2014-38728","url":null,"abstract":"<p><p>Craniosynostosis is a condition defined by premature closure of cranial vault sutures, which is associated with abnormalities of the brain and skull. Many causal relationships between discovered mutations and premature suture closure have been proposed but an understanding of the precise mechanisms remains elusive. This article describes a computational framework of biological processes underlying cranial growth that will enable a hypothesis driven investigation of craniosynostosis phenotypes using reaction-diffusion-advection methods and the finite element method. Primary centers of ossification in cranial vault are found using activator-substrate model that represents the behavior of key molecules for bone formation. Biomechanical effects due to the interaction between growing bone and soft tissue is investigated to elucidate the mechanism of growth of cranial vault.</p>","PeriodicalId":73488,"journal":{"name":"International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition","volume":"2014 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/IMECE2014-38728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33248748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}