International journal of oral implantology (Berlin, Germany)最新文献

{"title":"Benefit of azithromycin with platelet-rich fibrin in clinical osteoimmunology regarding autogenous bone grafting: A retrospective cohort study.","authors":"Nicolas Davido, Nicolas Boutin, Bernard Cannas, Benjamin Davido","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Autogenous bone grafting in oral surgery poses significant challenges, particularly in maintaining long-term bone stability. Osteoimmunology, which emphasises the role played by the immune system in bone formation and resorption, has gained attention for improving graft success rates. Azithromycin, a macrolide antibiotic, exhibits immunomodulatory properties, whereas platelet-rich fibrin contains growth factors that promote bone healing.</p><p><strong>Methods: </strong>The present retrospective study analysed 275 patients treated between 2014 and 2023 at a primary care centre in Paris, France. The inclusion criteria required patients to be aged over 18 years and to have undergone autogenous bone grafting using the split bone block technique. Three antibiotic regimens were compared: the standard of care, standard of care combined with platelet-rich fibrin, and standard of care combined with platelet-rich fibrin and azithromycin. The primary outcome was the occurrence of bone resorption or locoregional complications within a 4-month follow-up period.</p><p><strong>Results: </strong>The overall success rate was 75.3%, with major bone resorption observed in 24.7% of cases. Multivariate analysis identified penicillin allergy (P 0.01) and posterior bone defects (maxilla and mandible, P = 0.02 and P = 0.001, respectively), as predictors significantly associated with higher failure rates. In contrast, the combination of platelet-rich fibrin and azithromycin improved outcomes significantly (adjusted odds ratio 8.38, P 0.001).</p><p><strong>Conclusion: </strong>The combination of platelet-rich fibrin and azithromycin markedly enhanced the success of autogenous bone grafts, likely due to the immunomodulatory effects of azithromycin on the receptor activator of nuclear factor NF-κB ligand pathway. These findings support further investigation into this approach, particularly guided bone regeneration.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"159-168"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implant survival, peri-implant health and microbiological contamination of two-piece ceramic implants after 2 years of loading: Results from a prospective study.","authors":"Mika Giulini, Nizar Kassem, Frank Schwarz, Paul Weigl, Andreas Schwiertz, Robert Sader, Jonas Lorenz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Ceramic implants are gradually becoming an alternative to standard titanium implants; however, there is still a lack of scientific data on the former. Thus, the present study was conducted to assess the clinical and microbiological performance of a two-piece ceramic implant system after a mean follow-up period of 2 years.</p><p><strong>Materials and methods: </strong>A total of 17 patients from a collective of 21 from a private dental practice that met the inclusion criteria received 32 two-piece ceramic implants (CERALOG, BioHorizons Camlog, Basel, Switzerland). The implants were restored with single crowns or three-unit fixed partial dentures. Implant survival, probing pocket depth, bleeding on probing, mucosal recession/creeping, keratinised mucosa width, Papilla Presence Index, peri-implant marginal bone level and microbiological contamination were evaluated after a mean loading period of 24 months (range 12 to 41 months).</p><p><strong>Results: </strong>All implants survived and were suitable for retaining prostheses. Probing pocket depth of 3.7 mm ± 0.7 mm and bleeding on probing on 84% of implants were recorded. Sufficient keratinised mucosa width (6.6 ± 2.9 mm) was observed with no mucosal recession/creeping. The Papilla Presence Index varied between 0 and 4 with a mean value of 1.70 ± 1.07. Mean marginal bone loss was 1.2 ± 0.9 mm. Microbiological investigation revealed no statistically significant difference in the total number of bacteria between teeth and implants (P = 0.2278); however, probing pocket depth > 4 mm proved to be a significant predictor for an increased number of bacteria (P 0.001).</p><p><strong>Conclusion: </strong>Within the limitations of the present study, the investigated two-piece ceramic implant system achieved fully satisfying functional and microbiological results. Interpretation of the clinical, radiographic and microbiological results cannot support the hypothesis that ceramic implants are less affected by peri-implant disease.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"135-144"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of full-arch fixed implant-supported prostheses in patients lacking supportive peri-implant care: A cross-sectional study.","authors":"Umberto Gibello, Jacopo Lanzetti, Armando Crupi, Beatrice Longhi, Pedro Molinero-Mourelle, Andrea Roccuzzo, Francesco Pera","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical outcomes and prosthetic complications in patients rehabilitated with full-arch fixed implant-supported prostheses according to the Columbus Bridge Protocol who did not adhere to a structured supportive peri-implant care programme.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 56 patients (mean age 67.8 ± 9.2 years; 28.6% smokers; 80% response rate) rehabilitated with 229 implants (implant survival rate 100%) according to the Columbus Bridge Protocol. Patients were divided into three groups based on follow-up duration: 1 to 2 years (n = 19), 3 to 6 years (n = 16) and > 6 years (n = 21). Through a comprehensive examination, clinical parameters (probing depth, plaque index, bleeding on probing and keratinised tissue width) and mechanical and technical complications were examined by a single experienced operator. Plaque accumulation on the prosthesis was assessed through clinical images using a plaque disclosing solution and ImageJ software (National Institutes of Health, Bethesda, MD, USA). Finally, patient satisfaction was assessed using the Oral Health Impact Profile-14 scale.</p><p><strong>Results: </strong>Mean probing depth values remained stable across groups (2.03 to 2.49 mm, P = 0.125), with most sites ≤ 3 mm. No significant differences were found for bleeding on probing among groups (14.8% to 23.1%, P = 0.331). Plaque levels were high both at implant (43.8% to 57.1%, P = 0.233) and prosthesis level (42.9% to 47.0%, P = 0.707), with no significant differences between groups (P > 0.05). Keratinised tissue width ranged from 3.05 to 3.49 mm (P = 0.650). Prosthetic complications showed an increasing trend as follow-up duration increased (5.3% at 1 to 2 years, 18.8% at 3 to 6 years and 33.3% at > 6 years) (P = 0.086). Overall Oral Health Impact Profile-14 scores indicated a high level of patient satisfaction.</p><p><strong>Conclusions: </strong>Despite the lack of adhesion to a supportive peri-implant care programme, reflected by the high plaque values at implant and prothesis level, the Columbus Bridge Protocol resulted in positive clinical outcomes; however, prosthetic complications occurred and increased over time.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"147-157"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of postoperative complications after lateral sinus floor augmentation: A multidisciplinary clinical consensus utilising the Delphi method.","authors":"Tiziano Testori, Claudio Stacchi, Pietro Felice, Enrico M Strappa, Charlotte Gemelli, Tommaso Clauser, Antonio Rapani, Muhammad H Saleh, Gustavo Avila-Ortiz, Federico Berton, Michael M Bornstein, Daniele Botticelli, Jae-Kook Cha, Hsun-Liang Chan, Roberto Farina, Pablo Galindo-Moreno, Ui-Won Jung, Hyun-Chang Lim, Teresa Lombardi, Thomas Starch-Jensen, Andreas Stavropoulos, Silvio Taschieri, Daniel Thoma, Leonardo Trombelli, Stephen Wallace, Matteo Chiapasco, Ole T Jensen, Jaime Lozada, Michael A Pikos, Roberto Pistilli, Istvan Urban, Pascal Valentini, Francesco Zuffetti, Giovanni Felisati, Alberto Saibene, John R Craig, Hom-Lay Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To achieve a consensus among international experts regarding the management of postoperative complications after maxillary sinus floor elevation.</p><p><strong>Materials and methods: </strong>A total of 32 experts were enrolled and divided into dental implant providers (21), experts with a well-established reputation as sinus specialists (8), ear, nose and throat specialists (2), and experts with a well-established reputation as ear, nose and throat specialists (1). Before starting, a systematic literature search was conducted on the topic, and a list of articles was sent to the panel. The development group formulated 20 statements, which were sent out in the form of a survey. After each round, the statements upon which a consensus was not reached were reformulated based on anonymous comments from participants. A total of three rounds were planned.</p><p><strong>Results: </strong>After the third round, a consensus was reached on 15 key statements regarding the management of postoperative complications following sinus floor elevation. Agreement was established on issues including common postoperative symptoms, use of radiographic assessments, the necessity of surgical interventions such as partial or total graft removal, and the potential need for functional endoscopic sinus surgery. Near-consensus was achieved on additional points concerning normal postoperative symptoms, timing of total graft removal and approaches to late graft infections.</p><p><strong>Conclusions: </strong>The present Delphi consensus suggests that postoperative symptoms such as pain and swelling are generally manageable with appropriate pharmacological treatment. It also outlines conditions where radiographic evaluation is recommended for further assessment. Surgical options, including partial or total graft removal and functional endoscopic sinus surgery, are recommended based on the clinical scenario and response to initial treatments. Variability in practices, particularly regarding antibiotic use and specific intervention timing, suggests a need for further research to be conducted in order to standardise treatment protocols and address gaps in evidence.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"119-133"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echo-guided soft tissue harvesting: A novel approach identifying tissue thickness, density, vascularisation and a safe harvesting zone in the palatal region.","authors":"Leonardo Mancini, Lorenzo Tavelli, Shayan Barootchi, Ronald E Jung, Daniel S Thoma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To utilise high-frequency ultrasound echo intensity as a method for identifying a safe harvesting zone and assessing tissue thickness, density and vascularisation in the palatal region for soft tissue harvesting.</p><p><strong>Materials and methods: </strong>Four consecutive patients requiring soft tissue augmentation were recruited. Optical scans were taken and imported into design software, where customised guides were developed based on the patient's palatal anatomy and the harvesting zone. The guides were tailored to fit the shape of the ultrasound probe. They were 3D printed and allowed for a standardised examination of the palate, the identification of a safe harvesting zone and the evaluation of tissue thickness, quality and vascularisation using high-frequency ultrasound. Following these steps and using an echo-harvesting guide, a de-epithelialised free gingival graft was obtained, ensuring preservation of the main vascular flow while avoiding fatty or glandular tissues.</p><p><strong>Results: </strong>In all four cases, high-frequency ultrasound scans were successfully obtained and the mean measured soft tissue thickness increased from 3.2 mm (anterior) to 6.0 mm (posterior), with a mean transversal increase from 0.9 to 6.0 mm. Ultrasound imaging revealed a layer of hypoechogenic fatty/glandular tissue located 3 to 4 mm beneath the epithelial layer. Using colour Doppler analysis, the vascular flow was identified and mapped to help design a safe harvesting zone. The tissue density, evaluated using a grayscale analysis, showed hypoechogenicity corresponding to fatty/glandular tissues and areas with blood vessels, whereas dense connective tissue appeared isoechoic. This differentiation allowed for precise localisation of the safe harvesting zone, an optimal zone for connective tissue harvesting, while ensuring that regions with higher fat/glandular content and/or large vascular structures were avoided.</p><p><strong>Conclusion: </strong>The echo-guided harvesting approach is a promising technique for soft tissue palatal harvesting, enabling clinicians to identify a standardised safe zone away from major blood vessels when assessing tissue quality and quantity. This approach enhances surgical precision and control, and facilitates preoperative planning for alternative treatments when graft size or tissue quality or quantity are inadequate due to proximity to the greater palatine artery. It is crucial to note that a learning curve is required to interpret the obtained images accurately and integrate this tool into daily clinical practice.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"169-179"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Peri-implant tissue stability: The PROS concept.","authors":"Jonathan Misch, Abdusalam E Alrmali, Pablo Galindo-Fernandez, Muhammad H A Saleh, Hom-Lay Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The following amendments are made to the published article: Int J Oral Implantol 2025;18(1):73-84; First published 17 March 2025.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"181-183"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indications, techniques and complications associated with full-arch rehabilitation using trans-sinus implants: A systematic review and prevalence meta-analysis.","authors":"Francesco Gianfreda, Donato Antonacci, Filiberto Mastrangelo, Carlo Raffone, Leonardo Mancini, Maria Scarpati Cioffari di Castiglione, Vito Carlo Alberto Caponio, Patrizio Bollero","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the failure rate of trans-sinus implants for full-arch rehabilitation in atrophic maxillae, comparing their outcomes to those achieved with axial and tilted implants.</p><p><strong>Materials and methods: </strong>The review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, including studies where patients underwent rehabilitation with trans-sinus implants alone or in combination with axial or zygomatic implants. The review was registered on the International Prospective Register of Systematic Reviews (ID: CRD42024537320). A meta-analysis using Haldane and hybrid corrections compared failure rates between implant types.</p><p><strong>Results: </strong>Out of 2,359 articles, 10 studies employing trans-sinus implants were selected. In the meta-analysis, the trans-sinus group was composed of 232 implants, 5 of which failed, compared to 5 of the 675 implants in the axial/tilted group. There were no statistically significant differences in failure rate between the groups (RRHaldane = 2.80, 95% confidence interval 0.89 to 8.77, P = 0.076; RRHybrid = 2.74, 95% confidence interval 0.91 to 8.17, P = 0.070). The pooled analysis indicated a comparable success rate.</p><p><strong>Conclusions: </strong>Trans-sinus implants represent a viable alternative, in terms of survival rate, to axial/tilted implants for rehabilitation of the atrophic maxilla, minimising the need for invasive procedures such as extensive bone grafting; however, further controlled clinical trials with longer follow-up periods are needed to confirm these results.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"105-116"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to get back in the game.","authors":"Craig M Misch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 2","pages":"95-96"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant human platelet-derived growth factor-BB-mediated reconstructive therapy of advanced peri-implantitis bone defects: A case series.","authors":"Alberto Monje, Ramón Pons, Shayan Barootchi, Muhammad H A Saleh, Paul S Rosen, Anton Sculean","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The treatment of advanced peri-implantitis-related bone defects is often associated with ineffective efforts to halt disease progression. The objective of this case series was to evaluate the performance of reconstructive therapy for the management of advanced peri-implantitis using recombinant human platelet-derived growth factor-BB as an adjunctive biological agent.</p><p><strong>Materials and methods: </strong>A prospective case series study on advanced intrabony peri-implantitis bone defects (≥ 50% bone loss) was performed. Clinical and radiographic variables were collected at baseline (after non-surgical therapy) and 12 months after surgical treatment. Implant surface decontamination of the intrabony component was carried out using titanium brushes and the electrolytic method. Before grafting, recombinant human platelet-derived growth factor-BB was applied on the implant surface. A mixture of mineralised allograft and xenograft hydrated with recombinant human platelet-derived growth factor-BB and covered by a collagen barrier membrane was used for reconstructive therapy. Disease resolution was defined as an absence of bleeding on probing, pocket depth 6 mm and no radiographic evidence of progressive bone loss. Descriptive statistics were performed to assess the effect of treatment on the clinical and radiographic variables.</p><p><strong>Results: </strong>A total of 10 patients exhibiting 13 advanced peri-implantitis-related bone defects were included. Implant survival at the 1-year follow-up was 100%. No major complications occurred during the early healing phase. All the clinical parameters, with the exception of keratinised mucosa, and radiographic parameters yielded statistical significance. In particular, mean pocket depth decreased by 4.5 mm and the mean Sulcus Bleeding Index was reduced by 1.8. Radiographic intrabony defects displayed a significantly narrower, shallower and less angled configuration at the 1-year follow-up. The disease resolution rate at implant level was 61.5%.</p><p><strong>Conclusion: </strong>The surgical reconstructive strategy involving the use of recombinant human platelet-derived growth factor-BB proved to be safe and effective for treating advanced peri-implantitis-related bone defects.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 1","pages":"47-57"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-implant tissue stability: The PROS concept.","authors":"Jonathan Misch, Abdusalam E Alrmali, Pablo Galindo-Fernandez, Muhammad H A Saleh, Hom-Lay Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This manuscript introduces a concept that aims to optimise peri-implant health and ensure stability of peri-implant tissues in dental implant therapy. It encompasses the principles of platform switching, restorative abutment design, optimal (internal conical) connection and subcrestal implant placement, and is thus referred to as the PROS concept. Platform switching involves strategic repositioning of the implant-abutment junction to contain inflammatory infiltrate, whereas restorative abutment design emphasises the importance of abutment height and contour in peri-implant tissue stability. Optimal (internal conical) connection focuses on minimising micromovements to reduce microgaps and enhancing stability, and subcrestal placement explores the benefits of implant placement depth on peri-implant tissue health. By integrating these principles, clinicians can enhance the predictability of peri-implant bone stability, leading to successful outcomes in dental implant therapy. This clinical guideline has been developed in accordance with the Appraisal of Guidelines for Research and Evaluation, ensuring methodological rigour and transparency, and enhancing its credibility and usability in clinical practice.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"18 1","pages":"73-84"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}