International journal of medical students最新文献

{"title":"The Prevalence of Frank’s Sign and the Diagnostic Accuracy in Coronary Artery Disease Among Chest Pain Patients at Lampang Hospital, Thailand","authors":"Kanjanaporn Thammasaranggoon, Narawish Khanthamoon, Pitsinee Sangphet, Aookrit Pattamapornpong, Yotsawee Chotechuang, Maytinee Srisubin, S. Ninwaranon, Jakkrawal Huntrakul","doi":"10.5195/ijms.2022.1760","DOIUrl":"https://doi.org/10.5195/ijms.2022.1760","url":null,"abstract":"Background: One of the leading cause of death in Thailand is coronary artery disease (CAD). There are several studies that demonstrated a significant correlation between diagonal earlobe creases (DELC) or Frank’s sign and CAD, but data in Thai populations still remains unclear. Because of Frank’s sign is easily to observe by health-care professional including medical students, so it was very interesting to use to identify risk of atherosclerosis of the patients in hospital which has limitation of resources. The purpose of the study was to assess the prevalence of Frank’s sign and evaluate the diagnostic accuracy in CAD among the angina chest pain patients at Lampang Hospital.\u0000Methods: This study was a cross-sectional, observational, study. Three hundred and nine patients with angina chest pain who underwent coronary angiography (CAG) and followed up at the coronary clinic at Lampang Hospital were enrolled in the study. Both ears of the patients were inspected for Frank’s sign. The accuracy of Frank’s sign was confirmed by three cardiologists and clinical data was collected in medical record form. We excluded the patients whose earlobe could not be clearly observed, including those with keloid/ulcer on the earlobe or those with no earlobe. The correlation of Frank’s sign and CAD were analyzed by using logistic regression and receiving operative curve (ROC) curve.  \u0000Results: 64.4% of the angina chest pain patients (N=199) have demonstrated for Frank’s sign, unilateral Frank’s sign in 12.3% (N=38) and bilateral Frank’s sign in 52.1% (N=161). Twenty-one patients (6.8%) were normal CAG and 288 patients (93.2%) were significant CAD, single vessel disease CAD (N=86), double vessel disease CAD (N=83) and triple vessel disease CAD (N=119). The diagnostic accuracy of the Frank’s sign revealed that 64.6% for the sensitivity and 38.1% for the specificity. Besides, the positive predictive value (PPV) was 0.935 and for negative predictive value (NPV) showed 0.073. Nevertheless, the positive likelihood ratio (LR+) was 1.032 and 0.947 for the negative likelihood ratio (LR-). Moreover, the area under the curve (AuROC) of Frank’s sign with respect to detection of CAD was 0.513 (95% Confidence Interval was 0.385-0.642, P= 0.838).\u0000 \u0000Conclusion: Frank’s sign was observed in two-third of angina chest pain patients at Lampang Hospital and mostly of the patients with Frank’s sign were significant CAD. The results of this study showed that Frank’s sign was a simple, non-expensive and non-invasive method for medical student and health-care professional to identify risk of CAD.","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84322266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Anemia on Cognitive Ability in School-going Adolescents in an Urban Area in India","authors":"Devyani V. Pattebahadur, D. Patil","doi":"10.5195/ijms.2022.1754","DOIUrl":"https://doi.org/10.5195/ijms.2022.1754","url":null,"abstract":"Background: \u0000Anemia is a major nutritional health problem in India. It poses a significant threat to health due to a decrease in oxygen availability to the body. This predisposes the anemic individual to an increased risk of heart problems, stroke, motor or cognitive developmental delays, infections, and other disturbances. Some studies found a correlation between anemia and low IQ scores while others found no such correlation. The authors decided to perform this study to determine whether such a correlation exists in adolescents, a group that is susceptible to anemia. \u0000  \u0000Methods: \u0000This was a cross-sectional study involving 28 school-going adolescents of an urban area in the age group of 12-15 years, selected by simple random sampling. Individuals with a prior diagnosis of a medical or psychiatric condition were excluded. After obtaining permission from school authorities, ethics committee approval, parental consent, and assent, participants were interviewed using pro forma. Hemoglobin estimation was done by using hemoglobin strips. Cognitive status examination was performed by using Malin’s Intelligence Scale for Indian Children, Addenbrooke’s Cognitive Examination – Revised, and Mini-Mental State Examination. The data was analyzed using Microsoft Excel version 2010. \u0000  \u0000Results: \u000089% of the study population was anemic and 11% was non-anemic. The mean IQ score was 92.4; the mean ACE-R score was 84.2; the mean MMSE score was 26.6. Unpaired t-test was used to analyze the data; tests were done at a 5% significance level. The IQ score +/- standard deviation (SD) in the anemic group was 83.96 +/- 7.74. This score did not reveal any statistically significant difference from the non-anemic group’s IQ score (p = 0.76). The ACE-R score +/- standard deviation (SD) in the anemic group was 84.04 +/- 7.84. This score did not reveal any statistically significant difference from the non-anemic group’s ACE-R score (p = 0.70). The MMSE score +/- standard deviation (SD) in the anemic group was 26.48 +/- 1.66. This score did not reveal any statistically significant difference from the non-anemic group’s MMSE score (p = 0.125). \u0000  \u0000Conclusion: \u0000The findings suggest that the average IQ, MMSE, and ACE-R scores are lower in the anemic group than in the non-anemic group. However, no statistically significant correlation between hemoglobin level and cognitive function was found in this study. \u0000  \u0000Key Words: Anemia, Intelligence, Cognition, Adolescent (Source: MeSH-NLM). \u0000  \u0000Figure or Table: \u0000  \u0000Comparison of cognitive status examination scores in anemic and normal groups \u0000 \u0000 \u0000 \u0000 \u0000Parameter \u0000 \u0000 \u0000Group \u0000 \u0000 \u0000Mean \u0000 \u0000 \u0000Standard Deviation (S.D.) \u0000 \u0000 \u0000Standard Error of Mean \u0000 \u0000 \u0000p-value by unpaired t-test \u0000 \u0000 \u0000 \u0000 \u0000MMSE Score \u0000 \u0000 \u0000Anemic \u0000 \u0000 \u000026.48 \u0000 \u0000 \u00001.66 \u0000 \u0000 \u00000.332 \u0000 \u0000 \u00000.125 \u0000 \u0000 \u0000 \u0000 \u0000Normal \u0000 \u0000 \u000027.67 \u0000 \u0000 \u00001.53 \u0000 \u0000 \u00000.883 \u0000 \u0000 \u0000 \u0000 \u0000Intelligence Quotient \u0000 \u0000 \u0000Anemic \u0000 \u0000 \u000087.22 \u0000 \u0000 \u00005.97 \u0000 \u0000 \u00001.19 \u0000 \u0000 \u00000.76 \u0000 \u0000 \u0000 \u0000 \u0000Normal \u0000 \u0000 \u000093.02 \u0000 \u0000 \u00004.93 \u0000 \u0000 \u00002.85 \u0000 \u0000 \u0000 \u0000 \u0000ACE-R Score","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87141462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Work Practices and Health Problems Among Filling Station Attendants in Ile Ife","authors":"Sodiq O. Lawal, Abdulafeez I. Muhammad, Opeyemi A. Muili, T. O. Ojo","doi":"10.5195/ijms.2022.1835","DOIUrl":"https://doi.org/10.5195/ijms.2022.1835","url":null,"abstract":"Background: Filling Station Attendants are exposed to hazards in their workplaces, which could be physical, chemical, ergonomic, biological, mechanical, or psychosocial. The study aimed to assess the work practices and health problems among filling station attendants in Ile-Ife.\u0000Methods:  This study was conducted in Ile Ife, Osun State, Nigeria using a descriptive cross-sectional study design. There are 218 filling stations in Ile Ife. The total sampling method was used for selection and a sample size of 200 was obtained. Data was collected via Interviewer administered questionnaires with sections assessing sociodemographic characteristics, work practices, occupational hazards, and health problems using close-ended questions. An observational Checklist assessing the safety measures put in place by the management was also obtained. Data were analyzed using Statistical Package for Social Sciences (SPSS) and a p-value of 0.05 was found to be statistically significant.\u0000Results: Majority of the filling station attendants (74%) were not aware of workplace safety practices. Of those that were aware, 78% were aware of PPE while the commonest available PPE was working clothes (36%). One hundred and twelve attendants (56%) indicated that the PPEs available for them were not adequate. Concerning training, about 62.5% had prior safety training of which only 66% and 56% of them could use fire extinguishers and spill kits respectively. Regarding occupational hazards,74.5% of the attendants were aware of the various hazards, the commonest being fire outbreak (69.5). The commonest work-related problem was musculoskeletal disorders (60.5%) while the least common was gastro-intestinal tract problems (8%). There was a significant association between age, working durations of the respondents, and skin problems with p-values of 0.021 and 0.035 respectively. There was also a significant association between BMI and respiratory problems with a p-value of 0.029.\u0000 Conclusion: This study assessed work practices and health problems among filling station attendants. There was poor availability of PPE, inadequate use of PPE as well as poor work safety practices among filling station attendants. Regarding health problems, neurological and eye problems were found to be the commonest among filling station attendants in Ile Ife. There were also significant associations between some sociodemographic characteristics and some health problems such as age and skin problems, working duration and skin problems, BMI, and respiratory problems.","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90254711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical & Dental Students' Perceptions of Health and Well-Being","authors":"H. Mumtaz, M. Rahat, Mehwish Javed, Nadia Zohair, S. Qayyum","doi":"10.5195/ijms.2022.1747","DOIUrl":"https://doi.org/10.5195/ijms.2022.1747","url":null,"abstract":"Objective: As a way to examine how medical & dental students adhere to different dimensions of well-being within the framework of physical, emotional and spiritual well-being,\u0000Methods: A cross-sectional questionnaire study of Riphah International University's 300 medical & dental students from each gender was done from January to December 2010. Predictive Analysis Software (PASW) version 18 assessed the replies ranging from \"no,\" \"sometimes,\" \"usually,\" and \"yes/always\" (numbered 0-4).\u0000Results: The study population consisted of 287 out of the 300 questionnaires, or 95.7% of the total. A total of 103 men (35.89 percent) and 184 women (64.11 percent) participated in the poll. P values of 0.0159 and 0.0240 show that illness and athletic participation have an effect on physical well-being based on gender. Mood swings and family friends had p values of 0.0059 and 0.00, respectively, in relation to emotional well-being. P values of 0.0024 and 0.0116 show that prayer and spiritual fasting have an effect on spiritual well-being. It is clear that spiritual wellbeing is distinct from emotional and bodily wellness, as shown by Tukey's simultaneous comparison t-values (d.f. = 858).\u0000Conclusion: As part of their basic curriculum, medical students should be taught stress and time management methods in order to better handle the stress and demands of practicing medicine. Colleges and institutions need to increase and enhance their research on gender bias in health and wellness.","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76202377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Medical Students in Disseminating Scientific Knowledge - The First IJMS WCMSR","authors":"P. Shah, Cesare Mercalli, Adnan Mujanović, V. Kipkorir, Ciara Egan, Arkadeep Dhali, Camila Velandia, M. Găman, J. Puyana, F. Bonilla-Escobar","doi":"10.5195/ijms.2022.1931","DOIUrl":"https://doi.org/10.5195/ijms.2022.1931","url":null,"abstract":"","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77518297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Undergraduate Research Experience in Term of Benefits, Barriers and Mentorship from Student's Perspectives: A Mixed Quantitative-Qualitative Method","authors":"Hayat Abdoallah Ahmed","doi":"10.5195/ijms.2022.1749","DOIUrl":"https://doi.org/10.5195/ijms.2022.1749","url":null,"abstract":"Background \u0000Undergraduate research has many demonstrated benefits like enhancement of student’s critical thinking, understanding of research process, and soft skills development, yet so many challenges are facing medical students with availability of time being the most cited among many undergraduates. The aim of this study was to assess the undergraduates research experience in terms of benefits, barriers and mentorship from students perspectives. \u0000Methods             \u0000This study used a mixed quantitative-qualitative approach. The quantitative part was observational, analytical cross-sectional study design with census sampling and 900 participants from 3 batches. The qualitative part constructed in 6 focus group discussions with thematic analysis. The data were collected using standardized pre-validated questionnaire for the quantitative data, and structured questions for the qualitative data. Statistical analysis for the quantitative data was performed using Statistical Package for Social Science (SPSS) ® version No. 26, while qualitative data were analyzed using ATLAS.ti 9 software. \u0000Results \u0000From 950 census of the three batches, 900 student filled the questionnaire with 94.7% response rate. The mean age of the participants was 24.7, with 69 % females. After finishing their research only 7.7% published their work (65.3% journal, 16.7% conferences presentations). The highest gains reported from this experience were understanding the research process in the medical field, learning to work independently, and ability to read and understand primary literature, while the lowest were learning laboratory techniques, clarification of career path, and confidence in their potential to be science teachers. Themes generated from the qualitative data regarding undergraduate research benefits were: 1. Research knowledge, 2. Soft skills and 3. Scientific/Academic paradigm. The three most reported barriers were research knowledge and skills (44.4%), mentorship (24.4%), and time management (21.7%). \u0000When assessing mentorship, 28.9% indicated that their supervisor was about average “He was very good, He wasn't always available, but when available he tries to give us everything he can, generally he was so nice” group3, participant4, 15.8%  said he/she is outstanding as a teacher and mentor “she was so supportive (supportive as a supervisor, teacher and even as a mom), she was trying to get the best out of us “ group1, participant1. We investigated the association between students evaluation of their supervisors and their evaluation of the overall research experience, these two variables were moderately correlated (r=.31 ,  P = .000). Also there is a significant positive correlation between supervisor`s evaluation and students tendency to choose another research experience as undergraduates (r= .2 , P= .000). Nevertheless, Supervisor`s evaluation also correlate with the overall benefits from the research experience (r= .2  , P =.000). \u0000Conclusion \u0000Undergraduate re","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86333507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of p66Shc Gene Expression in Liquid Biopsy of Diabetic Patients. Is it Possible to Predict the Onset of Renal Disease?","authors":"Diogo P. Simões, Matheus Moreira Perez, Beatriz da C. Aguiar Alves, J. F. Araújo Encinas, Joyce R. Santos Raimundo, Catherine G. Costas Arcia, Vanessa Lopes Mathia, Maria I. Sacchi Mendonça, L. B. Mesiano Maifrino, N. Murad, F. L. Affonso Fonseca, Glaucia Luciano da Veiga","doi":"10.5195/ijms.2022.1306","DOIUrl":"https://doi.org/10.5195/ijms.2022.1306","url":null,"abstract":"Background: Diabetic nephropathy (DN) is a disorder affecting glomerular function that, histologically, is due to the presence of glomerulosclerosis accompanied with endothelial dysfunction of the afferent and efferent renal arterioles. Insulin resistance in diabetic patients is known to be one of the causes of endothelial dysfunction because it increases oxidative stress, and one of the main genes regulating the production pathways of reactive oxygen species is p66Shc. The aim of this study was to evaluate the p66Shc gene expression as a precocious biomarker of renal dysfunction in diabetic patients, using liquids samples of urine sediment and peripheral blood.\u0000Methods: 29 diabetic patients and 37 healthy donors were recruited from the Centro Universitário FMABC outpatient clinic. The RT-gPCR technique was applied to evaluate p66Shc gene expression in urine and peripheral blood samples from diabetic patients, which were compared with healthy donors.\u0000Results: There was no significant expression of p66Shc gene in samples from diabetic patients compared with healthy donors. However, p66Shc expression in the blood samples of diabetics (0.02417±0.078652-ΔCT, n=29) was 3.6 times higher than in healthy participants (0.00689±0.01758, n=37) while in the urine samples, it was 1.48 times higher in diabetics group (0.02761±0.05412-ΔCT) than in CTL group (0.0186±0.02199).\u0000Conclusion: There was no significant p66Shc gene expression in peripheral blood and urine samples of diabetic patients without kidney injury compared with healthy donors, although there is a tendency for this gene to participate in the oxidative imbalance present in diabetes.","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86007625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COP27 Climate Change Conference: Urgent Action Needed for Africa and the World","authors":"Gregory E. Erhabor, Lilia Zakhama, Paul Yonga, Mohammad Sahar Yassien, James Tumwine, Abdelmadjid Snouber, Siaka Sidibé, Arash Rashidian, Friday Okonofua, David Ofori-Adjei, Fhumulani Mavis Mulaudzi, Joy Muhia, Bob Mash, James Kigera, Jean-Marie Kayembe Ntumba, Abraham Haileamlak, Aiah A. Gbakima, Chris Zielinski","doi":"10.5195/ijms.2022.1693","DOIUrl":"https://doi.org/10.5195/ijms.2022.1693","url":null,"abstract":"","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134904138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxoplasmosis-Associated Lymphadenopathy: Description of a Series of Cases in a Reference Center","authors":"Danna Sofía Salazar Bermúdez, María Fernanda Bocanegra Valencia, Humberto Alejandro Nati Castillo, J. E. Gómez Marín","doi":"10.5195/ijms.2022.1847","DOIUrl":"https://doi.org/10.5195/ijms.2022.1847","url":null,"abstract":"Background: Toxoplasmosis has a more severe manifestation in pregnant women and immunocompromised individuals. Up to 15% of immunocompetent individuals who have acquired the infection may be asymptomatic, however in others the symptoms may be confused with another infection and cause more severe manifestations such as ocular toxoplasmosis which is the most common cause of chorioretinitis and can lead to retinal necrosis. Considering that the clinical characteristics of lymphadenopathy-related toxoplasmosis in Colombia have not been reported despite its high frequency, it is essential to define its clinical presentation.\u0000Objective: The objective was to describe a series of cases, their evolution, clinical characteristics and response to treatment of lymphadenopathy due to toxoplasmosis in a first level health care institution in Armenia, Colombia.\u0000Methods: 106 medical records with a diagnosis of toxoplasmosis-associated lymphadenopathy were reviewed from 2006 to 2022 at the Universidad del Quindío health center. Cases that met the following criteria were included: Presence of lymphadenopathies accompanied or not by fever and positive IgM or IgG anti-Toxoplasma test. Clinical presentation, accompanying symptoms and laboratory tests were analyzed. In the patients who had follow-up, the response to treatment was analyzed.\u0000Results: Of 106 cases, 100 met the selection criteria, 59% male, 30% adolescent. Coinfections occurred in 3% with Epstein-Barr virus (EBV) and 2% Cytomegalovirus. The location was predominately of cervical adenopathies (83%). The main associated symptom was fever with 37%. The main treatment received was Pyrimethamine/Sulfadoxine with 37% having an adequate response.\u0000Conclusions: The clinical manifestations of the infection should guide us to consider the possible presence of lymph node toxoplasmosis. Timely diagnosis and treatment prevent severity and complications in our environment such as ocular involvement which greatly impacts the quality of life of the population.","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89282815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Reproductive Parameters with Dermatoglyphics in Breast Cancer Patients, Healthy and High-Risk Individuals","authors":"Rahul Rangan, S. Shedge, S. Kakade","doi":"10.5195/ijms.2022.1750","DOIUrl":"https://doi.org/10.5195/ijms.2022.1750","url":null,"abstract":"Background\u0000Breast cancer has a wide array of risk factors, and its confounding reproductive aetiologies have been paramount in defining the predictive ability of the disease. Similarly, a strong link between qualitative dermatoglyphic patterns and predisposition to breast cancer has been well documented through genetic linkage. Therefore, this study aimed to discern the affiliation between the aforementioned risk factors of breast cancer. \u0000 \u0000Methods\u0000The study was carried out in 3 groups of 90 age-matched individuals of - breast cancer patients, high-risk individuals and healthy individuals. A detailed reproductive history was taken including factors such as age at menarche, menstrual regularity, age at menopause (if attained), breastfeeding, obstetric parameters and age at first live birth. Qualitative dermatoglyphics were procured through the standardised ink and paper method to get a remarkable rolled fingerprint. The variations in gynaecological and obstetric parameters and qualitative dermatoglyphic patterns were studied and their significance was computed using the chi-square test on InStat software where p values < 0.05 were considered significant with a 95% confidence interval.\u0000 \u0000Results\u0000Highly significant values (p<0.0001) were found in all gynaecological and obstetric parameters where a higher frequency of whorls in breast cancer patients, arches in high-risk individuals and an equivalent frequency of arches and whorls were predisposed to healthy individuals.\u0000 \u0000Limitations\u0000Although this study might have identified certain predominating patterns with higher frequency, the consistency might vary from place to place due to differing dermatoglyphics according to ethnicity. \u0000A small number of patients receiving chemotherapy experienced - chemotherapy-induced adermatoglyphia - where the loss of fingerprints or very faint fingerprints was difficult to perceive. These patients were not included in the study to ensure maximum efficacy in interpreting the dermatoglyphics.\u0000 \u0000Conclusion\u0000Previous attempts failed to link dermatoglyphic indices and reproductive parameters, this study found a significant correlation between the variables in the three distinct groups. Most breast cancer patients are diagnosed late with a majority presenting to doctors in advanced stages where survival rates are marginal, so by this method, we can get a simple, practical, non-invasive and easily affordable screening technique for the above risk factors. This technique could also be employed for non-symptomatic women who might have a positive family history of breast cancer as a part of risk assessment for early diagnosis and treatment. Therefore, paving way for further research into the prognostic abilities of gynaecological parameters through qualitative dermatoglyphic indices.","PeriodicalId":73459,"journal":{"name":"International journal of medical students","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85848205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}