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Immuno-oncology technology最新文献

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83P Effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery in patients with resectable esophageal squamous cell carcinoma: A retrospective cohort study
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100826
X. Liao, X. Chen, W. Hong, F. Chen, G. Li, L. Li
{"title":"83P Effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery in patients with resectable esophageal squamous cell carcinoma: A retrospective cohort study","authors":"X. Liao, X. Chen, W. Hong, F. Chen, G. Li, L. Li","doi":"10.1016/j.iotech.2024.100826","DOIUrl":"10.1016/j.iotech.2024.100826","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100826"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
4MO Role of ctDNA tumor fraction to select immunotherapy based regimens in advanced non-small cell lung cancer
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100888
F.G. Dall'Olio , W.S. Zrafi , D. Vasseur , C.A. Garcia , K. Beshiri , A. Marinello , D. Planchard , L. Lacroix , F. Barlesi , E. Rouleau , A. Italiano , L. Pasquina , R. Madison , B. Besse
{"title":"4MO Role of ctDNA tumor fraction to select immunotherapy based regimens in advanced non-small cell lung cancer","authors":"F.G. Dall'Olio , W.S. Zrafi , D. Vasseur , C.A. Garcia , K. Beshiri , A. Marinello , D. Planchard , L. Lacroix , F. Barlesi , E. Rouleau , A. Italiano , L. Pasquina , R. Madison , B. Besse","doi":"10.1016/j.iotech.2024.100888","DOIUrl":"10.1016/j.iotech.2024.100888","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100888"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
91P Territorial disparities in the use of hospitalization at home for immune checkpoint inhibitors infusion in France between 2021 and 2022
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100834
A.C. Toffart , G. Casanova , M. Pierre , H. Lemasson , V. Moreau-Mallet , N. Pagès , R. Jolivel , A. Panès , M. Chartier , M. Pérol
{"title":"91P Territorial disparities in the use of hospitalization at home for immune checkpoint inhibitors infusion in France between 2021 and 2022","authors":"A.C. Toffart , G. Casanova , M. Pierre , H. Lemasson , V. Moreau-Mallet , N. Pagès , R. Jolivel , A. Panès , M. Chartier , M. Pérol","doi":"10.1016/j.iotech.2024.100834","DOIUrl":"10.1016/j.iotech.2024.100834","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100834"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
47P Correlation of clinical, genetic and transcriptomic traits with PD-L1 positivity in TNBC patients
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.101007
A. Semertzidou , S. Hassanieh , E.M. Wigmore , O. Arqués , Z. Lai , A.E. Storti , M. Heininen-Brown , S. Willis , B. Nuttall , M. Scaltriti , R. Stewart , E. De Bruin , H. Angell
{"title":"47P Correlation of clinical, genetic and transcriptomic traits with PD-L1 positivity in TNBC patients","authors":"A. Semertzidou , S. Hassanieh , E.M. Wigmore , O. Arqués , Z. Lai , A.E. Storti , M. Heininen-Brown , S. Willis , B. Nuttall , M. Scaltriti , R. Stewart , E. De Bruin , H. Angell","doi":"10.1016/j.iotech.2024.101007","DOIUrl":"10.1016/j.iotech.2024.101007","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 101007"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
15P Verteporfin might potentiate the effects of anti-PD-1 therapy in melanoma-bearing mice model
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100898
S.A. Kovács , T. Kovács , A. Lánczky , Á. Paál , Z. Hegedus , A. Kovács , L. Szabó , N. Sayour , Z. Varga , P. Ferdinandy , J.T. Fekete , B. Győrffy
{"title":"15P Verteporfin might potentiate the effects of anti-PD-1 therapy in melanoma-bearing mice model","authors":"S.A. Kovács , T. Kovács , A. Lánczky , Á. Paál , Z. Hegedus , A. Kovács , L. Szabó , N. Sayour , Z. Varga , P. Ferdinandy , J.T. Fekete , B. Győrffy","doi":"10.1016/j.iotech.2024.100898","DOIUrl":"10.1016/j.iotech.2024.100898","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100898"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2O TILs and PD-L1 early dynamics in the randomized Neo-CheckRay phase II trial evaluating neo-adjuvant immuno-radiation and adenosine pathway blockade for early-stage, high risk ER+/HER2- breast cancer (BC)
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100886
A. De Caluwé , X. Catteau , Z. Denis , M. Carausu , I. Desmoulins , E. Romano , V. Remouchamps , A. Baten , P. Poortmans , C. Van Marcke , F. Rothé , M. Ignatiadis , M. Piccart , D. Larsimont , J. Stagg , C. Sotiriou , R.F. Salgado , L. Buisseret
{"title":"2O TILs and PD-L1 early dynamics in the randomized Neo-CheckRay phase II trial evaluating neo-adjuvant immuno-radiation and adenosine pathway blockade for early-stage, high risk ER+/HER2- breast cancer (BC)","authors":"A. De Caluwé , X. Catteau , Z. Denis , M. Carausu , I. Desmoulins , E. Romano , V. Remouchamps , A. Baten , P. Poortmans , C. Van Marcke , F. Rothé , M. Ignatiadis , M. Piccart , D. Larsimont , J. Stagg , C. Sotiriou , R.F. Salgado , L. Buisseret","doi":"10.1016/j.iotech.2024.100886","DOIUrl":"10.1016/j.iotech.2024.100886","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100886"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ESMO Immuno-Oncology Congress 2024 Officers
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/S2590-0188(24)00317-4
{"title":"ESMO Immuno-Oncology Congress 2024 Officers","authors":"","doi":"10.1016/S2590-0188(24)00317-4","DOIUrl":"10.1016/S2590-0188(24)00317-4","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 101020"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
99P Real-world management of ir-colitis: A Danish 10-year cohort study
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100842
S.K. Petersen , S. Madley , J. Kjeldsen , L. Bastholt , C.H. Ruhlmann
{"title":"99P Real-world management of ir-colitis: A Danish 10-year cohort study","authors":"S.K. Petersen , S. Madley , J. Kjeldsen , L. Bastholt , C.H. Ruhlmann","doi":"10.1016/j.iotech.2024.100842","DOIUrl":"10.1016/j.iotech.2024.100842","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100842"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Durable complete response after combined treatment with tumor-infiltrating lymphocytes and oncolytic adenovirus (TILT-123) in a patient with metastatic mucosal melanoma 转移性粘膜黑色素瘤患者在肿瘤浸润淋巴细胞和溶瘤腺病毒（TILT-123）联合治疗后的持久完全缓解。
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100726
T.J. Monberg , T. Kudling , B. Albieri , S. Pakola , E. Ellebaek , M. Donia , R.L. Eefsen , C. von Buchwald , C. Kistler , J.M. Santos , J. Clubb , L. Haybout , M.C.W. Westergaard , D.C.A. Quixabeira , E. Jirovec , R. Havunen , S. Sorsa , V. Cervera-Carrascon , A. Hemminki , I.M. Svane
{"title":"Durable complete response after combined treatment with tumor-infiltrating lymphocytes and oncolytic adenovirus (TILT-123) in a patient with metastatic mucosal melanoma","authors":"T.J. Monberg ,&nbsp;T. Kudling ,&nbsp;B. Albieri ,&nbsp;S. Pakola ,&nbsp;E. Ellebaek ,&nbsp;M. Donia ,&nbsp;R.L. Eefsen ,&nbsp;C. von Buchwald ,&nbsp;C. Kistler ,&nbsp;J.M. Santos ,&nbsp;J. Clubb ,&nbsp;L. Haybout ,&nbsp;M.C.W. Westergaard ,&nbsp;D.C.A. Quixabeira ,&nbsp;E. Jirovec ,&nbsp;R. Havunen ,&nbsp;S. Sorsa ,&nbsp;V. Cervera-Carrascon ,&nbsp;A. Hemminki ,&nbsp;I.M. Svane","doi":"10.1016/j.iotech.2024.100726","DOIUrl":"10.1016/j.iotech.2024.100726","url":null,"abstract":"<div><h3>Background</h3><div>Despite significant advancements in the treatment of malignant melanoma, metastatic mucosal melanoma remains a therapeutic challenge due to its complex pathogenesis, distinct pathological characteristics, and limited response to immunotherapy. Combining different immunotherapeutic approaches offers a potential strategy to address these challenges. Tumor-infiltrating lymphocyte (TIL) therapy and oncolytic virus therapy represent promising treatment modalities that may synergize with each other.</div></div><div><h3>Patient and methods</h3><div>We present a case of a 48-year-old woman with metastatic sinonasal mucosal melanoma who achieved a durable complete pathological response following treatment with multiple injections of the oncolytic virus TILT-123 (igrelimogene litadenorepvec) and a single infusion of TILs, without preconditioning chemotherapy or postconditioning interleukin-2.</div></div><div><h3>Results</h3><div>Immunohistochemical analysis and single-cell sequencing revealed interesting alterations in injected and noninjected tumors as well as in peripheral blood, during the treatment course, suggesting that TILT-123 facilitated TIL engraftment into the tumor, ultimately leading to a complete response.</div></div><div><h3>Conclusions</h3><div>This case underscores the potential of combined immunotherapeutic approaches as a promising strategy for patients with metastatic mucosal melanoma.</div></div>","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100726"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10P Tumor-infiltrating lymphocytes and tertiary lymphoid structures in oral cavity squamous cell carcinoma in non-smokers and non-drinkers: Predict clinical outcome
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100893
I.A. Laklouk
{"title":"10P Tumor-infiltrating lymphocytes and tertiary lymphoid structures in oral cavity squamous cell carcinoma in non-smokers and non-drinkers: Predict clinical outcome","authors":"I.A. Laklouk","doi":"10.1016/j.iotech.2024.100893","DOIUrl":"10.1016/j.iotech.2024.100893","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100893"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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