Interdisciplinary cardiovascular and thoracic surgery最新文献

{"title":"Brain-first strategy for infective endocarditis with infectious intracranial aneurysm: Coil embolization followed by endoscopic mitral valve repair.","authors":"Shigeru Hattori, Soh Hosoba, Takahiro Fujinawa, Yusuke Gunji","doi":"10.1093/icvts/ivag255","DOIUrl":"https://doi.org/10.1093/icvts/ivag255","url":null,"abstract":"<p><p>Infective endocarditis (IE) complicated by infectious intracranial aneurysms (IIAs) presents a therapeutic dilemma, as cardiopulmonary bypass (CPB) with systemic heparinization may trigger aneurysm rupture, whereas delaying surgery carries the risks of the disease worsening. A 38-year-old man presented with active IE caused by Streptococcus agalactiae with severe mitral regurgitation and a symptomatic 5-mm infectious intracranial aneurysm located in the distal left posterior cerebral artery. Urgent cardiac surgery was required but the aneurysm carried a substantial risk of rupture during CPB, endovascular coil embolization was performed first. Five days later, endoscopic minimally invasive mitral valve repair with an autologous pericardial patch was performed without complications. The patient was discharged after four weeks of antibiotic therapy. At six months postoperatively, the patient remains asymptomatic without recurrent infection or valve dysfunction. A staged strategy consisting of preoperative endovascular treatment followed by minimally invasive valve surgery may represent a safe and effective approach for patients with IE complicated by infectious intracranial aneurysms, allowing cardiac surgery while minimizing the risk of intracranial hemorrhage.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8F small-bore versus conventional 24F chest drainage strategies within a standardized thoracic ERAS pathway after Uniportal VATS pulmonary resection.","authors":"Lan Li, Fengyue Cheng, Minglong Li, Wenqi Sun, Ping Cai, Weimin Zhang, Yuan Weng, Jinyou Li","doi":"10.1093/icvts/ivag244","DOIUrl":"https://doi.org/10.1093/icvts/ivag244","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate associations between an 8F small-bore drainage strategy and short-term recovery compared with conventional 24F chest tube drainage after uniportal video-assisted thoracoscopic surgery pulmonary resection within an enhanced recovery after surgery pathway.</p><p><strong>Methods: </strong>We retrospectively studied 217 consecutive pulmonary nodule patients undergoing uniportal video-assisted thoracoscopic surgery pulmonary resection from April 2023 to June 2025. Drain selection reflected routine preference of two senior surgeon teams, not randomization or temporal protocol change. Primary outcomes were postoperative day 3 visual analogue scale pain, chest tube duration, and length of stay. Multivariable regression, inverse probability of treatment weighting, procedure subgroups, and Spearman correlations were used; secondary and exploratory outcomes were interpreted without multiplicity adjustment.</p><p><strong>Results: </strong>For median outcomes, bracketed values denote [1st quartile; 3rd quartile]. The 8F group (n = 97) had lower postoperative day 3 pain (2 [2; 4] vs 3 [2; 4], P = 0.018), shorter tube duration (2 [2; 2] vs 2 [2; 3] days, P < 0.001), and shorter length of stay (4 [4; 5] vs 5 [4; 6] days, P < 0.001) than the 24F group (n = 120). No reinsertion, additional pleural intervention, prolonged air leak, or 30-day readmission occurred. Weighted estimates remained consistent for tube duration and length of stay.</p><p><strong>Conclusions: </strong>In this retrospective cohort, the 8F strategy was associated with faster short-term recovery. Because drain caliber, insertion site, and fixation differed and allocation was non-randomized, findings are hypothesis-generating rather than proof of causal superiority or safety equivalence.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant robotic pericardial window and mediastinal tumor biopsy under intraoperative ultrasound guidance.","authors":"Alfonso Fiorelli, Vincenzo Di Filippo, Antimo Leva, Gaetana Messina","doi":"10.1093/icvts/ivag254","DOIUrl":"https://doi.org/10.1093/icvts/ivag254","url":null,"abstract":"<p><p>Herein, we reported the case of an 83-year-old woman with an undiagnosed mediastinal mass and a loculated, symptomatic pericardial effusion, managed by concomitant robotic pericardial window and tumor biopsy under intraoperative ultrasound guidance, with a final diagnosis of B-cell lymphoma. The patient underwent chemo-immunotherapy; at 6-month follow-up, echocardiogram and chest CT showed tumor shrinkage and no effusion recurrence.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repair of the Anterior mitral leaflet in a growing porcine model using a partially resorbable knitted patch.","authors":"J H Jedrzejczyk, M Hazekamp, M Palmen, S Nemoto, J Honge, J Hjortnaes, T D Jeppesen, J M Hasenkam","doi":"10.1093/icvts/ivag229","DOIUrl":"https://doi.org/10.1093/icvts/ivag229","url":null,"abstract":"<p><p>Mitral valve repair using patch materials is frequently limited by degeneration, inflammation, and calcification, particularly in younger patients. This study evaluated the feasibility and functional durability of a partially resorbable hybrid warp-knitted bioscaffold (Synfolium, Teijin Medical Technologies, Osaka, Japan) for mitral reconstruction in a growing porcine model. In a six-month-old Danish Landrace pig (80 kg), the mitral A2 segment was replaced with a 10 × 30 mm Synfolium patch via left thoracotomy. Postoperative echocardiography demonstrated normal valve function. After 181 days, echocardiography was repeated prior to sacrifice, followed by macroscopic inspection, histological analysis, and high-resolution micro-computed tomography (micro-CT) of the explanted valve. During follow-up, the animal grew to 159 kg. Six-month echocardiography demonstrated preserved valve function with minimal regurgitation despite a 62% increase in annular diameter. Macroscopically, the patch was fully integrated and endothelialised, with no signs of structural failure. Histology demonstrated low-grade chronic inflammation confined to suture interfaces, with no fibrosis or inflammation within the patch matrix. No calcification was identified on histology or micro-CT. In this growing porcine model, mitral leaflet reconstruction using a Synfolium patch preserved valve competence and resisted calcification over six months despite substantial cardiac growth. These findings are encouraging, although repetition of the study is required to confirm the results.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-minute walk distance and long-term outcomes in contemporary left ventricular assist device recipients: the ELEVATE Registry.","authors":"William Herrik Nielsen, Finn Gustafsson, Steven Shaw, Jens Garbade, Michiel Morshuis, Daniel Zimpfer, Jacob Lavee, Laura Walker, Carlye Kraemer, Carlo Gazzola, Diyar Saeed","doi":"10.1093/icvts/ivag241","DOIUrl":"https://doi.org/10.1093/icvts/ivag241","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the prognostic value of Six-minute Walk Distance (6MWD) in stable HeartMate 3 (HM3) recipients.</p><p><strong>Methods: </strong>Data from patients with available 6MWD at six months post-implant were obtained from the prospective, multicenter ELEVATE registry. Overall survival and adverse event rates were analyzed using Cox regression models adjusted for age and sex, with 6MWD as a continuous predictor, and stratified by median distance (350 m).</p><p><strong>Results: </strong>6MWD at six months was available in 194 HM3 recipients. Patients walking <median were older (57 vs. 52 years, p = 0.002), had more comorbidities, and reported lower quality of life. 6MWD correlated positively with hemoglobin (r = 0.20, p = 0.006) and EQ-5D VAS (r = 0.23, p = 0.004), and inversely with NYHA class (r=-0.47, p < 0.0001). Kaplan-Meier analyses of patients walking < > 350 m showed no significant differences in survival (log-rank p = 0.379), right heart failure (p = 0.334), or rehospitalization (p = 0.243), while survival free from hemocompatibility-related adverse events differed significantly, although marginally (p = 0.049). Cox models confirmed that 6MWD had no independent prognostic value for mortality (HR 0.98, 95% CI 0.96-1.01, p = 0.26) or secondary outcomes. However, patients with <median 6MWD experienced higher rates of major bleeding (IRR 2.88, p < 0.001), major infection (IRR 2.14, p < 0.0001), and renal dysfunction (IRR 4.78, p = 0.033).</p><p><strong>Conclusions: </strong>Shorter 6MWD six months after HM3 implantation was associated with a higher risk of some AEs but was not prognostic for mortality, HF recurrence, or rehospitalization risk. The prognostic value of 6MWD in HF patients without circulatory support cannot be extrapolated to patients treated with current LVADs.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital, patient-centered carepath for cardiac surgical care with continuous remote patient monitoring.","authors":"Guylian Stevens, Jelle Fleerakkers, Jules François, Phillipe Ballaux, Koen Cathenis, Pascal Verdonck","doi":"10.1093/icvts/ivag253","DOIUrl":"https://doi.org/10.1093/icvts/ivag253","url":null,"abstract":"<p><p>Postoperative complications and readmissions remain common after cardiac surgery, and intermittent manual vital-sign checks leave patients unmonitored for much of the recovery period. We implemented a phygital care pathway combining Enhanced Recovery After Surgery (ERAS) protocols, and 21-day continuous remote monitoring (heart rate, respiratory rate, temperature, blood pressure, oxygen saturation) with daily review and escalation to a cardiac surgeon when indicated. Quality of Recovery (QoR-15) was assessed on preoperative days -1 and postoperative days 3 and 7, and patient-reported experience (PREM) on day 30. Outcomes in 221 monitored patients (May-November 2025) were compared, retrospectively, with a historical, non-monitored cohort of 206 patients. In the monitored patients, a good-to-excellent QoR increase from 25% to 56% between days 3 and 7 was noticed. Seventy-five patients (34%) required 98 interventions, most commonly primary-care referral or medication adjustment. Thirty-day readmission (12.7% vs 12.1%, Fisher p = 0.88) and mortality (0.45% vs 1.4%, Fisher p = 0.36) did not differ significantly from the control cohort; the monitored group was significantly younger (66.7 vs 70.1 years, p = 0.0004), reflecting probable selection bias from smartphone and digital-literacy eligibility criteria. PREM scores were high (>91%). This pilot demonstrates the feasibility of a digital, patient-centered cardiac surgical pathway; readmission and mortality findings are hypothesis-generating and require prospective confirmation.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the first quality assessment framework for the endocarditis multi-disciplinary team meeting.","authors":"Victoria Rizzo, Evgeny Raevsky, Christopher Primus, Ceri Davies, Satya Das, Cristina Suarez, Shirish Ambekar, Neil Roberts, Nandor Marczin, Rakesh Uppal, Kulvinder Lall, Simon Woldman, Thanos Athanasiou, Tayana Soukup","doi":"10.1093/icvts/ivag219","DOIUrl":"https://doi.org/10.1093/icvts/ivag219","url":null,"abstract":"<p><strong>Objective: </strong>Endocarditis is increasing in incidence with substantial morbidity and mortality. The endocarditis multi-disciplinary team (MDT) is a core guideline recommendation with clear patient outcome benefits by expediting diagnosis, coordinating investigations and management. There is significant variability in content and specialist input, with no validated metric available to assess decision-making or demonstrate improvement over time. MDT-MODe (Metric-for-the-Observation-of-Decision-making) is a validated quality assessment tool extensively utilised for cancer MDTs. This paper describes adaptation of the psychometrically tested MDT-MODe to an endocarditis setting, resulting in the development of MDT-MODIE (Metric-for-the-Observation-of-Decision-making for Infective-Endocarditis).</p><p><strong>Methods: </strong>An expert interview panel was engaged at a single high-volume London centre. Domains were assessed and analysed using a content validity index, through which final MDT-MODIE was defined. Feasibility testing was conducted during MDTs between September 2024 - April 2025. Inter-rater reliability was assessed using intraclass correlation coefficients (ICC), while internal validation was evaluated through point-biserial correlation coefficients. Statistical analyses performed using IBM SPSS Statistics (version29.0).</p><p><strong>Results: </strong>Domains scored as excellent or good were included in MDT-MODIE. Feasibility and reliability testing was performed with 152 patient discussions assessed, and scores matched to decision outcomes for each patient. Inter-rater reliability confirmed across all domains (p < 0.001). Internal Validation demonstrated a positive correlation between overall MODIE scores and MDT decision-making outcomes (rpb(96)=.216, p=0.033).</p><p><strong>Conclusions: </strong>MDT-MODIE provides a reliable framework for evaluating endocarditis MDT decision-making, which has undergone preliminary validation. It addresses a key gap in the literature, supporting cardiac centres in assessing quality of guideline-recommended MDTs and monitoring improvement over time.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of primary mitral valve surgery in pediatric patients: Results from a bi-centric study.","authors":"Alain Poncelet, Jean Rubay, Gebrine El Khoury, Simon Van Bockstaele, Paulien Van Nuffel, Thomas Martens, Katrien François, Thierry Bove","doi":"10.1093/icvts/ivag250","DOIUrl":"https://doi.org/10.1093/icvts/ivag250","url":null,"abstract":"<p><strong>Objectives: </strong>Due to heterogenous mitral valve(MV) disease expression, primary MV surgery in children might be challenging, entailing suboptimal results.</p><p><strong>Methods: </strong>In this bi-centric collaboration all children undergoing primary MV surgery from 1987 to 2023 were included. Patients with atrioventricular septal defect and univentricular physiology were excluded. Study end-points were survival and need for MV reoperation and/or replacement, including multivariable risk factor analysis.</p><p><strong>Results: </strong>Overall 109 patients underwent 158 procedures for predominantly mitral regurgitation(MR)(n = 82, 74.5%) and stenosis(MS)(n = 27, 25.5%), respectively at a median age of 5.7y(IQR 1.6-12) and 0.6y(IQR 0.3-1.2)(p < 0.001). Associated cardiac procedures were performed in 49(45.0%) patients. Primary repair was successful in 103(94.5%) patients, but required 10 early reinterventions(4 re-repair and 6 replacement). Overall 5-year survival was 83.2±4.0% without difference between MV phenotypes(p = 0.871). Risk factors for mortality were MV repair in the first year of life, associated intracardiac correction, and open chest or need for ECMO at completion of surgery. The cumulative incidence of MV reoperation and replacement at 5 years were respectively 27.0±4.7% and 16.5±4.0%, in disadvantage of MS phenotype. MV repair during infancy, MS phenotype, use of commissural or Alfieri-repair and the need for early MV re-repair were significant predictors for later MV reoperation or replacement.</p><p><strong>Conclusion: </strong>Although primary mitral valve surgery in children remains challenging, an acceptable repair is achievable in more than 90%. Whereas younger age at repair is a strong predictor of clinical outcome, repair durability is equally depending on the type of MV disease in disadvantage of the stenosis phenotype.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year durability of aortic root preservation in type A aortic dissection: A single centre experience in 1,333 patients.","authors":"Zheng Zuo, Jun Li, Junyu Zhai, Lili Dong, Hao Lai, Chunsheng Wang","doi":"10.1093/icvts/ivag249","DOIUrl":"https://doi.org/10.1093/icvts/ivag249","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the mid-term outcomes of aortic root preservation in patients with acute type A aortic dissection (ATAAD) and significant preoperative aortic regurgitation (AR).</p><p><strong>Methods: </strong>The study included patients who underwent surgical repair for ATAAD with aortic root preservation from 2005 to 2024. Root preservation was preferred unless limited by severely damaged root intima, significant AR with cusp lesions, dilated sinus, or connective tissue disorder. Patients were stratified into an AR group (moderate or severe AR) and a non-AR group (less than moderate AR). Primary outcomes included overall survival and freedom from recurrent AR.</p><p><strong>Results: </strong>Totally 1,333 patients were included into AR group (n = 369) and non-AR group (n = 964). Overall 30-day mortality was 11.3% (15.2% AR group vs 9.9% non-AR group; P = .006); however, preoperative AR was not associated with early mortality after multivariate adjustment. Overall survival at 10 years was comparable between groups (93.6% vs 92.3%). Freedom from recurrent AR at 10 years was 88% in the AR group compared to 97.1% in the non-AR group (P < .001). In multivariable analysis, intraoperative residual mild AR (Hazard ratio [HR] 4.08, P = .001) and connective tissue disorders (HR 4.36, P = .018) were the strongest predictors of recurrence. Without presence of intraoperative residual mild AR, preoperative moderate/severe AR did not increase risk or late recurrence.</p><p><strong>Conclusions: </strong>Aortic root preservation demonstrated satisfactory mid-term outcomes and may represent a safe and durable strategy for ATAAD with significant preoperative AR. Intraoperative residual mild AR increases risk of recurrence, warranting closer monitoring.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of treatment-related complications on long-term outcomes in recurrence-free survivors with locally advanced non-small cell lung cancer after Trimodality therapy.","authors":"Kazuhiro Okada, Ken Suzawa, Hideki Aoyama, Tsuyoshi Ryuko, Kumi Nakajima, Haruchika Yamamoto, Shin Tanaka, Hidejiro Torigoe, Kazuhiko Shien, Kentaroh Miyoshi, Kotaro Yoshio, Mikio Okazaki, Seiichiro Sugimoto, Takao Hiraki, Junichi Soh, Shinichi Toyooka","doi":"10.1093/icvts/ivag247","DOIUrl":"https://doi.org/10.1093/icvts/ivag247","url":null,"abstract":"<p><strong>Objectives: </strong>Trimodality therapy, consisting of induction chemoradiotherapy followed by surgery, remains a viable treatment option for locally advanced non-small cell lung cancer (LA-NSCLC). However, because this approach constitutes highly intensive local therapy, late adverse events may contribute to long-term, non-cancer-related outcomes. This study sought to clarify the prognostic impact of these events in recurrence-free patients treated with trimodality therapy.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients who underwent trimodality therapy from January 1999 to December 2021 and remained recurrence-free during the follow-up.</p><p><strong>Results: </strong>Of the 199 patients who received trimodality therapy, 112 (56.3%) remained recurrence-free and were included in this analysis. Their median age at surgery was 62.5 years. The clinical stages were stage II (n = 27), stage III (n = 85). The median follow-up was 11.5 years, and the overall survival rates among patients without recurrence at 3, 5, and 10 years were 90.0%, 84.4%, and 71.5%, respectively. Multivariable analysis showed chronic lung injury extending beyond the anatomical segment (P = 0.04) was independent prognostic factors.</p><p><strong>Conclusions: </strong>We observed an association between treatment-related pulmonary morbidity and long-term survival among recurrence-free patients after trimodality therapy. These findings suggest that minimizing treatment-related complications may be important for long-term outcomes.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}