International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering最新文献_第5页

Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness. 卤烷诱导无意识过程中α节律的生物物理模型。

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 2013-01-01 DOI: 10.1109/NER.2013.6696130

Sujith Vijayan, ShiNung Ching, Patrick L Purdon, Emery N Brown, Nancy J Kopell

{"title":"Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness.","authors":"Sujith Vijayan, ShiNung Ching, Patrick L Purdon, Emery N Brown, Nancy J Kopell","doi":"10.1109/NER.2013.6696130","DOIUrl":"https://doi.org/10.1109/NER.2013.6696130","url":null,"abstract":"During the induction of general anesthesia there is a shift in power from the posterior regions of the brain to the frontal cortices; this shift in power is called anteriorization. For many anesthetics, a prominent feature of anteriorization is a shift specifically in the alpha band (8-13 Hz) from posterior to frontal cortices. Here we present a biophysical computational model that describes thalamocortical circuit-level dynamics underlying anteriorization of the alpha rhythm in the case of halothane. Halothane potentiates GABAA and increases potassium leak conductances. According to our model, an increase in potassium leak conductances hyperpolarizes and silences the high-threshold thalamocortical (HTC) cells, a specialized subset of thalamocortical cells that fire at the alpha frequency at relatively depolarized membrane potentials (>-60 mV) and are thought to be the generators of quiet awake occipital alpha. At the same time the potentiation of GABAA imposes an alpha time scale on both the cortical and the thalamic component of the frontal portion of our model. The alpha activity in the frontal component is further strengthened by reciprocal thalamocortical feedback. Thus, we argue that the dual molecular targets of halothane induce the anteriorization of the alpha rhythm by increasing potassium leak conductances, which abolishes occipital alpha, and by potentiating GABAA, which induces frontal alpha. These results provide a computational modeling formulation for studying highly detailed biophysical mechanisms of anesthetic action in silico.","PeriodicalId":73414,"journal":{"name":"International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering","volume":" ","pages":"1104-1107"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/NER.2013.6696130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32721181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Combining Wireless Neural Recording and Video Capture for the Analysis of Natural Gait. 结合无线神经记录和视频捕捉的自然步态分析。

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 2011-04-01 DOI: 10.1109/NER.2011.5910623

Justin D Foster, Oren Freifeld, Paul Nuyujukian, Stephen I Ryu, Michael J Black, Krishna V Shenoy

{"title":"Combining Wireless Neural Recording and Video Capture for the Analysis of Natural Gait.","authors":"Justin D Foster, Oren Freifeld, Paul Nuyujukian, Stephen I Ryu, Michael J Black, Krishna V Shenoy","doi":"10.1109/NER.2011.5910623","DOIUrl":"https://doi.org/10.1109/NER.2011.5910623","url":null,"abstract":"Neural control of movement is typically studied in constrained environments where there is a reduced set of possible behaviors. This constraint may unintentionally limit the applicability of findings to the generalized case of unconstrained behavior. We hypothesize that examining the unconstrained state across multiple behavioral contexts will lead to new insights into the neural control of movement and help advance the design of neural prosthetic decode algorithms. However, to pursue electrophysiological studies in such a manner requires a more flexible framework for experimentation. We propose that head-mounted neural recording systems with wireless data transmission, combined with markerless computer-vision based motion tracking, will enable new, less constrained experiments. As a proof-of-concept, we recorded and wirelessly transmitted broadband neural data from 32 electrodes in premotor cortex while acquiring single-camera video of a rhesus macaque walking on a treadmill. We demonstrate the ability to extract behavioral kinematics using an automated computer vision algorithm without use of markers and to predict kinematics from the neural data. Together these advances suggest that a new class of \"freely moving monkey\" experiments should be possible and should help broaden our understanding of the neural control of movement.","PeriodicalId":73414,"journal":{"name":"International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering","volume":"2011 ","pages":"613-616"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/NER.2011.5910623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33340724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

A multi-timescale adaptive threshold model for the SAI tactile afferent to predict response to mechanical vibration. SAI触觉传入的多时间尺度自适应阈值模型预测机械振动响应。

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 2011-01-01 DOI: 10.1109/NER.2011.5910511

Anila F Jahangiri, Gregory J Gerling

引用次数: 2

Spiking Neural Network Decoder for Brain-Machine Interfaces. 脑机接口的脉冲神经网络解码器。

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 2011-01-01 DOI: 10.1109/NER.2011.5910570

Julie Dethier, Vikash Gilja, Paul Nuyujukian, Shauki A Elassaad, Krishna V Shenoy, Kwabena Boahen

{"title":"Spiking Neural Network Decoder for Brain-Machine Interfaces.","authors":"Julie Dethier, Vikash Gilja, Paul Nuyujukian, Shauki A Elassaad, Krishna V Shenoy, Kwabena Boahen","doi":"10.1109/NER.2011.5910570","DOIUrl":"https://doi.org/10.1109/NER.2011.5910570","url":null,"abstract":"We used a spiking neural network (SNN) to decode neural data recorded from a 96-electrode array in premotor/motor cortex while a rhesus monkey performed a point-to-point reaching arm movement task. We mapped a Kalman-filter neural prosthetic decode algorithm developed to predict the arm's velocity on to the SNN using the Neural Engineering Framework and simulated it using Nengo, a freely available software package. A 20,000-neuron network matched the standard decoder's prediction to within 0.03% (normalized by maximum arm velocity). A 1,600-neuron version of this network was within 0.27%, and run in real-time on a 3GHz PC. These results demonstrate that a SNN can implement a statistical signal processing algorithm widely used as the decoder in high-performance neural prostheses (Kalman filter), and achieve similar results with just a few thousand neurons. Hardware SNN implementations-neuromorphic chips-may offer power savings, essential for realizing fully-implantable cortically controlled prostheses.","PeriodicalId":73414,"journal":{"name":"International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/NER.2011.5910570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31968953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Thalamic bursts mediate pattern recognition 丘脑爆发介导模式识别

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 2009-06-23 DOI: 10.1109/NER.2009.5109358

M. Jändel

引用次数: 2

Application of Matched-Filtering to Extract EEG Features and Decouple Signal Contributions from Multiple Seizure Foci in Brain Malformations. 应用匹配滤波提取脑电信号特征并解耦脑畸形中多个癫痫病灶的信号贡献。

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 2009-06-23 DOI: 10.1109/NER.2009.5109346

Catherine Stamoulis, Bernard S Chang

{"title":"Application of Matched-Filtering to Extract EEG Features and Decouple Signal Contributions from Multiple Seizure Foci in Brain Malformations.","authors":"Catherine Stamoulis, Bernard S Chang","doi":"10.1109/NER.2009.5109346","DOIUrl":"https://doi.org/10.1109/NER.2009.5109346","url":null,"abstract":"Developmental brain malformations often cause intractable and in many cases generalized and/or multifocal seizures. Surgical intervention is not possible in these cases as it is difficult to isolate the epileptogenic foci. Scalp EEG signals recorded during such seizures include coupled contributions from different sources. If it was possible to decouple these contributions based on differences in both their signatures and inter-arrival times at different electrodes, it would subsequently be possible to estimate the locations of the seizure foci. For this purpose, we applied matched filtering to scalp EEG data from 3 patients with multifocal seizures, using patient-specific source-related short EEG segments as the template waveforms. These segments were assumed to be seizure-related based on distinct sets of inter-arrival times at different channels and alternating signal polarities. We present preliminary results and demonstrate that matched filtering can be successfully applied to extract decoupled signal components from the EEG, generated by potentially distinct sources, and thus with distinct inter-arrival times but partially overlapping spectra.","PeriodicalId":73414,"journal":{"name":"International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering","volume":"2009 ","pages":"514-517"},"PeriodicalIF":0.0,"publicationDate":"2009-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/NER.2009.5109346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28958863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

In Vivo Application of Electrical Rejuvenation Pulses to Chronically Implanted Neural Macroelectrodes in Nonhuman Primates for Regulation of Interface Properties 在非人类灵长类动物长期植入的神经大电极上应用电恢复脉冲调节界面特性

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering Pub Date : 1900-01-01 DOI: 10.1109/NER52421.2023.10123750

K. P. O'Sullivan, J. Baker, B. Philip, M. Orazem, K. Otto, C. Butson

{"title":"In Vivo Application of Electrical Rejuvenation Pulses to Chronically Implanted Neural Macroelectrodes in Nonhuman Primates for Regulation of Interface Properties","authors":"K. P. O'Sullivan, J. Baker, B. Philip, M. Orazem, K. Otto, C. Butson","doi":"10.1109/NER52421.2023.10123750","DOIUrl":"https://doi.org/10.1109/NER52421.2023.10123750","url":null,"abstract":"Chronically implanted neural electrodes have become an increasingly important tool in both research and clinical applications, where long-term viability and stability of the electrode-tissue interface (ETI) may be a critical factor in device performance. However, chronic implantation of electrodes in brain tissue typically results in distinct changes to the electrode-tissue interface (ETI), observed as a semicircular arc “tissue component” in Nyquist plots of electrochemical impedance spectroscopy (EIS) measurements. These alterations to electrode-tissue interface properties can interfere with electrode recording characteristics, increase stimulation thresholds, and may create unpredictable behavior in closed-loop applications where neural recordings are used as a control signal. Previous work1,2has demonstrated the potential for direct-current electrical rejuvenation to reduce the impact of “tissue component” impedance on measured EIS spectra in microelectrodes chronically implanted in rodents. Our aim here is to further investigate this phenomenon using macroelectrodes in nonhuman primates (NHPs). Scaled versions of human deep brain stimulation (DBS) and electrocorticography (ECoG) electrodes were chronically implanted in an adult male rhesus macaque nonhuman primate. Both direct-current and alternating-current electrical rejuvenation pulses were found to be sufficiently effective at reducing the appearance of “tissue component” in EIS measurements and dropping impedance, with further investigation needed to determine optimal parameters.","PeriodicalId":73414,"journal":{"name":"International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering","volume":"34 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73596748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0